Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0016 | 0.0028 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0116 | 0.3934 | 1 |
Schistosoma mansoni | immunophilin | 0.0116 | 0.3934 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0116 | 0.3934 | 0.3934 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0116 | 0.3934 | 1 |
Schistosoma mansoni | immunophilin | 0.0116 | 0.3934 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0638 | 0.0638 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0116 | 0.3934 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0016 | 0.0028 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0066 | 0.0038 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0116 | 0.3934 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0638 | 0.1622 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0016 | 0.0028 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0116 | 0.3934 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.01 | 0.3311 | 0.8416 |
Schistosoma mansoni | lamin | 0.0031 | 0.0638 | 0.1562 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0116 | 0.3934 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.027 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0016 | 0.0028 | 0.5 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0116 | 0.3934 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0016 | 0.0028 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0116 | 0.3934 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0116 | 0.3934 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0016 | 0.0028 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0116 | 0.3934 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0116 | 0.3934 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0016 | 0.0028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0028 | 0.0028 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0638 | 0.1562 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0638 | 0.0612 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0116 | 0.3934 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0638 | 0.0638 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0638 | 0.1622 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0638 | 0.1622 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0116 | 0.3934 | 1 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0016 | 0.0028 | 0.0071 |
Schistosoma mansoni | immunophilin | 0.01 | 0.3311 | 0.8404 |
Onchocerca volvulus | 0.0031 | 0.0638 | 1 | |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0016 | 0.0028 | 0.0028 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0638 | 0.0612 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0116 | 0.3934 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0116 | 0.3934 | 0.3917 |
Echinococcus multilocularis | fk506 binding protein | 0.0116 | 0.3934 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0116 | 0.3934 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0116 | 0.3934 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0116 | 0.3934 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0116 | 0.3934 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0016 | 0.0028 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0616 | 0.0616 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0116 | 0.3934 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0016 | 0.0028 | 0.5 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0016 | 0.0028 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0116 | 0.3934 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0016 | 0.0028 | 0.0028 |
Leishmania major | fk506-binding protein 1-like protein | 0.0116 | 0.3934 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0016 | 0.0028 | 0.0028 |
Schistosoma mansoni | lamin | 0.0031 | 0.0638 | 0.1562 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3311 | 0.3311 |
Echinococcus multilocularis | 0.0016 | 0.0028 | 0.0071 | |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0638 | 0.1622 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0116 | 0.3934 | 1 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0016 | 0.0028 | 0.0071 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0116 | 0.3934 | 0.3917 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0116 | 0.3934 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0638 | 0.1622 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.01 | 0.3311 | 0.8416 |
Trichomonas vaginalis | immunophilin, putative | 0.0116 | 0.3934 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0116 | 0.3934 | 0.3934 |
Onchocerca volvulus | 0.0031 | 0.0638 | 1 | |
Echinococcus granulosus | lamin | 0.0031 | 0.0638 | 0.1622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.