Detailed information for compound 1473763

Basic information

Technical information
  • TDR Targets ID: 1473763
  • Name: 2-dimethylaminoethyl 3-chloro-1-benzothiophen e-2-carboxylate
  • MW: 283.774 | Formula: C13H14ClNO2S
  • H donors: 0 H acceptors: 1 LogP: 3.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCOC(=O)c1sc2c(c1Cl)cccc2)C
  • InChi: 1S/C13H14ClNO2S/c1-15(2)7-8-17-13(16)12-11(14)9-5-3-4-6-10(9)18-12/h3-6H,7-8H2,1-2H3
  • InChiKey: PADDSAMWWZFBND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-dimethylaminoethyl 3-chlorobenzothiophene-2-carboxylate
  • 3-chloro-2-benzothiophenecarboxylic acid 2-dimethylaminoethyl ester
  • 3-chlorobenzothiophene-2-carboxylic acid 2-dimethylaminoethyl ester
  • EU-0002216
  • 3-Chloro-benzo[b]thiophene-2-carboxylic acid 2-dimethylamino-ethyl ester
  • BAS 00016259
  • Oprea1_589971
  • TimTec1_006411
  • Oprea1_658485
  • CBDivE_013460

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.036 0.1144
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0207 0.089
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.018 0.018
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0628 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0481 0.0567
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0124 0.0146
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.0988 0.0988
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0164 0.0164
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Echinococcus multilocularis geminin 0.0165 0.193 0.193
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Mycobacterium leprae conserved hypothetical protein 0.0043 0.036 1
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0124 0.1809
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0117 0.1307 0.1307
Echinococcus multilocularis dna polymerase eta 0.0019 0.0041 0.0041
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0375 0.7299
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.1144
Trypanosoma brucei heat shock protein, putative 0.0032 0.0207 0.2827
Brugia malayi Bromodomain containing protein 0.0075 0.0766 0.2431
Echinococcus multilocularis FTZ F1 alpha 0.003 0.018 0.018
Brugia malayi nuclear receptor NHR-88 0.003 0.018 0.0573
Loa Loa (eye worm) hypothetical protein 0.0026 0.0137 0.0435
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.0229 0.0229
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0041 0.0048
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3392 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0164 0.1921 0.6098
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0308 0.0364
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.036 0.0954
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0117 0.1307 0.1541
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.2163 0.255
Entamoeba histolytica hypothetical protein 0.0035 0.0251 0.357
Brugia malayi Bromodomain containing protein 0.0147 0.1693 0.5375
Brugia malayi beta-lactamase family protein 0.0043 0.036 0.1144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.018 0.0213
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.036 0.0954
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.036 0.6981
Trypanosoma brucei heat shock protein, putative 0.0032 0.0207 0.2827
Schistosoma mansoni endoplasmin 0.0032 0.0207 0.0244
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0207 0.089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.018 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.018 0.0573
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0207 0.2827
Brugia malayi jmjC domain containing protein 0.0025 0.0115 0.0366
Loa Loa (eye worm) RNA binding protein 0.0062 0.0595 0.1888
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.0229 0.027
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1037 0.1223
Brugia malayi beta-lactamase family protein 0.0043 0.036 0.1144
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.018 0.0573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.018 0.0573
Plasmodium falciparum heat shock protein 90 0.0032 0.0207 1
Loa Loa (eye worm) MBCTL1 0.0053 0.0481 0.1527
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.018 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.018 0.0573
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0308 0.0308
Echinococcus granulosus cathepsin b 0.0164 0.1921 0.2266
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0129
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.0573
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0165 0.1287
Onchocerca volvulus Huntingtin homolog 0.0119 0.1339 1
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0398 0.1263
Schistosoma mansoni thyroid hormone receptor 0.003 0.018 0.0213
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0115 0.0136
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.018 0.0573
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0398 0.0469
Echinococcus multilocularis lamin dm0 0.0026 0.0137 0.0137
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0105 0.1156 0.3669
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0398 0.0469
Brugia malayi Steroid receptor seven-up type 2 0.003 0.018 0.0573
Schistosoma mansoni heat shock protein 0.0032 0.0207 0.0244
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.018 0.0573
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.036 0.0954
Brugia malayi hypothetical protein 0.0119 0.1339 0.4251
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.036 0.9565
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0244 0.0776
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0706 0.0833
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0375 0.1784
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0049 0.0176
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0375 1
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0207 0.0656
Echinococcus granulosus lamin 0.0026 0.0137 0.0162
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0319 0.1014
Onchocerca volvulus 0.0046 0.0398 0.217
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.036 0.1706
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.018 0.0573
Plasmodium falciparum phd finger protein, putative 0.0028 0.0165 0.7335
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0207 0.2827
Brugia malayi intermediate filament protein 0.0026 0.0137 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.018 0.0573
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.018 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.018 0.0573
Loa Loa (eye worm) hypothetical protein 0.0053 0.0481 0.1527
Echinococcus granulosus heat shock protein 0.0032 0.0207 0.0244
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.018 0.0573
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0628 0.313
Echinococcus granulosus FTZ F1 alpha 0.003 0.018 0.0213
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0054 0.0499 0.7791
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.018 0.018
Echinococcus granulosus heat shock protein 90 0.0025 0.0124 0.0146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0119 0.1339 0.4251
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0628 0.0741
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.018 0.0213
Echinococcus multilocularis zinc finger protein 0.0038 0.0293 0.0293
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.2163 0.2163
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0375 0.5687
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0124 0.2479
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0041 0.0048
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0164 0.1921 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0398 0.217
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.0573
Brugia malayi PHD-finger family protein 0.0049 0.0427 0.1357
Entamoeba histolytica hypothetical protein 0.0035 0.0251 0.357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.018 0.0573
Brugia malayi heat shock protein 90 0.0032 0.0207 0.0656
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0124 0.1809
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.036 0.0954
Schistosoma mansoni heat shock protein 0.0032 0.0207 0.0244
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.018 0.0213
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0124 0.0448
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.018 0.0573
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Echinococcus multilocularis cathepsin b 0.0164 0.1921 0.1921
Loa Loa (eye worm) hypothetical protein 0.0025 0.0115 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.018 0.0573
Echinococcus granulosus lamin dm0 0.0026 0.0137 0.0162
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.018 0.018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.018 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0595 0.0701
Plasmodium vivax endoplasmin, putative 0.0032 0.0207 0.3732
Schistosoma mansoni hypothetical protein 0.0165 0.193 0.2276
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0165 0.0523
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0115 0.0404
Echinococcus multilocularis transcription factor eb 0.0105 0.1156 0.1156
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0137 0.0435
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0628 0.1995
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.036 0.0954
Entamoeba histolytica hypothetical protein 0.0035 0.0251 0.357
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.0368 0.0434
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0251 0.0295
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0054 0.0499 0.2441
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0229 0.027
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.848 0.848
Loa Loa (eye worm) hypothetical protein 0.008 0.0828 0.2627
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0115 0.0136
Echinococcus granulosus phd:f box containing protein 0.0025 0.0115 0.0136
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0165 0.0194
Treponema pallidum heat shock protein 90 0.0025 0.0124 0.5
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0164 0.0193
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.1037 0.1223
Loa Loa (eye worm) hypothetical protein 0.0083 0.0876 0.278
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0115 0.0115
Onchocerca volvulus 0.0043 0.036 0.1857
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0115 0.0136
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0375 0.7299
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.0573
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0595 0.1888
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0041 0.0129
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0115 0.4215
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0555 0.1762
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0165 0.2013
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0398 0.0398
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0207 0.3732
Brugia malayi jmjC domain containing protein 0.0025 0.0115 0.0366
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0375 0.6773
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.018 0.0213
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0481 0.0481
Echinococcus granulosus peregrin 0.0033 0.0225 0.0265
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0398 0.0398
Entamoeba histolytica hypothetical protein 0.0035 0.0251 0.357
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0416
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0481 0.1527
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.0368 0.0368
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.018 0.018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.036 0.0954
Mycobacterium tuberculosis Conserved protein 0.0043 0.036 0.0954
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.018 0.0213
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0115 0.0366
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0041 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.018 0.018
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0279 0.0279
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.018 0.0213
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0008
Giardia lamblia Cathepsin B precursor 0.0054 0.0499 1
Trypanosoma brucei ISWI complex protein 0.003 0.0185 0.2448
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.2773 0.2773
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.036 0.1706
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.036 0.0425
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.018 0.0213
Brugia malayi hypothetical protein 0.023 0.2773 0.8802
Brugia malayi MH2 domain containing protein 0.0116 0.13 0.4126
Giardia lamblia Grp94/Hsp90 0.0025 0.0124 0.1809
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0207 0.089
Echinococcus granulosus heat shock protein 90 0.0032 0.0207 0.0244
Loa Loa (eye worm) endoplasmin 0.0032 0.0207 0.0656
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Schistosoma mansoni lamin 0.0026 0.0137 0.0162
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0481 0.0567
Brugia malayi TAR-binding protein 0.0062 0.0595 0.1888
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0628 0.0741
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0229 0.027
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.13 0.4126
Brugia malayi PHD-finger family protein 0.0028 0.0165 0.0523
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0165 0.1287
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0628 0.1995
Trichomonas vaginalis esterase, putative 0.0043 0.036 0.6981
Giardia lamblia PHD finger protein 15 0.0028 0.0165 0.2708
Mycobacterium leprae Probable lipase LipE 0.0043 0.036 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.018 0.0213
Loa Loa (eye worm) inositol-1 0.0045 0.0375 0.119
Toxoplasma gondii ABC1 family protein 0.0043 0.036 0.6393
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.848 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0124 0.1809
Giardia lamblia Cathepsin B precursor 0.0054 0.0499 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0041 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.036 0.6981
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.018 0.0573
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.1144
Plasmodium vivax hypothetical protein, conserved 0.0043 0.036 1
Echinococcus multilocularis heat shock protein 90 0.0025 0.0124 0.0124
Mycobacterium ulcerans hypothetical protein 0.0043 0.036 0.9565
Trypanosoma cruzi ISWI complex protein 0.003 0.0185 0.0772
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0151 0.1746 0.2059
Loa Loa (eye worm) steroid hormone receptor 0.003 0.018 0.0573
Schistosoma mansoni inositol monophosphatase 0.0045 0.0375 0.0442
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0398 0.0469
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0375 0.0375
Brugia malayi RNA binding protein 0.0062 0.0595 0.1888
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0706 0.0706
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0595 0.1888
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0595 0.0701
Brugia malayi nuclear hormone receptor 0.003 0.018 0.0573
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.018 0.0573
Onchocerca volvulus Huntingtin homolog 0.0119 0.1339 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.1585 0.5032
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0375 0.0442
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0405 0.1285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0229 0.027
Echinococcus multilocularis heat shock protein 90 0.0032 0.0207 0.0207
Echinococcus granulosus endoplasmin 0.0025 0.0124 0.0146
Onchocerca volvulus 0.0043 0.036 0.1857
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.1144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0008
Trypanosoma brucei heat shock protein, putative 0.0032 0.0207 0.2827
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0115 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.018 0.0573
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0054 0.0499 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0054 0.0499 0.7791
Brugia malayi mbt repeat family protein 0.0046 0.0398 0.1263
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.018 0.0213
Loa Loa (eye worm) hypothetical protein 0.0259 0.315 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0626 0.1986
Echinococcus multilocularis peregrin 0.0033 0.0225 0.0225
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0314 0.0817
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0375 0.1784
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.1037 0.3291
Schistosoma mansoni zinc finger protein 0.0038 0.0293 0.0345
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.018 0.0213
Echinococcus granulosus geminin 0.0165 0.193 0.2276
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.036 0.1144
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0124 0.0247
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.018 0.0213
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.1144
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0595 0.0595
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0314 0.8061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0164 0.1921 0.2266
Echinococcus granulosus survival motor neuron protein 1 0.023 0.2773 0.327
Echinococcus granulosus dna polymerase eta 0.0019 0.0041 0.0048
Mycobacterium tuberculosis Conserved protein 0.0043 0.036 0.0954
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0164 0.1921 0.2266
Brugia malayi jmjC domain containing protein 0.0025 0.0115 0.0366
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0124 0.141
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0164 0.1921 0.2266
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0207 0.3628
Schistosoma mansoni nuclear hormone receptor 0.003 0.018 0.0213
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.018 0.0213
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0207 0.2386
Echinococcus granulosus microtubule associated protein 2 0.0671 0.848 1
Brugia malayi mbt repeat family protein 0.0046 0.0398 0.1263
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0279 0.0329
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0207 0.089
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0124 0.0448
Loa Loa (eye worm) hypothetical protein 0.0028 0.0165 0.0523
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0375 0.5687
Onchocerca volvulus 0.003 0.018 0.036
Echinococcus multilocularis heat shock protein 0.0032 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0047 0.0405 0.0477
Schistosoma mansoni hypothetical protein 0.003 0.0185 0.0218
Mycobacterium ulcerans beta-lactamase 0.0043 0.036 0.9565
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.018 0.036
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0375 0.5687
Onchocerca volvulus Bile acid receptor homolog 0.003 0.018 0.036
Brugia malayi ecdysteroid receptor 0.003 0.018 0.0573
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0207 0.3628
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0229 0.027
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0041 0.0041
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0124 0.1809
Leishmania major hypothetical protein, conserved 0.0025 0.0115 0.1271
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.018 0.018
Echinococcus granulosus cathepsin b 0.0164 0.1921 0.2266
Schistosoma mansoni hypothetical protein 0.004 0.0319 0.0377
Loa Loa (eye worm) hypothetical protein 0.0046 0.0398 0.1263
Onchocerca volvulus 0.0047 0.0405 0.2226
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0151 0.1746 0.1746
Schistosoma mansoni inositol monophosphatase 0.0045 0.0375 0.0442
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0041 0.0008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.018 0.036
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0628 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0165 0.0194
Loa Loa (eye worm) hypothetical protein 0.0025 0.0115 0.0366
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0628 0.0628
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0375 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0041 0.0048
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0041 0.0129
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.036 0.6981
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.018 0.018
Schistosoma mansoni survival motor neuron protein 0.0047 0.0405 0.0477
Schistosoma mansoni endoplasmin 0.0032 0.0207 0.0244
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0049 0.0176
Schistosoma mansoni jumonji domain containing protein 0.0131 0.1499 0.1768
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.036 0.6981
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0398 0.0469
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.1144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.036 0.0425
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0164 0.1921 0.2266
Trypanosoma brucei heat shock protein, putative 0.0032 0.0207 0.2827
Schistosoma mansoni lamin 0.0026 0.0137 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.018 0.0213
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0229 0.0229
Brugia malayi Endoplasmin precursor 0.0032 0.0207 0.0656
Mycobacterium tuberculosis Conserved protein 0.0043 0.036 0.0954
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0595 0.0701
Loa Loa (eye worm) hypothetical protein 0.023 0.2773 0.8802
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0115 0.1271
Loa Loa (eye worm) hypothetical protein 0.0075 0.0768 0.2437
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0251 0.0295
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0115 0.0136
Echinococcus multilocularis endoplasmin 0.0025 0.0124 0.0124
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.036 0.036
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0595 0.0701
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.018 0.0573
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0207 0.2827
Trypanosoma brucei heat shock protein, putative 0.0032 0.0207 0.2827
Leishmania major hypothetical protein, conserved 0.003 0.0185 0.2448
Echinococcus granulosus transcription factor eb 0.0105 0.1156 0.1363
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0398 0.0469
Brugia malayi hypothetical protein 0.0035 0.0251 0.0795
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0229 0.027
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1037 0.1223
Onchocerca volvulus Alhambra homolog 0.0028 0.0165 0.0229
Echinococcus multilocularis cathepsin b 0.0164 0.1921 0.1921
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.018 0.0573
Trypanosoma cruzi ISWI complex protein 0.003 0.0185 0.0772
Mycobacterium ulcerans lipase LipD 0.0043 0.036 0.9565
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0115 0.0136
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0054 0.0499 0.0588
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0041 0.0129
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0115 0.0115
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.036 0.0954
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0251 0.0251
Schistosoma mansoni hypothetical protein 0.0165 0.193 0.2276
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.036 0.544
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0481 0.0481
Brugia malayi Inositol-1 0.0045 0.0375 0.119
Echinococcus multilocularis lamin 0.0026 0.0137 0.0137
Brugia malayi beta-lactamase 0.0043 0.036 0.1144
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0137 0.0435
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0207 0.2386
Loa Loa (eye worm) hypothetical protein 0.0104 0.1149 0.3648
Onchocerca volvulus 0.0043 0.036 0.1857
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.036 0.0425
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.0573
Brugia malayi steroid hormone receptor 0.003 0.018 0.0573
Schistosoma mansoni hypothetical protein 0.0035 0.0251 0.0295
Loa Loa (eye worm) hypothetical protein 0.0164 0.1921 0.6098
Brugia malayi photoreceptor-specific nuclear receptor 0.0259 0.315 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0041 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0115 0.0366
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Brugia malayi jmjC domain containing protein 0.0096 0.1037 0.3291
Echinococcus granulosus zinc finger protein 0.0038 0.0293 0.0345
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0115 0.0136
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0207 0.089
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0115 0.0366
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.1144
Schistosoma mansoni thyroid hormone receptor 0.003 0.018 0.0213
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0481 0.0567
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0595 0.1888
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.018 0.0573
Toxoplasma gondii cathepsin B 0.0054 0.0499 1
Schistosoma mansoni bromodomain containing protein 0.0124 0.1397 0.1648
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0115 0.0404
Loa Loa (eye worm) hypothetical protein 0.0033 0.0229 0.0727
Loa Loa (eye worm) hypothetical protein 0.0119 0.1339 0.4251
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0207 0.2827
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.0368 0.0434
Schistosoma mansoni hypothetical protein 0.0028 0.0165 0.0194
Schistosoma mansoni zinc finger protein 0.003 0.0185 0.0218
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0628 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.036 0.6981
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.0573
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.036 0.9565
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0137 0.0435
Trypanosoma brucei heat shock protein, putative 0.0032 0.0207 0.2827
Leishmania major hypothetical protein, conserved 0.0043 0.036 0.544
Echinococcus granulosus intermediate filament protein 0.0026 0.0137 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0595 0.0701
Loa Loa (eye worm) beta-lactamase 0.0043 0.036 0.1144
Echinococcus granulosus dna polymerase kappa 0.0019 0.0041 0.0048
Trypanosoma brucei heat shock protein, putative 0.0032 0.0207 0.2827
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.0573
Brugia malayi jmjC domain containing protein 0.0025 0.0115 0.0366
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0104 0.1149 0.3648
Schistosoma mansoni coup transcription factor 0.003 0.018 0.0213
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0165 0.0165
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.018 0.0213
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0375 0.7299
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0115 0.0115
Brugia malayi jmjC domain containing protein 0.0151 0.1746 0.5541
Brugia malayi Bromodomain containing protein 0.0033 0.0225 0.0713
Schistosoma mansoni hypothetical protein 0.0282 0.3446 0.4064
Leishmania major heat shock protein 83-1 0.0032 0.0207 0.2827
Loa Loa (eye worm) cathepsin B 0.0054 0.0499 0.1583
Echinococcus multilocularis musashi 0.0026 0.0137 0.0137
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.018 0.0213
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0115 0.0115
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0115 0.0136
Giardia lamblia Cathepsin B precursor 0.0054 0.0499 1
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0207 0.2827
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.13 0.4126
Schistosoma mansoni intermediate filament proteins 0.0026 0.0137 0.0162
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0628 0.313
Trypanosoma brucei heat shock protein, putative 0.0032 0.0207 0.2827
Echinococcus granulosus tar DNA binding protein 0.0062 0.0595 0.0701

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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