Detailed information for compound 1473833

Basic information

Technical information
  • TDR Targets ID: 1473833
  • Name: 1-[4-[di(phenyl)methyl]piperazin-1-yl]-2-(4-p yrimidin-2-ylpiperazin-1-yl)ethanone
  • MW: 456.583 | Formula: C27H32N6O
  • H donors: 0 H acceptors: 3 LogP: 3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)C(c1ccccc1)c1ccccc1)CN1CCN(CC1)c1ncccn1
  • InChi: 1S/C27H32N6O/c34-25(22-30-14-16-33(17-15-30)27-28-12-7-13-29-27)31-18-20-32(21-19-31)26(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-13,26H,14-22H2
  • InChiKey: CTQJCMKYFLZBIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-[di(phenyl)methyl]-1-piperazinyl]-2-[4-(2-pyrimidinyl)-1-piperazinyl]ethanone
  • ASN 08245435

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Cell death protein 3 homolog 0.0028 0.025 0.3334
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.1036 0.1045
Onchocerca volvulus 0.0024 0.0156 0.1827
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0156 0.0324
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.025 0.0218
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0122
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0019 0.0068 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0122
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0971 0.0977
Echinococcus multilocularis geminin 0.0169 0.3027 0.4771
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0019 0.0068 0.0216
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.025 0.0592
Schistosoma mansoni lipoxygenase 0.0126 0.218 0.218
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0019 0.0068 0.0071
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0106 0.0071
Plasmodium vivax glycine--tRNA ligase, putative 0.0019 0.0068 0.0031
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.025 0.0592
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.0982 0.0982
Echinococcus granulosus prolyl tRNA synthetase mitochondrial 0.0062 0.0917 0.1445
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.0982 0.0988
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0019 0.0068 0.0026
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0119 0.2052 0.3235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0019 0.0068 0.0071
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0971 0.0971
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0106 0.0167
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0499 0.955 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0019 0.0068 0.0107
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0982 0.1548
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0137
Schistosoma mansoni caspase-3 (C14 family) 0.0106 0.1785 0.1785
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0361 0.0377
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0195 0.354 0.558
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0216
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0045
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0195 0.354 1
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.025 0.0218
Giardia lamblia Prolyl-tRNA synthetase 0.0019 0.0068 0.5
Mycobacterium ulcerans putative regulatory protein 0.0038 0.045 0.0432
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0106 0.1785 0.2814
Schistosoma mansoni hypothetical protein 0.0021 0.0106 0.0106
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0106 0.0167
Schistosoma mansoni lipoxygenase 0.0088 0.143 0.143
Trypanosoma cruzi metacaspase, putative 0.0028 0.025 0.0218
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0971 0.0981
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0019 0.0068 0.0071
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0156 0.0324
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1036 0.1045
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0499 0.955 1
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0074 0.1144 0.1198
Schistosoma mansoni polycystin 1-related 0.0021 0.0106 0.0106
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0195 0.354 0.558
Leishmania major dihydroorotate dehydrogenase 0.0499 0.955 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0043 0.0068
Treponema pallidum prolyl-tRNA synthetase 0.0074 0.1144 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0106 0.1785 0.2814
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.025 0.0592
Trypanosoma cruzi metacaspase, putative 0.0028 0.025 0.0218
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0043 0.0137
Echinococcus multilocularis RUN 0.0021 0.0106 0.0167
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0499 0.955 1
Schistosoma mansoni prolyl-tRNA synthetase 0.0062 0.0917 0.0917
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0156 0.0093
Trypanosoma brucei metacaspase 5, putative 0.0028 0.025 0.0192
Echinococcus granulosus caspase 2 0.0028 0.025 0.0394
Plasmodium vivax proline--tRNA ligase, putative 0.0019 0.0068 0.0031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0982 0.1028
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0038 0.002
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.025 0.0218
Schistosoma mansoni loxhd1 0.0021 0.0106 0.0106
Plasmodium vivax vivapain-2 0.0018 0.0043 0.0005
Mycobacterium ulcerans hypothetical protein 0.0024 0.0156 0.0124
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0195 0.354 0.3678
Echinococcus granulosus single minded 2 0.0038 0.045 0.0709
Schistosoma mansoni single-minded 0.0052 0.0717 0.0717
Brugia malayi hypothetical protein 0.0174 0.3135 0.3283
Echinococcus granulosus caspase 8 0.0028 0.025 0.0394
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0122
Plasmodium vivax threonine--tRNA ligase, putative 0.0019 0.0068 0.0031
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0106 0.0071
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.025 0.0592
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0043 0.0068
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0019 0.0068 0.0026
Brugia malayi PAS domain containing protein 0.0052 0.0717 0.075
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0156 0.0119
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0043 0.0068
Trypanosoma brucei metacaspase MCA2 0.0028 0.025 0.0192
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0195 0.354 1
Brugia malayi glycyl-tRNA synthetase 0.0019 0.0068 0.0071
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0019 0.0068 0.0026
Plasmodium falciparum dihydroorotate dehydrogenase 0.0499 0.955 1
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0106 0.0167
Chlamydia trachomatis threonine--tRNA ligase 0.0019 0.0068 0.0268
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0663 0.0663
Brugia malayi Cytochrome P450 family protein 0.0024 0.0167 0.0175
Plasmodium falciparum threonine--tRNA ligase 0.0019 0.0068 0.0031
Brugia malayi Zinc finger, C2H2 type family protein 0.0195 0.354 0.3706
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0156 0.0124
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0019 0.0068 0.0031
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0043 0.0005
Schistosoma mansoni hypothetical protein 0.0169 0.3027 0.3027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0156 0.0498
Onchocerca volvulus 0.0049 0.0663 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0156 0.0093
Loa Loa (eye worm) hypothetical protein 0.005 0.0671 0.2141
Leishmania major threonyl-tRNA synthetase, putative 0.0019 0.0068 0.0026
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0043 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Leishmania major metacaspase, putative 0.0028 0.025 0.0218
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0971 0.0977
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0045
Echinococcus granulosus geminin 0.0169 0.3027 0.4771
Schistosoma mansoni hypothetical protein 0.0169 0.3027 0.3027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.025 0.0592
Onchocerca volvulus 0.0021 0.0106 0.1012
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0717 0.0717
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0019 0.0068 0.0068
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0195 0.354 1
Trypanosoma brucei metacaspase MCA3 0.0028 0.025 0.0192
Brugia malayi bHLH-PAS transcription factor 0.0038 0.045 0.0471
Trypanosoma brucei metacaspase 0.0028 0.025 0.0192
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0043 0.0045
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0043 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0971 0.0971
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1036 0.1045
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0971 0.0981
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.025 0.025
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0043 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0156 0.0164
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0156 0.0164
Loa Loa (eye worm) hypothetical protein 0.0024 0.0156 0.0498
Leishmania major cathepsin L-like protease 0.0068 0.1036 0.1045
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0156 0.0164
Echinococcus multilocularis caspase 8 0.0028 0.025 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.025 0.0592
Loa Loa (eye worm) hypothetical protein 0.0024 0.0156 0.0498
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0499 0.955 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.0982 0.1548
Plasmodium vivax metacaspase 1, putative 0.0028 0.025 0.0222
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0156 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0195 0.354 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0499 0.955 1
Trypanosoma cruzi metacaspase, putative 0.0028 0.025 0.0218
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0019 0.0068 0.0107
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0195 0.354 1
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0499 0.955 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0019 0.0068 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0156 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.025 0.0592
Echinococcus multilocularis caspase 0.0106 0.1785 0.2814
Echinococcus granulosus RUN 0.0021 0.0106 0.0167
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0499 0.955 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0156 0.0119
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0122
Plasmodium vivax proline--tRNA ligase, putative 0.0062 0.0917 0.0923
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0671 0.2141
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0971 0.0999
Plasmodium vivax hypothetical protein, conserved 0.0028 0.025 0.0222
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.025 0.0592
Giardia lamblia Threonyl-tRNA synthetase 0.0019 0.0068 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.025 0.0592
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0919 0.0922
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0106 0.0167
Loa Loa (eye worm) hypothetical protein 0.0034 0.0361 0.115
Schistosoma mansoni rab6-interacting 0.0021 0.0106 0.0106
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0819 0.2612
Loa Loa (eye worm) ctsf protein 0.0018 0.0043 0.0137
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0982 0.0992
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0671 0.0703
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0019 0.0068 0.0071
Trypanosoma brucei Metacaspase-4 0.0028 0.025 0.0192
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0043 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Echinococcus granulosus caspase 3 0.0078 0.1225 0.1931
Loa Loa (eye worm) hypothetical protein 0.0074 0.1144 0.3648
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0156 0.0144
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0019 0.0068 0.0026
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0019 0.0068 0.0031
Echinococcus multilocularis prolyl tRNA synthetase, mitochondrial 0.0062 0.0917 0.1445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Schistosoma mansoni microsomal glutathione s-transferase 0.0119 0.2052 0.2052
Leishmania major cathepsin L-like protease 0.0068 0.1036 0.1045
Echinococcus multilocularis glycyl tRNA synthetase 0.0019 0.0068 0.0107
Schistosoma mansoni dihydroorotate dehydrogenase 0.0499 0.955 0.955
Toxoplasma gondii MAPEG family protein 0.0119 0.2052 0.2113
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0045
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0045
Brugia malayi hypothetical protein 0.0021 0.0106 0.0111
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.0982 0.101
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0499 0.955 1
Plasmodium falciparum metacaspase-like protein 0.0028 0.025 0.0222
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0028 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.025 0.0592
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0156 0.0124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0122
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0156 0.0324
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0045
Echinococcus granulosus Threonyl tRNA synthetase C 0.0019 0.0068 0.0107
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0195 0.354 1
Brugia malayi Doublecortin family protein 0.0021 0.0106 0.0111
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.025 0.0592
Plasmodium falciparum proline--tRNA ligase 0.0019 0.0068 0.0031
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0045
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0019 0.0068 0.0107
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0106 0.0167
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0499 0.955 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.025 0.0592
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0195 0.354 0.558
Onchocerca volvulus 0.0038 0.045 0.6554
Echinococcus multilocularis cysteine protease 0.0018 0.0043 0.0068
Brugia malayi Met-10+ like-protein 0.0054 0.0765 0.0801
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0043 0.0043
Loa Loa (eye worm) cysteine protease 0.0018 0.0043 0.0137
Brugia malayi hypoxia-induced factor 1 0.0161 0.2868 0.3004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0106 0.0337
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0971 0.1531
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0074 0.1144 0.1135
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0019 0.0068 0.0216
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0499 0.955 1
Schistosoma mansoni caspase-7 (C14 family) 0.0106 0.1785 0.1785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0156 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.025 0.0592
Onchocerca volvulus 0.0021 0.0106 0.1012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0971 0.1531
Schistosoma mansoni glycyl-tRNA synthetase 0.0019 0.0068 0.0068
Echinococcus multilocularis tumor protein p63 0.0337 0.6344 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0216
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.025 0.0218
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.218 0.3436
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0167 0.0532
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0043 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0671 0.0703
Echinococcus granulosus caspase 0.0106 0.1785 0.2814
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0019 0.0068 0.0071
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.045 0.0709
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0019 0.0068 0.0026
Loa Loa (eye worm) hypoxia-induced factor 1 0.0161 0.2868 0.9149
Schistosoma mansoni hypothetical protein 0.0034 0.0361 0.0361
Plasmodium falciparum proline--tRNA ligase, putative 0.0062 0.0917 0.0923
Echinococcus granulosus glycyl tRNA synthetase 0.0019 0.0068 0.0107
Echinococcus granulosus cathepsin l1 0.0018 0.0043 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1036 0.1021
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.0982 0.0992
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0043 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0156 0.0144
Loa Loa (eye worm) hypothetical protein 0.0049 0.0663 0.2116
Plasmodium falciparum metacaspase 1 0.0028 0.025 0.0222
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0019 0.0068 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0337
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1036 0.1045
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.025 0.0592
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0019 0.0068 0.0071
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0106 0.0167
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0499 0.955 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0195 0.354 0.558
Schistosoma mansoni rab6-interacting 0.0021 0.0106 0.0106
Echinococcus multilocularis caspase 2 0.0028 0.025 0.0394
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0499 0.955 1
Echinococcus granulosus microsomal glutathione S transferase 3 0.0119 0.2052 0.3235
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0337
Brugia malayi Cell death protein 3 precursor 0.0028 0.025 0.0262
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0797
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0019 0.0068 0.0026
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0074 0.1144 0.1162
Loa Loa (eye worm) fibroinase 0.0018 0.0043 0.0137
Echinococcus granulosus tumor protein p63 0.0337 0.6344 1
Echinococcus multilocularis cysteine protease 0.0018 0.0043 0.0068
Trypanosoma cruzi metacaspase, putative 0.0028 0.025 0.0218
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.218 0.3436
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.025 0.0218
Plasmodium vivax vivapain-2 0.0018 0.0043 0.0005
Toxoplasma gondii glycyl-tRNA synthetase 0.0019 0.0068 0.0026
Leishmania major cathepsin L-like protease 0.0068 0.1036 0.1045
Mycobacterium tuberculosis Probable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase) 0.0054 0.0765 0.0783
Chlamydia trachomatis proline--tRNA ligase 0.0074 0.1144 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0748 0.0742
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0019 0.0068 0.0068
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0156 0.0124
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0195 0.354 1
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0019 0.0068 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0971 0.0981
Brugia malayi hypothetical protein 0.0021 0.0106 0.0111
Echinococcus multilocularis caspase 3 0.0078 0.1225 0.1931
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.025 0.0592
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0028 0.025 0.0262
Giardia lamblia Glycyl-tRNA synthetase 0.0019 0.0068 0.5
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0043 0.0005
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0019 0.0068 0.0051
Loa Loa (eye worm) hypothetical protein 0.0174 0.3135 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0156 0.0119
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0156 0.0124

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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