Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0536 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.3172 | 0.8267 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3172 | 0.8267 | 0.8267 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0536 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3172 | 0.8267 | 1 |
Onchocerca volvulus | 0.0536 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3172 | 0.8267 | 0.8267 |
Onchocerca volvulus | 0.0536 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3172 | 0.8267 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3172 | 0.8267 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0536 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3172 | 0.8267 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.3725 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3172 | 0.8267 | 1 |
Onchocerca volvulus | 0.0536 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0536 | 0 | 0.5 |
Onchocerca volvulus | 0.0536 | 0 | 0.5 | |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.3725 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3172 | 0.8267 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3172 | 0.8267 | 0.8267 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0536 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3172 | 0.8267 | 0.8267 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.3725 | 1 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0536 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3725 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1904 | 0.4289 | 0.4289 |
Onchocerca volvulus | 0.0536 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.3172 | 0.8267 | 0.8267 |
Loa Loa (eye worm) | hypothetical protein | 0.3172 | 0.8267 | 0.8267 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.61 uM | Inhibition of human recombinant COX2 expressed in baculovirus infected SF21 cell | ChEMBL. | 20974503 |
Inhibition (binding) | Inhibition of human recombinant COX1 expressed in baculovirus infected SF21 cell | ChEMBL. | 20974503 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.