Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0316 | 0.0867 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.1758 | 0.4815 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0027 | 0.0041 | 0.0041 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0316 | 0.034 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 0.0332 | 0.0908 |
Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.0332 | 0.0908 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0027 | 0.0041 | 0.0112 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0316 | 0.034 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0041 | 0.0112 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0316 | 0.0617 |
Trypanosoma brucei | isopentenyl-diphosphate delta-isomerase (type II) | 0.0377 | 0.3442 | 0.6712 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | 0.1051 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0027 | 0.0041 | 0.0112 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0041 | 0.0112 |
Leishmania major | isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative | 0.0377 | 0.3442 | 0.9429 |
Leishmania major | cytochrome p450-like protein | 0.0027 | 0.0041 | 0.0112 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0316 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0316 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0316 | 0.0617 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0041 | 0.0112 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.055 | 0.5129 | 1 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | 0.1051 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0398 | 0.3651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.3651 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.055 | 0.5129 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.9305 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0027 | 0.0041 | 0.0112 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0398 | 0.3651 | 1 |
Entamoeba histolytica | isopentenyl-diphosphate delta-isomerase, putative | 0.0377 | 0.3442 | 1 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD1 | 0.0377 | 0.3442 | 0.3442 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0316 | 0.0617 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0041 | 0.0112 |
Mycobacterium ulcerans | isopentenyl pyrophosphate isomerase | 0.0377 | 0.3442 | 0.3442 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0398 | 0.3651 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0027 | 0.0041 | 0.008 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0398 | 0.3651 | 0.7118 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0316 | 0.0867 |
Treponema pallidum | hypothetical protein | 0.1051 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.