Detailed information for compound 1474052

Basic information

Technical information
  • TDR Targets ID: 1474052
  • Name: 1-[di(phenyl)methyl]-4-[(2-methoxyphenyl)meth yl]piperazine
  • MW: 372.503 | Formula: C25H28N2O
  • H donors: 0 H acceptors: 0 LogP: 4.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CN1CCN(CC1)C(c1ccccc1)c1ccccc1
  • InChi: 1S/C25H28N2O/c1-28-24-15-9-8-14-23(24)20-26-16-18-27(19-17-26)25(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-15,25H,16-20H2,1H3
  • InChiKey: ZACALRGLMFHCPU-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-[di(phenyl)methyl]-4-(2-methoxybenzyl)piperazine
  • AIDS-303644
  • AIDS303644
  • Piperazine, 1-(diphenylmethyl)-4-[(2-methoxyphenyl)methyl]-
  • STK115151

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) prolyl oligopeptidase 0.0189 0.2915 0.1256
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0487 1 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0146 0.1897 0.1774
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0317 0.5971 0.5971
Trypanosoma brucei prolyl endopeptidase 0.0146 0.1897 0.1897
Echinococcus multilocularis prolyl endopeptidase 0.0146 0.1897 0.1774
Toxoplasma gondii proteasome subunit beta type, putative 0.0487 1 1
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0317 0.5971 0.5971
Echinococcus multilocularis proteasome (prosome, macropain) 0.0487 1 1
Trypanosoma cruzi prolyl endopeptidase 0.0146 0.1897 0.1897
Echinococcus granulosus proteasome prosome macropain 0.0487 1 1
Trypanosoma brucei proteasome beta 6 subunit 0.0317 0.5971 0.5971
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0487 1 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0487 1 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0189 0.2915 0.2808
Plasmodium vivax proteasome subunit beta type-5, putative 0.0487 1 1
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0317 0.5971 0.591
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0073 0.0149 0.0149
Plasmodium falciparum proteasome subunit beta type-5 0.0487 1 1
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0487 1 1
Loa Loa (eye worm) proteasome subunit beta type 1 0.0317 0.5971 0.5028
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0146 0.1897 0.1774
Brugia malayi prolyl oligopeptidase family protein 0.0146 0.1897 0.1774
Brugia malayi proteasome subunit beta type 1 0.0317 0.5971 0.591
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0073 0.0149 0.0149
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0118 0.1236 0.1236
Echinococcus granulosus prolyl endopeptidase 0.0146 0.1897 0.1774
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0073 0.0149 0.0149
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0189 0.2915 0.2808
Leishmania major proteasome beta 5 subunit, putative 0.0487 1 1
Toxoplasma gondii prolyl endopeptidase 0.0146 0.1897 0.1774
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0317 0.5971 0.591
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0146 0.1897 0.1897
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0189 0.2915 0.2808
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0487 1 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0317 0.5971 0.5971
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0073 0.0149 0.0149
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0487 1 1
Mycobacterium ulcerans proteasome PrcB 0.0487 1 1
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0317 0.5971 0.591
Brugia malayi prolyl oligopeptidase family protein 0.0189 0.2915 0.2808
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0487 1 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0073 0.0149 0.0149
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0487 1 1
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0487 1 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0317 0.5971 0.591
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0487 1 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0189 0.2915 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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