Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0317 | 0.5971 | 0.5028 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0146 | 0.1897 | 0.1897 |
Brugia malayi | proteasome subunit beta type 1 | 0.0317 | 0.5971 | 0.591 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0487 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0189 | 0.2915 | 0.2808 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0189 | 0.2915 | 0.2808 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0146 | 0.1897 | 0.1897 |
Echinococcus granulosus | prolyl endopeptidase | 0.0146 | 0.1897 | 0.1774 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0317 | 0.5971 | 0.591 |
Trypanosoma brucei | prolyl endopeptidase | 0.0146 | 0.1897 | 0.1897 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0317 | 0.5971 | 0.5971 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0073 | 0.0149 | 0.0149 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0146 | 0.1897 | 0.1774 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0487 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0487 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0317 | 0.5971 | 0.5971 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0487 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0073 | 0.0149 | 0.0149 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0317 | 0.5971 | 0.5971 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0146 | 0.1897 | 0.1774 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0317 | 0.5971 | 0.5971 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0317 | 0.5971 | 0.591 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0189 | 0.2915 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0189 | 0.2915 | 0.2808 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0073 | 0.0149 | 0.0149 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0118 | 0.1236 | 0.1236 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0073 | 0.0149 | 0.0149 |
Echinococcus granulosus | proteasome prosome macropain | 0.0487 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0487 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0189 | 0.2915 | 0.1256 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0487 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0487 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0317 | 0.5971 | 0.591 |
Mycobacterium ulcerans | proteasome PrcB | 0.0487 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0189 | 0.2915 | 0.2808 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0487 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0073 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0487 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0487 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0487 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0146 | 0.1897 | 0.1774 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0487 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0487 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0487 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0146 | 0.1897 | 0.1774 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0146 | 0.1897 | 0.1774 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0317 | 0.5971 | 0.591 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0487 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.