Detailed information for compound 1474054

Basic information

Technical information
  • TDR Targets ID: 1474054
  • Name: N-[[3-bromo-4-[(4-chlorophenyl)methoxy]-5-met hoxyphenyl]methyl]-3-morpholin-4-ylpropan-1-a mine
  • MW: 483.826 | Formula: C22H28BrClN2O3
  • H donors: 1 H acceptors: 0 LogP: 4.07 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CNCCCN2CCOCC2)cc(c1OCc1ccc(cc1)Cl)Br
  • InChi: 1S/C22H28BrClN2O3/c1-27-21-14-18(15-25-7-2-8-26-9-11-28-12-10-26)13-20(23)22(21)29-16-17-3-5-19(24)6-4-17/h3-6,13-14,25H,2,7-12,15-16H2,1H3
  • InChiKey: YBTUSMAEEWIFBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[3-bromo-4-[(4-chlorophenyl)methoxy]-5-methoxy-phenyl]methyl]-3-morpholino-propan-1-amine
  • N-[[3-bromo-4-[(4-chlorophenyl)methoxy]-5-methoxyphenyl]methyl]-3-morpholinopropan-1-amine
  • [3-bromo-4-(4-chlorobenzyl)oxy-5-methoxy-benzyl]-(3-morpholinopropyl)amine
  • N-[[3-bromo-4-[(4-chlorophenyl)methoxy]-5-methoxy-phenyl]methyl]-3-morpholin-4-yl-propan-1-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii proteasome subunit beta type, putative 0.0398 0.8021 1
Brugia malayi proteasome subunit alpha type 6 0.0051 0.0836 0.1042
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0051 0.0836 0.1039
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0252 0.4994 0.6062
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0051 0.0836 0.0653
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0051 0.0836 0.5
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0051 0.0836 0.0673
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.5689 0.5688
Trypanosoma brucei proteasome alpha 7 subunit 0.0051 0.0836 0.0653
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0334 0.0331
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0398 0.8021 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.123 0.1074
Brugia malayi proteasome subunit beta type 1 0.0252 0.4994 0.6226
Onchocerca volvulus Prolyl endopeptidase homolog 0.0141 0.2692 0.7203
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0836 0.0653
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.123 0.0548
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0175 0.0172
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0051 0.0836 0.0653
Loa Loa (eye worm) hypothetical protein 0.0041 0.0632 0.0785
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0252 0.4994 0.4905
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0051 0.0836 0.0653
Echinococcus granulosus GPCR family 2 0.0019 0.0175 0.0172
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0051 0.0836 0.0653
Schistosoma mansoni survival motor neuron protein 0.0058 0.0986 0.0825
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0051 0.0836 0.0673
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0064 0.1105 0.0375
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0836 0.0653
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0334 0.0331
Echinococcus granulosus proteasome prosome macropain 0.0398 0.8021 0.802
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0051 0.0836 0.0833
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0051 0.0836 0.0833
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0334 0.0162
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0051 0.0836 0.0653
Leishmania major proteasome beta 5 subunit, putative 0.0398 0.8021 1
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0051 0.0836 0.0673
Loa Loa (eye worm) hypothetical protein 0.0117 0.2206 0.2748
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.1385 0.1382
Loa Loa (eye worm) hypothetical protein 0.0074 0.1304 0.1623
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Mycobacterium tuberculosis Probable peptidase 0.0064 0.1105 0.0375
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.114 0.1049
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0051 0.0836 0.0833
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0051 0.0836 0.0653
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0051 0.0836 0.1039
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0051 0.0836 0.0653
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0498 0.0618
Echinococcus granulosus proteasome subunit alpha type 6 0.0051 0.0836 0.0833
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.123 0.1166
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0051 0.0836 0.0653
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0182 0.3544 0.3543
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0252 0.4994 0.6062
Toxoplasma gondii proteasome subunit 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0836 0.0653
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0051 0.0836 0.0653
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0051 0.0836 0.0653
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0051 0.0836 0.0673
Loa Loa (eye worm) proteasome subunit beta type 1 0.0252 0.4994 0.6225
Loa Loa (eye worm) hypothetical protein 0.0019 0.0175 0.0215
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0051 0.0836 0.0653
Loa Loa (eye worm) prolyl oligopeptidase 0.0182 0.3544 0.4417
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.2206 0.2067
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0836 0.0653
Toxoplasma gondii prolyl endopeptidase 0.0141 0.2692 0.3069
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0051 0.0836 0.0653
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.1385 0.1382
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0051 0.0836 0.0653
Plasmodium vivax proteasome subunit beta type-2, putative 0.0051 0.0836 0.0653
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0051 0.0836 0.0653
Echinococcus granulosus Proteasome subunit alpha type 7 0.0051 0.0836 0.0833
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0398 0.8021 1
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0051 0.0836 0.0653
Schistosoma mansoni cpg binding protein 0.0037 0.0539 0.0371
Mycobacterium ulcerans proteasome PrcB 0.0398 0.8021 1
Plasmodium vivax proteasome subunit beta type-1, putative 0.0252 0.4994 0.6062
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1026 0.128
Trypanosoma cruzi 20S proteasome subunit 0.0051 0.0836 0.0653
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0051 0.0836 0.0653
Brugia malayi Proteasome A-type and B-type family protein 0.0398 0.8021 1
Echinococcus multilocularis prolyl endopeptidase 0.0141 0.2692 0.269
Brugia malayi prolyl oligopeptidase family protein 0.0141 0.2692 0.3357
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0252 0.4994 0.5787
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0064 0.1105 0.0375
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0051 0.0836 0.0673
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0836 0.0653
Toxoplasma gondii proteasome subunit alpha1, putative 0.0051 0.0836 0.0653
Brugia malayi prolyl oligopeptidase family protein 0.007 0.123 0.1533
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0051 0.0836 0.0653
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0051 0.0836 0.0653
Trypanosoma brucei prolyl endopeptidase 0.0141 0.2692 0.3069
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0398 0.8021 1
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0398 0.8021 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0051 0.0836 0.0653
Plasmodium vivax proteasome subunit beta type-6, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0051 0.0836 0.0653
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0398 0.8021 0.7985
Toxoplasma gondii heat shock protein hslv, putative 0.0051 0.0836 0.0653
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0051 0.0836 0.0833
Leishmania major oligopeptidase b 0.0064 0.1105 0.0375
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.1385 0.1382
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.214 0.1815
Echinococcus granulosus geminin 0.0205 0.4014 0.4013
Echinococcus granulosus Proteasome subunit alpha beta 0.0051 0.0836 0.0833
Giardia lamblia Proteasome subunit beta type 3 0.0051 0.0836 0.0653
Loa Loa (eye worm) hypothetical protein 0.0286 0.5689 0.7092
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0051 0.0836 0.0673
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0051 0.0836 0.0653
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0051 0.0836 0.0653
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0334 0.0416
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0051 0.0836 0.0653
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0051 0.0836 0.0653
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.123 0.1166
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.5689 0.5688
Toxoplasma gondii peptidase, T1 family protein 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0051 0.0836 0.0653
Giardia lamblia 20S proteasome alpha subunit 5 0.0051 0.0836 0.0653
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0334 0.0416
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.2125 0.2123
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0051 0.0836 0.0653
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0051 0.0836 0.0653
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0252 0.4994 0.6062
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0051 0.0836 0.0653
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0175 0.0218
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0836 0.0653
Echinococcus granulosus prolyl endopeptidase 0.0141 0.2692 0.269
Giardia lamblia 20S proteasome alpha subunit 3 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0051 0.0836 0.0653
Brugia malayi Proteasome A-type and B-type family protein 0.0051 0.0836 0.1042
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0683 0.068
Brugia malayi proteasome subunit beta type 3 0.0051 0.0836 0.1042
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0398 0.8021 1
Schistosoma mansoni hypothetical protein 0.0058 0.0986 0.0825
Brugia malayi hypothetical protein 0.0286 0.5689 0.7093
Schistosoma mansoni transient receptor potential channel 0.0078 0.1385 0.1231
Trypanosoma cruzi oligopeptidase b 0.0064 0.1105 0.1004
Loa Loa (eye worm) hypothetical protein 0.0044 0.0683 0.0848
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0252 0.4994 0.4992
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0175 0.0172
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0051 0.0836 0.0673
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0051 0.0836 0.0673
Schistosoma mansoni cpg binding protein 0.0035 0.0498 0.0329
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0398 0.8021 1
Echinococcus multilocularis proteasome subunit beta type 7 0.0051 0.0836 0.0833
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0051 0.0836 0.0653
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0051 0.0836 0.0833
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0051 0.0836 0.0653
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0175 0.0172
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.2206 0.2204
Brugia malayi proteasome subunit alpha type 1 0.0051 0.0836 0.1042
Trypanosoma brucei proteasome beta 7 subunit 0.0051 0.0836 0.0653
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0051 0.0836 0.0833
Giardia lamblia Proteasome subunit beta type 2 0.0051 0.0836 0.0653
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0051 0.0836 0.0653
Brugia malayi Proteasome A-type and B-type family protein 0.0051 0.0836 0.1042
Echinococcus granulosus cpg binding protein 0.0037 0.0539 0.0537
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0064 0.1105 0.0375
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0175 0.0218
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0836 0.0653
Brugia malayi Proteasome A-type and B-type family protein 0.0051 0.0836 0.1042
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0398 0.8021 1
Echinococcus granulosus subfamily T1A non peptidase ue 0.0051 0.0836 0.0833
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0064 0.1105 0.1004
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0051 0.0836 0.0653
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0051 0.0836 0.1039
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0051 0.0836 0.0833
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0986 0.1229
Brugia malayi proteasome subunit alpha type 4 0.0051 0.0836 0.1042
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0051 0.0836 0.0653
Onchocerca volvulus Notchless protein homolog 0.0051 0.0836 0.1108
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0051 0.0836 0.0653
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0632 0.0788
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0051 0.0836 0.0653
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0051 0.0836 0.1039
Brugia malayi proteasome subunit beta type 2 0.0051 0.0836 0.1042
Loa Loa (eye worm) PAS-3 protein 0.0051 0.0836 0.1039
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0051 0.0836 0.0653
Plasmodium vivax proteasome subunit beta type-3, putative 0.0051 0.0836 0.0653
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0252 0.4994 0.6062
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0182 0.3544 0.3543
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0051 0.0836 0.0653
Loa Loa (eye worm) hypothetical protein 0.006 0.1026 0.1277
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0051 0.0836 0.0653
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0051 0.0836 0.1039
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.2125 0.2123
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0836 0.0653
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0398 0.8021 1
Onchocerca volvulus 0.0058 0.0986 0.16
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi prolyl endopeptidase 0.0141 0.2692 0.3069
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0398 0.8021 1
Trypanosoma brucei proteasome beta 6 subunit 0.0252 0.4994 0.6062
Echinococcus multilocularis geminin 0.0205 0.4014 0.4013
Echinococcus multilocularis proteasome subunit alpha type 6 0.0051 0.0836 0.0833
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0051 0.0836 0.1039
Schistosoma mansoni transient receptor potential channel 0.0078 0.1385 0.1231
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0051 0.0836 0.0653
Giardia lamblia 20S proteasome alpha subunit 2 0.0051 0.0836 0.0653
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1026 0.1277
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0051 0.0836 0.0653
Brugia malayi hypothetical protein 0.0043 0.0677 0.0844
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0051 0.0836 0.0653
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.123 0.1227
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0051 0.0836 0.0673
Schistosoma mansoni hypothetical protein 0.0041 0.0632 0.0465
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0252 0.4994 0.6062
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0051 0.0836 0.0673
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0051 0.0836 0.0653
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0051 0.0836 0.0653
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.123 0.1227
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0051 0.0836 0.0673
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.1385 0.1382
Schistosoma mansoni hypothetical protein 0.0494 1 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0539 0.0537
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0051 0.0836 0.0653
Echinococcus multilocularis GPCR, family 2 0.0019 0.0175 0.0172
Trypanosoma cruzi oligopeptidase b 0.0064 0.1105 0.1004
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0836 0.0653
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0051 0.0836 0.0653
Brugia malayi proteasome subunit alpha type 2 0.0051 0.0836 0.1042
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0182 0.3544 1
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0051 0.0836 0.0653
Toxoplasma gondii proteasome subunit alpha type, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0051 0.0836 0.0653
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0836 0.0653
Loa Loa (eye worm) hypothetical protein 0.004 0.0602 0.0747
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0051 0.0836 0.0653
Plasmodium vivax proteasome subunit beta type-7, putative 0.0051 0.0836 0.0653
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0051 0.0836 0.0673
Plasmodium vivax proteasome subunit beta type-5, putative 0.0398 0.8021 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0051 0.0836 0.0833
Giardia lamblia 20S proteasome alpha subunit 6 0.0051 0.0836 0.0653
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0051 0.0836 0.0833
Giardia lamblia 20S proteasome alpha subunit 7 0.0051 0.0836 0.0653
Echinococcus multilocularis proteasome subunit beta type 6 0.0051 0.0836 0.0833
Schistosoma mansoni cpg binding protein 0.0037 0.0539 0.0371
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0051 0.0836 0.0833
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0836 0.0653
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0836 0.0653
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0051 0.0836 0.0653
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0051 0.0836 0.0673
Echinococcus granulosus proteasome subunit alpha type 2 0.0051 0.0836 0.0833
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0334 0.0162
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1026 0.128
Giardia lamblia 20S proteasome alpha subunit 1 0.0051 0.0836 0.0653
Loa Loa (eye worm) proteasome subunit beta type 3 0.0051 0.0836 0.1039
Brugia malayi Proteasome subunit alpha type 7-1 0.0051 0.0836 0.1042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1303 0.1148
Schistosoma mansoni hypothetical protein 0.0205 0.4014 0.3908
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0051 0.0836 0.0833
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0051 0.0836 0.0673
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0051 0.0836 0.0653
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0051 0.0836 0.0673
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0836 0.0653
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0051 0.0836 0.1039
Brugia malayi 20S proteasome alpha5 subunit 0.0051 0.0836 0.1042
Echinococcus granulosus proteasome subunit beta type 6 0.0051 0.0836 0.0833
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0051 0.0836 0.1039
Brugia malayi prolyl oligopeptidase family protein 0.0182 0.3544 0.4419
Brugia malayi CXXC zinc finger family protein 0.0035 0.0498 0.0621
Loa Loa (eye worm) proteasome subunit beta type 2 0.0051 0.0836 0.1039
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0051 0.0836 0.0653
Brugia malayi proteasome subunit alpha type 3 0.0051 0.0836 0.1042
Giardia lamblia 20S proteasome alpha subunit 4 0.0051 0.0836 0.0653
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0051 0.0836 0.0653
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.2206 0.2204
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0051 0.0836 0.0653
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0141 0.2692 0.2562
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0051 0.0836 0.0653
Echinococcus multilocularis proteasome subunit alpha type 2 0.0051 0.0836 0.0833
Echinococcus multilocularis proteasome (prosome, macropain) 0.0398 0.8021 0.802
Schistosoma mansoni transient receptor potential channel 0.0117 0.2206 0.2067
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0051 0.0836 0.0653
Giardia lamblia Proteasome subunit beta type 1 0.0252 0.4994 0.6062
Toxoplasma gondii proteasome beta subunit 0.0051 0.0836 0.0653
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0051 0.0836 0.0653
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.123 0.1166
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0683 0.068
Loa Loa (eye worm) hypothetical protein 0.0027 0.0334 0.0413
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0064 0.1105 0.1004
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0064 0.1105 0.1004
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0051 0.0836 0.0653
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0051 0.0836 0.0833
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0064 0.1105 0.0375
Loa Loa (eye worm) hypothetical protein 0.0027 0.0334 0.0413
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0182 0.3544 0.343
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0683 0.0851
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0141 0.2692 0.2584
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0051 0.0836 0.0653
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0051 0.0836 0.0833
Echinococcus granulosus proteasome subunit beta t family 0.0051 0.0836 0.0833
Echinococcus granulosus proteasome subunit beta type 7 0.0051 0.0836 0.0833
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0051 0.0836 0.0673
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0252 0.4994 0.6062
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0334 0.0413
Plasmodium falciparum proteasome subunit beta type-5 0.0398 0.8021 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0175 0.0215
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0051 0.0836 0.0653
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0051 0.0836 0.0653
Schistosoma mansoni hypothetical protein 0.0205 0.4014 0.3908
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.123 0.1166
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0051 0.0836 0.0653
Trypanosoma brucei oligopeptidase b 0.0064 0.1105 0.1004
Brugia malayi Proteasome subunit alpha type 1 0.0051 0.0836 0.1042
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0836 0.0653
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0051 0.0836 0.0653
Loa Loa (eye worm) hypothetical protein 0.0141 0.2692 0.3355
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0141 0.2692 0.2562
Plasmodium falciparum proteasome subunit beta type-4 0.0051 0.0836 0.0653
Plasmodium vivax proteasome subunit beta type-4, putative 0.0051 0.0836 0.0653
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0252 0.4994 0.4992
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.123 0.1166
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0051 0.0836 0.0653
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0175 0.0172
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0051 0.0836 0.0833
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0051 0.0836 0.1039
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0051 0.0836 0.0653
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0051 0.0836 0.0653
Loa Loa (eye worm) hypothetical protein 0.0043 0.0677 0.0841
Trypanosoma brucei prolyl oligopeptidase, putative 0.0064 0.1105 0.1004
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0051 0.0836 0.0653
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0051 0.0836 0.0653
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0051 0.0836 0.0673

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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