Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | transcription elongation factor s-II, putative | 0.0057 | 0 | 0.5 |
Entamoeba histolytica | DNA (cytosine-5)-methyltransferase, putative | 0.0305 | 0.5022 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0218 | 0.3268 | 0.6508 |
Echinococcus granulosus | cpg binding protein | 0.0218 | 0.3268 | 0.6508 |
Brugia malayi | CXXC zinc finger family protein | 0.0218 | 0.3268 | 0.8319 |
Schistosoma mansoni | cpg binding protein | 0.0218 | 0.3268 | 0.6508 |
Trypanosoma cruzi | MIZ/SP-RING zinc finger, putative | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0218 | 0.3268 | 0.8319 |
Echinococcus granulosus | DNA methyltransferase 2, putative | 0.0305 | 0.5022 | 1 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0251 | 0.3928 | 0.7823 |
Plasmodium vivax | DNA (cytosine-5)-methyltransferase, putative | 0.0305 | 0.5022 | 0.5 |
Toxoplasma gondii | C-5 cytosine-specific DNA methylase superfamily protein | 0.0305 | 0.5022 | 0.5022 |
Toxoplasma gondii | DNA methyltransferase 2, putative | 0.0305 | 0.5022 | 0.5022 |
Toxoplasma gondii | hypothetical protein | 0.0552 | 1 | 1 |
Leishmania major | modification methylase-like protein | 0.0305 | 0.5022 | 1 |
Trypanosoma brucei | cytosine-specific DNA methylase, putative | 0.0305 | 0.5022 | 1 |
Onchocerca volvulus | 0.0218 | 0.3268 | 0.8319 | |
Trypanosoma cruzi | transcription elongation factor-like protein, putative | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.3928 | 1 |
Echinococcus granulosus | disco interacting protein 2 | 0.0251 | 0.3928 | 0.7823 |
Schistosoma mansoni | cpg binding protein | 0.0218 | 0.3268 | 0.6508 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0251 | 0.3928 | 0.7823 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0057 | 0 | 0.5 |
Onchocerca volvulus | 0.0251 | 0.3928 | 1 | |
Echinococcus multilocularis | DNA methyltransferase 2, putative | 0.0305 | 0.5022 | 1 |
Schistosoma mansoni | DNA (cytosine-5)-methyltransferase | 0.0305 | 0.5022 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0057 | 0 | 0.5 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0251 | 0.3928 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0218 | 0.3268 | 0.6508 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.