Detailed information for compound 1474231

Basic information

Technical information
  • TDR Targets ID: 1474231
  • Name: N-[(5-chloro-3-methoxy-2-propan-2-yloxyphenyl )methyl]ethanamine
  • MW: 257.756 | Formula: C13H20ClNO2
  • H donors: 1 H acceptors: 0 LogP: 3.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNCc1cc(Cl)cc(c1OC(C)C)OC
  • InChi: 1S/C13H20ClNO2/c1-5-15-8-10-6-11(14)7-12(16-4)13(10)17-9(2)3/h6-7,9,15H,5,8H2,1-4H3
  • InChiKey: NBADQJVECXDTDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(5-chloro-2-isopropoxy-3-methoxy-phenyl)methyl]ethanamine
  • N-[(5-chloro-2-isopropoxy-3-methoxyphenyl)methyl]ethanamine
  • (5-chloro-2-isopropoxy-3-methoxy-benzyl)-ethyl-amine
  • N-[(5-chloro-3-methoxy-2-propan-2-yloxy-phenyl)methyl]ethanamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tar DNA binding protein 0.0322 0.4392 0.4372
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1727 0.1697
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0045 0.0009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0044 0.0009
Loa Loa (eye worm) hypothetical protein 0.0101 0.1221 0.1273
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0792 0.0759
Brugia malayi jmjC domain containing protein 0.0194 0.2551 0.5807
Loa Loa (eye worm) acetyltransferase 0.0143 0.1823 0.1919
Loa Loa (eye worm) hypothetical protein 0.0068 0.0734 0.075
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0888 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0004
Brugia malayi hypothetical protein 0.0026 0.0131 0.0299
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0211 0.0176
Echinococcus granulosus dna polymerase kappa 0.002 0.0044 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0045 0.0103
Echinococcus multilocularis dna polymerase eta 0.002 0.0044 0.0009
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0039 0.0026
Schistosoma mansoni DNA polymerase eta 0.002 0.0044 0.0009
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0613 0.0579
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0317 0.479
Leishmania major DNA polymerase kappa, putative 0.002 0.0044 0.0066
Schistosoma mansoni coup transcription factor 0.002 0.0045 0.0009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0256 0.3444 0.8921
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0044 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0734 0.1671
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0112 0.1376 0.3493
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0489 0.1158
Echinococcus multilocularis snurportin 1 0.0666 0.9347 0.9344
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0039 0.0026
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0039 0.032 0.327
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.05 0.0466
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.028 0.0245
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0367 0.0841
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0039 0.0026
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.1765 0.1736
Plasmodium falciparum glutathione reductase 0.0039 0.032 0.2124
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0489 0.1158
Leishmania major DNA polymerase eta, putative 0.002 0.0044 0.0066
Echinococcus granulosus thioredoxin glutathione reductase 0.0114 0.1397 0.1366
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0256 0.3444 0.8921
Loa Loa (eye worm) hypothetical protein 0.0059 0.0613 0.062
Echinococcus granulosus neuropeptide s receptor 0.0463 0.6427 0.6414
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0317 0.3079
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0659 0.0625
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0045 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0045 0.0103
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1552 0.1629
Giardia lamblia PHD finger protein 15 0.0059 0.0613 1
Trypanosoma brucei unspecified product 0.002 0.0044 0.0066
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0039 0.032 0.327
Schistosoma mansoni ran 0.0046 0.0422 0.0387
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0613 0.0579
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0149 0.0846
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0066
Entamoeba histolytica hypothetical protein 0.0077 0.0868 0.9316
Loa Loa (eye worm) TAR-binding protein 0.0322 0.4392 0.4679
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0888 1
Trypanosoma cruzi trypanothione reductase, putative 0.0112 0.1376 1
Brugia malayi Importin beta-1 subunit 0.0062 0.0659 0.1499
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0211 0.0176
Onchocerca volvulus 0.0286 0.388 1
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.0176
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0422 0.6638
Trypanosoma brucei trypanothione reductase 0.0112 0.1376 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0792 0.0759
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0284 0.3855 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1727 0.1697
Echinococcus granulosus importin subunit beta 1 0.0062 0.0659 0.0625
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0194 0.2551 0.2524
Loa Loa (eye worm) hypothetical protein 0.0099 0.1184 0.1234
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0039 0.032 0.2124
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0045 0.0009
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0039 0.032 0.2124
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0211 0.0481
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0422 0.0387
Schistosoma mansoni jumonji domain containing protein 0.0154 0.1977 0.1949
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0367 0.2474
Toxoplasma gondii NADPH-glutathione reductase 0.0039 0.032 0.2124
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0317 0.2097
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0888 0.0855
Entamoeba histolytica hypothetical protein 0.0077 0.0868 0.9316
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0066
Brugia malayi PHD-finger family protein 0.0019 0.0039 0.0089
Entamoeba histolytica hypothetical protein 0.0077 0.0868 0.9316
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0659 0.465
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0045 0.0009
Brugia malayi Pre-SET motif family protein 0.0036 0.028 0.0637
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1184 0.2696
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0045 0.0103
Onchocerca volvulus 0.0036 0.028 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0045 0.0103
Echinococcus multilocularis dna polymerase kappa 0.002 0.0044 0.0009
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.1823 0.1794
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0666 0.9347 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0422 0.0387
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.032 0.2124
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0868 0.0835
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0422 0.096
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.05 0.0946
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0256 0.3444 0.8891
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0888 0.0855
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.0176
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0039 0.032 0.0286
Brugia malayi AF-10 protein 0.0019 0.0039 0.0089
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0044 0.0066
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0131 0.0714
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0367 0.2474
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.05 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0211 0.0188
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0045 0.0103
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0868 0.0835
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0868 0.0835
Schistosoma mansoni nuclear hormone receptor 0.002 0.0045 0.0009
Brugia malayi PHD-finger family protein 0.0059 0.0613 0.1395
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0066
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0125 0.1557 0.1527
Entamoeba histolytica hypothetical protein 0.0051 0.0489 0.5028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.028 0.0245
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0044 0.0066
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0172 0.0391
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0039 0.032 0.2124
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.032 0.2124
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.6427 0.6414
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0045 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0045 0.001
Brugia malayi steroid hormone receptor 0.002 0.0045 0.0103
Brugia malayi TAR-binding protein 0.0322 0.4392 1
Leishmania major trypanothione reductase 0.0112 0.1376 1
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.032 0.2124
Treponema pallidum NADH oxidase 0.0039 0.032 0.2317
Schistosoma mansoni hypothetical protein 0.0077 0.0868 0.0835
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.032 0.2124
Schistosoma mansoni hypothetical protein 0.0068 0.0734 0.0701
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0489 0.3382
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0039 0.032 0.2124
Brugia malayi RNA binding protein 0.0322 0.4392 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.001
Trichomonas vaginalis set domain proteins, putative 0.0286 0.388 1
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0613 0.062
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0039 0.0026
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0039 0.032 0.0729
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.032 0.2124
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.032 0.2124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.032 0.2124
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0659 0.465
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0613 0.4306
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0039 0.032 0.2124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.032 0.2124
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0888 0.0855
Echinococcus multilocularis geminin 0.0711 1 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0888 0.1994
Loa Loa (eye worm) hypothetical protein 0.0081 0.0928 0.0959
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0045 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0058 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0322 0.4392 0.4372
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0422 0.288
Echinococcus multilocularis peregrin 0.0063 0.0663 0.063
Brugia malayi jmjC domain containing protein 0.0072 0.0792 0.1803
Schistosoma mansoni hypothetical protein 0.0711 1 1
Plasmodium falciparum thioredoxin reductase 0.0039 0.032 0.2124
Brugia malayi Probable ClpP-like protease 0.0078 0.0888 0.2022
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0888 0.6361
Schistosoma mansoni hypothetical protein 0.0019 0.0039 0.0003
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0422 0.288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1727 0.1697
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0066
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0888 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0045 0.0009
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0946 0.0914
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0322 0.4392 0.4679
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.6427 0.6414
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0044 0.0101
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0131 0.0714
Brugia malayi Bromodomain containing protein 0.0063 0.0663 0.151
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0125 0.1557 0.1527
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0045 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0367 0.2474
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0045 0.0009
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0888 0.6361
Leishmania major hypothetical protein, conserved 0.0026 0.0131 0.0714
Brugia malayi MH2 domain containing protein 0.0124 0.1552 0.3534
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0422 0.288
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0888 1
Plasmodium vivax importin-beta 2, putative 0.0062 0.0659 0.465
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.001
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0039 0.032 0.2124
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0045 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0284 0.3855 1
Loa Loa (eye worm) thioredoxin reductase 0.0112 0.1376 0.1439
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.05 0.1194
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.152 0.1594
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0131 0.0714
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0928 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0045 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0322 0.4392 0.4372
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0613 0.4306
Brugia malayi hypothetical protein 0.0077 0.0868 0.1976
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0131 0.0714
Brugia malayi jmjC domain containing protein 0.0019 0.0036 0.0081
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.1727 0.1816
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0039 0.032 0.0724
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0131 0.0714
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0045 0.0009
Brugia malayi ecdysteroid receptor 0.002 0.0045 0.0103
Brugia malayi Thioredoxin reductase 0.0112 0.1376 0.3131
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0367 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0322 0.4392 0.4372
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0045 0.0103
Plasmodium vivax thioredoxin reductase, putative 0.0112 0.1376 1
Entamoeba histolytica Ran family GTPase 0.0046 0.0422 0.4267
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0256 0.3444 0.8921
Brugia malayi glutathione reductase 0.0112 0.1376 0.3131
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0613 0.4306
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0039 0.032 0.0286
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.6427 0.6414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0045 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0045 0.0103
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.1823 0.1794
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0045 0.0009
Echinococcus multilocularis GPCR, family 2 0.0031 0.0211 0.0176
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0044 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0045 0.0103
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.001
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0888 0.6361
Schistosoma mansoni ran 0.0046 0.0422 0.0387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1727 0.1697
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0039 0.032 0.2124
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0256 0.3444 0.8921
Echinococcus multilocularis tar DNA binding protein 0.0322 0.4392 0.4372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.028 0.0245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1727 0.1697
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0422 0.288
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0066
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.0176
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0045 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0009
Toxoplasma gondii thioredoxin reductase 0.0112 0.1376 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0045 0.0103
Trichomonas vaginalis ran, putative 0.0046 0.0422 0.0983
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0039 0.0026
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1552 0.1629
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0888 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0039 0.032 0.2124
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0284 0.3855 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0066
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0261 0.0226
Schistosoma mansoni hypothetical protein 0.0666 0.9347 0.9344
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0946 0.0914
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0211 0.0188
Schistosoma mansoni hypothetical protein 0.0031 0.0211 0.0176
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0131 0.0714
Echinococcus granulosus dna polymerase eta 0.002 0.0044 0.0009
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.05 0.0466
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0045 0.001
Echinococcus granulosus snurportin 1 0.0666 0.9347 0.9344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.032 0.2124
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0172 0.0391
Onchocerca volvulus Alhambra homolog 0.0059 0.0613 0.148
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0044 0.0101
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0103
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0792 0.0759
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0044 0.0066
Brugia malayi Pre-SET motif family protein 0.0251 0.338 0.7695
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.032 0.2124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0045 0.001
Brugia malayi RNA, U transporter 1 0.0177 0.2314 0.5268
Plasmodium falciparum importin beta, putative 0.0062 0.0659 0.465
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0928 1
Schistosoma mansoni tar DNA-binding protein 0.0322 0.4392 0.4372
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1727 0.1697
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0044 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0039 0.032 0.2124
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0792 0.0812
Brugia malayi jmjC domain containing protein 0.0019 0.0036 0.0081
Entamoeba histolytica hypothetical protein 0.0077 0.0868 0.9316
Schistosoma mansoni thyroid hormone receptor 0.002 0.0045 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0045 0.0103
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0211 0.0176
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0039 0.0026
Toxoplasma gondii hypothetical protein 0.0027 0.0149 0.0846
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.028 0.0245
Leishmania major GTP-binding protein, putative 0.0046 0.0422 0.288
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0045 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0045 0.0103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.028 0.0245
Brugia malayi jmjC domain containing protein 0.0019 0.0036 0.0081
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0044 0.0066
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0044 0.0066
Loa Loa (eye worm) hypothetical protein 0.0062 0.0659 0.0669
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0044 0.0009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0422 0.288
Plasmodium vivax glutathione reductase, putative 0.0112 0.1376 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0066
Mycobacterium tuberculosis Probable reductase 0.0256 0.3444 0.8921
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0125 0.1557 0.1634
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0066
Plasmodium falciparum glutathione reductase 0.0112 0.1376 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0131 0.0714
Loa Loa (eye worm) glutathione reductase 0.0112 0.1376 0.1439
Brugia malayi jmjC domain containing protein 0.0019 0.0036 0.0081
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0045 0.0103
Schistosoma mansoni importin beta-1 0.0062 0.0659 0.0625
Plasmodium falciparum thioredoxin reductase 0.0112 0.1376 1
Loa Loa (eye worm) RNA binding protein 0.0322 0.4392 0.4679
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0367 0.0841
Giardia lamblia NADH oxidase lateral transfer candidate 0.0039 0.032 0.4855
Echinococcus granulosus FTZ F1 alpha 0.002 0.0045 0.0009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0211 0.0176
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0058 0.0133
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0045 0.0009
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0888 0.6361
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0045 0.0009
Echinococcus multilocularis thioredoxin glutathione reductase 0.0114 0.1397 0.1366
Mycobacterium tuberculosis Probable dehydrogenase 0.0256 0.3444 0.8921
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0045 0.0009
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0114 0.1407 0.1376
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.1823 0.415
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0194 0.2551 0.2524
Schistosoma mansoni hypothetical protein 0.0059 0.0613 0.0579
Trichomonas vaginalis glutathione reductase, putative 0.0039 0.032 0.0719
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.032 0.2124
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0066
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0888 1
Brugia malayi nuclear hormone receptor 0.002 0.0045 0.0103
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0284 0.3855 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0044 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.028 0.0245
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.032 0.2124
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0422 0.0414
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.1727 0.3931
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0066
Brugia malayi RNA recognition motif domain containing protein 0.0322 0.4392 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0045 0.0009
Loa Loa (eye worm) hypothetical protein 0.0078 0.0888 0.0915
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0422 0.288
Loa Loa (eye worm) hypothetical protein 0.0036 0.028 0.0262
Leishmania major importin beta-1 subunit, putative 0.0051 0.0489 0.3382
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0125 0.1557 0.3544
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0039 0.032 0.0286
Echinococcus granulosus GPCR family 2 0.0031 0.0211 0.0176
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1184 0.1234
Plasmodium falciparum phd finger protein, putative 0.0059 0.0613 0.4306
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0045 0.0009
Plasmodium vivax SET domain protein, putative 0.0036 0.028 0.1822
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0659 0.465
Brugia malayi nuclear receptor NHR-88 0.002 0.0045 0.0103
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0045 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0045 0.0103
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1727 0.1697
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0045 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0045 0.0009
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0149 0.0846
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0792 0.0759
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.028 0.0245
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0045 0.0009
Schistosoma mansoni hypothetical protein 0.0711 1 1
Echinococcus granulosus peregrin 0.0063 0.0663 0.063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0045 0.0009
Trichomonas vaginalis mercuric reductase, putative 0.0039 0.032 0.0719
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.032 0.2124
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0211 0.0481
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0045 0.0009
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0613 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0045 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0322 0.4392 0.4372
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0045 0.0009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.338 0.3592
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0045 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0045 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0039 0.032 0.327
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.028 0.1822
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0489 0.1158
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1184 0.2696

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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