Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | transcription factor BTF3, putative | 0.0042 | 0.0025 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.05 | 0.6011 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0025 | 0.0303 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.0832 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.0081 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.05 | 0.6011 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.0081 | 0.1013 |
Loa Loa (eye worm) | plexin A | 0.0086 | 0.029 | 0.3487 |
Echinococcus granulosus | plexin a4 | 0.0086 | 0.029 | 0.3617 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0269 | 0.3229 |
Schistosoma mansoni | transcription factor btf3 | 0.0042 | 0.0025 | 0.0301 |
Mycobacterium ulcerans | proteasome PrcA | 0.1684 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.05 | 0.6011 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.0832 | 1 |
Loa Loa (eye worm) | ICD-1 protein | 0.0042 | 0.0025 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.05 | 0.6011 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.0802 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.0832 | 1 |
Echinococcus granulosus | transcription factor btf3 | 0.0042 | 0.0025 | 0.0312 |
Schistosoma mansoni | plexin | 0.0042 | 0.0025 | 0.0303 |
Schistosoma mansoni | plexin | 0.0073 | 0.0209 | 0.2517 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.0832 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.0081 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.0081 | 1 |
Leishmania major | basic transcription factor 3a, putative | 0.0042 | 0.0025 | 0.5 |
Brugia malayi | plexin A | 0.0086 | 0.029 | 0.3487 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.0055 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.0055 | 0.5 |
Brugia malayi | beta-NAC-like protein | 0.0042 | 0.0025 | 0.0301 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.0081 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0025 | 0.0303 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.0025 | 0.5 |
Brugia malayi | Plexin repeat family protein | 0.0073 | 0.0209 | 0.2517 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.0025 | 0.5 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.1684 | 1 | 0.5 |
Echinococcus multilocularis | plexin a4 | 0.0086 | 0.029 | 0.3487 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.0081 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.0269 | 0.3229 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0269 | 0.3229 |
Onchocerca volvulus | 0.0073 | 0.0209 | 0.5 | |
Echinococcus multilocularis | transcription factor btf3 | 0.0042 | 0.0025 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0209 | 0.2517 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.0055 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.