Detailed information for compound 1474436

Basic information

Technical information
  • TDR Targets ID: 1474436
  • Name: 2-(cyclohexylmethylamino)-N-[3-(dimethylsulfa moyl)phenyl]acetamide
  • MW: 353.48 | Formula: C17H27N3O3S
  • H donors: 2 H acceptors: 3 LogP: 2.22 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)S(=O)(=O)N(C)C)CNCC1CCCCC1
  • InChi: 1S/C17H27N3O3S/c1-20(2)24(22,23)16-10-6-9-15(11-16)19-17(21)13-18-12-14-7-4-3-5-8-14/h6,9-11,14,18H,3-5,7-8,12-13H2,1-2H3,(H,19,21)
  • InChiKey: RYVFSBZRAJZZKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(cyclohexylmethylamino)-N-[3-(dimethylsulfamoyl)phenyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0069 0.3146 0.567
Schistosoma mansoni tar DNA-binding protein 0.0069 0.3146 0.567
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.3146 0.291
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0058 0.224 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0333 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.3146 0.291
Echinococcus multilocularis muscleblind protein 1 0.0147 1 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0333 0.5
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0 0.5
Trichomonas vaginalis beta-hexosaminidase, putative 0.0058 0.224 1
Schistosoma mansoni beta-hexosaminidase B 0.0093 0.5293 1
Echinococcus multilocularis beta hexosaminidase subunit alpha 0.0058 0.224 0.1973
Loa Loa (eye worm) TAR-binding protein 0.0069 0.3146 0.291
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0333 0.5
Echinococcus multilocularis beta hexosaminidase subunit beta 0.0093 0.5293 0.5131
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0333 0.5
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0333 0.5
Echinococcus granulosus tar DNA binding protein 0.0069 0.3146 0.291
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0333 0.5
Echinococcus multilocularis muscleblind protein 0.0147 1 1
Entamoeba histolytica beta-N-acetylhexosaminidase, beta subunit 0.0093 0.5293 1
Echinococcus multilocularis tar DNA binding protein 0.0069 0.3146 0.291
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0333 0.5
Loa Loa (eye worm) hypothetical protein 0.0147 1 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0 0.5
Brugia malayi RNA binding protein 0.0069 0.3146 0.291
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0093 0.5293 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.3146 0.567
Brugia malayi TAR-binding protein 0.0069 0.3146 0.291
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0093 0.5293 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.3146 0.567
Schistosoma mansoni tar DNA-binding protein 0.0069 0.3146 0.567
Trichomonas vaginalis beta-hexosaminidase, putative 0.0058 0.224 1
Echinococcus granulosus beta hexosaminidase subunit beta 0.0093 0.5293 0.5131
Entamoeba histolytica beta-N-acetylhexosaminidase, alpha subunit 0.0093 0.5293 1
Loa Loa (eye worm) hypothetical protein 0.0147 1 1
Loa Loa (eye worm) glycosyl hydrolase family 20 0.0093 0.5293 0.5131
Echinococcus granulosus muscleblind protein 0.0147 1 1
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0093 0.5293 0.5131
Echinococcus granulosus beta hexosaminidase subunit alpha 0.0058 0.224 0.1973
Schistosoma mansoni beta-hexosaminidase B 0.0093 0.5293 1
Trichomonas vaginalis beta-hexosaminidase, putative 0.0058 0.224 1
Loa Loa (eye worm) RNA binding protein 0.0069 0.3146 0.291

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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