Detailed information for compound 1475257

Basic information

Technical information
  • TDR Targets ID: 1475257
  • Name: N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl] -N',N'-dimethyl-N-(phenylmethyl)ethane-1,2-di amine
  • MW: 404.544 | Formula: C26H32N2O2
  • H donors: 0 H acceptors: 0 LogP: 4.73 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OCc1ccccc1)CN(Cc1ccccc1)CCN(C)C
  • InChi: 1S/C26H32N2O2/c1-27(2)16-17-28(19-22-10-6-4-7-11-22)20-24-14-15-25(26(18-24)29-3)30-21-23-12-8-5-9-13-23/h4-15,18H,16-17,19-21H2,1-3H3
  • InChiKey: JQQLEPVHIXSHCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzyl-[4-(benzyloxy)-3-methoxy-benzyl]-(2-dimethylaminoethyl)amine
  • STK105835

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/FER protein kinase 0.0076 0.5931 0.5957
Giardia lamblia Kinase, NEK 0.0076 0.5931 0.5
Echinococcus granulosus tyrosine kinase 0.0107 0.9957 0.9957
Loa Loa (eye worm) RGC/RGC protein kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Loa Loa (eye worm) TK/EPH protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0107 0.9957 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Onchocerca volvulus 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Brugia malayi Raf kinase 0.0076 0.5931 0.5957
Echinococcus granulosus epidermal growth factor receptor 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Brugia malayi SH2 domain containing protein 0.0107 0.9957 1
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus multilocularis protein kinase 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase Src64B 0.0107 0.9957 0.9957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Echinococcus multilocularis protein KINase family member (kin 25) 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0076 0.5931 0.5931
Loa Loa (eye worm) TK/FER protein kinase 0.0107 0.9957 1
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Echinococcus multilocularis heat shock protein 70 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0049 0.2353 0.2363
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 0.9957 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0077 0.5974 0.5974
Schistosoma mansoni protein kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.5931 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Entamoeba histolytica serine/threonine kinase, putative 0.0076 0.5931 0.5957
Echinococcus multilocularis epidermal growth factor receptor 0.0076 0.5931 0.5957
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0077 0.5974 0.6
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0076 0.5931 0.5957
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0076 0.5931 0.5957
Trypanosoma brucei protein kinase, putative 0.0077 0.5974 1
Onchocerca volvulus 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/ALK protein kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0107 0.9957 1
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase Src42A 0.0107 0.9957 0.9957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Onchocerca volvulus 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase csk 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus granulosus raf serine:threonine protein kinase 0.0076 0.5931 0.5931
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0076 0.5931 0.5931
Loa Loa (eye worm) TK protein kinase 0.0076 0.5931 0.5957
Brugia malayi hypothetical protein 0.0107 0.9957 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0076 0.5931 0.5931
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0076 0.5931 0.5957
Schistosoma mansoni protein kinase 0.0077 0.5974 0.6
Giardia lamblia Kinase 0.0076 0.5931 0.5
Plasmodium falciparum protein kinase, putative 0.0077 0.5974 1
Loa Loa (eye worm) TK/FER protein kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0076 0.5931 0.5957
Entamoeba histolytica ankyrin repeat protein 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 0.9957 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0076 0.5931 0.5957
Echinococcus multilocularis insulin receptor 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase Blk 0.0107 0.9957 1
Schistosoma mansoni tyrosine kinase 0.0107 0.9957 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0107 0.9957 0.9957
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0107 0.9957 1
Echinococcus granulosus tyrosine kinase 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 0.9957 1
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.0107 0.9957 1
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.5931 0.5
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0077 0.5974 1
Echinococcus granulosus activin receptor type 0.0077 0.5974 0.5974
Onchocerca volvulus 0.0107 0.9957 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus multilocularis integrin linked protein kinase 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0076 0.5931 0.5931
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0076 0.5931 0.5931
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0107 0.9957 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0076 0.5931 0.5
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0076 0.5931 0.5931
Echinococcus granulosus activated cdc42 kinase 1 0.0076 0.5931 0.5931
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.2353 0.2363
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Brugia malayi bone morphogenetic protein type 1 receptor 0.0076 0.5931 0.5957
Loa Loa (eye worm) RGC/RGC protein kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0107 0.9957 0.9957
Echinococcus granulosus tyrosine protein kinase 0.0076 0.5931 0.5931
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0076 0.5931 0.5957
Echinococcus multilocularis raf serine:threonine protein kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.5931 0.5
Schistosoma mansoni protein kinase 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0107 0.9957 0.9957
Onchocerca volvulus 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0107 0.9957 1
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis CAMK family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis protein kinase atn1, putative 0.0076 0.5931 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK protein kinase 0.0107 0.9957 1
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus multilocularis tyrosine protein kinase 0.0076 0.5931 0.5957
Brugia malayi SRC-1 0.0107 0.9957 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0076 0.5931 0.5931
Onchocerca volvulus 0.0076 0.5931 0.5957
Schistosoma mansoni protein kinase 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/ACK protein kinase 0.0076 0.5931 0.5957
Echinococcus granulosus protein kinase 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0107 0.9957 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Schistosoma mansoni protein kinase 0.0077 0.5974 0.6
Loa Loa (eye worm) serine/threonine protein kinase 0.0076 0.5931 0.5957
Schistosoma mansoni kinase 0.0049 0.2353 0.2363
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0031 0.0043 0.0044
Brugia malayi Furin-like cysteine rich region family protein 0.0076 0.5931 0.5957
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Entamoeba histolytica cysteine surface protein, putative 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0107 0.9957 1
Schistosoma mansoni protein kinase 0.0077 0.5974 0.6
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Brugia malayi Tyrosine-protein kinase abl-1 0.0107 0.9957 1
Brugia malayi integrin-linked kinase 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.0107 0.9957 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Brugia malayi ephrin receptor 1 precursor 0.0076 0.5931 0.5957
Echinococcus multilocularis cyclin dependent kinase 9 0.0049 0.2353 0.2363
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.3861 0.3877
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0076 0.5931 0.5957
Onchocerca volvulus 0.0107 0.9957 1
Schistosoma mansoni protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0107 0.9957 1
Brugia malayi cyclin-dependent kinase 9 0.0049 0.2353 0.2363
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0107 0.9957 1
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Onchocerca volvulus 0.0107 0.9957 1
Schistosoma mansoni protein tyrosine kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.5931 0.5957
Echinococcus multilocularis protein tyrosine kinase 0.0076 0.5931 0.5957
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0076 0.5931 0.5957
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0076 0.5931 0.5957
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0077 0.5974 1
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0076 0.5931 0.5
Echinococcus multilocularis ephrin type A receptor 4 A 0.0076 0.5931 0.5957
Echinococcus multilocularis kinase suppressor of Ras 1 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0107 0.9957 1
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.5931 0.5
Entamoeba histolytica receptor protein kinase, putative 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/ROR protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Leishmania major protein kinase, putative 0.0077 0.5974 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0076 0.5931 0.5957
Schistosoma mansoni protein kinase 0.0076 0.5931 0.5957
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0077 0.5974 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0076 0.5931 0.5931
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.2353 0.2363
Loa Loa (eye worm) TK/FAK protein kinase 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosin kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase Srms 0.0107 0.9957 0.9957
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0107 0.9957 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0076 0.5931 0.5957
Brugia malayi hypothetical protein 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0107 0.9957 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase Fyn 0.0107 0.9957 0.9957
Trichomonas vaginalis TK family protein kinase 0.0076 0.5931 0.5
Brugia malayi Protein kinase domain containing protein 0.0107 0.9957 1
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Entamoeba histolytica serine/threonine kinase, putative 0.0076 0.5931 0.5957
Brugia malayi Tyrosine-protein kinase PR2 0.0076 0.5931 0.5957
Schistosoma mansoni protein kinase 0.0076 0.5931 0.5957
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0077 0.5974 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0107 0.9957 1
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Onchocerca volvulus 0.0076 0.5931 0.5957
Plasmodium vivax tyrosine kinase-like protein, putative 0.0076 0.5931 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK protein kinase 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase Abl 0.0107 0.9957 1
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0076 0.5931 0.5957
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0107 0.9957 1
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0076 0.5931 0.5957
Brugia malayi Immunoglobulin I-set domain containing protein 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.0107 0.9957 1
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Schistosoma mansoni protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica serine/threonine kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Echinococcus granulosus integrin linked protein kinase 0.0076 0.5931 0.5931
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0107 0.9957 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0076 0.5931 0.5931
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0107 0.9957 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0076 0.5931 0.5957
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.5931 0.5
Brugia malayi hypothetical protein 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosin kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0107 0.9957 1
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus granulosus fibroblast growth factor receptor 4 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Brugia malayi Cytochrome P450 family protein 0.006 0.3861 0.3877
Echinococcus multilocularis cyclin dependent kinase 9 0.0057 0.3463 0.3479
Brugia malayi Receptor family ligand binding region containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK protein kinase 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0107 0.9957 1
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) SRC-1 0.0107 0.9957 1
Loa Loa (eye worm) TK/FER protein kinase 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0076 0.5931 0.5931
Schistosoma mansoni tyrosine kinase 0.0107 0.9957 1
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus granulosus cyclin dependent kinase 9 0.0049 0.2353 0.2353
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Echinococcus granulosus cyclin dependent kinase 9 0.0057 0.3463 0.3463
Echinococcus granulosus tyrosine kinase 0.0107 0.9957 0.9957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Onchocerca volvulus 0.0076 0.5931 0.5957
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0107 0.9957 0.9957
Entamoeba histolytica tyrosin kinase, putative 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Onchocerca volvulus 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica receptor protein kinase, putative 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase csk 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Echinococcus granulosus protein tyrosine kinase 0.0076 0.5931 0.5931
Loa Loa (eye worm) TK protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0076 0.5931 0.5931
Loa Loa (eye worm) TK/CSK protein kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.5931 0.5
Loa Loa (eye worm) hypothetical protein 0.0107 0.9957 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase Fyn 0.0107 0.9957 0.9957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Echinococcus multilocularis FL cytokine receptor 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus multilocularis natriuretic peptide receptor 1 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase Blk 0.0107 0.9957 0.9957
Loa Loa (eye worm) TK/Met protein kinase 0.0076 0.5931 0.5957
Giardia lamblia Kinase, NEK 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0076 0.5931 0.5931
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Onchocerca volvulus 0.0076 0.5931 0.5957
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Schistosoma mansoni ephrin receptor 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase ABL1 0.0107 0.9957 0.9957
Echinococcus granulosus ephrin type A receptor 4 A 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus granulosus c src tyrosine kinase 0.0107 0.9957 0.9957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0107 0.9957 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.5931 0.5
Echinococcus multilocularis activin receptor type 0.0077 0.5974 0.6
Schistosoma mansoni hypothetical protein 0.0076 0.5931 0.5957
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.5931 0.5957
Loa Loa (eye worm) RGC/RGC protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Onchocerca volvulus 0.0107 0.9957 1
Entamoeba histolytica tyrosine kinase, putative 0.0076 0.5931 0.5957
Loa Loa (eye worm) protein kinase domain-containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica protein kinase, putative 0.0031 0.0043 0.0044
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Brugia malayi protein-tyrosine kinase 0.0107 0.9957 1
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Entamoeba histolytica serine/threonine kinase, putative 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase pr2 0.0076 0.5931 0.5957
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Brugia malayi Guanylyl cyclase protein 23 0.0076 0.5931 0.5957
Entamoeba histolytica serine/threonine kinase, putative 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine kinase 0.0107 0.9957 1
Echinococcus multilocularis tyrosine kinase 0.0076 0.5931 0.5957
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0107 0.9957 1
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Echinococcus granulosus receptor type guanylyl cyclase 0.0076 0.5931 0.5931
Entamoeba histolytica hypothetical protein, conserved 0.0076 0.5931 0.5957
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0076 0.5931 0.5957
Onchocerca volvulus 0.0107 0.9957 1
Entamoeba histolytica serine/threonine kinase, putative 0.0076 0.5931 0.5957
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK protein kinase 0.0076 0.5931 0.5957
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0076 0.5931 0.5931
Loa Loa (eye worm) TK/FER protein kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0076 0.5931 0.5957
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0076 0.5931 0.5931
Loa Loa (eye worm) TK/EGFR protein kinase 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Echinococcus multilocularis activated cdc42 kinase 1 0.0076 0.5931 0.5957
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0107 0.9957 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.0107 0.9957 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0076 0.5931 0.5931
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0107 0.9957 1
Loa Loa (eye worm) TK protein kinase 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK protein kinase 0.0076 0.5931 0.5957
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0107 0.9957 0.9957
Entamoeba histolytica protein kinase domain containing protein 0.0077 0.5974 0.6
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.0107 0.9957 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.0076 0.5931 0.5957
Echinococcus multilocularis transfer RNA-Thr 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.0107 0.9957 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0076 0.5931 0.5931
Trichomonas vaginalis AGC family protein kinase 0.0076 0.5931 0.5
Echinococcus granulosus natriuretic peptide receptor 1 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Entamoeba histolytica hypothetical protein 0.0076 0.5931 0.5957
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0076 0.5931 0.5931
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Plasmodium vivax protein kinase, putative 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis STE family protein kinase 0.0076 0.5931 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0076 0.5931 0.5931
Entamoeba histolytica ankyrin repeat protein 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Entamoeba histolytica tyrosin kinase, putative 0.0076 0.5931 0.5957
Brugia malayi Protein kinase domain containing protein 0.0107 0.9957 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0076 0.5931 0.5957
Giardia lamblia Protein 21.1 0.0076 0.5931 0.5
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Brugia malayi SH2 domain containing protein 0.0107 0.9957 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase csk 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0107 0.9957 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0076 0.5931 0.5
Brugia malayi Protein kinase domain containing protein 0.0076 0.5931 0.5957
Echinococcus multilocularis protein kinase 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase csk 0.0076 0.5931 0.5957
Echinococcus granulosus tyrosine protein kinase Fyn 0.0107 0.9957 0.9957
Echinococcus granulosus insulin receptor 0.0076 0.5931 0.5931
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0076 0.5931 0.5957
Onchocerca volvulus 0.0107 0.9957 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0076 0.5931 0.5957
Echinococcus granulosus activated cdc42 kinase 1 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0076 0.5931 0.5
Echinococcus granulosus tyrosine protein kinase shark 0.0107 0.9957 0.9957
Echinococcus multilocularis tyrosine protein kinase HCK 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.0107 0.9957 1
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Schistosoma mansoni serine/threonine RGC 0.0076 0.5931 0.5957
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0076 0.5931 0.5957
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0107 0.9957 1
Brugia malayi C-terminal src kinase protein 1 0.0076 0.5931 0.5957
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0076 0.5931 0.5957
Onchocerca volvulus Tyrosine kinase homolog 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/RYK protein kinase 0.0076 0.5931 0.5957
Schistosoma mansoni ephrin receptor 0.0076 0.5931 0.5957
Schistosoma mansoni protein kinase 0.0076 0.5931 0.5957
Echinococcus multilocularis receptor type guanylyl cyclase 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Schistosoma mansoni tyrosine kinase 0.0076 0.5931 0.5957
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0076 0.5931 0.5957
Plasmodium vivax tyrosine kinase-like protein, putative 0.0076 0.5931 0.5
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0076 0.5931 0.5957
Loa Loa (eye worm) hypothetical protein 0.0076 0.5931 0.5957
Echinococcus granulosus kinase suppressor of Ras 1 0.0076 0.5931 0.5931
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0076 0.5931 0.5957
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0076 0.5931 0.5957
Loa Loa (eye worm) TK/FER protein kinase 0.0107 0.9957 1
Entamoeba histolytica protein kinase, putative 0.0076 0.5931 0.5957
Trichomonas vaginalis TKL family protein kinase 0.0076 0.5931 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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