Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0082 | 0.0074 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0046 | 0.0082 | 0.0048 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.0778 | 0.1055 |
Brugia malayi | TAZ zinc finger family protein | 0.0098 | 0.0227 | 0.0219 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.142 | 0.3878 | 0.9967 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.0104 | 0.0095 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0091 | 0.0083 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1424 | 0.3889 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0385 | 0.1018 | 0.101 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0703 | 0.1898 | 0.4879 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0046 | 0.0082 | 0.0048 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.142 | 0.3878 | 0.9967 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0035 | 0.0091 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0035 | 0.0027 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0283 | 0.0738 | 0.0707 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.0244 | 0.0212 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0078 | 0.02 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0009 | 0.0022 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.065 | 0.0686 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.0082 | 0.0073 |
Loa Loa (eye worm) | cytochrome P450 | 0.0028 | 0.0033 | 0.0242 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0082 | 0.0639 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.0244 | 0.0212 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1424 | 0.3889 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.0436 | 0.0071 |
Echinococcus granulosus | CREB binding protein | 0.0098 | 0.0227 | 0.0583 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0283 | 0.0738 | 0.0707 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.3636 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.3636 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.3636 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.3636 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0078 | 0.007 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0032 | 0.0084 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.065 | 0.0686 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.0513 | 0.0505 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.3636 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.0778 | 0.1055 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.0009 | 0.0022 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0082 | 0.0049 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.0277 | 0.0244 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.065 | 0.0686 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0283 | 0.0738 | 0.5989 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0283 | 0.0738 | 0.073 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0385 | 0.1018 | 0.0988 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0009 | 0.0022 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.065 | 0.0686 |
Brugia malayi | Protein kinase domain containing protein | 0.0283 | 0.0738 | 0.073 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0703 | 0.1898 | 0.4879 |
Echinococcus multilocularis | 0.0028 | 0.0033 | 0.0086 | |
Echinococcus multilocularis | CREB binding protein | 0.0067 | 0.0142 | 0.0364 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 0.0778 | 0.0127 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1424 | 0.3889 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.065 | 0.0686 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.142 | 0.3878 | 0.3857 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0385 | 0.1018 | 0.0988 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.0778 | 0.1055 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0078 | 0.007 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0035 | 0.0091 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0078 | 0.007 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.3636 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.0726 | 0.589 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0082 | 0.0049 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0385 | 0.1018 | 0.0988 |
Leishmania major | cytochrome p450-like protein | 0.0046 | 0.0082 | 0.0048 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0078 | 0.02 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0035 | 0.0027 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.0513 | 0.4151 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.0009 | 0.0022 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0035 | 0.0027 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0385 | 0.1018 | 0.0988 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.0104 | 0.0267 |
Echinococcus multilocularis | 0.038 | 0.1006 | 0.2587 | |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0385 | 0.1018 | 0.8272 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.3636 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0078 | 0.02 |
Echinococcus granulosus | hypothetical protein | 0.038 | 0.1006 | 0.2587 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0385 | 0.1018 | 0.1745 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.0778 | 0.1055 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.3636 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.3636 | 1 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0091 | 0.0083 |
Brugia malayi | Cytochrome P450 family protein | 0.0066 | 0.0138 | 0.013 |
Echinococcus granulosus | dual specificity | 0.0283 | 0.0738 | 0.1898 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0091 | 0.0083 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0082 | 0.0049 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1424 | 0.3889 | 1 |
Brugia malayi | hypothetical protein | 0.0241 | 0.0621 | 0.0613 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0385 | 0.1018 | 0.101 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.0778 | 0.1055 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.3636 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0046 | 0.0082 | 0.0048 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.3636 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0703 | 0.1898 | 0.1891 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0241 | 0.0621 | 0.1597 |
Echinococcus multilocularis | dual specificity | 0.0283 | 0.0738 | 0.1898 |
Onchocerca volvulus | 0.0029 | 0.0035 | 0.0463 | |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0033 | 0.0025 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1424 | 0.3889 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.0778 | 0.1055 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.1424 | 0.3889 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0082 | 0.0639 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0385 | 0.1018 | 0.0988 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0385 | 0.1018 | 0.101 |
Trypanosoma brucei | cytochrome P450, putative | 0.0046 | 0.0082 | 0.0048 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0251 | 0.065 | 0.5269 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0082 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0009 | 0.0039 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0283 | 0.0738 | 0.0707 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.3636 | 1 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.0244 | 0.0212 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0078 | 0.0605 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.0082 | 0.0635 |
Loa Loa (eye worm) | CBP-B | 0.0068 | 0.0144 | 0.1144 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0165 | 0.0411 | 0.6926 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0241 | 0.0621 | 0.1597 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.0436 | 0.0071 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0098 | 0.0227 | 0.0219 |
Schistosoma mansoni | cytochrome P450 | 0.0028 | 0.0033 | 0.0025 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.0277 | 0.0244 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0105 | 0.0244 | 0.0212 |
Giardia lamblia | Kinase, CMGC CLK | 0.0385 | 0.1018 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0078 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0035 | 0.0259 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0019 | 0.0009 | 0.0022 |
Echinococcus multilocularis | RUN | 0.0019 | 0.0009 | 0.0022 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0035 | 0.0027 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.0778 | 0.1055 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0082 | 0.0211 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0035 | 0.0027 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0066 | 0.0138 | 0.1098 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.3636 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0046 | 0.0082 | 0.0073 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.0244 | 0.0212 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0035 | 0.0002 |
Brugia malayi | follicle stimulating hormone receptor | 0.0461 | 0.123 | 0.1223 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0082 | 0.0074 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0098 | 0.0227 | 0.0219 |
Onchocerca volvulus | 0.023 | 0.059 | 1 | |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0385 | 0.1018 | 0.0988 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.1006 | 0.8174 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0082 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.0621 | 0.5034 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0145 | 0.0357 | 0.0325 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.142 | 0.3878 | 0.9967 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0145 | 0.0357 | 0.0325 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.0104 | 0.0267 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 0.0778 | 0.0127 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0385 | 0.1018 | 0.101 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0385 | 0.1018 | 0.101 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0078 | 0.02 |
Echinococcus granulosus | CREB binding protein | 0.0061 | 0.0123 | 0.0316 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0082 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0083 | 0.0646 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.059 | 0.0514 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0082 | 0.0074 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.0778 | 0.1055 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0009 | 0.0039 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1424 | 0.3889 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0082 | 0.0211 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0461 | 0.123 | 1 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0385 | 0.1018 | 0.2618 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.0082 | 0.0049 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0035 | 0.0027 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0385 | 0.1018 | 0.0988 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0082 | 0.0049 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.142 | 0.3878 | 0.9967 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0035 | 0.0091 |
Onchocerca volvulus | 0.0049 | 0.0091 | 0.1424 | |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.0244 | 0.0212 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0251 | 0.065 | 0.0642 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0283 | 0.0738 | 0.0707 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0019 | 0.0009 | 0.0022 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0145 | 0.0357 | 0.0325 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.3636 | 1 | 0.5 |
Echinococcus granulosus | RUN | 0.0019 | 0.0009 | 0.0022 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0298 | 0.0778 | 0.5 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0385 | 0.1018 | 0.2618 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.0244 | 0.0212 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.0082 | 0.0635 |
Brugia malayi | Cytochrome P450 family protein | 0.0028 | 0.0033 | 0.0025 |
Brugia malayi | cytochrome P450 | 0.0028 | 0.0033 | 0.0025 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.0009 | 0.0039 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.142 | 0.3878 | 0.3872 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.0726 | 0.589 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0046 | 0.0082 | 0.0635 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.065 | 0.0686 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0028 | 0.0033 | 0.0086 |
Leishmania major | protein kinase, putative | 0.0385 | 0.1018 | 0.0988 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.0277 | 0.0244 |
Leishmania major | protein kinase, putative | 0.0385 | 0.1018 | 0.0988 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.0277 | 0.0244 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.