Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0277 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0277 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.2251 | 0.1871 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0277 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0.0468 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.2455 | 0.2084 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0085 | 0.2323 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0277 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0277 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0085 | 0.2323 | 0.1946 |
Brugia malayi | Protein kinase domain containing protein | 0.0085 | 0.2323 | 0.1946 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0085 | 0.2323 | 0.1946 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0088 | 0.2455 | 0.2084 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0085 | 0.2323 | 0.2323 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0051 | 0.0973 | 0.0529 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0051 | 0.0973 | 0.0973 |
Brugia malayi | cell division control protein 2 homolog | 0.0085 | 0.2323 | 0.1946 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0085 | 0.2323 | 0.1946 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0277 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0277 | 1 | 1 |
Echinococcus multilocularis | dual specificity | 0.0088 | 0.2455 | 0.2455 |
Schistosoma mansoni | immunophilin | 0.0277 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.8479 | 0.8404 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0277 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0277 | 1 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0088 | 0.2455 | 0.2084 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0038 | 0.0468 | 0.0468 |
Echinococcus multilocularis | fk506 binding protein | 0.0277 | 1 | 1 |
Echinococcus granulosus | dual specificity | 0.0088 | 0.2455 | 0.2455 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0085 | 0.2323 | 0.1946 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0085 | 0.2323 | 0.1946 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0085 | 0.2323 | 0.2323 |
Giardia lamblia | Kinase, CMGC CDK | 0.0085 | 0.2323 | 0.1946 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0085 | 0.2323 | 0.1946 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.0973 | 0.0529 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0277 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0085 | 0.2323 | 0.1946 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0038 | 0.0468 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0051 | 0.0973 | 0.0529 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0.0973 | 0.0529 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0088 | 0.2455 | 0.2084 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0051 | 0.0973 | 0.0529 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0085 | 0.2323 | 0.2323 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0239 | 0.8479 | 0.8479 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0277 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0277 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0085 | 0.2323 | 0.1946 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0038 | 0.0468 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0277 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0277 | 1 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0277 | 1 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0277 | 1 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0277 | 1 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0085 | 0.2323 | 0.1946 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.0973 | 0.0529 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0277 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0051 | 0.0973 | 0.0529 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0085 | 0.2323 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2384 | 0.201 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0085 | 0.2323 | 0.2323 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0085 | 0.2323 | 0.1946 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0085 | 0.2323 | 0.1946 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0277 | 1 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0277 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0051 | 0.0973 | 0.0973 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0038 | 0.0468 | 0.5 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0088 | 0.2455 | 0.2084 |
Entamoeba histolytica | protein kinase, putative | 0.0088 | 0.2455 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2384 | 0.201 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0038 | 0.0468 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0085 | 0.2323 | 0.2323 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0085 | 0.2323 | 0.1946 |
Schistosoma mansoni | immunophilin | 0.0277 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0085 | 0.2323 | 0.2323 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0088 | 0.2455 | 0.2084 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0277 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0051 | 0.0973 | 0.0529 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.0973 | 0.0529 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0277 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.0973 | 0.0529 |
Plasmodium falciparum | protein kinase 5 | 0.0085 | 0.2323 | 0.1946 |
Echinococcus multilocularis | 0.0038 | 0.0468 | 0.0468 | |
Brugia malayi | MAP kinase sur-1 | 0.0051 | 0.0973 | 0.0529 |
Entamoeba histolytica | hypothetical protein | 0.0088 | 0.2455 | 0.2084 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0239 | 0.8479 | 0.8479 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0085 | 0.2323 | 0.1946 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0051 | 0.0973 | 0.0973 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0038 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0085 | 0.2323 | 0.1946 |
Onchocerca volvulus | 0.0038 | 0.0468 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0038 | 0.0468 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.0277 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0051 | 0.0973 | 0.0529 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0277 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0085 | 0.2323 | 0.1946 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0085 | 0.2323 | 0.1946 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0085 | 0.2323 | 0.2323 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.0973 | 0.0529 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.0973 | 0.0529 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0277 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0085 | 0.2323 | 0.1946 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0088 | 0.2455 | 0.2084 |
Echinococcus granulosus | cyclin dependent kinase | 0.0085 | 0.2323 | 0.2323 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0051 | 0.0973 | 0.0973 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0051 | 0.0973 | 0.2721 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.0973 | 0.0529 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0085 | 0.2323 | 0.1946 |
Entamoeba histolytica | protein kinase, putative | 0.0088 | 0.2455 | 0.2084 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0085 | 0.2323 | 0.1946 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0277 | 1 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0088 | 0.2455 | 0.2084 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0277 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0051 | 0.0973 | 0.0529 |
Schistosoma mansoni | immunophilin | 0.0239 | 0.8479 | 0.8404 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0038 | 0.0468 | 0.0468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.