Detailed information for compound 1475593

Basic information

Technical information
  • TDR Targets ID: 1475593
  • Name: N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2,6-dime thylquinolin-4-amine
  • MW: 306.358 | Formula: C19H18N2O2
  • H donors: 1 H acceptors: 1 LogP: 4.21 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c(Nc1ccc3c(c1)OCCO3)cc(n2)C
  • InChi: 1S/C19H18N2O2/c1-12-3-5-16-15(9-12)17(10-13(2)20-16)21-14-4-6-18-19(11-14)23-8-7-22-18/h3-6,9-11H,7-8H2,1-2H3,(H,20,21)
  • InChiKey: NOGWKIKUGIOGRI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2,6-dimethyl-quinolin-4-amine
  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2,6-dimethyl-4-quinolinamine
  • 2,3-dihydro-1,4-benzodioxin-7-yl-(2,6-dimethyl-4-quinolyl)amine
  • ZINC00120767
  • Oprea1_201083
  • Oprea1_868572
  • EU-0043921

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0149 0.6749 0.6728
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.1283 0.1227
Chlamydia trachomatis glycogen phosphorylase 0.0212 1 1
Giardia lamblia Glycogen phosphorylase 0.0212 1 1
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.5085 0.5085
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0064 0.0064
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.5085 0.5085
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0149 0.6749 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2132 0.2132
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0456 0.0587
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0456 0.0456
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2132 0.2132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1875 0.1875
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.5085 0.5085
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.1272 0.1272
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0456 0.0456
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.1489 0.2132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1875 0.1875
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.3029 0.3029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.006 0.2132 0.2132
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.0097 0.4063 0.4025
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0149 0.6749 0.6728
Schistosoma mansoni hypothetical protein 0.0041 0.1145 0.1145
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0064 0.0064
Echinococcus granulosus glycogen phosphorylase 0.0212 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.1272 0.1272
Loa Loa (eye worm) hypothetical protein 0.0074 0.2827 0.2827
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0066 0.0052
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0052 0.1699 0.1646
Loa Loa (eye worm) acetyltransferase 0.0163 0.7433 0.7433
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0456 0.0456
Loa Loa (eye worm) dUTP diphosphatase 0.0149 0.6749 0.6749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0456 0.0395
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0149 0.6749 0.6749
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0064 0.0064
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.3029 0.3029
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0149 0.6749 1
Brugia malayi acetyltransferase, GNAT family protein 0.0163 0.7433 0.7433
Schistosoma mansoni glycogen phosphorylase 0.0092 0.3763 0.3763
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.1489 0.2132
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0456 1
Schistosoma mansoni glycogen phosphorylase 0.0212 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0064 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0064 0.0064
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0149 0.6749 0.6728
Loa Loa (eye worm) hypothetical protein 0.004 0.1069 0.1069
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.0052 0.1699 0.1646
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.4883 0.4883
Brugia malayi dUTP diphosphatase 0.0149 0.6749 0.6749
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0064 0.0064
Entamoeba histolytica glycogenphosphorylase, putative 0.0092 0.3763 0.3723
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0092 0.3763 1
Entamoeba histolytica hypothetical protein 0.0097 0.4063 0.4025
Brugia malayi Transient-receptor-potential like protein 0.0044 0.1272 0.1272
Entamoeba histolytica glycogen phosphorylase, putative 0.0212 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1875 0.1875
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.1283 0.1227
Echinococcus multilocularis Glycosyl transferase, family 35 0.0212 1 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.0212 1 1
Schistosoma mansoni transient receptor potential channel 0.0078 0.3029 0.3029
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0149 0.6749 0.6728
Schistosoma mansoni glycogen phosphorylase 0.0212 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0254
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.7197 0.7197
Echinococcus granulosus Glycosyl transferase family 35 0.0212 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1875 0.1875
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0092 0.3763 1
Echinococcus granulosus dUTP pyrophosphatase 0.0149 0.6749 0.6749
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0149 0.6749 0.6083
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0149 0.6749 0.6728
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0052 0.1699 0.5
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.1272 0.1272
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0163 0.7433 0.7433
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0456 0.0456
Loa Loa (eye worm) glycogen phosphorylase 0.0212 1 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0456 1
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.4883 0.4883
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0064 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2132 0.2132
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1145 0.1145
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0117 0.5085 0.5085
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0149 0.6749 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.3029 0.3029
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.1489 0.1435
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.1489 0.1435
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.3029 0.3029
Entamoeba histolytica glycogen phosphorylase, putative 0.0092 0.3763 0.3723
Echinococcus multilocularis dUTP pyrophosphatase 0.0149 0.6749 0.6749
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0149 0.6749 0.6728
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0052 0.1699 0.1646
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0066 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0149 0.6749 0.6728
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0163 0.7433 0.7433
Entamoeba histolytica glycogen phosphorylase, putative 0.0212 1 1
Schistosoma mansoni transient receptor potential channel 0.0117 0.5085 0.5085
Entamoeba histolytica hypothetical protein 0.0149 0.6749 0.6728
Onchocerca volvulus Glycogen phosphorylase homolog 0.0212 1 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1875 0.1875
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1875 0.1875
Trichomonas vaginalis glycogen phosphorylase, putative 0.0212 1 1
Echinococcus granulosus glycogen phosphorylase 0.0212 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1875 0.1875
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.0041 0.1145 0.1145
Entamoeba histolytica hypothetical protein 0.0028 0.0456 0.0395
Entamoeba histolytica glycogen phosphorylase, putative 0.0092 0.3763 0.3723
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0149 0.6749 1
Schistosoma mansoni transient receptor potential channel 0.0078 0.3029 0.3029
Echinococcus multilocularis glycogen phosphorylase 0.0212 1 1
Echinococcus multilocularis glycogen phosphorylase 0.0212 1 1
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0149 0.6749 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0254 0.4849
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0149 0.6749 0.6728
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.1489 0.1489

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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