Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | steroid hormone receptor | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0255 | 0.0255 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0978 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0255 | 0.0255 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1488 | 0.1488 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1954 | 0.1954 |
Brugia malayi | Animal haem peroxidase family protein | 0.0207 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0207 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.122 | 0.122 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0082 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0207 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0061 | 0.2794 | 0.2794 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0255 | 0.0255 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2794 | 0.2794 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0027 | 0.0027 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0255 | 0.0255 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0082 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0255 | 0.0255 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1488 | 0.1488 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.2794 | 0.2794 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0255 | 0.0255 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0082 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0255 | 0.0255 |
Schistosoma mansoni | peroxidasin | 0.0207 | 1 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.1142 | 0.1142 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0313 | 0.0313 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1954 | 0.1954 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0005 | 0.0027 | 0.0027 |
Brugia malayi | Peroxidasin | 0.0207 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1954 | 0.1954 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0551 | 0.0551 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.2794 | 0.2794 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.1142 | 0.1142 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.2794 | 0.2794 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0255 | 0.0255 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0978 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0255 | 0.0255 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0255 | 0.0255 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1954 | 0.1954 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.2678 | 0.2678 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0027 | 0.0027 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0255 | 0.0255 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0082 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0255 | 0.0255 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.1142 | 0.1142 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0255 | 0.0255 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0255 | 0.0255 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0255 | 0.0255 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0112 | 0.0112 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0978 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1954 | 0.1954 |
Onchocerca volvulus | 0.0207 | 1 | 1 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0255 | 0.0255 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0207 | 1 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0313 | 0.0313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2794 | 0.2794 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0027 | 0.0027 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0082 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0082 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0255 | 0.0255 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1488 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2794 | 0.2794 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0978 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.122 | 0.122 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0255 | 0.0255 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1488 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2794 | 0.2794 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0255 | 0.0255 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0978 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0207 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.2794 | 0.2794 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.2794 | 0.2794 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0082 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0082 | 0.5 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0008 | 0.019 | 0.019 |
Echinococcus granulosus | peroxidasin | 0.0207 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0082 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0255 | 0.0255 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1954 | 0.1954 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0255 | 0.0255 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0112 | 0.0112 |
Brugia malayi | Animal haem peroxidase family protein | 0.0207 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0255 | 0.0255 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1488 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0112 | 0.0112 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0082 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0255 | 0.0255 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1488 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0005 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0255 | 0.0255 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.2794 | 0.2794 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0207 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0207 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0207 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0207 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.1142 | 0.1142 | |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0978 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1954 | 0.1954 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0978 | 0.0978 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1954 | 0.1954 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0255 | 0.0255 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0255 | 0.0255 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0255 | 0.0255 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0255 | 0.0255 |
Onchocerca volvulus | Dual oxidase homolog | 0.0207 | 1 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0313 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0196 | 0.0196 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0082 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0082 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0255 | 0.0255 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0255 | 0.0255 |
Onchocerca volvulus | Peroxidase homolog | 0.0207 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Onchocerca volvulus | 0.0207 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0027 | 0.0027 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.122 | 0.122 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0255 | 0.0255 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0082 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0207 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0255 | 0.0255 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.2368 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0027 | 0.0027 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.2794 | 0.2794 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | nuclear receptor RXR | 0.0005 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0978 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.122 | 0.122 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0255 | 0.0255 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0082 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.2794 | 0.2794 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0255 | 0.0255 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0255 | 0.0255 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.0027 | 0.0027 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | Blistered cuticle protein 3 | 0.0207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0082 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0255 | 0.0255 |
Echinococcus multilocularis | peroxidasin | 0.0207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0255 | 0.0255 |
Onchocerca volvulus | 0.001 | 0.0255 | 0.0255 | |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0005 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0255 | 0.0255 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0255 | 0.0255 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0255 | 0.0255 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0027 | 0.0027 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0255 | 0.0255 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0255 | 0.0255 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0255 | 0.0255 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1488 | 0.1488 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1954 | 0.1954 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1488 | 0.1488 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0978 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1488 | 0.1488 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0207 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0082 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0082 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0255 | 0.0255 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0082 | 0.5 |
Onchocerca volvulus | 0.0207 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.