Detailed information for compound 1475648

Basic information

Technical information
  • TDR Targets ID: 1475648
  • Name: N-[1-(6-bicyclo[2.2.1]heptanyl)ethyl]-2-(4-ch loro-5-methyl-3-nitropyrazol-1-yl)acetamide
  • MW: 340.805 | Formula: C15H21ClN4O3
  • H donors: 1 H acceptors: 4 LogP: 3.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1nc(c(c1C)Cl)[N+](=O)[O-])NC(C1CC2CC1CC2)C
  • InChi: 1S/C15H21ClN4O3/c1-8(12-6-10-3-4-11(12)5-10)17-13(21)7-19-9(2)14(16)15(18-19)20(22)23/h8,10-12H,3-7H2,1-2H3,(H,17,21)
  • InChiKey: VVBYKTPVKNNWLX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-chloro-5-methyl-3-nitro-pyrazol-1-yl)-N-(1-norbornan-2-ylethyl)acetamide
  • 2-(4-chloro-5-methyl-3-nitro-1-pyrazolyl)-N-[1-(2-norbornanyl)ethyl]acetamide
  • 2-(4-chloro-5-methyl-3-nitro-pyrazol-1-yl)-N-[1-(2-norbornyl)ethyl]acetamide
  • N-[1-(6-bicyclo[2.2.1]heptanyl)ethyl]-2-(4-chloro-5-methyl-3-nitro-pyrazol-1-yl)ethanamide
  • SMR000159352
  • N-(1-bicyclo[2.2.1]hept-2-ylethyl)-2-{4-chloro-3-nitro-5-methyl-1H-pyrazol-1-yl}acetamide
  • ST5031779
  • MLS000539052
  • AK-968/12024015

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0382 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0688 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0541 0.0541
Brugia malayi EGF-like domain containing protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) animal heme peroxidase 0.0688 1 1
Schistosoma mansoni notch 0.0209 0.2835 0.2835
Echinococcus granulosus neurogenic locus notch protein 4 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Onchocerca volvulus Dual oxidase homolog 0.0688 1 1
Echinococcus multilocularis neurogenic locus notch protein 0.0209 0.2835 0.2835
Brugia malayi Animal haem peroxidase family protein 0.0688 1 1
Brugia malayi Blistered cuticle protein 3 0.0688 1 1
Echinococcus granulosus delta-like protein 1 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0382 0.5
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Brugia malayi Delta serrate ligand family protein 0.0209 0.2835 0.2835
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0541 0.0541
Giardia lamblia High cysteine protein 0.0209 0.2835 0.5
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0382 0.5
Loa Loa (eye worm) notch protein 0.0209 0.2835 0.2835
Brugia malayi Muscle positioning protein 4 0.0209 0.2835 0.2835
Schistosoma mansoni notch 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Echinococcus multilocularis notch 0.0209 0.2835 0.2835
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0312 0.5
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Schistosoma mansoni laminin gamma-3 chain 0.0209 0.2835 0.2835
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0382 0.5
Schistosoma mansoni peroxidasin 0.0688 1 1
Echinococcus multilocularis fibropellin Ia 0.0209 0.2835 0.2835
Brugia malayi Animal haem peroxidase family protein 0.0688 1 1
Brugia malayi EGF-like domain containing protein 0.0209 0.2835 0.2835
Echinococcus granulosus neural cadherin 0.0209 0.2835 0.2835
Schistosoma mansoni notch 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0541 0.0541
Echinococcus multilocularis neural cadherin 0.0209 0.2835 0.2835
Echinococcus multilocularis protein jagged 2 0.0209 0.2835 0.2835
Brugia malayi Cadherin domain containing protein 0.0209 0.2835 0.2835
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0209 0.2835 0.2835
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Brugia malayi notch-like transmembrane receptor 0.0209 0.2835 0.2835
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0541 0.0541
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0382 0.5
Schistosoma mansoni septate junction protein 0.0209 0.2835 0.2835
Schistosoma mansoni hypothetical protein 0.0209 0.2835 0.2835
Schistosoma mansoni notch 0.0209 0.2835 0.2835
Echinococcus multilocularis neurogenic locus notch protein 0.0209 0.2835 0.2835
Echinococcus granulosus neurogenic locus notch protein 0.0209 0.2835 0.2835
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0312 0.5
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0382 0.5
Schistosoma mansoni hypothetical protein 0.0209 0.2835 0.2835
Schistosoma mansoni inositol monophosphatase 0.0045 0.0382 0.0382
Onchocerca volvulus Chorion peroxidase homolog 0.0688 1 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0382 0.5
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Echinococcus multilocularis slit 2 protein 0.0209 0.2835 0.2835
Brugia malayi EGF-like domain containing protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Brugia malayi Calcium binding EGF domain containing protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Brugia malayi Calcium binding EGF domain containing protein 0.0209 0.2835 0.2835
Schistosoma mansoni cell polarity protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) animal heme peroxidase 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0615 0.0615
Loa Loa (eye worm) blistered cuticle protein 3 0.0688 1 1
Loa Loa (eye worm) inositol-1 0.0045 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Brugia malayi EGF-like domain containing protein 0.0209 0.2835 0.2835
Brugia malayi EGF-like domain containing protein 0.0209 0.2835 0.2835
Echinococcus multilocularis protein jagged 1 0.0209 0.2835 0.2835
Toxoplasma gondii EGF family domain-containing protein 0.0209 0.2835 1
Schistosoma mansoni hypothetical protein 0.0209 0.2835 0.2835
Onchocerca volvulus Peroxidasin homolog 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Brugia malayi Animal haem peroxidase family protein 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Schistosoma mansoni hypothetical protein 0.0209 0.2835 0.2835
Brugia malayi Peroxidasin 0.0688 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.033 0.033
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.187 0.187
Brugia malayi MH2 domain containing protein 0.0144 0.187 0.187
Echinococcus granulosus protein jagged 2 0.0209 0.2835 0.2835
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0382 0.5
Onchocerca volvulus 0.0688 1 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0209 0.2835 0.2835
Schistosoma mansoni hypothetical protein 0.0209 0.2835 0.2835
Schistosoma mansoni notch 0.0209 0.2835 0.2835
Echinococcus multilocularis fat cadherin tumor suppressor 0.0209 0.2835 0.2835
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.187 0.187
Brugia malayi GCC2 and GCC3 family protein 0.0209 0.2835 0.2835
Schistosoma mansoni slit 0.0209 0.2835 0.2835
Echinococcus granulosus slit 2 protein 0.0209 0.2835 0.2835
Echinococcus multilocularis peroxidasin 0.0688 1 1
Brugia malayi Inositol-1 0.0045 0.0382 0.0382
Schistosoma mansoni hypothetical protein 0.0041 0.033 0.033
Brugia malayi Animal haem peroxidase family protein 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.033 0.033
Brugia malayi Calcium binding EGF domain containing protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Onchocerca volvulus 0.0688 1 1
Onchocerca volvulus Peroxidasin homolog 0.0688 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0382 0.5
Loa Loa (eye worm) Notch2 0.0209 0.2835 0.2835
Echinococcus multilocularis neurogenic locus protein delta 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Schistosoma mansoni notch 0.0209 0.2835 0.2835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0541 0.0541
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0382 0.5
Schistosoma mansoni peroxidasin 0.0688 1 1
Echinococcus granulosus protein jagged 1 0.0209 0.2835 0.2835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0541 0.0541
Echinococcus granulosus neurogenic locus protein delta 0.0209 0.2835 0.2835
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Brugia malayi EGF-like domain containing protein 0.0209 0.2835 0.2835
Brugia malayi Animal haem peroxidase family protein 0.0688 1 1
Echinococcus granulosus peroxidasin 0.0688 1 1
Schistosoma mansoni hypothetical protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Echinococcus granulosus neurogenic locus notch protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0615 0.0615
Onchocerca volvulus Peroxidase homolog 0.0688 1 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0382 0.0382
Onchocerca volvulus Peroxidase homolog 0.0688 1 1
Echinococcus granulosus protein jagged 1 0.0209 0.2835 0.2835
Brugia malayi Cadherin domain containing protein 0.0209 0.2835 0.2835
Echinococcus granulosus notch 0.0209 0.2835 0.2835
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0382 0.0382
Echinococcus granulosus fibropellin Ia 0.0209 0.2835 0.2835
Echinococcus multilocularis neurogenic locus protein delta 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Echinococcus multilocularis protein jagged 1 0.0209 0.2835 0.2835
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0541 0.0541
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0541 0.0541
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0615 0.0615
Onchocerca volvulus 0.0688 1 1
Brugia malayi EGF-like domain containing protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0209 0.2835 0.2835
Schistosoma mansoni hypothetical protein 0.0209 0.2835 0.2835
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Echinococcus granulosus protein jagged 2 0.0209 0.2835 0.2835

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.