Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.043 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.043 | 0.043 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0072 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0072 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0072 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0072 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0043 | 0.043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0043 | 0.043 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0072 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.043 | 0.043 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0042 | 0 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0043 | 0.043 | 0.043 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0043 | 0.043 | 0.043 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.043 | 0.043 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0043 | 0.043 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0072 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0043 | 0.043 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.043 | 0.043 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0043 | 0.043 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.043 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0043 | 0.043 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human recombinant MAOB expressed in baculovirus infected BTI insect cells assessed as hydrogen peroxide production at 100 uM after 15 mins by Amplex red assay | ChEMBL. | 20702005 | |
Inhibition (binding) | Inhibition of human recombinant MAOA expressed in baculovirus infected BTI insect cells assessed as hydrogen peroxide production at 100 uM after 15 mins by Amplex red assay | ChEMBL. | 20702005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.