Detailed information for compound 1476487

Basic information

Technical information
  • TDR Targets ID: 1476487
  • Name: 3-(2-bromo-6-chloro-4-methylphenoxy)-N-(pheny lmethyl)propan-1-amine
  • MW: 368.696 | Formula: C17H19BrClNO
  • H donors: 1 H acceptors: 0 LogP: 5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(Cl)c(c(c1)Br)OCCCNCc1ccccc1
  • InChi: 1S/C17H19BrClNO/c1-13-10-15(18)17(16(19)11-13)21-9-5-8-20-12-14-6-3-2-4-7-14/h2-4,6-7,10-11,20H,5,8-9,12H2,1H3
  • InChiKey: XETJGRBNXWEFOH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2-bromo-6-chloro-4-methyl-phenoxy)-N-(phenylmethyl)propan-1-amine
  • benzyl-[3-(2-bromo-6-chloro-4-methyl-phenoxy)propyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0418 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0056 0.1806
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0084 0.1855
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.1196 0.4118
Trichomonas vaginalis MYB3r3, putative 0.0028 0.0056 0.1806
Schistosoma mansoni hypothetical protein 0.0037 0.0102 0.0353
Loa Loa (eye worm) hypothetical protein 0.0133 0.0607 0.2089
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.007 0.0272 0.6446
Entamoeba histolytica hypothetical protein 0.0037 0.0102 0.8819
Entamoeba histolytica hypothetical protein 0.0037 0.0102 0.8819
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.007 0.0272 0.0938
Leishmania major DNA polymerase kappa, putative 0.004 0.0115 0.2603
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0084 0.1855
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0178 0.0699
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1383 0.7155 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0222 0.1071 0.1487
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0115 0.0396
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 0.6446
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0084 0.1855
Loa Loa (eye worm) hypothetical protein 0.0141 0.0645 0.2221
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.007 0.0272 0.6446
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0115 0.2603
Echinococcus multilocularis dna polymerase eta 0.0066 0.0252 0.0868
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0115 0.2603
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0028 0.0057 0.0167
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 0.6446
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 0.6446
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.007 0.0272 0.6446
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.007 0.0272 0.1072
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0056 0.4472
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 0.6446
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0109 0.2453
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.007 0.0272 0.0938
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0084 0.0106
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.007 0.0272 0.6446
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.007 0.0272 0.6446
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0543 0.2753 0.2691
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0115 0.2603
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0272 0.6446
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0084 0.0076
Brugia malayi RNA binding protein 0.0065 0.0251 0.0987
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0272 0.6446
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0502 0.2539 0.8744
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0572 0.2903 1
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.0418 0.1439
Schistosoma mansoni hypothetical protein 0.0035 0.0092 0.0317
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 0.6446
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0084 0.0076
Trypanosoma brucei trypanothione reductase 0.0097 0.0418 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0272 0.6446
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0251 0.0863
Trypanosoma brucei unspecified product 0.0027 0.0051 0.1031
Plasmodium falciparum phosphodiesterase delta, putative 0.007 0.0272 0.6446
Trypanosoma brucei unspecified product 0.0027 0.0051 0.1031
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0115 0.2603
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.007 0.0272 0.0938
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0272 0.0938
Loa Loa (eye worm) hypothetical protein 0.0572 0.2903 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Echinococcus granulosus tar DNA binding protein 0.0065 0.0251 0.0863
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0084 0.1855
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0247 0.1201 0.1669
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.007 0.0272 0.0938
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0008 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0251 0.0863
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0102 0.0353
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0008 0.0029
Brugia malayi glutathione reductase 0.0097 0.0418 0.1645
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.007 0.0272 0.0938
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0178 0.0612
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.0418 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.007 0.0272 0.0938
Plasmodium falciparum glutathione reductase 0.0034 0.0084 0.1855
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0115 0.2603
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.007 0.0272 0.0938
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0084 0.1855
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0272 0.0938
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0272 0.6446
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0247 0.1201 0.1669
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Leishmania major DNA polymerase eta, putative 0.0038 0.0109 0.2453
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.007 0.0272 0.1072
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0115 0.0149
Brugia malayi hypothetical protein 0.0037 0.0102 0.0403
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0056 0.4472
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0222 0.1071 0.1487
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0084 0.1855
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0115 0.2603
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0272 0.6446
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0084 0.1855
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0056 0.4472
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Trichomonas vaginalis pc-MYB2, putative 0.0028 0.0056 0.1806
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0115 0.0453
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0502 0.2539 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0115 0.0396
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0056 0.1806
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.007 0.0272 0.0938
Giardia lamblia DINP protein human, muc B family 0.004 0.0115 0.0368
Brugia malayi TAR-binding protein 0.0065 0.0251 0.0987
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Leishmania major DNA polymerase eta, putative 0.0066 0.0252 0.5948
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0502 0.2539 0.8744
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0084 0.0291
Brugia malayi MH2 domain containing protein 0.0246 0.1196 0.4709
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.007 0.0272 0.0938
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0084 0.1855
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0029
Echinococcus granulosus dna polymerase kappa 0.004 0.0115 0.0396
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0251 0.0863
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0084 0.1855
Trichomonas vaginalis pc-MYB2, putative 0.0028 0.0056 0.1806
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.007 0.0272 0.0938
Loa Loa (eye worm) hypothetical protein 0.007 0.0272 0.0938
Entamoeba histolytica hypothetical protein 0.0037 0.0102 0.8819
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0247 0.1201 0.0213
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0572 0.2903 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.007 0.0272 0.6446
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Echinococcus granulosus dna polymerase eta 0.0066 0.0252 0.0868
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 0.6446
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0115 0.0107
Schistosoma mansoni hypothetical protein 0.0349 0.1736 0.5978
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.0418 0.0573
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0252 0.0992
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0572 0.2903 1
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0115 0.0107
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0272 0.0938
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0272 0.1072
Loa Loa (eye worm) PDE1B protein 0.007 0.0272 0.0938
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0272 0.1072
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0056 0.4472
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0057 0.1833
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0543 0.2753 0.2747
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.007 0.0272 0.6446
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0084 0.0076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Trichomonas vaginalis C-MYB, putative 0.0028 0.0056 0.1806
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0272 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0272 0.0938
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.007 0.0272 0.1072
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0272 1
Leishmania major hypothetical protein, conserved 0.007 0.0272 0.6446
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0084 0.1855
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0051 0.1031
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0272 0.0938
Echinococcus multilocularis dna polymerase kappa 0.004 0.0115 0.0396
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0115 0.2603
Mycobacterium tuberculosis Probable reductase 0.0222 0.1071 0.1487
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0222 0.1071 0.1487
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0008 0.0033
Mycobacterium tuberculosis Probable oxidoreductase 0.0247 0.1201 0.1669
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0084 0.0291
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0084 0.1855
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0272 0.0938
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0084 0.1855
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0056 0.1806
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0251 0.0863
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.007 0.0272 0.6446
Trichomonas vaginalis MYB72, putative 0.0028 0.0056 0.1806
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0008 0.0029
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0572 0.2903 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0272 0.6446
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0084 0.1855
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.007 0.0272 0.0938
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0084 0.0076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0084 0.0332
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0115 0.4039
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0115 0.0149
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Onchocerca volvulus 0.0133 0.0607 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0115 0.2603
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0572 0.2903 1
Plasmodium vivax glutathione reductase, putative 0.0097 0.0418 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0084 0.1855
Loa Loa (eye worm) hypothetical protein 0.0035 0.0092 0.0317
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0084 0.1855
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0272 0.0938
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Leishmania major trypanothione reductase 0.0097 0.0418 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0272 0.1072
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.0418 0.1439
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0056 0.4472
Trypanosoma brucei unspecified product 0.004 0.0115 0.2603
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0272 0.6446
Loa Loa (eye worm) RNA binding protein 0.0065 0.0251 0.0863
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0272 1
Giardia lamblia Hypothetical protein 0.007 0.0272 0.0911
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.007 0.0272 0.0938
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0084 0.1855
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0115 0.2603
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0272 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0272 0.6446
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0251 0.0863
Toxoplasma gondii thioredoxin reductase 0.0097 0.0418 0.1414
Plasmodium vivax phosphodiesterase gamma, putative 0.007 0.0272 0.6446
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0272 1
Treponema pallidum NADH oxidase 0.0034 0.0084 0.0076
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0543 0.2753 0.2764
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0115 0.2603
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0251 0.0863
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Loa Loa (eye worm) glutathione reductase 0.0097 0.0418 0.1439
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0115 0.0396
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0572 0.2903 1
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0252 0.5948
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0272 0.6446
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Echinococcus multilocularis geminin 0.0349 0.1736 0.5978
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0084 0.1855
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0084 0.2878
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0084 0.1855
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Trichomonas vaginalis MYB, putative 0.0028 0.0057 0.1833
Mycobacterium tuberculosis Probable dehydrogenase 0.0222 0.1071 0.1487
Echinococcus granulosus geminin 0.0349 0.1736 0.5978
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0115 0.2603
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0037 0.0148
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0084 0.0262
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0251 0.0863
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0084 0.0076
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0109 0.0347
Leishmania major cAMP-specific phosphodiesterase, putative 0.007 0.0272 0.6446
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0056 0.1806
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0115 0.2603
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.007 0.0272 0.0938
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.007 0.0272 0.6446
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0252 0.5948
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0115 0.2603
Giardia lamblia Myb 1-like protein 0.0028 0.0057 0.0167
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0251 0.0987
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0272 0.6446
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0115 0.0396
Plasmodium falciparum phosphodiesterase gamma, putative 0.007 0.0272 0.6446
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0084 0.1855
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0115 0.0396
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0056 0.1806
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 0.6446
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0272 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0037 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0051 0.1031
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0084 0.0262
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0051 0.1031
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.007 0.0272 0.0938
Plasmodium falciparum thioredoxin reductase 0.0097 0.0418 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0115 0.2603
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0222 0.1071 0.1487
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0115 0.2603
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0084 0.2878
Giardia lamblia hypothetical protein 0.007 0.0272 0.0911
Trypanosoma brucei cAMP-specific phosphodiesterase 0.007 0.0272 0.6446
Loa Loa (eye worm) hypothetical protein 0.0144 0.0661 0.2275
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0115 0.4039
Trichomonas vaginalis C-MYB, putative 0.0028 0.0056 0.1806
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0057 0.1833
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0092 0.0363
Entamoeba histolytica hypothetical protein 0.0037 0.0102 0.8819
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0102 0.0353
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.007 0.0272 0.0938
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0029
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0115 1
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.1196 0.4118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0272 0.0911
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0115 0.2603
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0056 0.1806
Schistosoma mansoni DNA polymerase eta 0.0066 0.0252 0.0868
Schistosoma mansoni hypothetical protein 0.0349 0.1736 0.5978
Loa Loa (eye worm) hypothetical protein 0.0051 0.0178 0.0612
Plasmodium falciparum glutathione reductase 0.0097 0.0418 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0115 0.2603
Plasmodium falciparum thioredoxin reductase 0.0034 0.0084 0.1855
Loa Loa (eye worm) hypothetical protein 0.007 0.0272 0.0938
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0543 0.2753 0.948
Leishmania major hypothetical protein, conserved 0.007 0.0272 0.6446
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0084 0.1855
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0084 0.1855
Loa Loa (eye worm) hypothetical protein 0.0133 0.0607 0.2089
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.007 0.0272 0.0938
Plasmodium falciparum cGMP-specific phosphodiesterase 0.007 0.0272 0.6446
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0115 0.2603
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0084 0.0291
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0272 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.0418 0.1439
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0178 0.0699
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0084 0.0262
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0251 0.0863
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1383 0.7155 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0502 0.2539 0.8744
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.007 0.0272 0.0938
Loa Loa (eye worm) hypothetical protein 0.0133 0.0607 0.2089
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0572 0.2903 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0252 0.0868
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0272 0.6446
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0272 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0102 0.0353
Brugia malayi Thioredoxin reductase 0.0097 0.0418 0.1645

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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