Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1333 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Brugia malayi | Animal haem peroxidase family protein | 0.0027 | 0.0052 | 0.0516 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0369 | 0.3682 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Echinococcus multilocularis | geminin | 0.017 | 0.1142 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1333 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0369 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0027 | 0.0052 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1001 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0369 | 0.2909 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Brugia malayi | Animal haem peroxidase family protein | 0.0027 | 0.0052 | 0.0516 |
Trichomonas vaginalis | MYB, putative | 0.003 | 0.0075 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0027 | 0.0052 | 0.0516 |
Brugia malayi | hypothetical protein | 0.0152 | 0.1001 | 1 |
Brugia malayi | Peroxidasin | 0.0027 | 0.0052 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0369 | 0.2909 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.0957 | 0.7138 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.003 | 0.0075 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0149 | 0.0892 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0369 | 0.2909 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.0369 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.0369 | 0.3682 |
Giardia lamblia | Myb 1-like protein | 0.003 | 0.0075 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.1142 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0027 | 0.0052 | 0.0516 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.003 | 0.0075 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.0369 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0027 | 0.0052 | 0.0516 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1333 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0027 | 0.0052 | 0.0516 |
Onchocerca volvulus | 0.0152 | 0.1001 | 1 | |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.0957 | 0.7138 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0027 | 0.0052 | 0.0516 |
Echinococcus granulosus | geminin | 0.017 | 0.1142 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0376 | 0.2709 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0052 | 0.0516 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0369 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0027 | 0.0052 | 0.0516 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0149 | 0.0892 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0027 | 0.0052 | 0.0516 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0376 | 0.2709 | 0.2709 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0369 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0082 | 0.0815 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.1142 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0082 | 0.0815 |
Brugia malayi | Blistered cuticle protein 3 | 0.0027 | 0.0052 | 0.0516 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.