Detailed information for compound 1476492

Basic information

Technical information
  • TDR Targets ID: 1476492
  • Name: N'-phenyl-2-pyridin-1-ium-1-ylacetohydrazide
  • MW: 228.27 | Formula: C13H14N3O+
  • H donors: 2 H acceptors: 1 LogP: 2.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C[n+]1ccccc1)NNc1ccccc1
  • InChi: 1S/C13H13N3O/c17-13(11-16-9-5-2-6-10-16)15-14-12-7-3-1-4-8-12/h1-10,14H,11H2/p+1
  • InChiKey: IWVBNIIMFMPYET-UHFFFAOYSA-O  

Network

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Synonyms

  • N'-phenyl-2-pyridin-1-ium-1-yl-acetohydrazide
  • N'-phenyl-2-(1-pyridin-1-iumyl)acetohydrazide
  • N'-phenyl-2-pyridin-1-ium-1-yl-ethanehydrazide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.013 0.824
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0101 0.0212
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0118 0.2714
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0145 0.9233
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0083 0.0306
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0457 0.2277 0.6232
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0049 0.3081
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.3081
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0457 0.2277 0.6232
Giardia lamblia DINP protein human, muc B family 0.0058 0.0158 0.0692
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0145 0.9233
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0145 0.353
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0145 0.0334
Trypanosoma brucei unspecified product 0.004 0.0062 0.1038
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0062 0.1038
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0058 0.0158 0.0368
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0194 0.0469
Brugia malayi MH2 domain containing protein 0.0482 0.2412 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0145 0.353
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Echinococcus multilocularis geminin 0.0684 0.3487 0.9578
Loa Loa (eye worm) hypothetical protein 0.0051 0.0121 0.0403
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0121 0.0409
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0027 0.0018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0027 0.1739
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.013 0.824
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.022 0.1017 0.1392
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0062 0.1038
Brugia malayi glutathione reductase 0.0096 0.0362 0.1418
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0145 0.353
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Schistosoma mansoni alpha-glucosidase 0.0145 0.062 0.1647
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0027 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0101 0.0327
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0145 0.0334
Plasmodium falciparum glutathione reductase 0.0096 0.0362 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.3081
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0362 0.1412
Brugia malayi Smad1 0.0033 0.0025 0.0006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Leishmania major hypothetical protein, conserved 0.0056 0.0145 0.353
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.013 0.0291
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0457 0.2277 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0295 0.1132
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.013 0.0291
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0194 0.0469
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0145 0.0334
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.013 0.0441
Schistosoma mansoni alpha-glucosidase 0.0145 0.062 0.1647
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0145 0.0334
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0101 0.0321
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.3081
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.013 0.3062
Brugia malayi hypothetical protein 0.0312 0.1509 0.6221
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0145 0.0506
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0049 0.0066
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0056 0.0145 0.0334
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.353
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0145 0.353
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0145 0.353
Loa Loa (eye worm) hypothetical protein 0.0035 0.0035 0.0044
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Mycobacterium tuberculosis Probable oxidoreductase 0.0244 0.1148 0.1575
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0145 0.353
Schistosoma mansoni DNA polymerase eta 0.0084 0.0295 0.0748
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Echinococcus granulosus dna polymerase kappa 0.0058 0.0158 0.0368
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0027 0.012
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0145 0.0334
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.0145 0.353
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0101 0.0212
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.022 0.1017 0.1392
Mycobacterium tuberculosis Probable dehydrogenase 0.022 0.1017 0.1392
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0158 0.0183
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Brugia malayi hypothetical protein 0.0109 0.0428 0.1695
Onchocerca volvulus Huntingtin homolog 0.0127 0.0523 0.136
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0062 0.1038
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0194 0.0715
Brugia malayi TAR-binding protein 0.0065 0.0194 0.0715
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0049 0.0066
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0145 0.0334
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.0295 0.8
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0745 0.1992
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0145 0.0334
Entamoeba histolytica hypothetical protein 0.0109 0.0428 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0392
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0194 0.0469
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.0158 0.3891
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0538 0.2711 0.2691
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0145 0.0334
Loa Loa (eye worm) hypothetical protein 0.0312 0.1509 0.6219
Brugia malayi MH2 domain containing protein 0.0033 0.0025 0.0006
Leishmania major DNA polymerase eta, putative 0.0084 0.0295 0.8
Trypanosoma brucei glucosidase, putative 0.0037 0.0049 0.0632
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.191 1 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.0145 0.353
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.191 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0118 0.2714
Trypanosoma brucei protein kinase, putative 0.0053 0.013 0.3062
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0244 0.1148 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0194 0.0469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0101 0.0212
Leishmania major DNA polymerase eta, putative 0.0044 0.0083 0.1659
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0145 0.353
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0145 0.0334
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0145 0.0334
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0145 0.0512
Onchocerca volvulus Huntingtin homolog 0.0127 0.0523 0.136
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0158 0.3891
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.013 0.3062
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0158 0.3891
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Leishmania major hypothetical protein, conserved 0.005 0.0118 0.2714
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.0745 0.3016
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.353
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0145 0.0334
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0145 0.0512
Echinococcus granulosus tar DNA binding protein 0.0065 0.0194 0.0469
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.013 0.0291
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0056 0.0145 0.353
Loa Loa (eye worm) glutathione reductase 0.0096 0.0362 0.1412
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0457 0.2277 0.6232
Brugia malayi MH1 domain containing protein 0.0033 0.0025 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0118 0.2714
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0428 0.1116
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0083 0.1659
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.013 0.3062
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0027 0.0008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0049 0.3081
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0056 0.0145 0.353
Brugia malayi MAP kinase sur-1 0.0053 0.013 0.0447
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.3639 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0049 0.0632
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0145 0.0512
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0158 0.3891
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Toxoplasma gondii thioredoxin reductase 0.0096 0.0362 0.1335
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.0158 0.0183
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0027 0.0101
Brugia malayi hypothetical protein 0.005 0.0118 0.0398
Brugia malayi ImpB/MucB/SamB family protein 0.0084 0.0295 0.1138
Loa Loa (eye worm) MH2 domain-containing protein 0.0482 0.2412 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0457 0.2277 0.6232
Schistosoma mansoni hypothetical protein 0.0109 0.0428 0.1116
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1372 0.7139 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0101 0.0212
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.013 0.0479
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0145 0.0512
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.013 0.0291
Plasmodium vivax glutathione reductase, putative 0.0096 0.0362 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0058 0.0158 0.0557
Onchocerca volvulus 0.0312 0.1509 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.3081
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0145 0.9233
Mycobacterium tuberculosis Putative ferredoxin reductase 0.022 0.1017 0.1392
Entamoeba histolytica deoxycytidyl transferase, putative 0.0058 0.0158 0.2872
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0362 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0244 0.1148 0.1575
Trypanosoma brucei DNA polymerase eta, putative 0.0084 0.0295 0.8
Brugia malayi hypothetical protein 0.0127 0.0523 0.2091
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0145 0.353
Echinococcus granulosus geminin 0.0684 0.3487 0.9578
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0121 0.0409
Trypanosoma brucei unspecified product 0.0058 0.0158 0.3891
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0145 0.353
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Echinococcus multilocularis dna polymerase kappa 0.0058 0.0158 0.0368
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0457 0.2277 0.8398
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.353
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.191 1 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.013 0.3062
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0027 0.0008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0745 0.1992
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.353
Entamoeba histolytica hypothetical protein 0.0109 0.0428 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0049 0.0179
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0145 0.353
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.353
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0058 0.0158 0.0368
Loa Loa (eye worm) transcription factor SMAD2 0.0482 0.2412 1
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.3639 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0049 0.0632
Plasmodium falciparum thioredoxin reductase 0.0096 0.0362 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0362 0.0933
Brugia malayi MH2 domain containing protein 0.0033 0.0025 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.013 0.0291
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0145 0.0334
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0145 0.353
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0118 0.0436
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0145 0.0334
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.0158 1
Trypanosoma brucei unspecified product 0.004 0.0062 0.1038
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0145 0.0334
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.353
Loa Loa (eye worm) hypothetical protein 0.0127 0.0523 0.2086
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0145 0.353
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0538 0.2711 0.2691
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0158 0.0131
Entamoeba histolytica hypothetical protein 0.0109 0.0428 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0145 0.0334
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.353
Giardia lamblia Hypothetical protein 0.0056 0.0145 0.0639
Echinococcus multilocularis dna polymerase eta 0.0084 0.0295 0.0748
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0101 0.0212
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0027 0.1739
Echinococcus granulosus dna polymerase eta 0.0084 0.0295 0.0748
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0194 0.0469
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0145 0.0334
Loa Loa (eye worm) hypothetical protein 0.0127 0.0523 0.2086
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0145 0.353
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0145 0.0512
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0538 0.2711 0.2767
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0457 0.2277 0.6232
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0145 0.9233
Loa Loa (eye worm) PDE1B protein 0.0056 0.0145 0.0506
Loa Loa (eye worm) hypothetical protein 0.0457 0.2277 0.9434
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0049 0.3081
Brugia malayi Thioredoxin reductase 0.0096 0.0362 0.1418
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.0145 0.353
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0049 0.0106
Leishmania major DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0145 0.0334
Leishmania major trypanothione reductase 0.0096 0.0362 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Schistosoma mansoni alpha glucosidase 0.0037 0.0049 0.0066
Brugia malayi RNA binding protein 0.0065 0.0194 0.0715
Brugia malayi MH1 domain containing protein 0.0033 0.0025 0.0006
Mycobacterium tuberculosis Probable reductase 0.022 0.1017 0.1392
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.013 0.824
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0049 0.3081
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0145 0.353
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.0158 0.0563
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.013 0.057
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Leishmania major hypothetical protein, conserved 0.0056 0.0145 0.353
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0158 0.0131
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0244 0.1148 0.1575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0101 0.0212
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0056 0.0145 0.0512
Loa Loa (eye worm) RNA binding protein 0.0065 0.0194 0.071
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0145 0.0334
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.0745 0.1992
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0145 0.9233
Loa Loa (eye worm) hypothetical protein 0.0056 0.0145 0.0506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0101 0.0212
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0362 0.047
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.013 0.3062
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Schistosoma mansoni hypothetical protein 0.0684 0.3487 0.9578
Schistosoma mansoni hypothetical protein 0.0684 0.3487 0.9578
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0401 0.1982 0.8197
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0027 0.0101
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.0158 1
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0145 0.353
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0145 0.9233
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0058 0.0158 0.0368
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0145 0.0334
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0118 0.2714
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0401 0.1982 0.5415
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0145 0.353
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0428 0.1116
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0145 0.353
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0194 0.071
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0362 0.0933
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.013 0.824
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.022 0.1017 0.1392
Schistosoma mansoni terminal deoxycytidyl transferase 0.0058 0.0158 0.0368
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0049 0.01
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0145 0.353
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0121 0.0403
Loa Loa (eye worm) hypothetical protein 0.0056 0.0145 0.0506
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0145 0.9233
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0145 0.0334
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0362 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0401 0.1982 0.8198
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0145 0.353
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0118 0.2714
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.013 0.3062
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0049 0.0632
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0194 0.071
Trypanosoma brucei trypanothione reductase 0.0096 0.0362 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0145 0.353
Echinococcus granulosus microtubule associated protein 2 0.0713 0.3639 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1372 0.7139 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0049 0.3081
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0158 0.3891
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.013 0.3062
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0035 0.005
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0538 0.2711 1
Entamoeba histolytica hypothetical protein 0.0109 0.0428 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0145 0.9233
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.0745 0.302
Schistosoma mansoni hypothetical protein 0.0035 0.0035 0.0029
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0194 0.0469
Giardia lamblia hypothetical protein 0.0056 0.0145 0.0639
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0428 0.1116
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0401 0.1982 0.5415
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0145 0.353
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0145 0.0537
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0118 0.2714
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0145 0.0334
Loa Loa (eye worm) hypothetical protein 0.0056 0.0145 0.0506

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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