Detailed information for compound 1476546

Basic information

Technical information
  • TDR Targets ID: 1476546
  • Name: N-[(2R)-1-cyclohexyl-3-[[(2S)-1-(methyl-nitro soamino)-3-phenylpropan-2-yl]-nitrosoamino]pr opan-2-yl]-N-(2-phenylethyl)nitrous amide
  • MW: 494.629 | Formula: C27H38N6O3
  • H donors: 0 H acceptors: 3 LogP: 7.26 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=NN(C[C@@H](N(C[C@H](N(CCc1ccccc1)N=O)CC1CCCCC1)N=O)Cc1ccccc1)C
  • InChi: 1S/C27H38N6O3/c1-31(28-34)21-26(19-24-13-7-3-8-14-24)33(30-36)22-27(20-25-15-9-4-10-16-25)32(29-35)18-17-23-11-5-2-6-12-23/h2-3,5-8,11-14,25-27H,4,9-10,15-22H2,1H3/t26-,27+/m0/s1
  • InChiKey: RZMVAKXWRLAOJS-RRPNLBNLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1R)-1-(cyclohexylmethyl)-2-[[(1S)-1-[(methyl-nitroso-amino)methyl]-2-phenyl-ethyl]-nitroso-amino]ethyl]-N-(2-phenylethyl)nitrous amide
  • N-[(1R)-1-(cyclohexylmethyl)-2-[[(1S)-1-[(methyl-nitrosoamino)methyl]-2-phenylethyl]-nitrosoamino]ethyl]-N-(2-phenylethyl)nitrous amide
  • N-[(1R)-1-[[[(1S)-1-(benzyl)-2-(methyl-nitroso-amino)ethyl]-nitroso-amino]methyl]-2-cyclohexyl-ethyl]-N-(2-phenylethyl)nitrous amide
  • N-[(2R)-1-cyclohexyl-3-[[(2S)-1-(methyl-nitroso-amino)-3-phenyl-propan-2-yl]-nitroso-amino]propan-2-yl]-N-(2-phenylethyl)nitrous amide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0156 0.1874 0.3083
Echinococcus granulosus nuclear receptor nhr 48 0.0046 0.0296 0.0088
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.004 0.0209 0.0327
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0041 0.0236 0.1259
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0097 0.1025 0.1687
Brugia malayi nuclear receptor RXR 0.0051 0.0374 0.0615
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0041 0.0236 0.0388
Onchocerca volvulus 0.0041 0.0236 0.2302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0097 0.1025 0.1687
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0156 0.1874 0.3083
Brugia malayi orphan nuclear receptor NR2E1 0.0046 0.0296 0.0486
Mycobacterium ulcerans NADH dehydrogenase 0.0041 0.0236 0.1259
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.004 0.0209 0.0344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0296 0.0285
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0041 0.0236 0.0388
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0236 0.0372
Onchocerca volvulus 0.0046 0.0296 0.2884
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.1874 0.3071
Schistosoma mansoni zinc finger protein 0.0046 0.0296 0.0285
Trypanosoma cruzi trypanothione reductase, putative 0.0451 0.6078 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0156 0.1874 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0331 0.0321
Echinococcus granulosus thioredoxin glutathione reductase 0.0451 0.6078 0.5994
Echinococcus multilocularis geminin 0.0178 0.2187 0.2179
Brugia malayi nuclear hormone receptor 0.0046 0.0296 0.0486
Schistosoma mansoni hypothetical protein 0.0041 0.0236 0.0226
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0046 0.0296 0.0486
Echinococcus multilocularis glutamate synthase 0.0041 0.0236 0.0226
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0156 0.1874 0.3083
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0097 0.1025 0.0833
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0051 0.0374 0.0364
Plasmodium falciparum glutathione reductase 0.0156 0.1874 0.2803
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0041 0.0236 0.0162
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0236 0.0162
Onchocerca volvulus 0.0046 0.0296 0.2884
Plasmodium falciparum thioredoxin reductase 0.0451 0.6078 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0156 0.1874 0.3083
Onchocerca volvulus Bile acid receptor homolog 0.0097 0.1025 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0236 0.0046
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0041 0.0236 0.0388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0331 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0097 0.1025 0.1687
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.0209 0.0199
Schistosoma mansoni thyroid hormone receptor 0.0097 0.1025 0.1016
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0041 0.0236 0.0388
Loa Loa (eye worm) hypothetical protein 0.0097 0.1025 0.1687
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0041 0.0236 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0097 0.1025 0.1687
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0041 0.0236 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0041 0.0236 0.0028
Brugia malayi Peptidase family M1 containing protein 0.004 0.0209 0.0344
Schistosoma mansoni sulfide quinone reductase 0.0041 0.0236 0.0226
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0041 0.0236 0.0388
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0296 0.0285
Loa Loa (eye worm) hypothetical protein 0.0051 0.0374 0.0615
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.1025 0.0833
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0097 0.1025 0.1016
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0236 0.0372
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0097 0.1025 0.1687
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0046 0.0296 0.0285
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0156 0.1874 0.2803
Loa Loa (eye worm) programmed cell death 8 0.0041 0.0236 0.0388
Mycobacterium ulcerans dehydrogenase 0.0041 0.0236 0.1259
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Trichomonas vaginalis mercuric reductase, putative 0.0156 0.1874 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0331 0.0544
Schistosoma mansoni glutamate synthase 0.0041 0.0236 0.0226
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0236 0.0162
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0041 0.0236 0.1259
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0156 0.1874 0.1865
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0097 0.1025 1
Loa Loa (eye worm) aminopeptidase N 0.004 0.0209 0.0344
Brugia malayi nuclear receptor NHR-88 0.0097 0.1025 0.1687
Echinococcus multilocularis FTZ F1 alpha 0.0097 0.1025 0.1016
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0041 0.0236 0.0388
Mycobacterium ulcerans glutamate synthase subunit beta 0.0041 0.0236 0.1259
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0156 0.1874 1
Mycobacterium ulcerans monoxygenase 0.0041 0.0236 0.1259
Mycobacterium tuberculosis Probable oxidoreductase 0.0156 0.1874 0.3083
Schistosoma mansoni microtubule-associated protein tau 0.0726 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0097 0.1025 0.1016
Schistosoma mansoni nuclear receptor 0.0046 0.0296 0.0285
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0115 0.1282 0.2109
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0156 0.1874 0.1865
Brugia malayi nuclear hormone receptor family member nhr-6 0.0046 0.0296 0.0486
Loa Loa (eye worm) hypothetical protein 0.0051 0.0374 0.0615
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0041 0.0236 0.0388
Plasmodium falciparum glutathione reductase 0.0451 0.6078 1
Leishmania major NADH dehydrogenase, putative 0.0041 0.0236 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.1025 0.1687
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.004 0.0209 0.0344
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0041 0.0236 0.1259
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0156 0.1874 1
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0041 0.0236 0.1259
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.004 0.0209 0.0199
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0041 0.0236 0.0388
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0041 0.0236 0.0162
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0374 0.0615
Brugia malayi hypothetical protein 0.0046 0.0296 0.0486
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0041 0.0236 0.1259
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0097 0.1025 0.0833
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0041 0.0236 1
Toxoplasma gondii NADPH-glutathione reductase 0.0156 0.1874 0.2803
Echinococcus multilocularis thyroid hormone receptor alpha 0.0097 0.1025 0.1016
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0097 0.1025 0.0833
Loa Loa (eye worm) thioredoxin reductase 0.0451 0.6078 1
Brugia malayi nuclear receptor NHR-67 0.0046 0.0296 0.0486
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0156 0.1874 1
Entamoeba histolytica aminopeptidase, putative 0.004 0.0209 0.8857
Schistosoma mansoni coup transcription factor 0.0097 0.1025 0.1016
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0041 0.0236 0.0388
Schistosoma mansoni disulfide oxidoreductase 0.0041 0.0236 0.0226
Loa Loa (eye worm) hypothetical protein 0.0097 0.1025 0.1687
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0097 0.1025 0.1016
Treponema pallidum NADH oxidase 0.0156 0.1874 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0115 0.1282 0.2109
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0041 0.0236 0.1259
Mycobacterium tuberculosis Probable dehydrogenase 0.0041 0.0236 0.0388
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0236 0.0162
Echinococcus granulosus glutamate synthase 0.0041 0.0236 0.0028
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0041 0.0236 0.0162
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0156 0.1874 0.17
Brugia malayi Thioredoxin reductase 0.0451 0.6078 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.0017
Plasmodium vivax glutathione reductase, putative 0.0451 0.6078 1
Schistosoma mansoni retinoic acid receptor RXR 0.0097 0.1025 0.1016
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.0209 0.0199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0331 0.0124
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0374 0.0364
Brugia malayi nuclear receptor RXR 0.0046 0.0296 0.0486
Loa Loa (eye worm) hypothetical protein 0.0041 0.0236 0.0388
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Leishmania major hypothetical protein, conserved 0.0041 0.0236 0.0388
Entamoeba histolytica disulphide oxidoreductase, putative 0.0041 0.0236 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0041 0.0236 0.0028
Loa Loa (eye worm) hypothetical protein 0.0051 0.0374 0.0615
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0097 0.1025 0.1687
Loa Loa (eye worm) hypothetical protein 0.0097 0.1025 0.1687
Brugia malayi tailless protein 0.0046 0.0296 0.0486
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0097 0.1025 0.1016
Schistosoma mansoni thyroid hormone receptor 0.0097 0.1025 0.1016
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0296 0.0486
Brugia malayi Peptidase family M1 containing protein 0.004 0.0209 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0097 0.1025 0.1687
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0041 0.0236 0.0372
Trichomonas vaginalis glutamate synthase, putative 0.0041 0.0236 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0097 0.1025 0.1687
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0097 0.1025 0.1687
Echinococcus granulosus FTZ F1 alpha 0.0097 0.1025 0.0833
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0041 0.0236 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0156 0.1874 0.2836
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0296 0.2884
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0156 0.1874 0.2836
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0041 0.0236 0.1259
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0156 0.1874 0.2803
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0331 0.0321
Brugia malayi nuclear receptor NHR-88 0.0046 0.0296 0.0486
Brugia malayi steroid hormone receptor 0.0097 0.1025 0.1687
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0331 0.0321
Brugia malayi glutathione reductase 0.0451 0.6078 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0156 0.1874 0.3071
Echinococcus multilocularis thioredoxin glutathione reductase 0.0451 0.6078 0.6074
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0041 0.0236 0.1259
Trypanosoma brucei NADH dehydrogenase 0.0041 0.0236 0.0046
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0051 0.0374 0.0168
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0046 0.0296 0.0088
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0097 0.1025 0.0833
Leishmania major trypanothione reductase 0.0451 0.6078 1
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0041 0.0236 0.1259
Brugia malayi ecdysone receptor 0.0046 0.0296 0.0486
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0156 0.1874 0.3071
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0097 0.1025 0.1016
Brugia malayi nuclear hormone receptor 0.0097 0.1025 0.1687
Schistosoma mansoni steroid hormone receptor ad4bp 0.0097 0.1025 0.1016
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.0209 0.0199
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0041 0.0236 0.0028
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0041 0.0236 0.0388
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0331 0.0544
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0051 0.0374 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0097 0.1025 0.1687
Trypanosoma cruzi trypanothione reductase, putative 0.0156 0.1874 0.3071
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0156 0.1874 0.3083
Mycobacterium ulcerans ferredoxin reductase 0.0041 0.0236 0.1259
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0097 0.1025 0.1687
Mycobacterium ulcerans hypothetical protein 0.0041 0.0236 0.1259
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0097 0.1025 0.1687
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.004 0.0209 0.0199
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.0017
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0236 0.0046
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0097 0.1025 0.0833
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0041 0.0236 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0097 0.1025 0.1687
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0156 0.1874 0.2836
Trichomonas vaginalis apoptosis inducing factor, putative 0.0041 0.0236 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0097 0.1025 0.1687
Schistosoma mansoni sulfide quinone reductase 0.0041 0.0236 0.0226
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0156 0.1874 1
Brugia malayi hypothetical protein 0.004 0.0209 0.0344
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0097 0.1025 0.1016
Echinococcus granulosus ecdysone induced protein 78C 0.0097 0.1025 0.0833
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0046 0.0296 0.0285
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0041 0.0236 0.0028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0046 0.0296 0.0486
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0097 0.1025 0.1016
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0296 0.0285
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0097 0.1025 0.1016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.1025 0.1016
Loa Loa (eye worm) glutathione reductase 0.0451 0.6078 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0046 0.0296 0.0285
Trypanosoma cruzi Aminopeptidase M1, putative 0.004 0.0209 0.0327
Schistosoma mansoni glutamate synthase 0.0041 0.0236 0.0226
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0041 0.0236 0.0388
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0041 0.0236 0.1259
Loa Loa (eye worm) nuclear receptor NHR-67 0.0046 0.0296 0.0486
Leishmania major hypothetical protein, conserved 0.0041 0.0236 0.0388
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.1874 0.3071
Loa Loa (eye worm) nuclear hormone receptor 0.0046 0.0296 0.0486
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0097 0.1025 0.1016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0296 0.0088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.1874 0.3071
Brugia malayi photoreceptor-specific nuclear receptor 0.0097 0.1025 0.1687
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0041 0.0236 0.0226
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0041 0.0236 0.1259
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0046 0.0296 0.0285
Echinococcus multilocularis ecdysone induced protein 78C 0.0097 0.1025 0.1016
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0156 0.1874 0.2836
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0041 0.0236 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0097 0.1025 0.1687
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0097 0.1025 0.1687
Onchocerca volvulus 0.0097 0.1025 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.1874 0.3071
Loa Loa (eye worm) hypothetical protein 0.0097 0.1025 0.1687
Entamoeba histolytica thioredoxin reductase, putative 0.0041 0.0236 1
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0296 0.0285
Echinococcus granulosus geminin 0.0178 0.2187 0.202
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0296 0.0088
Brugia malayi glutamate synthase 0.0041 0.0236 0.0388
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.0209 0.0199
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0236 0.0162
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Schistosoma mansoni glutamate synthase 0.0041 0.0236 0.0226
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.1025 0.1016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0097 0.1025 0.1687
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0041 0.0236 1
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0374 0.0615
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0236 0.0372
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0041 0.0236 1
Echinococcus multilocularis microtubule associated protein 2 0.0726 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.1025 0.1687
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0041 0.0236 0.0388
Brugia malayi conserved hypotetical protein 0.0046 0.0296 0.0486
Onchocerca volvulus 0.004 0.0209 0.2039
Trypanosoma cruzi NADH dehydrogenase, putative 0.0041 0.0236 0.0372
Schistosoma mansoni hypothetical protein 0.0178 0.2187 0.2179
Trypanosoma cruzi NADH dehydrogenase, putative 0.0041 0.0236 0.0372
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0041 0.0236 0.0046
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0236 0.0162
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0156 0.1874 0.3083
Plasmodium vivax thioredoxin reductase, putative 0.0451 0.6078 1
Schistosoma mansoni hypothetical protein 0.0178 0.2187 0.2179
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.004 0.0209 0.0199
Schistosoma mansoni nuclear receptor 0.0046 0.0296 0.0285
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0051 0.0374 0.0615
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0156 0.1874 0.2803
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0041 0.0236 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0331 0.0321
Brugia malayi hypothetical protein 0.0051 0.0374 0.0615
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0041 0.0236 0.0226
Schistosoma mansoni nuclear hormone receptor 0.0097 0.1025 0.1016
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0451 0.6078 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0097 0.1025 0.1687
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0296 0.0285
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0041 0.0236 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0097 0.1025 0.1687
Mycobacterium ulcerans aminopeptidase N PepN 0.004 0.0209 0.1115
Loa Loa (eye worm) DR-78 0.0046 0.0296 0.0486
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0041 0.0236 0.0162
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0156 0.1874 0.3083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.1874 0.3071
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0296 0.0486
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0156 0.1874 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0097 0.1025 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0041 0.0236 0.0226
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.0017
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0296 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.1025 0.0833
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0041 0.0236 0.0372
Echinococcus multilocularis aminopeptidase N 0.004 0.0209 0.0199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0331 0.0124
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0156 0.1874 0.2803
Brugia malayi nuclear hormone receptor family member odr-7 0.0046 0.0296 0.0486
Loa Loa (eye worm) hypothetical protein 0.0046 0.0296 0.0486
Toxoplasma gondii thioredoxin reductase 0.0451 0.6078 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0097 0.1025 0.1687
Loa Loa (eye worm) hypothetical protein 0.0097 0.1025 0.1687
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0041 0.0236 0.0226
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0041 0.0236 0.0226
Loa Loa (eye worm) hypothetical protein 0.0097 0.1025 0.1687
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0156 0.1874 0.3071
Giardia lamblia NADH oxidase lateral transfer candidate 0.0156 0.1874 1
Trypanosoma brucei trypanothione reductase 0.0451 0.6078 1
Brugia malayi hypothetical protein 0.0046 0.0296 0.0486
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0041 0.0236 0.0388
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0097 0.1025 0.1016
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0041 0.0236 0.1259
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.004 0.0209 0.0199
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0156 0.1874 1
Brugia malayi ecdysteroid receptor 0.0097 0.1025 0.1687
Trichomonas vaginalis glutamate synthase, putative 0.0041 0.0236 0.0162
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0041 0.0236 0.0388
Trichomonas vaginalis glutathione reductase, putative 0.0156 0.1874 1
Leishmania major hypothetical protein, conserved 0.0041 0.0236 0.0388
Echinococcus granulosus thyroid hormone receptor alpha 0.0046 0.0296 0.0088
Loa Loa (eye worm) hypothetical protein 0.0051 0.0374 0.0615
Brugia malayi Steroid receptor seven-up type 2 0.0097 0.1025 0.1687
Mycobacterium tuberculosis Probable reductase 0.0041 0.0236 0.0388
Echinococcus multilocularis nuclear receptor nhr 48 0.0046 0.0296 0.0285
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0041 0.0236 0.0226
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0156 0.1874 0.3083
Onchocerca volvulus 0.004 0.0209 0.2039
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0296 0.2884
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0236 0.0372
Plasmodium falciparum thioredoxin reductase 0.0156 0.1874 0.2803
Loa Loa (eye worm) hypothetical protein 0.0051 0.0374 0.0615
Loa Loa (eye worm) hypothetical protein 0.0097 0.1025 0.1687
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0041 0.0236 0.0028
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0041 0.0236 0.0388
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0156 0.1874 0.2803
Brugia malayi hypothetical protein 0.0051 0.0374 0.0615
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0097 0.1025 0.1016
Loa Loa (eye worm) steroid hormone receptor 0.0097 0.1025 0.1687
Trypanosoma cruzi aminopeptidase, putative 0.004 0.0209 0.0327
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0041 0.0236 0.0372
Schistosoma mansoni nuclear receptor nhr-48 0.0046 0.0296 0.0285

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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