Detailed information for compound 1476669

Basic information

Technical information
  • TDR Targets ID: 1476669
  • Name: 8-[[(4-ethoxyphenyl)amino]methyl]-7-hydroxy-4 -propylchromen-2-one
  • MW: 353.412 | Formula: C21H23NO4
  • H donors: 2 H acceptors: 2 LogP: 4.26 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1cc(=O)oc2c1ccc(c2CNc1ccc(cc1)OCC)O
  • InChi: 1S/C21H23NO4/c1-3-5-14-12-20(24)26-21-17(14)10-11-19(23)18(21)13-22-15-6-8-16(9-7-15)25-4-2/h6-12,22-23H,3-5,13H2,1-2H3
  • InChiKey: MGYNYYHOKFPVGP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[[(4-ethoxyphenyl)amino]methyl]-7-hydroxy-4-propyl-chromen-2-one
  • 8-[[(4-ethoxyphenyl)amino]methyl]-7-hydroxy-4-propyl-2-chromenone
  • 8-[[(4-ethoxyphenyl)amino]methyl]-7-hydroxy-4-propyl-coumarin
  • ZINC06662472

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0017 0.0009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0116 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0054 0.0117 0.1829
Brugia malayi Pre-SET motif family protein 0.0221 0.064 0.064
Leishmania major DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Echinococcus granulosus lamin dm0 0.003 0.0044 0.0109
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0017 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0017 0.0267
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.012 0.0111
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0117 0.0115
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0017 0.0009
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.3213 1 1
Schistosoma mansoni hypothetical protein 0.033 0.0982 0.098
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1255 0.3874 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0017 0.0009
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1255 0.3874 1
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0017 0.0017
Brugia malayi intermediate filament protein 0.003 0.0044 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.014 0.0357
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.3213 1 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.012 0.0288
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0009 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0366 0.0358
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0366 0.0358
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0044 0.0044
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.3213 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0017 0.0009
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0017 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.1255 0.3874 1
Echinococcus granulosus dna polymerase kappa 0.0022 0.0017 0.0039
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0202 0.0582 0.9099
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.014 0.0357
Leishmania major DNA polymerase eta, putative 0.0022 0.0017 0.0009
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.3213 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0048 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.014 0.0357
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.0366 0.0941
Brugia malayi mbt repeat family protein 0.0054 0.0117 0.0117
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.012 0.0111
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.012 0.0304
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0215 0.0623 0.1603
Schistosoma mansoni ap endonuclease 0.0019 0.0009 0.0007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0048 0.004
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0017 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0582 0.058
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.3213 1 1
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.3213 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1255 0.3874 1
Brugia malayi RNA recognition motif domain containing protein 0.0202 0.0582 0.0582
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0002 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0116 0.1813
Onchocerca volvulus 0.0251 0.0735 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0101 0.0256
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0048 0.0046
Schistosoma mansoni lamin 0.003 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0754
Plasmodium vivax SET domain protein, putative 0.0032 0.0048 0.004
Entamoeba histolytica hypothetical protein 0.0075 0.0183 0.0452
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.012 0.0304
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.012 0.0111
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0183 0.0468
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0017 0.0017
Schistosoma mansoni intermediate filament proteins 0.003 0.0044 0.0042
Echinococcus multilocularis dna polymerase eta 0.0022 0.0017 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0101 0.0099
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.1813
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0183 0.0181
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.014 0.014
Entamoeba histolytica hypothetical protein 0.0075 0.0183 0.0452
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0048 0.0046
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0048 0.012
Onchocerca volvulus 0.0032 0.0048 0.006
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0017 0.0022
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0117 0.1829
Schistosoma mansoni DNA polymerase eta 0.0022 0.0017 0.0015
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1255 0.3874 1
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.012 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.014 0.0357
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0017 0.0009
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0215 0.0623 0.1603
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0101 0.0099
Echinococcus multilocularis lamin dm0 0.003 0.0044 0.0109
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0116 0.0116
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0017 0.0015
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0117 0.0115
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.0366 0.0358
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0101 0.0256
Brugia malayi Pre-SET motif family protein 0.0032 0.0048 0.0048
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1255 0.3874 1
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0582 0.058
Schistosoma mansoni ap endonuclease 0.0019 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0063 0.0988
Plasmodium falciparum dihydroorotate dehydrogenase 0.3213 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0101 0.1578
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1255 0.3874 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0267
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0117 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0101 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0582 0.058
Giardia lamblia DINP protein human, muc B family 0.0022 0.0017 0.0769
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.064 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0048 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0117 0.0297
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0017 0.0015
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1255 0.3874 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0045 0.011
Brugia malayi hypothetical protein 0.0075 0.0183 0.0183
Echinococcus multilocularis lamin 0.003 0.0044 0.0109
Echinococcus multilocularis tar DNA binding protein 0.0202 0.0582 0.1499
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0009 0.0133
Echinococcus multilocularis musashi 0.003 0.0044 0.0109
Echinococcus granulosus dna polymerase eta 0.0022 0.0017 0.0039
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.012 0.0111
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.012 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1255 0.3874 1
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.3213 1 1
Brugia malayi Zinc finger, C2H2 type family protein 0.1255 0.3874 0.3874
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0366 0.0364
Schistosoma mansoni lamin 0.003 0.0044 0.0042
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0002 0.0031
Trypanosoma brucei protein kinase, putative 0.0055 0.012 0.0111
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.0366 0.0358
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0017 0.0039
Entamoeba histolytica hypothetical protein 0.0075 0.0183 0.0452
Leishmania major dihydroorotate dehydrogenase 0.3213 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0031
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0048 0.012
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.3213 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0009 0.0017
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0017 0.0039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0101 0.0101
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.012 0.0111
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1255 0.3874 0.3869
Brugia malayi mbt repeat family protein 0.0054 0.0117 0.0117
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0017 0.0039
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.3213 1 1
Loa Loa (eye worm) MBCTL1 0.0061 0.014 0.2192
Entamoeba histolytica hypothetical protein 0.0075 0.0183 0.0452
Brugia malayi TAR-binding protein 0.0202 0.0582 0.0582
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.014 0.0138
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.1255 0.3874 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1255 0.3874 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Brugia malayi RNA binding protein 0.0202 0.0582 0.0582
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0101 0.0256
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0002 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0366 0.0364
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0017 0.0009
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0009 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.0366 0.0941
Schistosoma mansoni dihydroorotate dehydrogenase 0.3213 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.012 0.0288
Trichomonas vaginalis set domain proteins, putative 0.0251 0.0735 0.1881
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0017 0.0009
Echinococcus granulosus lamin 0.003 0.0044 0.0109
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0063 0.0063
Trypanosoma brucei unspecified product 0.0022 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0689
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0017 0.0022
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0117 0.1055
Schistosoma mansoni hypothetical protein 0.0075 0.0183 0.0181
Loa Loa (eye worm) TAR-binding protein 0.0202 0.0582 0.9099
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.012 0.1871
Brugia malayi MAP kinase sur-1 0.0055 0.012 0.012
Onchocerca volvulus 0.0054 0.0117 0.1055
Loa Loa (eye worm) hypothetical protein 0.0061 0.014 0.2192
Echinococcus granulosus tar DNA binding protein 0.0202 0.0582 0.1499
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0582 0.058
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.3213 1 1
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.3213 1 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.012 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.012 0.0288
Loa Loa (eye worm) RNA binding protein 0.0202 0.0582 0.9099
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0582 0.058
Loa Loa (eye worm) intermediate filament protein 0.003 0.0044 0.0689
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0048 0.0046
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.012 0.0304
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0366 0.0358
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0009 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0017 0.0009
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.0366 0.0358
Echinococcus granulosus intermediate filament protein 0.003 0.0044 0.0109
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0117 0.0297
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.012 0.0288
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0044 0.0689
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0661
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0117 0.0297
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.012 0.0304
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Schistosoma mansoni hypothetical protein 0.0036 0.0063 0.0061
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0117 0.0297
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0183 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.012 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0017 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0101 0.0256

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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