Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0044 | 0.202 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.202 | 0.5 |
Toxoplasma gondii | cathepsin B | 0.0044 | 0.202 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0044 | 0.202 | 0.202 |
Echinococcus granulosus | cathepsin b | 0.0134 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0134 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.202 | 0.5 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0044 | 0.202 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.202 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0134 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | cathepsin B | 0.0044 | 0.202 | 0.202 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0044 | 0.202 | 0.202 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0134 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0044 | 0.202 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0134 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0134 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.