Detailed information for compound 1476906

Basic information

Technical information
  • TDR Targets ID: 1476906
  • Name: 4-(3-chlorophenyl)-3-(dimethylaminomethyl)thi an-4-ol
  • MW: 285.833 | Formula: C14H20ClNOS
  • H donors: 1 H acceptors: 1 LogP: 2.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CC1CSCCC1(O)c1cccc(c1)Cl)C
  • InChi: 1S/C14H20ClNOS/c1-16(2)9-12-10-18-7-6-14(12,17)11-4-3-5-13(15)8-11/h3-5,8,12,17H,6-7,9-10H2,1-2H3
  • InChiKey: QKNJHOKHYFXNOT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(3-chlorophenyl)-3-(dimethylaminomethyl)tetrahydrothiopyran-4-ol
  • 4-(3-chlorophenyl)-3-(dimethylaminomethyl)-4-tetrahydrothiopyranol
  • Oprea1_508624
  • AE-641/30155028

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Glycogen phosphorylase homolog 0.0244 0.1023 1
Entamoeba histolytica hypothetical protein 0.0035 0.0091 0.0178
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0018
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0004 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0127 0.05 0.0497
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0051
Onchocerca volvulus 0.0049 0.0153 0.0988
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0018
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0183 0.0466
Giardia lamblia DINP protein human, muc B family 0.002 0.0022 0.0178
Brugia malayi RNA binding protein 0.0127 0.05 0.05
Echinococcus granulosus lamin dm0 0.0028 0.0058 0.0142
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0157 0.1496
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0004
Schistosoma mansoni lamin 0.0028 0.0058 0.0055
Plasmodium vivax SET domain protein, putative 0.0029 0.0063 0.0059
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.2257 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0091 0.0178
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0479 0.0476
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0106 0.0404 0.04
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.014 0.0354
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.0798 0.205
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0152 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0049 0.0152 0.1483
Brugia malayi Zinc finger, C2H2 type family protein 0.0881 0.3864 0.3864
Trypanosoma brucei trypanothione reductase 0.0046 0.0137 0.0133
Schistosoma mansoni glycogen phosphorylase 0.0244 0.1023 0.102
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.2257 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.018 0.1759
Brugia malayi TAR-binding protein 0.0127 0.05 0.05
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0153 0.0388
Echinococcus multilocularis lamin dm0 0.0028 0.0058 0.0142
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0157 0.153
Leishmania major dihydroorotate dehydrogenase 0.2257 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0616
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0137 0.0133
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0022 0.0047
Echinococcus multilocularis dna polymerase eta 0.002 0.0022 0.0051
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0886 0.3883 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0091 0.0088
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0051
Leishmania major DNA polymerase kappa, putative 0.002 0.0022 0.0018
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0479 0.0475
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2257 1 1
Brugia malayi glutathione reductase 0.0046 0.0137 0.0137
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0479 0.0475
Entamoeba histolytica glycogen phosphorylase, putative 0.0106 0.0404 0.099
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0058 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0157 0.0393
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0479 0.0475
Brugia malayi mbt repeat family protein 0.0049 0.0153 0.0153
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0398 0.0394
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0886 0.3883 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0881 0.3864 0.9952
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0152 0.1483
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0183 0.0183
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0157 0.0152
Entamoeba histolytica hypothetical protein 0.0035 0.0091 0.0178
Brugia malayi MAP kinase sur-1 0.005 0.0157 0.0157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.018 0.0457
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.0798 0.205
Giardia lamblia Glycogen phosphorylase 0.0244 0.1023 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0398 0.0394
Trichomonas vaginalis set domain proteins, putative 0.023 0.0961 0.2467
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0886 0.3883 1
Echinococcus granulosus dna polymerase kappa 0.002 0.0022 0.0051
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0157 0.0152
Brugia malayi Pre-SET motif family protein 0.0202 0.0836 0.0836
Echinococcus multilocularis tar DNA binding protein 0.0127 0.05 0.1281
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0157 0.0152
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.2257 1 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0886 0.3883 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0157 0.0152
Schistosoma mansoni dihydroorotate dehydrogenase 0.2257 1 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0058 0.0055
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0881 0.3864 0.9952
Schistosoma mansoni hypothetical protein 0.0035 0.0091 0.0088
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0881 0.3864 0.3862
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0541
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0479 0.0475
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0479 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0018
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0183 0.0466
Plasmodium vivax glutathione reductase, putative 0.0046 0.0137 0.0133
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0153 0.0388
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0022 0.0018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0058 0.0563
Loa Loa (eye worm) glycogen phosphorylase 0.0244 0.1023 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.05 0.0497
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.2257 1 1
Brugia malayi hypothetical protein 0.0035 0.0091 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.018 0.0457
Loa Loa (eye worm) TAR-binding protein 0.0127 0.05 0.4886
Loa Loa (eye worm) hypothetical protein 0.0028 0.0058 0.0563
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0886 0.3883 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0063 0.0156
Loa Loa (eye worm) hypothetical protein 0.0033 0.0083 0.0808
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0157 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0063 0.0061
Echinococcus granulosus glycogen phosphorylase 0.0244 0.1023 0.2629
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.014 0.0354
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0003 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0022 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.018 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0018
Entamoeba histolytica glycogen phosphorylase, putative 0.0106 0.0404 0.099
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2257 1 1
Echinococcus multilocularis Glycosyl transferase, family 35 0.0244 0.1023 0.2629
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0063 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0018
Treponema pallidum NADH oxidase 0.0016 0.0004 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0479 0.1227
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0881 0.3864 0.9952
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.018 0.0457
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0063 0.0061
Entamoeba histolytica hypothetical protein 0.0035 0.0091 0.0178
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.05 0.05
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0886 0.3883 1
Echinococcus multilocularis glycogen phosphorylase 0.0244 0.1023 0.2629
Brugia malayi mbt repeat family protein 0.0049 0.0153 0.0153
Onchocerca volvulus 0.023 0.0961 0.9362
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0091 0.0228
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0157 0.0397
Schistosoma mansoni lamin 0.0028 0.0058 0.0055
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0398 0.0394
Echinococcus granulosus glycogen phosphorylase 0.0244 0.1023 0.2629
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2257 1 1
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0127 0.05 0.0497
Leishmania major trypanothione reductase 0.0046 0.0137 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0018
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0137 0.1342
Leishmania major DNA polymerase eta, putative 0.002 0.0022 0.0018
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0157 0.0397
Chlamydia trachomatis glycogen phosphorylase 0.0244 0.1023 1
Echinococcus granulosus lamin 0.0028 0.0058 0.0142
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0137 0.0133
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0218
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0091 0.0228
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0022 0.0018
Brugia malayi carbohydrate phosphorylase 0.0244 0.1023 0.1023
Loa Loa (eye worm) hypothetical protein 0.0049 0.0153 0.1496
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0479 0.0476
Entamoeba histolytica glycogen phosphorylase, putative 0.0244 0.1023 0.2591
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.008
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0157 0.0152
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.05 0.4886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.018 0.0177
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.045 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0479 0.0475
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.2257 1 1
Entamoeba histolytica glycogenphosphorylase, putative 0.0106 0.0404 0.099
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0022 0.0018
Echinococcus granulosus intermediate filament protein 0.0028 0.0058 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0018
Loa Loa (eye worm) RNA binding protein 0.0127 0.05 0.4886
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0183 0.0466
Schistosoma mansoni glycogen phosphorylase 0.0106 0.0404 0.0402
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.045 0.0446
Echinococcus granulosus tar DNA binding protein 0.0127 0.05 0.1281
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0157 0.0393
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0153 0.0988
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0157 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0127 0.05 0.0497
Loa Loa (eye worm) hypothetical protein 0.0056 0.0183 0.1793
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0183 0.0466
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0018
Trichomonas vaginalis glycogen phosphorylase, putative 0.0244 0.1023 0.2626
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0153 0.015
Entamoeba histolytica glycogen phosphorylase, putative 0.0244 0.1023 0.2591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.018 0.0177
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0153 0.0388
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.018 0.0457
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0886 0.3883 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0022 0.0018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0063 0.0156
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0153 0.015
Schistosoma mansoni tar DNA-binding protein 0.0127 0.05 0.0497
Loa Loa (eye worm) glutathione reductase 0.0046 0.0137 0.1342
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0004
Echinococcus multilocularis lamin 0.0028 0.0058 0.0142
Trypanosoma brucei protein kinase, putative 0.005 0.0157 0.0152
Plasmodium falciparum thioredoxin reductase 0.0046 0.0137 0.0133
Schistosoma mansoni glycogen phosphorylase 0.0244 0.1023 0.102
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0479 0.1227
Echinococcus multilocularis musashi 0.0028 0.0058 0.0142
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0022 0.002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0137 0.0133
Plasmodium falciparum dihydroorotate dehydrogenase 0.2257 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0003 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0063 0.0156
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0022 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0018
Loa Loa (eye worm) MBCTL1 0.0056 0.0183 0.1793
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0881 0.3864 0.9952
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.2257 1 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0022 0.0051
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0002
Brugia malayi intermediate filament protein 0.0028 0.0058 0.0058
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.045 0.0446
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0153 0.015
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0157 0.0152
Mycobacterium tuberculosis Probable reductase 0.0104 0.0398 0.0394
Echinococcus multilocularis glycogen phosphorylase 0.0244 0.1023 0.2629
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0153 0.0388
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0106 0.0404 0.04
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Onchocerca volvulus 0.0029 0.0063 0.0056
Plasmodium falciparum glutathione reductase 0.0046 0.0137 0.0133
Brugia malayi Pre-SET motif family protein 0.0029 0.0063 0.0063
Schistosoma mansoni DNA polymerase eta 0.002 0.0022 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0063 0.0061
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0022 0.0218
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0058 0.0058
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0022 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.018 0.018
Echinococcus granulosus dna polymerase eta 0.002 0.0022 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0157 0.0393
Toxoplasma gondii thioredoxin reductase 0.0046 0.0137 0.0133
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0025
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0083 0.0083
Trypanosoma brucei unspecified product 0.002 0.0022 0.0018
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0058 0.0563
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0836 0.8179
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0022 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0157 0.0393
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0153 0.1496
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0022 0.0018
Echinococcus granulosus Glycosyl transferase family 35 0.0244 0.1023 0.2629
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0018
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0157 0.0397
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0183 0.0181
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0157 0.0152
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0157 0.0397
Brugia malayi Thioredoxin reductase 0.0046 0.0137 0.0137
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0398 0.0394
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0398 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0018
Trichomonas vaginalis glycogen phosphorylase, putative 0.0244 0.1023 0.2626
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.2257 1 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2257 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.045 0.0446
Schistosoma mansoni hypothetical protein 0.0299 0.1267 0.1265

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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