TDR Targets

Basic information

Technical information

TDR Targets ID: 1476912
Name: N-tert-butyl-3-(2-ethylbutanoylamino)benzamid e
MW: 290.401 | Formula: C17H26N2O2
H donors: 2 H acceptors: 2 LogP: 3.12 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCC(C(=O)Nc1cccc(c1)C(=O)NC(C)(C)C)CC
InChi: 1S/C17H26N2O2/c1-6-12(7-2)15(20)18-14-10-8-9-13(11-14)16(21)19-17(3,4)5/h8-12H,6-7H2,1-5H3,(H,18,20)(H,19,21)
InChiKey: RBIBJPCBHKQAOT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-tert-butyl-3-[(2-ethyl-1-oxobutyl)amino]benzamide
MLS000675672
N-(tert-butyl)-3-[(2-ethylbutanoyl)amino]benzamide
SMR000295148
STK175881
ZINC00614927

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.002	0.0023
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0224	0.0656	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0055	0.0125	0.0114
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Schistosoma mansoni	ap endonuclease	0.0019	0.0011	0.0001
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.002	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0022	0.002	0.0304
Echinococcus multilocularis	lamin	0.0033	0.0053	0.0137
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.014	0.0134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Brugia malayi	RNA binding protein	0.0205	0.0597	0.0592
Entamoeba histolytica	hypothetical protein	0.0076	0.0189	0.0461
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.3196	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0135	0.0376	0.0365
Giardia lamblia	Kinase, CMGC MAPK	0.0055	0.0125	1
Schistosoma mansoni	tar DNA-binding protein	0.0205	0.0597	0.0587
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0106	0.01
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0106	0.0272
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.3196	1	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0019	0.001	0.016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0106	0.0095
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.002	0.0009
Echinococcus multilocularis	GPCR, family 2	0.0019	0.001	0.0027
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.3196	1	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.1248	0.3875	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0011	0.5
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.002	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0146	0.2221
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0055	0.0125	0.0322
Echinococcus granulosus	SAM and MBT domain containing protein	0.0054	0.0122	0.0315
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0062	0.0146	0.0135
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0219	0.0638	0.1647
Echinococcus multilocularis	lamin dm0	0.0033	0.0053	0.0137
Leishmania major	DNA polymerase eta, putative	0.0022	0.002	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Echinococcus granulosus	histone acetyltransferase MYST2	0.0062	0.0146	0.0376
Brugia malayi	RNA recognition motif domain containing protein	0.0205	0.0597	0.0592
Schistosoma mansoni	sex comb on midleg homolog	0.0054	0.0122	0.0112
Loa Loa (eye worm)	hypothetical protein	0.006	0.014	0.2133
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0106	0.0095
Echinococcus granulosus	mitogen activated protein kinase 3	0.0055	0.0125	0.0322
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0052	0.0133
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0053	0.0808
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.014	0.0134
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0076	0.0189	0.0489
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.002	0.0009
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.002	0.0014
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.1248	0.3875	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.001	0.0005
Echinococcus granulosus	intermediate filament protein	0.0033	0.0053	0.0137
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.1248	0.3875	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0052	0.0041
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0011	0.017
Echinococcus multilocularis	polycomb protein SCMH1	0.0054	0.0122	0.0315
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0055	0.0125	0.0114
Giardia lamblia	DINP protein human, muc B family	0.0022	0.002	0.0774
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Brugia malayi	hypothetical protein	0.0076	0.0189	0.0184
Leishmania major	dihydroorotate dehydrogenase	0.3196	1	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.002	0.0009
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0125	0.0114
Brugia malayi	mbt repeat family protein	0.0054	0.0122	0.0117
Plasmodium vivax	SET domain protein, putative	0.0032	0.0052	0.0041
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.0125	0.0114
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.1248	0.3875	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Loa Loa (eye worm)	TAR-binding protein	0.0205	0.0597	0.91
Brugia malayi	Pre-SET motif family protein	0.0032	0.0052	0.0046
Schistosoma mansoni	DNA polymerase eta	0.0022	0.002	0.0009
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0011	0.0006
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.3196	1	1
Onchocerca volvulus		0.0054	0.0122	0.1001
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0011	0.0029
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.1248	0.3875	0.3868
Onchocerca volvulus		0.0255	0.0753	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0052	0.0133
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0135	0.0376	0.0971
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.001	0.0027
Schistosoma mansoni	ap endonuclease	0.0019	0.0011	0.0001
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.001	0.0027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Schistosoma mansoni	lamin	0.0033	0.0053	0.0043
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.001	0.016
Entamoeba histolytica	hypothetical protein	0.0076	0.0189	0.0461
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0052	0.0041
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0054	0.0122	0.0112
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.1248	0.3875	1
Echinococcus granulosus	tar DNA binding protein	0.0205	0.0597	0.154
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0055	0.0125	0.0114
Brugia malayi	Zinc finger, C2H2 type family protein	0.1248	0.3875	0.3871
Schistosoma mansoni	dihydroorotate dehydrogenase	0.3196	1	1
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0053	0.0808
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.002	0.0304
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0076	0.0189	0.0489
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.002	0.0009
Echinococcus multilocularis	mitogen activated protein kinase	0.0055	0.0125	0.0322
Onchocerca volvulus		0.0033	0.0053	0.0018
Echinococcus granulosus	lamin	0.0033	0.0053	0.0137
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.3196	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0106	0.0095
Toxoplasma gondii	aldehyde dehydrogenase	0.0135	0.0376	0.0365
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0011	0.0029
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0055	0.0125	0.0114
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0125	0.0294
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0106	0.0272
Plasmodium falciparum	dihydroorotate dehydrogenase	0.3196	1	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.002	0.0009
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.3196	1	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0052	0.0789
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0106	0.161
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0135	0.0376	0.0365
Leishmania major	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Brugia malayi	intermediate filament protein	0.0033	0.0053	0.0048
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.002	0.0009
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.1248	0.3875	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0122	0.186
Entamoeba histolytica	hypothetical protein	0.0076	0.0189	0.0461
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0135	0.0376	0.0971
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0055	0.0125	0.0114
Schistosoma mansoni	lamin	0.0033	0.0053	0.0043
Brugia malayi	TAR-binding protein	0.0205	0.0597	0.0592
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.008	0.0075
Schistosoma mansoni	aldehyde dehydrogenase	0.0135	0.0376	0.0366
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0125	0.0294
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0054	0.0122	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0041	0.008	0.122
Schistosoma mansoni	hypothetical protein	0.0335	0.1004	0.0995
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0125	0.0294
Entamoeba histolytica	hypothetical protein	0.0076	0.0189	0.0461
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0048	0.0124
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0125	0.0294
Schistosoma mansoni	aldehyde dehydrogenase	0.0135	0.0376	0.0366
Schistosoma mansoni	tar DNA-binding protein	0.0205	0.0597	0.0587
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.001	0.0005
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.002	0.0051
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0062	0.0146	0.0376
Schistosoma mansoni	tar DNA-binding protein	0.0205	0.0597	0.0587
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.3196	1	1
Trypanosoma brucei	unspecified product	0.0022	0.002	0.0009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0052	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0053	0.0808
Schistosoma mansoni	sex comb on midleg homolog	0.0054	0.0122	0.0112
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.002	0.0009
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0135	0.0376	0.0365
Schistosoma mansoni	transcription factor LCR-F1	0.0076	0.0189	0.0179
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0052	0.0041
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0062	0.0146	0.014
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.002	0.0014
Schistosoma mansoni	tar DNA-binding protein	0.0205	0.0597	0.0587
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.1248	0.3875	1
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0053	0.0043
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0062	0.0146	0.0376
Brugia malayi	Pre-SET motif family protein	0.0224	0.0656	0.0651
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.002	0.0009
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.014	0.2133
Loa Loa (eye worm)	MBCTL1	0.0062	0.0146	0.2221
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.002	0.0009
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.3196	1	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0052	0.0133
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.002	0.0009
Echinococcus multilocularis	dna polymerase eta	0.0022	0.002	0.0051
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.002	0.0023
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.3196	1	1
Echinococcus granulosus	dna polymerase eta	0.0022	0.002	0.0051
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.1248	0.3875	1
Schistosoma mansoni	hypothetical protein	0.0076	0.0189	0.0179
Brugia malayi	mbt repeat family protein	0.0054	0.0122	0.0117
Schistosoma mansoni	hypothetical protein	0.0041	0.008	0.007
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.002	0.0009
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.001	0.0027
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0062	0.0146	0.0376
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.1248	0.3875	1
Trichomonas vaginalis	set domain proteins, putative	0.0255	0.0753	0.192
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0135	0.0376	0.0365
Echinococcus granulosus	mitogen activated protein kinase	0.0055	0.0125	0.0322
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0053	0.0048
Echinococcus multilocularis	tar DNA binding protein	0.0205	0.0597	0.154
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.3196	1	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0219	0.0638	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0051	0.0779
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0106	0.0272
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.1248	0.3875	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0054	0.0122	0.1001
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.1248	0.3875	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0135	0.0376	0.0365
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.0125	0.0114
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0055	0.0125	0.0114
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.002	0.0051
Echinococcus granulosus	lamin dm0	0.0033	0.0053	0.0137
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.002	0.0009
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0106	0.0272
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0205	0.0597	0.91
Schistosoma mansoni	tar DNA-binding protein	0.0205	0.0597	0.0587
Echinococcus granulosus	dna polymerase kappa	0.0022	0.002	0.0051
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0005	0.0083
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.001	0.0027
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0055	0.0125	0.1902
Echinococcus granulosus	polycomb protein SCMH1	0.0054	0.0122	0.0315
Loa Loa (eye worm)	RNA binding protein	0.0205	0.0597	0.91
Trypanosoma brucei	protein kinase, putative	0.0055	0.0125	0.0114
Echinococcus multilocularis	musashi	0.0033	0.0053	0.0137
Loa Loa (eye worm)	mbt repeat family protein	0.0054	0.0122	0.186
Onchocerca volvulus		0.0033	0.0053	0.0018
Brugia malayi	MAP kinase sur-1	0.0055	0.0125	0.0119
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.002	0.0009
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.3196	1	1
Echinococcus granulosus	GPCR family 2	0.0019	0.001	0.0027
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0052	0.0041

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0112 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.1689 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1368208

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1476912