Detailed information for compound 1476952

Basic information

Technical information
  • TDR Targets ID: 1476952
  • Name: 2-ethyl-1-(2-phenylethyl)benzimidazole
  • MW: 250.338 | Formula: C17H18N2
  • H donors: 0 H acceptors: 1 LogP: 4.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nc2c(n1CCc1ccccc1)cccc2
  • InChi: 1S/C17H18N2/c1-2-17-18-15-10-6-7-11-16(15)19(17)13-12-14-8-4-3-5-9-14/h3-11H,2,12-13H2,1H3
  • InChiKey: OXROMPOQODQDGU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • BAS 10319458
  • ZINC00099300
  • STOCK2S-46969
  • 2-Ethyl-1-phenethyl-1H-benzoimidazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) reprolysin 0.0089 0.0078 0.0078
Brugia malayi hypothetical protein 0.0035 0.0007 0.0007
Brugia malayi Glutamate receptor 1 precursor 0.0033 0.0005 0.0005
Echinococcus multilocularis MAM 0.0092 0.0082 0.0102
Onchocerca volvulus 0.0035 0.0008 0.0119
Brugia malayi Furin-like cysteine rich region family protein 0.046 0.056 0.056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0028 0.0034
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0043 0.007
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0227 0.0258 0.0258
Plasmodium falciparum LCCL domain-containing protein 0.0049 0.0026 0.0408
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0083 0.007 0.1593
Toxoplasma gondii type I fatty acid synthase, putative 0.0061 0.0041 0.0807
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0049 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.3005 0.3871 0.3871
Echinococcus multilocularis protein kinase c epsilon type 0.0094 0.0084 0.0105
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0097 0.0089 0.0924
Echinococcus granulosus disintegrin and metalloproteinase 0.0037 0.001 0.001
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0105 0.0098 0.1032
Loa Loa (eye worm) Carm1-pending protein 0.0035 0.0008 0.0008
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0338 0.0401 1
Echinococcus granulosus integrin alpha ps 0.0323 0.0382 0.0382
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0085 0.0073 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0009 0.0009
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0057 0.0036 0.0036
Brugia malayi EGF-like domain containing protein 0.0136 0.0139 0.0139
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.0029 0.0242
Brugia malayi angiogenesis inhibito 0.0052 0.003 0.003
Echinococcus granulosus discoidin domain containing receptor 2 0.0049 0.0026 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Schistosoma mansoni hypothetical protein 0.0049 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0052 0.003 0.003
Echinococcus multilocularis 0.01 0.0092 0.0115
Schistosoma mansoni integrin beta subunit 0.2909 0.3746 0.3746
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0338 0.0401 0.4491
Schistosoma mansoni hypothetical protein 0.0323 0.0382 0.0382
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0066 0.0048 0.0503
Echinococcus granulosus sodium:myo inositol cotransporter 0.0147 0.0154 0.0154
Giardia lamblia Tenascin precursor 0.0136 0.0139 0.0336
Trichomonas vaginalis hypothetical protein 0.0136 0.0139 0.0228
Mycobacterium tuberculosis Conserved hypothetical protein 0.01 0.0092 0.2157
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0035 0.0008 0.0009
Echinococcus multilocularis c4b binding protein beta chain 0.0035 0.0008 0.001
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0492 0.0602 0.0751
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0136 0.0139 0.0228
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0055 0.0034 0.064
Schistosoma mansoni chromatin regulatory protein sir2 0.0709 0.0884 0.0884
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0116 0.0112 0.2677
Plasmodium vivax plasmepsin V, putative 0.0392 0.0472 1
Onchocerca volvulus 0.0035 0.0008 0.0119
Schistosoma mansoni hypothetical protein 0.0035 0.0008 0.0008
Toxoplasma gondii histone deacetylase SIR2-like 0.0105 0.0098 0.2165
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.0281 0.0281
Trypanosoma brucei oligopeptidase b 0.0051 0.0029 0.0242
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.01 0.0092 0.2021
Plasmodium vivax apical sushi protein, putative 0.0035 0.0008 0.0012
Echinococcus granulosus discoidin domain receptor 0.0049 0.0026 0.0026
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0028 0.0034
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0105 0.0098 0.1032
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0062 0.0043 0.0768
Brugia malayi prolyl oligopeptidase family protein 0.0129 0.013 0.013
Brugia malayi hypothetical protein 0.0035 0.0008 0.0008
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1528 0.1949 0.32
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0634 0.0787 0.0787
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0035 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.01 0.0092 0.0092
Schistosoma mansoni inositol transporter 0.0147 0.0154 0.0154
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.001 0.001
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0035 0.0008 0.0008
Mycobacterium leprae Probable polyketide synthase Pks1 0.0088 0.0076 0.1333
Schistosoma mansoni discoidin domain receptor 0.0049 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.0401 0.0658
Schistosoma mansoni site-1 peptidase (S08 family) 0.0338 0.0401 0.0401
Mycobacterium ulcerans polyketide synthase 0.0088 0.0076 0.1272
Echinococcus granulosus glutamate NMDA receptor subunit 0.0281 0.0328 0.0328
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1528 0.1949 0.32
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0037 0.001 0.0013
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0147 0.0154 0.0192
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0338 0.0401 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0007
Brugia malayi Will die slowly protein 0.0202 0.0225 0.0225
Giardia lamblia Tenascin-X 0.0136 0.0139 0.0336
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0135 0.0137 0.0137
Leishmania major oligopeptidase b 0.0051 0.0029 0.0242
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Schistosoma mansoni integrin alpha-ps 0.0415 0.0502 0.0502
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Toxoplasma gondii prolyl endopeptidase 0.0129 0.013 0.2931
Plasmodium falciparum LCCL domain-containing protein 0.0049 0.0026 0.0408
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0713 0.089 0.111
Brugia malayi neuroendocrine convertase 1 precursor 0.487 0.6297 0.6297
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0069 0.1086
Plasmodium vivax NAD-dependent deacetylase, putative 0.0105 0.0098 0.1953
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Schistosoma mansoni ATP-binding cassette transporter 0.0035 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0057 0.0036 0.0036
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0057 0.0036 0.0045
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0085 0.0073 0.1191
Schistosoma mansoni septate junction protein 0.0058 0.0037 0.0037
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0105 0.0098 0.231
Schistosoma mansoni hypothetical protein 0.0057 0.0036 0.0036
Loa Loa (eye worm) TK/ALK protein kinase 0.0092 0.0082 0.0082
Echinococcus granulosus lysine specific histone demethylase 1A 0.0492 0.0602 0.0602
Echinococcus multilocularis protein will die slowly 0.0202 0.0225 0.0281
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0142 0.0146 0.0146
Mycobacterium ulcerans monoamine oxidase 0.01 0.0092 0.1696
Leishmania major sir2-family protein-like protein 0.0105 0.0098 0.1032
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0008 0.0012
Echinococcus multilocularis serine:threonine protein kinase N2 0.0086 0.0074 0.0092
Brugia malayi SWIRM domain containing protein 0.0533 0.0656 0.0656
Brugia malayi AMP-binding enzyme family protein 0.008 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0492 0.0602 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Brugia malayi Reprolysin 0.0052 0.003 0.003
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0057 0.0036 0.0036
Echinococcus multilocularis discoidin domain containing receptor 2 0.0049 0.0026 0.0033
Echinococcus multilocularis discoidin domain containing receptor 2 0.0049 0.0026 0.0033
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0043 0.0017 0.0017
Onchocerca volvulus 0.0035 0.0008 0.0119
Echinococcus granulosus nmda type glutamate receptor 0.0119 0.0117 0.0117
Loa Loa (eye worm) WD40 repeat protein 0.0202 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.7717 1 1
Loa Loa (eye worm) integrin alpha pat-2 0.1803 0.2308 0.2308
Brugia malayi Kelch motif family protein 0.0786 0.0985 0.0985
Echinococcus multilocularis prolyl endopeptidase 0.0129 0.013 0.0162
Trichomonas vaginalis hypothetical protein 0.1528 0.1949 0.32
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0118 0.0115 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Giardia lamblia hypothetical protein 0.0136 0.0139 0.0336
Loa Loa (eye worm) transcriptional regulator 0.0105 0.0098 0.0098
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0098 0.0161
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.0029 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.0401 0.0658
Onchocerca volvulus 0.0035 0.0008 0.0119
Loa Loa (eye worm) TK/EGFR protein kinase 0.046 0.056 0.056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0033 0.0005 0.0005
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0097 0.0089 0.0924
Loa Loa (eye worm) hypothetical protein 0.0978 0.1234 0.1234
Brugia malayi Integrin alpha cytoplasmic region family protein 0.089 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0281 0.0328 0.0409
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0338 0.0401 0.0401
Brugia malayi hypothetical protein 0.0757 0.0947 0.0947
Echinococcus multilocularis high affinity choline transporter 1 0.0038 0.0011 0.0014
Toxoplasma gondii bicoid-interacting protein BIN3 0.0035 0.0008 0.0007
Brugia malayi hypothetical protein 0.0035 0.0007 0.0007
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0028 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0033 0.0005 0.0005
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0071 0.0055 0.0757
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0049 0.0026 0.0043
Schistosoma mansoni glutamate receptor NMDA 0.0281 0.0328 0.0328
Onchocerca volvulus 0.0202 0.0225 0.3431
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0008 0.0012
Toxoplasma gondii rhoptry neck protein RON1 0.0035 0.0008 0.0013
Echinococcus multilocularis C type lectin domian containing protein 0.0035 0.0008 0.001
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0028 0.0028
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0105 0.0098 0.0098
Loa Loa (eye worm) transcriptional regulator 0.0709 0.0884 0.0884
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0049 0.0026 0.0033
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0105 0.0098 0.0098
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0338 0.0401 0.0501
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0007 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0007
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0033 0.0005 0.0007
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0007 0.0007
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.01 0.0092 0.1824
Brugia malayi Integrin beta pat-3 precursor 0.4958 0.6411 0.6411
Brugia malayi transcriptional regulator, Sir2 family protein 0.0105 0.0098 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0533 0.0656 0.0656
Toxoplasma gondii F5/8 type C domain-containing protein 0.0049 0.0026 0.0452
Loa Loa (eye worm) hypothetical protein 0.0136 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0083 0.007 0.1593
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0061 0.0042 0.0885
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0088 0.0076 0.1272
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Echinococcus multilocularis growth factor receptor bound protein 2 0.0129 0.0129 0.0162
Echinococcus granulosus integrin alpha 3 0.095 0.1198 0.1198
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1528 0.1949 0.32
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0062 0.0043 0.0851
Brugia malayi NAD-dependent deacetylase SIRT1 0.0105 0.0098 0.0098
Toxoplasma gondii subtilisin SUB7 0.0338 0.0401 0.9399
Loa Loa (eye worm) hypothetical protein 0.0049 0.0026 0.0026
Echinococcus granulosus protein arginine N methyltransferase 8 0.0062 0.0043 0.0043
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0338 0.0401 0.0401
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0037 0.001 0.001
Onchocerca volvulus Prolyl endopeptidase homolog 0.0129 0.013 0.1983
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.01 0.0092 0.1696
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0709 0.0884 0.1451
Echinococcus multilocularis solute carrier family 5 0.0147 0.0154 0.0192
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.013 0.013
Onchocerca volvulus 0.0035 0.0008 0.0119
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0028 0.0028
Loa Loa (eye worm) subtilase 0.0338 0.0401 0.0401
Schistosoma mansoni protein kinase 0.0135 0.0137 0.0137
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0709 0.0884 1
Onchocerca volvulus 0.0035 0.0007 0.0111
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0338 0.0401 0.0401
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0042 0.0016 0.0016
Echinococcus granulosus protein arginine methyltransferase 0.0062 0.0043 0.0043
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0713 0.089 0.089
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0062 0.0043 0.0054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1865 0.2389 0.3921
Schistosoma mansoni growth factor receptor-bound protein 0.0129 0.0129 0.0129
Onchocerca volvulus 0.0136 0.0139 0.2115
Trichomonas vaginalis WD repeat domain, putative 0.0202 0.0225 0.0369
Schistosoma mansoni hypothetical protein 0.0057 0.0036 0.0036
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0007
Plasmodium vivax subtilisin-like protease 1 0.0338 0.0401 0.8482
Loa Loa (eye worm) acyl carrier protein 0.0039 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Schistosoma mansoni hypothetical protein 0.0202 0.0225 0.0225
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0007
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0367 0.0439 0.4925
Schistosoma mansoni furin-1 (S08 family) 0.3342 0.431 0.431
Schistosoma mansoni dihydroceramide desaturase 0.0037 0.001 0.001
Schistosoma mansoni protein kinase 0.0135 0.0137 0.0137
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0035 0.0008 0.0007
Echinococcus multilocularis discoidin domain receptor 0.0049 0.0026 0.0033
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0098 0.0161
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0033 0.0005 0.0005
Toxoplasma gondii rhoptry neck protein RON9 0.0035 0.0008 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.01 0.0092 0.1824
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0092 0.0082 0.0082
Loa Loa (eye worm) sirtuin 4 0.0105 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0338 0.0401 0.0401
Trypanosoma cruzi subtilisin peptidase 0.0338 0.0401 0.4491
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.01 0.0092 0.1754
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0129 0.0129 0.0129
Entamoeba histolytica PH domain containing protein kinase, putative 0.0077 0.0062 0.0619
Echinococcus granulosus discoidin domain containing receptor 2 0.0049 0.0026 0.0026
Echinococcus granulosus high affinity choline transporter 1 0.0038 0.0011 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0084 0.0084
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0105 0.0098 0.0122
Echinococcus granulosus fibrillin 1 0.0137 0.0141 0.0141
Echinococcus granulosus lysine specific histone demethylase 1A 0.01 0.0092 0.0092
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0005 0.0005
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0066 0.0048 0.0569
Plasmodium vivax hypothetical protein, conserved 0.01 0.0092 0.1824
Echinococcus multilocularis protoporphyrinogen oxidase 0.01 0.0092 0.0115
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Loa Loa (eye worm) hypothetical protein 0.0036 0.0009 0.0009
Echinococcus granulosus neuroendocrine convertase 2 0.487 0.6297 0.6297
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0088 0.0076 0.1757
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Toxoplasma gondii subtilisin SUB2 0.0338 0.0401 0.9399
Plasmodium falciparum apical sushi protein 0.0035 0.0008 0.0012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0119 0.0117 0.0145
Echinococcus multilocularis protein arginine methyltransferase 0.0062 0.0043 0.0054
Entamoeba histolytica SWIRM domain protein 0.0042 0.0016 0.0097
Echinococcus multilocularis epidermal growth factor receptor 0.046 0.056 0.0699
Echinococcus granulosus protein arginine N methyltransferase 7 0.0035 0.0008 0.0008
Mycobacterium ulcerans polyketide synthase 0.0082 0.0069 0.1086
Brugia malayi hypothetical protein 0.0092 0.0082 0.0082
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0105 0.0098 0.1953
Loa Loa (eye worm) hypothetical protein 0.0089 0.0078 0.0078
Onchocerca volvulus 0.0035 0.0008 0.0119
Mycobacterium ulcerans oxidoreductase 0.01 0.0092 0.1696
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0007 0.0007
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0089 0.0078 0.0078
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0007 0.0007
Echinococcus multilocularis Furin 1 0.1865 0.2389 0.2981
Brugia malayi Glutamate receptor 2 precursor 0.0033 0.0005 0.0005
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.0007 0.0012
Brugia malayi Disintegrin family protein 0.0037 0.001 0.001
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0338 0.0401 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0098 0.0161
Loa Loa (eye worm) fatty acid synthase 0.0084 0.0072 0.0072
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0033 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0007
Toxoplasma gondii subtilisin SUB5 0.0338 0.0401 0.9399
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.008 0.0066 0.1494
Brugia malayi hypothetical protein 0.01 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0492 0.0602 0.0602
Echinococcus granulosus c-Jun N-terminal kinases 0.0245 0.0281 0.0281
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0011 0.0085
Trypanosoma cruzi UDP-galactopyranose mutase 0.01 0.0092 0.0963
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0011 0.0011
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0042 0.0016 0.002
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0338 0.0401 1
Mycobacterium tuberculosis Possible oxidoreductase 0.01 0.0092 0.2157
Brugia malayi Sex muscle abnormal protein 5 0.0129 0.0129 0.0129
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0088 0.0076 0.1757
Echinococcus granulosus adam 0.0253 0.0291 0.0291
Echinococcus granulosus glutamate receptor subunit protein glur 0.0033 0.0005 0.0005
Mycobacterium ulcerans polyketide synthase Pks9 0.0054 0.0032 0.0075
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0338 0.0401 1
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0338 0.0401 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0082 0.0069 0.1086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1865 0.2389 0.3921
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0035 0.0008 0.0009
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0098 0.0161
Brugia malayi GH02984p 0.0038 0.0011 0.0011
Brugia malayi EGF-like domain containing protein 0.0136 0.0139 0.0139
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0105 0.0098 0.0098
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0082 0.0069 0.1582
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0159 0.0169 0.0169
Giardia lamblia Sirtuin type 2 0.0105 0.0098 0.0224
Loa Loa (eye worm) hypothetical protein 0.0097 0.0089 0.0089
Brugia malayi Sushi domain 0.0035 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.0011
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0049 0.0026 0.0026
Onchocerca volvulus 0.008 0.0066 0.1004
Echinococcus granulosus adam 17 protease 0.0037 0.001 0.001
Toxoplasma gondii hypothetical protein 0.0136 0.0139 0.3136
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0043 0.0043
Plasmodium vivax protoporphyrinogen oxidase, putative 0.01 0.0092 0.1824
Loa Loa (eye worm) hypothetical protein 0.0052 0.003 0.003
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0088 0.0076 0.1333
Brugia malayi Stress-activated protein kinase jnk-1 0.0245 0.0281 0.0281
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0105 0.0098 0.1953
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0338 0.0401 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0077 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0136 0.0139 0.0139
Loa Loa (eye worm) apoptosis regulator protein 0.0057 0.0036 0.0036
Echinococcus multilocularis integrin alpha ps 0.0323 0.0382 0.0476
Echinococcus granulosus growth factor receptor bound protein 2 0.0129 0.0129 0.0129
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0069 0.1086
Schistosoma mansoni tyrosine kinase 0.046 0.056 0.056
Onchocerca volvulus 0.0038 0.0011 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Giardia lamblia Neurogenic locus Notch protein precursor 0.0136 0.0139 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.0401 0.0658
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Mycobacterium leprae Polyketide synthase Pks13 0.0125 0.0124 0.2615
Brugia malayi ADAM-TS Spacer 1 family protein 0.0052 0.003 0.003
Brugia malayi hypothetical protein 0.0035 0.0008 0.0008
Toxoplasma gondii type I fatty acid synthase, putative 0.0088 0.0076 0.1644
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Schistosoma mansoni hypothetical protein 0.1528 0.1949 0.1949
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.125 0.1588 0.1588
Schistosoma mansoni chromatin regulatory protein sir2 0.0709 0.0884 0.0884
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Loa Loa (eye worm) glutamate receptor 2 0.0033 0.0005 0.0005
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0098 0.0098
Schistosoma mansoni apoptosis regulator bax 0.0057 0.0036 0.0036
Schistosoma mansoni integrin alpha 0.13 0.1654 0.1654
Loa Loa (eye worm) hypothetical protein 0.0136 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0026
Brugia malayi ADAMTS-like protease 0.0052 0.003 0.003
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0709 0.0884 0.0884
Entamoeba histolytica hypothetical protein, conserved 0.0105 0.0098 0.1032
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0098 0.0161
Giardia lamblia Neurogenic locus notch-like protein 0.0136 0.0139 0.0336
Mycobacterium ulcerans NAD-dependent deacetylase 0.0105 0.0098 0.1858
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0089 0.0078 0.0097
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0088 0.0076 0.1757
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0338 0.0401 1
Leishmania major silent information regulator 2, putative 0.0709 0.0884 1
Schistosoma mansoni high-affinity choline transporter 0.0038 0.0011 0.0011
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0492 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Schistosoma mansoni integrin alpha-ps 0.0673 0.0838 0.0838
Echinococcus multilocularis integrin beta 2 0.3666 0.4731 0.5905
Echinococcus multilocularis neuroendocrine convertase 2 0.487 0.6297 0.7859
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0062 0.0043 0.0768
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0105 0.0098 0.1032
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Loa Loa (eye worm) hypothetical protein 0.0387 0.0466 0.0466
Schistosoma mansoni hypothetical protein 0.0092 0.0082 0.0082
Echinococcus granulosus membrane bound transcription factor site 1 0.0338 0.0401 0.0401
Echinococcus granulosus sodium:glucose cotransporter 0.0147 0.0154 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Giardia lamblia High cysteine protein 0.0136 0.0139 0.0336
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0105 0.0098 0.0122
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0105 0.0098 0.0122
Echinococcus multilocularis glutamate receptor 2 0.005 0.0028 0.0034
Plasmodium falciparum subtilisin-like protease 1 0.0338 0.0401 0.8482
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0035 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.01 0.0092 0.1824
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0057 0.0036 0.0036
Echinococcus multilocularis membrane bound transcription factor site 1 0.0338 0.0401 0.0501
Echinococcus multilocularis protein jagged 2 0.0136 0.0139 0.0173
Echinococcus multilocularis integrin alpha ps 0.0738 0.0922 0.115
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0033 0.0005 0.0007
Echinococcus granulosus solute carrier family 5 0.0147 0.0154 0.0154
Giardia lamblia Tenascin-like 0.0136 0.0139 0.0336
Plasmodium vivax subtilisin-like protease 2, putative 0.0338 0.0401 0.8482
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0098 0.0161
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0709 0.0884 1
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Echinococcus granulosus glutamate receptor 2 0.005 0.0028 0.0028
Echinococcus multilocularis adam 0.0253 0.0291 0.0363
Mycobacterium ulcerans polyketide synthase Pks13 0.0125 0.0124 0.2563
Brugia malayi EGF-like domain containing protein 0.0136 0.0139 0.0139
Echinococcus granulosus sodium:glucose cotransporter 2 0.0147 0.0154 0.0154
Toxoplasma gondii SWIRM domain-containing protein 0.0042 0.0016 0.021
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0043 0.007
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0007 0.0007
Toxoplasma gondii subtilisin SUB6 0.0338 0.0401 0.9399
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1865 0.2389 0.3921
Onchocerca volvulus 0.0035 0.0008 0.0119
Brugia malayi Carm1-pending protein 0.0035 0.0008 0.0008
Toxoplasma gondii histone deacetylase SIR2 0.0105 0.0098 0.2165
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0129 0.013 0.1398
Toxoplasma gondii PA14 domain-containing protein 0.0049 0.0026 0.0452
Loa Loa (eye worm) integrin beta-2 0.4958 0.6411 0.6411
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0147 0.0154 0.0192
Loa Loa (eye worm) hypothetical protein 0.0045 0.002 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0007
Giardia lamblia Furin precursor putative serine protease 0.1528 0.1949 0.5299
Toxoplasma gondii histone lysine-specific demethylase 0.01 0.0092 0.2021
Giardia lamblia Hypothetical protein 0.0709 0.0884 0.2378
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0029 0.0242
Brugia malayi hypothetical protein 0.0035 0.0008 0.0008
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0085 0.0073 0.5
Plasmodium falciparum subtilisin-like protease 3 0.0338 0.0401 0.8482
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0089 0.0078 0.0078
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.7717 1 1
Entamoeba histolytica SWIRM domain protein 0.0042 0.0016 0.0097
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0098 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Schistosoma mansoni hypothetical protein 0.0092 0.0082 0.0082
Echinococcus granulosus fibrillin 2 0.0136 0.0139 0.0139
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0094 0.0084 0.0084
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0011 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1865 0.2389 0.3921
Mycobacterium tuberculosis Probable peptidase 0.0051 0.0029 0.0556
Schistosoma mansoni protein kinase 0.0135 0.0137 0.0137
Echinococcus multilocularis nmda type glutamate receptor 0.0119 0.0117 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.0401 0.0658
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.0029 0.0242
Onchocerca volvulus 0.0035 0.0008 0.0119
Schistosoma mansoni inositol transporter 0.0147 0.0154 0.0154
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.0029 0.0556
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0082 0.0069 0.1582
Echinococcus granulosus Furin 1 0.1865 0.2389 0.2389
Entamoeba histolytica hypothetical protein 0.0042 0.0016 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Trypanosoma brucei SIR2-like protein 4, putative 0.0105 0.0098 0.1032
Loa Loa (eye worm) hypothetical protein 0.0627 0.0778 0.0778
Toxoplasma gondii aspartyl protease ASP5 0.0357 0.0426 1
Onchocerca volvulus 0.0533 0.0656 1
Toxoplasma gondii subtilisin SUB8 0.0338 0.0401 0.9399
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0036 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Onchocerca volvulus 0.0036 0.0009 0.0131
Echinococcus granulosus integrin alpha ps 0.0738 0.0922 0.0922
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0089 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0092 0.0082 0.0082
Echinococcus granulosus methyltransferase protein 5 0.0035 0.0008 0.0008
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0097 0.0089 0.0924
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.0011
Echinococcus granulosus protein will die slowly 0.0202 0.0225 0.0225
Plasmodium vivax LCCL domain-containing protein 0.0049 0.0026 0.0408
Loa Loa (eye worm) hypothetical protein 0.0141 0.0145 0.0145
Trichomonas vaginalis hypothetical protein 0.0049 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0105 0.0098 0.0098
Schistosoma mansoni btb and poz domain-containing protein 0.0049 0.0026 0.0026
Brugia malayi GCC2 and GCC3 family protein 0.0044 0.0019 0.0019
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0007 0.0007
Toxoplasma gondii F5/8 type C domain-containing protein 0.0049 0.0026 0.0452
Schistosoma mansoni dock 0.0049 0.0026 0.0026
Schistosoma mansoni discoidin domain receptor 0.0049 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0007
Mycobacterium ulcerans dehydrogenase 0.01 0.0092 0.1696
Schistosoma mansoni amine oxidase 0.01 0.0092 0.0092
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0125 0.0124 0.2976
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0118 0.0115 0.0115
Onchocerca volvulus 0.0092 0.0082 0.1248
Onchocerca volvulus 0.0092 0.0082 0.1248
Brugia malayi Calcium binding EGF domain containing protein 0.0038 0.0011 0.0011
Brugia malayi Protein kinase domain containing protein 0.0092 0.0082 0.0082
Leishmania major arginine N-methyltransferase-like protein 0.0062 0.0043 0.0404
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4712 0.6091 1
Brugia malayi Protein kinase domain containing protein 0.0049 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Trypanosoma cruzi prolyl endopeptidase 0.0129 0.013 0.1398
Echinococcus granulosus integrin beta 2 0.3666 0.4731 0.4731
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0367 0.0439 0.4925
Trypanosoma brucei prolyl endopeptidase 0.0129 0.013 0.1398
Trypanosoma cruzi oligopeptidase b 0.0051 0.0029 0.0242
Loa Loa (eye worm) transcriptional regulator 0.0105 0.0098 0.0098
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0007 0.0007
Brugia malayi transcriptional regulator, Sir2 family protein 0.0105 0.0098 0.0098
Leishmania major UDP-galactopyranose mutase 0.01 0.0092 0.0963
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0097 0.0089 0.0924
Toxoplasma gondii subtilisin SUB10 0.0338 0.0401 0.9399
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0018 0.026
Loa Loa (eye worm) hypothetical protein 0.0415 0.0502 0.0502
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0709 0.0884 0.1103
Onchocerca volvulus 0.0035 0.0008 0.0119
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0029 0.0242
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0082 0.0069 0.1582
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Brugia malayi hypothetical protein 0.0097 0.0089 0.0089
Brugia malayi Protein arginine N-methyltransferase 0.0035 0.0008 0.0008
Loa Loa (eye worm) endoprotease bli-4 0.7717 1 1
Onchocerca volvulus 0.0134 0.0137 0.2082
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0125 0.0124 0.2976
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0082 0.0069 0.1148
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0098 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.01 0.0092 0.1696
Plasmodium falciparum subtilisin-like protease 2 0.0338 0.0401 0.8482
Brugia malayi amine oxidase, flavin-containing family protein 0.0142 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0136 0.0139 0.0139
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4712 0.6091 0.6091
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0082 0.0069 0.0069
Brugia malayi hypothetical protein 0.0035 0.0008 0.0008
Brugia malayi hypothetical protein 0.0035 0.0008 0.0008
Loa Loa (eye worm) glutamate receptor 1 0.0033 0.0005 0.0005
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0054 0.0032 0.0144
Mycobacterium tuberculosis Probable thioesterase TesA 0.0071 0.0055 0.121
Brugia malayi SWIRM domain containing protein 0.0042 0.0016 0.0016
Schistosoma mansoni c4b-binding protein beta chain 0.0035 0.0008 0.0008
Brugia malayi Integrin alpha pat-2 precursor 0.13 0.1654 0.1654
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0097 0.0089 0.0924
Echinococcus granulosus prolyl endopeptidase 0.0129 0.013 0.013
Onchocerca volvulus Putative cubilin 0.0038 0.0011 0.0168
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1865 0.2389 0.3921
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0338 0.0401 0.0401
Brugia malayi protein kinase C II. 0.0094 0.0084 0.0084
Onchocerca volvulus 0.0149 0.0155 0.2371
Loa Loa (eye worm) hypothetical protein 0.0057 0.0036 0.0036
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0069 0.1086
Brugia malayi Angiotensin-converting enzyme family protein 0.0634 0.0787 0.0787
Toxoplasma gondii subtilisin SUB4 0.0338 0.0401 0.9399
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0007
Brugia malayi EGF-like domain containing protein 0.0136 0.0139 0.0139
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0098 0.0098
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0245 0.0281 0.0351
Trypanosoma cruzi oligopeptidase b 0.0051 0.0029 0.0242
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4712 0.6091 1
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0005 0.0005
Onchocerca volvulus 0.0049 0.0026 0.04
Onchocerca volvulus Fatty acid synthase homolog 0.0154 0.0162 0.2476
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Brugia malayi pregnancy-associated plasma protein-A 0.0035 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Plasmodium vivax LCCL domain-containing protein 0.0049 0.0026 0.0408
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0088 0.0076 0.1272
Loa Loa (eye worm) hypothetical protein 0.0114 0.011 0.011
Echinococcus granulosus C type lectin domian containing protein 0.0035 0.0008 0.0008
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0117 0.0114 0.0114
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0709 0.0884 0.1451
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1865 0.2389 0.2389
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0011 0.0014
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0007 0.0009
Loa Loa (eye worm) proprotein convertase 2 0.1865 0.2389 0.2389
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Brugia malayi transcriptional regulator, Sir2 family protein 0.0709 0.0884 0.0884
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0043 0.007
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0367 0.0439 0.4925
Brugia malayi hypothetical protein 0.0117 0.0114 0.0114
Giardia lamblia High cysteine membrane protein Group 2 0.2846 0.3665 1
Echinococcus granulosus epidermal growth factor receptor 0.046 0.056 0.056
Mycobacterium ulcerans Sir2-like regulatory protein 0.0105 0.0098 0.1858
Echinococcus granulosus MAM 0.0092 0.0082 0.0082
Plasmodium falciparum protoporphyrinogen oxidase 0.01 0.0092 0.1824
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0786 0.0985 0.0985
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.0011
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0067 0.0049 0.1068
Onchocerca volvulus 0.0049 0.0026 0.04
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0098 0.0161
Plasmodium vivax hypothetical protein, conserved 0.01 0.0092 0.1824
Schistosoma mansoni protein arginine n-methyltransferase 0.0035 0.0008 0.0008
Mycobacterium ulcerans protoporphyrinogen oxidase 0.01 0.0092 0.1696
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0043 0.0043
Echinococcus granulosus furin 0.7717 1 1
Echinococcus multilocularis fibrillin 1 0.0137 0.0141 0.0176
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.0029 0.0242
Schistosoma mansoni SWI/SNF complex-related 0.0042 0.0016 0.0016
Brugia malayi celfurPC protein 0.6189 0.8013 0.8013
Toxoplasma gondii subtilisin SUB9 0.0338 0.0401 0.9399
Loa Loa (eye worm) AMP-binding enzyme family protein 0.008 0.0066 0.0066
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0007
Echinococcus granulosus c4b binding protein beta chain 0.0035 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.089 0.112 0.112
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.01 0.0092 0.0092
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0338 0.0401 0.0401
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0098 0.1953
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0082 0.0069 0.1148
Brugia malayi hypothetical protein 0.0035 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Mycobacterium ulcerans thioesterase TesA 0.0071 0.0055 0.0693
Loa Loa (eye worm) hypothetical protein 0.0035 0.0008 0.0008
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0028 0.0034
Loa Loa (eye worm) hypothetical protein 0.0757 0.0947 0.0947
Echinococcus multilocularis integrin alpha 3 0.095 0.1198 0.1495
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0049 0.0026 0.0489
Trypanosoma brucei subtilisin peptidase 0.0338 0.0401 0.4491
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0026
Trypanosoma cruzi UDP-galactopyranose mutase 0.01 0.0092 0.0963
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0035 0.0008 0.0007
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0085 0.0073 0.1681
Loa Loa (eye worm) hypothetical protein 0.0049 0.0026 0.0026
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0338 0.0401 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0082 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0026 0.0043
Onchocerca volvulus 0.0338 0.0401 0.6117
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0098 0.0098
Echinococcus multilocularis discoidin domain containing receptor 2 0.0049 0.0026 0.0033
Echinococcus multilocularis 0.6189 0.8013 1
Echinococcus multilocularis chromatin regulatory protein sir2 0.0709 0.0884 0.1103
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0069 0.0051 0.0051
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.013 0.013
Toxoplasma gondii F5/8 type C domain-containing protein 0.0049 0.0026 0.0452
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0054 0.0032 0.0075
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0005 0.0007
Giardia lamblia Tenascin-37 0.0136 0.0139 0.0336
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0088 0.0076 0.1333
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0007 0.0007
Echinococcus multilocularis disintegrin and metalloproteinase 0.0037 0.001 0.0013
Echinococcus granulosus protein kinase c epsilon type 0.0094 0.0084 0.0084
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0066 0.0048 0.0503
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0049 0.0026 0.0033
Brugia malayi hypothetical protein 0.0035 0.0008 0.0008
Schistosoma mansoni site-1 peptidase (S08 family) 0.0338 0.0401 0.0401
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4712 0.6091 0.7602
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0005 0.0005
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0049 0.0026 0.0043
Echinococcus granulosus discoidin domain containing receptor 2 0.0049 0.0026 0.0026
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0035 0.0008 0.0008
Echinococcus multilocularis fibrillin 2 0.0136 0.0139 0.0173
Giardia lamblia High cysteine protein 0.0136 0.0139 0.0336
Mycobacterium leprae Possible secreted protease 0.0338 0.0401 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0019 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Toxoplasma gondii subtilisin SUB11 0.0338 0.0401 0.9399
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0105 0.0098 0.1032
Echinococcus granulosus chromatin regulatory protein sir2 0.0709 0.0884 0.0884
Leishmania major subtilisin-like serine peptidase 0.0338 0.0401 0.4491
Loa Loa (eye worm) hypothetical protein 0.0129 0.013 0.013
Onchocerca volvulus 0.0035 0.0007 0.0111
Plasmodium falciparum plasmepsin V 0.0392 0.0472 1
Schistosoma mansoni sodium/solute symporter 0.0038 0.0011 0.0011
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0049 0.0025 0.0463
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0005 0.0005
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0105 0.0098 0.1032
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0338 0.0401 0.0658
Echinococcus multilocularis NMDA receptor 0.0033 0.0005 0.0007
Onchocerca volvulus 0.0035 0.0008 0.0119
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0105 0.0098 0.0224
Toxoplasma gondii subtilisin SUB1 0.0338 0.0401 0.9399
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0709 0.0884 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0098 0.0161
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1865 0.2389 0.3921
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0709 0.0884 1
Schistosoma mansoni growth factor receptor-bound protein 0.0129 0.0129 0.0129
Brugia malayi proprotein convertase 2 0.487 0.6297 0.6297
Chlamydia trachomatis protoporphyrinogen oxidase 0.01 0.0092 1
Schistosoma mansoni amine oxidase 0.01 0.0092 0.0092
Schistosoma mansoni chromatin regulatory protein sir2 0.0709 0.0884 0.0884
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0135 0.0137 0.0171
Toxoplasma gondii subtilisin SUB12 0.0338 0.0401 0.9399
Giardia lamblia Transcriptional regulator, Sir2 family 0.0105 0.0098 0.0224
Plasmodium vivax subtilisin-like serine protease, putative 0.0338 0.0401 0.8482
Echinococcus multilocularis integrin alpha ps 0.0673 0.0838 0.1045
Brugia malayi Pepsin A precursor 0.0035 0.0007 0.0007
Brugia malayi Subtilase family protein 0.0338 0.0401 0.0401
Mycobacterium ulcerans thioesterase 0.0071 0.0055 0.0693
Trichomonas vaginalis conserved hypothetical protein 0.1528 0.1949 0.32
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0709 0.0884 1
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.0401 0.0658
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0105 0.0098 0.1032
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0245 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.01 0.0092 0.0092

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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