Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 1068 aa | 927 aa | 29.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0145 | 0.5827 | 0.4667 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0057 | 0.1128 | 0.5 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0094 | 0.3115 | 0.6931 |
Echinococcus multilocularis | acetylcholinesterase | 0.0145 | 0.5827 | 0.4667 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0145 | 0.5827 | 0.5747 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0198 | 0.8704 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0081 | 0.2424 | 0.5294 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5827 | 0.6694 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0052 | 0.0879 | 0.1637 |
Echinococcus multilocularis | acetylcholinesterase | 0.0145 | 0.5827 | 0.4667 |
Echinococcus granulosus | carboxylesterase 5A | 0.0145 | 0.5827 | 0.4667 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.4411 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0145 | 0.5827 | 0.6694 |
Echinococcus granulosus | acetylcholinesterase | 0.0145 | 0.5827 | 0.4667 |
Echinococcus granulosus | acetylcholinesterase | 0.0145 | 0.5827 | 0.4667 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0145 | 0.5827 | 0.6694 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5827 | 0.6694 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0222 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0301 | 0.0346 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0115 | 0.4223 | 0.9555 |
Brugia malayi | Carboxylesterase family protein | 0.0145 | 0.5827 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0077 | 0.2175 | 0.3524 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2175 | 0.2499 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0118 | 0.4411 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0118 | 0.4411 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.4411 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.004 | 0.0188 | 0.0426 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0118 | 0.4411 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0081 | 0.2424 | 0.5294 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0118 | 0.4411 | 1 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0104 | 0.3654 | 0.6148 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0222 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0145 | 0.5827 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0094 | 0.3115 | 0.6931 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.004 | 0.0188 | 0.5 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0118 | 0.4411 | 0.7489 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.011 uM | Inhibition of PI3Kalpha | ChEMBL. | 20822905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.