Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.3795 | 0.3795 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.3795 | 0.3795 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3795 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.3795 | 0.3795 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.3795 | 0.3795 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.3795 | 0.3795 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.3795 | 0.3795 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3795 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3795 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.3795 | 0.3795 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0068 | 0.3795 | 0.3795 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3795 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3795 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.