Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.1607 | 0.5632 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0062 | 0.0128 | 0.0066 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0718 | 0.863 | 0.8622 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0062 | 0.0128 | 0.0128 |
Leishmania major | protein kinase, putative | 0.025 | 0.2565 | 0.2565 |
Trichomonas vaginalis | CMGC family protein kinase | 0.025 | 0.2565 | 0.9127 |
Brugia malayi | hexokinase type II | 0.0262 | 0.2716 | 0.2716 |
Schistosoma mansoni | hexokinase | 0.0824 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0241 | 0.2445 | 0.2445 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.1607 | 0.5632 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0062 | 0.0128 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0.0062 | 0.0062 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0.0062 | 0.0062 |
Onchocerca volvulus | 0.0824 | 1 | 1 | |
Onchocerca volvulus | 0.0517 | 0.6021 | 0.5259 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.173 | 0.6081 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0057 | 0.0062 | 0.0062 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.025 | 0.2565 | 0.2565 |
Treponema pallidum | hexokinase (hxk) | 0.0824 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0824 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0824 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0824 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0824 | 1 | 1 |
Onchocerca volvulus | 0.0824 | 1 | 1 | |
Schistosoma mansoni | microtubule-associated protein tau | 0.0718 | 0.863 | 0.8622 |
Echinococcus granulosus | hypothetical protein | 0.0248 | 0.2534 | 0.2487 |
Brugia malayi | MAP kinase sur-1 | 0.0057 | 0.0062 | 0.0062 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0062 | 0.0128 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0057 | 0.0062 | 0.0062 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.1607 | 0.5632 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0057 | 0.0062 | 0.0062 |
Trypanosoma cruzi | hexokinase, putative | 0.0824 | 1 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.025 | 0.2565 | 0.2565 |
Echinococcus multilocularis | 0.0248 | 0.2534 | 0.2487 | |
Trypanosoma brucei | hexokinase | 0.0824 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0824 | 1 | 1 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.025 | 0.2565 | 0.2519 |
Onchocerca volvulus | Hexokinase homolog | 0.0517 | 0.6021 | 0.5259 |
Onchocerca volvulus | 0.0824 | 1 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0269 | 0.2805 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2716 | 0.2716 |
Entamoeba histolytica | hexokinase 2 | 0.0824 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.173 | 0.6081 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0094 | 0.0542 | 0.0542 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.1607 | 0.5632 |
Leishmania major | hexokinase, putative | 0.0824 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0824 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0824 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0824 | 1 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.025 | 0.2565 | 0.2565 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.1607 | 0.5632 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.2565 | 0.2519 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0269 | 0.2805 | 0.2805 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.6605 | 0.6605 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0057 | 0.0062 | 0.0062 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0062 | 0.0128 | 0.0066 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0269 | 0.2805 | 1 |
Plasmodium falciparum | hexokinase | 0.0824 | 1 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0062 | 0.0128 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0824 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0824 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0057 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0269 | 0.2805 | 0.2805 |
Giardia lamblia | Kinase, CMGC CLK | 0.025 | 0.2565 | 1 |
Leishmania major | protein kinase, putative | 0.025 | 0.2565 | 0.2565 |
Trypanosoma brucei | hexokinase, putative | 0.0824 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0094 | 0.0542 | 0.0542 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.025 | 0.2565 | 0.2565 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.025 | 0.2565 | 0.2565 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0269 | 0.2805 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0824 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0057 | 0.0062 | 0.0062 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.025 | 0.2565 | 0.2565 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0269 | 0.2805 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0824 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0517 | 0.6021 | 0.6021 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0718 | 0.863 | 0.8622 |
Loa Loa (eye worm) | hexokinase | 0.0255 | 0.2625 | 0.2625 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.0073 | 0.0073 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0269 | 0.2805 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.1607 | 0.5632 |
Brugia malayi | Hexokinase family protein | 0.0255 | 0.2625 | 0.2625 |
Echinococcus multilocularis | hexokinase | 0.0824 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.2534 | 0.2534 |
Trypanosoma brucei | protein kinase, putative | 0.0057 | 0.0062 | 0.0062 |
Echinococcus multilocularis | hexokinase | 0.0824 | 1 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0062 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2716 | 0.2716 |
Brugia malayi | follicle stimulating hormone receptor | 0.0241 | 0.2445 | 0.2445 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.025 | 0.2565 | 0.2519 |
Brugia malayi | Protein kinase domain containing protein | 0.025 | 0.2565 | 0.2565 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.1607 | 0.5632 |
Loa Loa (eye worm) | hexokinase | 0.0517 | 0.6021 | 0.6021 |
Leishmania major | hexokinase, putative | 0.0824 | 1 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.025 | 0.2565 | 0.2565 |
Echinococcus multilocularis | hexokinase | 0.0824 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.025 | 0.2565 | 0.2519 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0269 | 0.2805 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0824 | 1 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0062 | 0.0128 | 0.0066 |
Echinococcus granulosus | hexokinase | 0.0824 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.025 | 0.2565 | 0.2519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.