TDR Targets

Basic information

Technical information

TDR Targets ID: 1477694
Name: N-[3-(4-chlorophenyl)-1-methyl-4-oxoquinolin- 2-yl]propanamide
MW: 340.803 | Formula: C19H17ClN2O2
H donors: 1 H acceptors: 2 LogP: 3.82 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=O)Nc1c(c2ccc(cc2)Cl)c(=O)c2c(n1C)cccc2
InChi: 1S/C19H17ClN2O2/c1-3-16(23)21-19-17(12-8-10-13(20)11-9-12)18(24)14-6-4-5-7-15(14)22(19)2/h4-11H,3H2,1-2H3,(H,21,23)
InChiKey: RGPZIRPMOXCGBS-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[3-(4-chlorophenyl)-1-methyl-4-oxo-2-quinolyl]propanamide
N-[3-(4-chlorophenyl)-4-keto-1-methyl-2-quinolyl]propionamide
N-[3-(4-chlorophenyl)-1-methyl-4-oxo-quinolin-2-yl]propanamide
ZINC05269613

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0002	0.0119
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0002	0.0032
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0071	0.0124	0.4689
Loa Loa (eye worm)	mbt repeat family protein	0.0055	0.0093	0.0093
Mycobacterium tuberculosis	Probable reductase	0.0125	0.0235	0.892
Plasmodium falciparum	glutathione reductase	0.0019	0.0019	0.1922
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0043	0.0998
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0023	0.0027	0.2093
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0005	0.0005
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0043	0.0998
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0043	0.0998
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0139	0.0263	1
Trichomonas vaginalis	chromobox protein, putative	0.0064	0.0111	1
Onchocerca volvulus		0.0011	0.0004	0.0168
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0019	0.0019
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.1945	0.3917	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0027	0.2742
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0028	0.0022
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0093	0.1384
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0038	0.0038
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0018	0.1565
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0055	0.0092	0.213
Leishmania major	hypothetical protein, conserved	0.0196	0.0378	0.0919
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0028	0.4912
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0027	0.0019
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0005	0.0005
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0023	0.0027	0.2093
Leishmania major	DNA polymerase eta, putative	0.0023	0.0028	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0093	0.0093
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0005	0.0069
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0005	0.0107
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0005	0.0107
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0027	0.2742
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0071	0.0124	0.2861
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0063	0.0109	0.2512
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0028	0.2473
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0027	0.2093
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0032	0.2874
Trichomonas vaginalis	Heterochromatin protein, putative	0.0011	0.0002	0.0119
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0028	0.0022
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0005	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0002	0.0002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0005	0.0005
Schistosoma mansoni	ap endonuclease	0.0023	0.0027	0.0398
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0027	0.0026
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0018	0.1565
Mycobacterium tuberculosis	Probable dehydrogenase	0.0125	0.0235	0.892
Trypanosoma cruzi	trypanothione reductase, putative	0.0055	0.0092	0.0187
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0005	0.0069
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0028	0.0038
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0037	0.2915
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0139	0.0263	1
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0005	0.0107
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0019	0.0019	0.1514
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0005	0.0107
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0027	0.0027
Plasmodium vivax	acyl-CoA synthetase, putative	0.0021	0.0023	0.2269
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Schistosoma mansoni	ferritin	0.001	0.0001	0.0012
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0063	0.0109	0.2512
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0005	0.0069
Schistosoma mansoni	apoferritin-2	0.001	0.0001	0.0012
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0028	0.0038
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0005	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0002	0.0119
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0028	0.1037
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0139	0.0263	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0005	0.0005
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0027	0.0991
Echinococcus granulosus	expressed protein	0.001	0.0001	0.0019
Entamoeba histolytica	hypothetical protein	0.0037	0.0055	1
Trichomonas vaginalis	chromobox protein, putative	0.0039	0.0059	0.5311
Schistosoma mansoni	chromobox protein	0.0011	0.0002	0.0032
Plasmodium vivax	glutathione reductase, putative	0.0055	0.0092	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0002	0.0002
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0125	0.0235	0.892
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.002	0.0742
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0005	0.0069
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.0178	0.0178
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0012	0.0006	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0005	0.0005
Trypanosoma brucei	unspecified product	0.0023	0.0028	0.0038
Toxoplasma gondii	exonuclease III APE	0.0023	0.0027	0.2029
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0002	0.0119
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0027	0.86
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0051	0.0051
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0011	0.0002	0.0049
Trypanosoma brucei	hypothetical protein, conserved	0.0196	0.0378	0.0933
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0028	0.0028
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0043	0.0998
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0059	0.6274
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0014	0.0009	0.0009
Entamoeba histolytica	hypothetical protein	0.0037	0.0055	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0036	0.0054	0.5666
Brugia malayi	hypothetical protein	0.0011	0.0002	0.0002
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0037	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0054	0.4808
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0023	0.0027	0.0981
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0005	0.0005
Trichomonas vaginalis	chromobox protein, putative	0.0039	0.0059	0.5311
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0011	0.0004	0.0054
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0028	0.0416
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0027	0.4684
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0014	0.0009	0.0009
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0005	0.0277
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0005	0.0069
Schistosoma mansoni	ferritin light chain	0.001	0.0001	0.0012
Brugia malayi	ecdysteroid receptor	0.0012	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0005	0.0005
Brugia malayi	Valyl-tRNA synthetase	0.0011	0.0002	0.0002
Brugia malayi	nuclear hormone receptor	0.0012	0.0005	0.0005
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0005	0.0005
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0071	0.0124	0.2861
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0005	0.0005
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0005	0.0107
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.013	0.1928
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0005	0.0005
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0.0037	0.1367
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0028	0.0038
Leishmania major	malonyl-coa decarboxylase-like protein	0.1945	0.3917	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0019	0.0019	0.1922
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0028	0.0038
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0005	0.0107
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0018	0.1565
Trypanosoma cruzi	hypothetical protein, conserved	0.0196	0.0378	0.0919
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0178	0.0178
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0005	0.0069
Echinococcus multilocularis	chromobox protein 1	0.0064	0.0111	0.2561
Brugia malayi	mbt repeat family protein	0.0055	0.0093	0.0093
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0023	0.0027	0.0018
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0125	0.0235	0.892
Echinococcus multilocularis	polycomb protein SCMH1	0.0055	0.0093	0.2153
Schistosoma mansoni	ferritin	0.001	0.0001	0.0012
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0028	1
Echinococcus granulosus	polycomb protein SCMH1	0.0055	0.0093	0.2153
Brugia malayi	Thioredoxin reductase	0.0055	0.0092	0.0092
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0055	0.0093	1
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0002	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0005	0.0005
Plasmodium falciparum	thioredoxin reductase	0.0055	0.0092	1
Schistosoma mansoni	apoferritin-2	0.001	0.0001	0.0012
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.495	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0005	0.0005
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0018	0.1565
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0028	0.1037
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0.0037	0.1367
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0054	0.4808
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0019	0.0019	0.0449
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0005	0.0069
Trichomonas vaginalis	hypothetical protein	0.0011	0.0002	0.0119
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0019	0.0019	0.1922
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0055	0.1267
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0028	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0054	0.0054
Brugia malayi	MH2 domain containing protein	0.0139	0.0262	0.0262
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0043	0.0998
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0002	0.0002
Schistosoma mansoni	coup transcription factor	0.0012	0.0005	0.0069
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0023	0.0027	0.234
Onchocerca volvulus		0.0055	0.0093	1
Schistosoma mansoni	ferritin	0.001	0.0001	0.0012
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0028	0.0037	0.2915
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0005	0.0107
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0005	0.0069
Echinococcus granulosus	thioredoxin glutathione reductase	0.0055	0.0092	0.213
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0002	0.0002
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0223	0.0433	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.0019	0.0016
Echinococcus granulosus	histone acetyltransferase MYST2	0.0063	0.0109	0.2512
Brugia malayi	Heterochromatin protein 1	0.0064	0.0111	0.0111
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0028	0.0037	0.1367
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0005	0.0005
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0028	0.0038
Plasmodium vivax	thioredoxin reductase, putative	0.0055	0.0092	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0005	0.0005
Onchocerca volvulus		0.0035	0.0051	0.5373
Trichomonas vaginalis	chromobox protein, putative	0.0064	0.0111	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0027	0.062
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0028	0.0028
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.002	0.0742
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0028	0.0022
Mycobacterium tuberculosis	Conserved protein	0.0023	0.0027	0.0981
Schistosoma mansoni	hypothetical protein	0.0342	0.0673	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0023	0.0023
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0002	0.0119
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0055	0.0093	0.2153
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0011	0.0002	0.0049
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0028	0.0647
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0015	0.0011	0.0895
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.0178	0.0178
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0114	0.9179
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0005	0.0107
Schistosoma mansoni	cpg binding protein	0.0035	0.0051	0.0758
Echinococcus multilocularis	expressed protein	0.001	0.0001	0.0019
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0125	0.0235	0.892
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0005	0.0005
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0019	0.0019	0.1922
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.0019	0.0016
Schistosoma mansoni	chromobox protein	0.0011	0.0002	0.0032
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0005	0.0107
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0005	0.0107
Schistosoma mansoni	chromobox protein	0.0064	0.0111	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0109	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0005	0.0005
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0019	0.0019	0.0016
Echinococcus multilocularis	cpg binding protein	0.0037	0.0055	0.1272
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0125	0.0235	0.892
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0027	0.0019
Echinococcus granulosus	SAM and MBT domain containing protein	0.0055	0.0093	0.2153
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0028	0.0038
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0018	0.1565
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0037	0.0037
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.0178	0.0178
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0223	0.0433	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0028	0.0416
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0005	0.0005
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0028	0.0028
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0023	0.0027	0.0018
Echinococcus granulosus	cpg binding protein	0.0037	0.0055	0.1272
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.0262	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0002	0.0119
Loa Loa (eye worm)	glutathione reductase	0.0055	0.0092	0.0092
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.002	0.0742
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0028	0.0028
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0023	0.0027	0.0614
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.0124	0.184
Plasmodium falciparum	thioredoxin reductase	0.0019	0.0019	0.1922
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0023	0.0027	0.2093
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0028	0.0037	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0002	0.0002
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0037	0.2915
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0002	0.0119
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0005	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0019	0.0019	0.071
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0019	0.0019	0.1514
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0027	0.2363
Schistosoma mansoni	cpg binding protein	0.0037	0.0055	0.0818
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0028	0.2473
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0028	0.0038
Echinococcus granulosus	Chromo domain	0.0011	0.0002	0.0049
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0028	0.0038
Loa Loa (eye worm)	MBCTL1	0.0063	0.0109	0.0109
Loa Loa (eye worm)	helicase	0.0011	0.0002	0.0002
Echinococcus multilocularis	chromobox protein 2	0.0011	0.0002	0.0049
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0037	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0023	0.0023
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0002	0.0119
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.0011	0.0002	0.0032
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0063	0.0109	0.0109
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0006	0.0091
Schistosoma mansoni	hypothetical protein	0.0031	0.0043	0.0642
Schistosoma mansoni	hypothetical protein	0.0031	0.0043	0.0642
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0063	0.0109	0.2512
Mycobacterium tuberculosis	Probable oxidoreductase	0.0139	0.0263	1
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0028	0.0647
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0005	0.0107
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0003	0.0003
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0018	0.1565
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0125	0.0235	0.892
Loa Loa (eye worm)	CHromoDomain protein family member	0.0012	0.0006	0.0006
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0002	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0043	0.0043
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0009	0.0789
Brugia malayi	SET domain containing protein	0.0011	0.0004	0.0004
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0028	0.2212
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0043	0.0043
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0005	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0032	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0116	0.0116
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0005	0.0005
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.0002	0.0002
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0005	0.0107
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0028	0.0038
Schistosoma mansoni	chromobox protein	0.0064	0.0111	0.1647
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0005	0.0005
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0002	0.0032
Echinococcus granulosus	chromobox protein 1	0.0064	0.0111	0.2561
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0005	0.0069
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0005	0.0005
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0019	0.0019	0.1922
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0043	0.0043
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0018	0.1565
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0005	0.0277
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0005	0.0107
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.0262	0.0262
Toxoplasma gondii	NADPH-glutathione reductase	0.0019	0.0019	0.1422
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0019	0.0019
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0124	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0002	0.0002
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0124	1
Toxoplasma gondii	thioredoxin reductase	0.0055	0.0092	0.7401
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0027	0.0034
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0028	0.0022
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0028	0.0416
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0005	0.0005
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0055	0.0092	0.3483
Leishmania major	trypanothione reductase	0.0055	0.0092	0.0187
Schistosoma mansoni	ferritin	0.001	0.0001	0.0012
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0005	0.0069
Plasmodium falciparum	glutathione reductase	0.0055	0.0092	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0002	0.0119
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0043	0.0043
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0037	0.6554
Brugia malayi	hypothetical protein	0.0037	0.0055	0.0055
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0028	0.0037	0.2915
Echinococcus multilocularis	ferritin	0.001	0.0001	0.0019
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0037	0.6554
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0003	0.0059
Schistosoma mansoni	hypothetical protein	0.0037	0.0055	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0023	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0005	0.0005
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0021	0.0023	1
Brugia malayi	Protein cec-1.	0.0011	0.0002	0.0002
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0019	0.0019	0.0449
Onchocerca volvulus		0.0012	0.0005	0.0277
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0021	0.0023	0.1768
Schistosoma mansoni	hypothetical protein	0.0031	0.0043	0.0642
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0011	0.0002	0.0002
Echinococcus granulosus	chromobox protein 1	0.0064	0.0111	0.2561
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0028	0.0038
Entamoeba histolytica	hypothetical protein	0.0037	0.0055	1
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0027	0.2363
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0028	0.0037	0.2915
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0005	0.0005
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0027	0.0019
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0063	0.0109	0.1616
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0005	0.0107
Trypanosoma brucei	trypanothione reductase	0.0055	0.0092	0.0202
Onchocerca volvulus		0.0028	0.0037	0.3795
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0124	1
Brugia malayi	steroid hormone receptor	0.0012	0.0005	0.0005
Echinococcus granulosus	dna polymerase eta	0.0023	0.0028	0.0647
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0071	0.0124	0.0268
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0019	0.0019	0.0016
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0019	0.0019	0.0019
Entamoeba histolytica	hypothetical protein	0.0037	0.0055	1
Schistosoma mansoni	hypothetical protein	0.0067	0.0116	0.1717
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0019	0.0019	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0027	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0005	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0011	0.0895
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0028	0.0038
Brugia malayi	CHD4 protein	0.0012	0.0006	0.0006
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0028	0.0038
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0028	0.2212
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0027	0.2114
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0037	0.2915
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0116	0.0116
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.0124	0.184
Schistosoma mansoni	ferritin light chain	0.001	0.0001	0.0012
Echinococcus granulosus	chromobox protein 2	0.0011	0.0002	0.0049
Brugia malayi	mbt repeat family protein	0.0055	0.0093	0.0093
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0023	0.0027	0.0018
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0055	0.1267
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0003	0.0059
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0005	0.0069
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0027	0.2093
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0002	0.0119
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0028	0.0647
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0005	0.0005
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0037	0.0037
Echinococcus granulosus	citrate lyase subunit beta protein	0.0023	0.0027	0.0614
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.0028	0.0022
Entamoeba histolytica	acyl-coA synthetase, putative	0.0028	0.0037	0.6554
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0093	0.1384
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0.0002	0.0119
Loa Loa (eye worm)	heterochromatin protein 1	0.0064	0.0111	0.0111
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0028	0.0022
Schistosoma mansoni	cpg binding protein	0.0037	0.0055	0.0818
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.1945	0.3917	1
Echinococcus multilocularis	Chromo domain	0.0011	0.0002	0.0049
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0028	0.0647
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0005	0.0107
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.1945	0.3917	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0005	0.0005
Trichomonas vaginalis	glutathione reductase, putative	0.0019	0.0019	0.1692
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.0002	0.0049
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0005	0.0005
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0028	0.0038
Echinococcus granulosus	ferritin	0.001	0.0001	0.0019
Trichomonas vaginalis	mercuric reductase, putative	0.0019	0.0019	0.1692
Toxoplasma gondii	aldehyde dehydrogenase	0.0071	0.0124	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.495	1	1
Brugia malayi	glutathione reductase	0.0055	0.0092	0.0092
Brugia malayi	M-phase phosphoprotein, mpp8	0.0011	0.0002	0.0002
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0019	0.0019	0.1514
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0055	0.0093	0.1384
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0055	0.0815
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0028	0.0037	0.1367
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0005	0.0277
Plasmodium falciparum	acyl-CoA synthetase	0.0021	0.0023	0.2269
Echinococcus multilocularis	chromobox protein 1	0.0064	0.0111	0.2561
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0028	0.0038
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0018	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0002	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0002	0.0119
Loa Loa (eye worm)	thioredoxin reductase	0.0055	0.0092	0.0092
Trichomonas vaginalis	chromobox protein, putative	0.0011	0.0002	0.0119
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0012	0.0006	0.0141
Treponema pallidum	NADH oxidase	0.0019	0.0019	0.7161
Brugia malayi	chromobox protein homolog 3	0.0036	0.0054	0.0054
Trypanosoma cruzi	hypothetical protein, conserved	0.0196	0.0378	0.0919
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.002	0.0742
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0019	0.0019	0.0289
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0027	0.062
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0037	0.2915
Schistosoma mansoni	hypothetical protein	0.0031	0.0043	0.0642
Onchocerca volvulus		0.0028	0.0038	0.3937
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0037	0.0044
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0005	0.0107
Echinococcus granulosus	GPCR family 2	0.0031	0.0043	0.0998
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0005	0.0005
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0005	0.0005
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0023	0.0829
Schistosoma mansoni	ap endonuclease	0.0023	0.0027	0.0398
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0028	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0002	0.0119
Echinococcus granulosus	Chromobox protein 3	0.0011	0.0002	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0023	0.0023
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0005	0.0069

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 195 um	PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)]	ChEMBL.	No reference
Potency (functional)	1.9953 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.4368 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1577094

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1477694