TDR Targets

Basic information

Technical information

TDR Targets ID: 147819
Name: 5-(3-bromophenyl)-3,4-dihydropyrazole-2-carbo thioamide
MW: 284.176 | Formula: C10H10BrN3S
H donors: 1 H acceptors: 0 LogP: 1.89 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Brc1cccc(c1)C1=NN(CC1)C(=S)N
InChi: 1S/C10H10BrN3S/c11-8-3-1-2-7(6-8)9-4-5-14(13-9)10(12)15/h1-3,6H,4-5H2,(H2,12,15)
InChiKey: FTQFCUZTYFDQCL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(3-bromophenyl)-2-pyrazoline-1-carbothioamide
3-(3-bromophenyl)-4,5-dihydropyrazole-1-carbothioamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.00770379	0.943944	1
Onchocerca volvulus	Cathepsin L homolog	0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.00136539	0.00176409	0.00176409
Echinococcus multilocularis	acetylcholinesterase	0.0080809	1	1
Echinococcus granulosus	acetylcholinesterase	0.0080809	1	1
Toxoplasma gondii	cathepsin CPL	0.00202198	0.0993625	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Schistosoma mansoni	cathepsin F (C01 family)	0.00202198	0.0993625	0.0993625
Brugia malayi	Carboxylesterase family protein	0.0080809	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.00202198	0.0993625	0.0977709
Loa Loa (eye worm)	hypothetical protein	0.00202198	0.0993625	0.0993625
Onchocerca volvulus		0.00202198	0.0993625	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.00202198	0.0993625	0.5
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.00136539	0.00176409	0.0177541
Onchocerca volvulus		0.00136539	0.00176409	0.0177541
Schistosoma mansoni	acetylcholinesterase	0.00136539	0.00176409	0.00176409
Plasmodium vivax	vivapain-2	0.00202198	0.0993625	0.5
Loa Loa (eye worm)	fibroinase	0.00202198	0.0993625	0.0993625
Onchocerca volvulus		0.00202198	0.0993625	1
Onchocerca volvulus		0.00202198	0.0993625	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0080809	1	1
Onchocerca volvulus		0.00202198	0.0993625	1
Echinococcus granulosus	carboxylesterase 5A	0.0080809	1	1
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Echinococcus multilocularis	carboxylesterase 5A	0.0080809	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.00202198	0.0993625	1
Loa Loa (eye worm)	carboxylesterase	0.0080809	1	1
Toxoplasma gondii	cathepsin CPL	0.00202198	0.0993625	0.5
Mycobacterium ulcerans	carboxylesterase, LipT	0.00136539	0.00176409	0.5
Onchocerca volvulus		0.00136539	0.00176409	0.0177541
Brugia malayi	Carboxylesterase family protein	0.00136539	0.00176409	0.00176409
Brugia malayi	Carboxylesterase family protein	0.00136539	0.00176409	0.00176409
Echinococcus granulosus	BC026374 protein S09 family	0.00136539	0.00176409	0.00176409
Onchocerca volvulus		0.00136539	0.00176409	0.0177541
Loa Loa (eye worm)	acetylcholinesterase 1	0.0080809	1	1
Echinococcus granulosus	carboxylesterase 5A	0.0080809	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.00202198	0.0993625	0.0993625
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.00136539	0.00176409	0.00176409
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Onchocerca volvulus		0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.00202198	0.0993625	1
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Loa Loa (eye worm)	fibroinase	0.00202198	0.0993625	0.0993625
Onchocerca volvulus	Cathepsin F homolog	0.00202198	0.0993625	1
Trypanosoma cruzi	cysteine peptidase, putative	0.00770379	0.943944	1
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Leishmania major	cathepsin L-like protease	0.00770379	0.943944	1
Onchocerca volvulus		0.00202198	0.0993625	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.00202198	0.0993625	0.0993625
Schistosoma mansoni	neuroligin 3 (S09 family)	0.00136539	0.00176409	0.00176409
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.00136539	0.00176409	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Brugia malayi	Carboxylesterase family protein	0.00136539	0.00176409	0.00176409
Entamoeba histolytica	cysteine protease, putative	0.00202198	0.0993625	1
Loa Loa (eye worm)	carboxylesterase	0.00136539	0.00176409	0.00176409
Schistosoma mansoni	neuroligin 3 (S09 family)	0.00136539	0.00176409	0.00176409
Brugia malayi	Carboxylesterase family protein	0.00136539	0.00176409	0.00176409
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.00202198	0.0993625	1
Brugia malayi	Carboxylesterase family protein	0.0080809	1	1
Brugia malayi	Carboxylesterase family protein	0.00136539	0.00176409	0.00176409
Echinococcus multilocularis	cysteine protease	0.00202198	0.0993625	0.0977709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Leishmania major	cathepsin L-like protease	0.00770379	0.943944	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.00202198	0.0993625	0.0977709
Onchocerca volvulus		0.00136539	0.00176409	0.0177541
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.00136539	0.00176409	0.5
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.00136539	0.00176409	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Onchocerca volvulus		0.00202198	0.0993625	1
Onchocerca volvulus		0.00202198	0.0993625	1
Plasmodium vivax	vivapain-2	0.00202198	0.0993625	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.00202198	0.0993625	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.00136539	0.00176409	0.5
Onchocerca volvulus		0.00136539	0.00176409	0.0177541
Echinococcus granulosus	acetylcholinesterase	0.0080809	1	1
Onchocerca volvulus		0.00136539	0.00176409	0.0177541
Mycobacterium ulcerans	carboxylesterase, LipT	0.00136539	0.00176409	0.5
Leishmania major	cathepsin L-like protease	0.00770379	0.943944	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Echinococcus multilocularis	cysteine protease	0.00202198	0.0993625	0.0977709
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Echinococcus granulosus	cathepsin l1	0.00202198	0.0993625	0.0993625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Plasmodium vivax	vivapain-2	0.00202198	0.0993625	0.5
Brugia malayi	Carboxylesterase family protein	0.00136539	0.00176409	0.00176409
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0080809	1	1
Echinococcus multilocularis	cysteine protease	0.00202198	0.0993625	0.0977709
Onchocerca volvulus	Cathepsin F homolog	0.00202198	0.0993625	1
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Leishmania major	cathepsin L-like protease	0.00770379	0.943944	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Echinococcus multilocularis	carboxylesterase 5A	0.0080809	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Plasmodium falciparum	cysteine proteinase falcipain 3	0.00202198	0.0993625	0.5
Trypanosoma cruzi	major cysteine proteinase, putative	0.00605495	0.69885	0.709804
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.00202198	0.0993625	0.0993625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.00202198	0.0993625	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.00202198	0.0993625	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Loa Loa (eye worm)	hypothetical protein	0.0080809	1	1
Echinococcus granulosus	cathepsin l1	0.00202198	0.0993625	0.0993625
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Onchocerca volvulus	Cathepsin L homolog	0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Schistosoma mansoni	acetylcholinesterase	0.00136539	0.00176409	0.00176409
Trichomonas vaginalis	spcc417.12 protein, putative	0.00136539	0.00176409	0.0177541
Onchocerca volvulus		0.00136539	0.00176409	0.0177541
Entamoeba histolytica	cysteine protease, putative	0.00202198	0.0993625	1
Loa Loa (eye worm)	cysteine protease	0.00202198	0.0993625	0.0993625
Brugia malayi	Carboxylesterase family protein	0.0080809	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.00202198	0.0993625	0.0993625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.00202198	0.0993625	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.00202198	0.0993625	0.0977709
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Schistosoma mansoni	cathepsin F (C01 family)	0.00202198	0.0993625	0.0993625
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Loa Loa (eye worm)	hypothetical protein	0.0080809	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.00136539	0.00176409	0.00176409
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.00202198	0.0993625	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.00202198	0.0993625	0.5
Trichomonas vaginalis	spcc417.12 protein, putative	0.00136539	0.00176409	0.0177541
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.00202198	0.0993625	0.0993625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.00136539	0.00176409	0.5
Loa Loa (eye worm)	carboxylesterase	0.00136539	0.00176409	0.00176409
Onchocerca volvulus		0.00202198	0.0993625	1
Echinococcus multilocularis	acetylcholinesterase	0.0080809	1	1
Schistosoma mansoni	gliotactin	0.00136539	0.00176409	0.00176409
Loa Loa (eye worm)	hypothetical protein	0.0080809	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.00202198	0.0993625	0.0977709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Onchocerca volvulus		0.00202198	0.0993625	1
Brugia malayi	Carboxylesterase family protein	0.00136539	0.00176409	0.00176409
Entamoeba histolytica	cysteine proteinase, putative	0.00202198	0.0993625	1
Leishmania major	cathepsin L-like protease	0.00770379	0.943944	1
Echinococcus granulosus	neuroligin	0.00136539	0.00176409	0.00176409
Onchocerca volvulus		0.00136539	0.00176409	0.0177541
Onchocerca volvulus		0.00202198	0.0993625	1
Brugia malayi	Papain family cysteine protease containing protein	0.00202198	0.0993625	0.0993625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Trypanosoma cruzi	cysteine peptidase, putative	0.00770379	0.943944	1
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Onchocerca volvulus		0.00136539	0.00176409	0.0177541
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Loa Loa (eye worm)	carboxylesterase	0.00136539	0.00176409	0.00176409
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.00136539	0.00176409	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Loa Loa (eye worm)	cysteine protease	0.00202198	0.0993625	0.0993625
Trypanosoma cruzi	cysteine peptidase, putative	0.00770379	0.943944	1
Trypanosoma cruzi	cruzipain precursor, putative	0.00770379	0.943944	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.00136539	0.00176409	0.00176409
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Plasmodium vivax	vivapain-2	0.00202198	0.0993625	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0080809	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.00202198	0.0993625	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.00202198	0.0993625	0.0993625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Schistosoma mansoni	gliotactin	0.00136539	0.00176409	0.00176409
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.00202198	0.0993625	0.0977709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Trypanosoma cruzi	cysteine peptidase, putative	0.00770379	0.943944	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Echinococcus multilocularis	acetylcholinesterase	0.0080809	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Brugia malayi	hypothetical protein	0.00136539	0.00176409	0.00176409
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.00136539	0.00176409	0.00176409
Brugia malayi	Cathepsin L-like precursor	0.00202198	0.0993625	0.0993625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Brugia malayi	hypothetical protein	0.00136539	0.00176409	0.00176409
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.00136539	0.00176409	0.00176409
Echinococcus granulosus	para nitrobenzyl esterase	0.00136539	0.00176409	0.00176409
Onchocerca volvulus	Cathepsin L homolog	0.00202198	0.0993625	1
Loa Loa (eye worm)	hypothetical protein	0.0080809	1	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.00136539	0.00176409	0.0177541
Loa Loa (eye worm)	hypothetical protein	0.00202198	0.0993625	0.0993625
Onchocerca volvulus		0.00136539	0.00176409	0.0177541
Echinococcus granulosus	BC026374 protein S09 family	0.00136539	0.00176409	0.00176409
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.00202198	0.0993625	0.0993625
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.00703534	0.844581	0.882353
Echinococcus granulosus	neuroligin	0.00136539	0.00176409	0.00176409
Trypanosoma cruzi	cruzipain precursor, putative	0.00770379	0.943944	1
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Onchocerca volvulus	Cathepsin L homolog	0.00202198	0.0993625	1
Brugia malayi	Carboxylesterase family protein	0.0080809	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Echinococcus granulosus	acetylcholinesterase	0.0080809	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.00136539	0.00176409	0.00176409
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.00136539	0.00176409	0.00176409
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.00202198	0.0993625	0.0977709
Echinococcus granulosus	cathepsin L cysteine proteinase	0.00202198	0.0993625	0.0993625
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Trypanosoma cruzi	cysteine peptidase, putative	0.00770379	0.943944	1
Loa Loa (eye worm)	ctsf protein	0.00202198	0.0993625	0.0993625
Echinococcus multilocularis	cathepsin L cysteine protease	0.00202198	0.0993625	0.0977709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Echinococcus granulosus	cathepsin l cysteine peptidase	0.00202198	0.0993625	0.0993625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Echinococcus granulosus	acetylcholinesterase	0.0080809	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.00202198	0.0993625	0.0977709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Onchocerca volvulus		0.00202198	0.0993625	1
Echinococcus multilocularis	acetylcholinesterase	0.0080809	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.00202198	0.0993625	0.0993625
Loa Loa (eye worm)	carboxylesterase	0.0080809	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.00202198	0.0993625	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.00770379	0.943944	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Loa Loa (eye worm)	carboxylesterase	0.00136539	0.00176409	0.00176409
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.00136539	0.00176409	0.00176409
Schistosoma mansoni	BC026374 protein (S09 family)	0.00136539	0.00176409	0.00176409
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Brugia malayi	Carboxylesterase family protein	0.00136539	0.00176409	0.00176409
Echinococcus multilocularis	cysteine protease	0.00202198	0.0993625	0.0977709
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.00703534	0.844581	0.882353
Loa Loa (eye worm)	ctsf protein	0.00202198	0.0993625	0.0993625
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.00202198	0.0993625	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.00202198	0.0993625	0.5
Echinococcus granulosus	para nitrobenzyl esterase	0.00136539	0.00176409	0.00176409
Trypanosoma cruzi	major cysteine proteinase, putative	0.00605495	0.69885	0.709804
Loa Loa (eye worm)	hypothetical protein	0.00136539	0.00176409	0.00176409
Echinococcus granulosus	cathepsin l cysteine peptidase	0.00202198	0.0993625	0.0993625
Onchocerca volvulus		0.00202198	0.0993625	1
Trypanosoma cruzi	cysteine peptidase, putative	0.00770379	0.943944	1
Onchocerca volvulus		0.00202198	0.0993625	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Cell survived (functional)	= 5 day	Trypanocidal activity in infected host cells	ChEMBL.	12061873
Cell survived (functional)	= 5 day	Trypanocidal activity in infected host cells	ChEMBL.	12061873
IC50 (binding)	= 200 nM	Inhibitory activity against Trypanosoma cruzi cathepsin L-like protease (cruzain) was determined using purified recombinant protein	ChEMBL.	12061873
IC50 (binding)	= 200 nM	Inhibitory activity against Trypanosoma cruzi cathepsin L-like protease (cruzain) was determined using purified recombinant protein	ChEMBL.	12061873
IC50 (functional)	= 13.2 uM	Antiamoebic activity against Entamoeba histolytica HM-1:IMSS	ChEMBL.	16495051
IC50 (functional)	= 13.2 uM	Antiamoebic activity against Entamoeba histolytica HM-1:IMSS	ChEMBL.	16495051

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Entamoeba histolytica	ChEMBL23	16495051

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL314026
PubChem: 11140610

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 147819