Detailed information for compound 147843

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.457 | Formula: C21H26N4O2
  • H donors: 3 H acceptors: 4 LogP: 4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCCCC1)CCCCc1ccc2c(c1)cc1c([nH]2)nc(n1)O
  • InChi: 1S/C21H26N4O2/c26-19(22-16-7-2-1-3-8-16)9-5-4-6-14-10-11-17-15(12-14)13-18-20(23-17)25-21(27)24-18/h10-13,16H,1-9H2,(H,22,26)(H2,23,24,25,27)
  • InChiKey: CJSUCKSZFYSKBS-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 3B, cGMP-inhibited References
Homo sapiens purinergic receptor P2Y, G-protein coupled, 12 Starlite/ChEMBL References
Homo sapiens phosphodiesterase 3A, cGMP-inhibited Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Echinococcus multilocularis dna polymerase eta 0.0085 0.0294 0.0419
Brugia malayi hypothetical protein 0.06 0.2996 0.4614
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0184 0.0241
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Schistosoma mansoni hypothetical protein 0.0034 0.0029 0.0008
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1934 1 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0184 0.0249
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1934 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0156 0.0205
Leishmania major DNA polymerase eta, putative 0.0044 0.0081 0.0126
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0545 0.271 0.2693
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.006 0.0057
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Giardia lamblia CDC8 0.0074 0.0235 0.069
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0184 0.0249
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0545 0.271 0.2693
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.022 0.1003 0.1377
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.022 0.1003 0.1377
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0047 0.0079
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0099 0.0367 0.0533
Trichomonas vaginalis MYB3r3, putative 0.0038 0.0046 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0184 0.0249
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0099 0.0367 0.0533
Schistosoma mansoni hypothetical protein 0.0512 0.2533 0.3897
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Schistosoma mansoni hypothetical protein 0.0109 0.0422 0.0618
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0156 0.0445
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Giardia lamblia Myb 1-like protein 0.0038 0.0047 0.0076
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0184 0.0249
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0156 0.0205
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0099 0.0367 0.0568
Brugia malayi thymidylate synthase 0.1261 0.6464 1
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0024 0.0037
Schistosoma mansoni hypothetical protein 0.0074 0.0235 0.0328
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0099 0.0367 0.0533
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0099 0.0367 0.0525
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0113 0.0138
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Loa Loa (eye worm) hypothetical protein 0.1099 0.5616 0.8682
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1389 0.7138 1
Trypanosoma brucei RNA helicase, putative 0.0109 0.0422 0.0618
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.9431
Trypanosoma cruzi DNA polymerase eta, putative 0.0085 0.0294 0.0454
Trypanosoma brucei thymidylate kinase, putative 0.0074 0.0235 0.0328
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0245 0.1132 0.1558
Echinococcus granulosus dna polymerase kappa 0.0059 0.0156 0.0205
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.9431
Trypanosoma brucei unspecified product 0.0059 0.0156 0.0205
Echinococcus multilocularis geminin 0.0512 0.2533 0.3897
Brugia malayi ImpB/MucB/SamB family protein 0.0085 0.0294 0.0419
Brugia malayi RNA binding protein 0.0064 0.0184 0.0249
Echinococcus multilocularis thymidylate kinase 0.0074 0.0235 0.0328
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0156 0.0241
Giardia lamblia DINP protein human, muc B family 0.0059 0.0156 0.0432
Loa Loa (eye worm) PDE1B protein 0.0099 0.0367 0.0525
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0616 0.3082 0.4749
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0081 0.0089
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0099 0.0367 0.0533
Trypanosoma brucei trypanothione reductase 0.0096 0.0355 0.0514
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.022 0.1003 0.1377
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0047 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0099 0.0367 0.0533
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0156 0.0241
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0156 0.0205
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0517 0.2563 0.3943
Trichomonas vaginalis MYB72, putative 0.0038 0.0046 0.0076
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.9431
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0099 0.0367 0.0533
Loa Loa (eye worm) transcription factor SMAD2 0.036 0.174 0.2659
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0355 0.0549
Trichomonas vaginalis C-MYB, putative 0.0038 0.0046 0.0076
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0099 0.0367 0.0533
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0081 0.0126
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0156 0.0241
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Loa Loa (eye worm) hypothetical protein 0.0099 0.0367 0.0525
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0156 0.0205
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0616 0.3082 0.4749
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0024 0.0037
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0616 0.3082 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Brugia malayi TAR-binding protein 0.0064 0.0184 0.0249
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0156 0.0186
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0046 0.0076
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0099 0.0367 0.0533
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Schistosoma mansoni hypothetical protein 0.0072 0.0224 0.0311
Echinococcus multilocularis thymidylate synthase 0.1261 0.6464 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0099 0.0367 0.0568
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0184 0.0249
Plasmodium falciparum phosphodiesterase gamma, putative 0.0099 0.0367 0.0533
Leishmania major hypothetical protein, conserved 0.0099 0.0367 0.0568
Echinococcus granulosus dna polymerase eta 0.0085 0.0294 0.0419
Plasmodium vivax thymidylate kinase, putative 0.0074 0.0235 0.0328
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0545 0.271 0.4171
Trypanosoma cruzi thymidylate kinase, putative 0.0074 0.0235 0.0363
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Loa Loa (eye worm) hypothetical protein 0.0085 0.0294 0.0411
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Plasmodium falciparum thioredoxin reductase 0.0096 0.0355 0.0514
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Trypanosoma brucei unspecified product 0.004 0.006 0.0057
Schistosoma mansoni hypothetical protein 0.0512 0.2533 0.3897
Giardia lamblia Hypothetical protein 0.0099 0.0367 0.1123
Mycobacterium ulcerans thymidylate kinase 0.0074 0.0235 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0156 0.0205
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1099 0.5616 0.8683
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0099 0.0367 0.0533
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0156 0.0445
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0099 0.0367 0.0533
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Mycobacterium tuberculosis Probable oxidoreductase 0.0245 0.1132 0.1558
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0156 0.0186
Trypanosoma cruzi thymidylate kinase, putative 0.0074 0.0235 0.0363
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0046 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0156 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.06 0.2996 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.006 0.0057
Plasmodium vivax glutathione reductase, putative 0.0096 0.0355 0.0514
Mycobacterium tuberculosis Hypothetical protein 0.06 0.2996 0.4177
Trypanosoma brucei thymidylate kinase, putative 0.0074 0.0235 0.0328
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Loa Loa (eye worm) thymidylate kinase 0.0074 0.0235 0.032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Brugia malayi MH2 domain containing protein 0.036 0.174 0.2665
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0099 0.0367 0.0568
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Trypanosoma brucei unspecified product 0.004 0.006 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0367 0.1156
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0099 0.0367 0.0533
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Mycobacterium ulcerans thymidylate synthase 0.1261 0.6464 0.6456
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0616 0.3082 0.4749
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Brugia malayi Thioredoxin reductase 0.0096 0.0355 0.0514
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0355 0.0514
Leishmania major hypothetical protein, conserved 0.0099 0.0367 0.0568
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.0533
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Schistosoma mansoni thymidylate kinase 0.0074 0.0235 0.0328
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0099 0.0367 0.0533
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0156 0.0241
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0099 0.0367 0.0533
Plasmodium vivax phosphodiesterase gamma, putative 0.0099 0.0367 0.0533
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0029 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0184 0.0249
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis C-MYB, putative 0.0038 0.0046 0.0076
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0099 0.0367 0.0533
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0099 0.0367 0.0533
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0156 0.0241
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0517 0.2563 0.3938
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0156 0.0197
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0156 0.5819
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.1156
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0156 0.0205
Plasmodium falciparum glutathione reductase 0.0096 0.0355 0.0514
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Brugia malayi glutathione reductase 0.0096 0.0355 0.0514
Echinococcus granulosus tar DNA binding protein 0.0064 0.0184 0.0249
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0156 0.0132
Loa Loa (eye worm) hypothetical protein 0.005 0.0113 0.013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0099 0.0367 0.0533
Entamoeba histolytica Thymidylate kinase, putative 0.0074 0.0235 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1261 0.6464 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1389 0.7138 1
Toxoplasma gondii thioredoxin reductase 0.0096 0.0355 0.0514
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0024 0.0037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.1156
Onchocerca volvulus 0.1261 0.6464 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Loa Loa (eye worm) MH2 domain-containing protein 0.036 0.174 0.2659
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0099 0.0367 0.0533
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.022 0.1003 0.1113
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0616 0.3082 0.4749
Loa Loa (eye worm) RNA binding protein 0.0064 0.0184 0.0241
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0355 0.0465
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0113 0.0138
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0224 0.0311
Trypanosoma brucei hypothetical protein, conserved 0.0099 0.0367 0.0533
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0616 0.3082 0.4749
Toxoplasma gondii thymidylate kinase 0.0074 0.0235 0.0328
Treponema pallidum thymidylate kinase (tmk) 0.0074 0.0235 0.0212
Mycobacterium tuberculosis Probable dehydrogenase 0.022 0.1003 0.1377
Leishmania major thymidylate kinase-like protein 0.0074 0.0235 0.0363
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Giardia lamblia hypothetical protein 0.0099 0.0367 0.1123
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0367 0.1156
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0156 0.0205
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0517 0.2563 0.3943
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0024 0.0037
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0355 0.0514
Leishmania major DNA polymerase kappa, putative 0.0059 0.0156 0.0241
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0099 0.0367 0.0533
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0074 0.0235 0.0212
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.9431
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0616 0.3082 0.4749
Echinococcus granulosus thymidylate synthase 0.1261 0.6464 1
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0156 0.0205
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Schistosoma mansoni DNA polymerase eta 0.0085 0.0294 0.0419
Leishmania major cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Loa Loa (eye worm) hypothetical protein 0.0099 0.0367 0.0525
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Loa Loa (eye worm) hypothetical protein 0.1 0.5097 0.7875
Plasmodium falciparum thymidylate kinase 0.0074 0.0235 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1934 1 1
Echinococcus granulosus geminin 0.0512 0.2533 0.3897
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Leishmania major trypanothione reductase 0.0096 0.0355 0.0549
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0099 0.0367 0.0533
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.06 0.2996 0.4634
Leishmania major DNA polymerase eta, putative 0.0085 0.0294 0.0454
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis MYB, putative 0.0038 0.0047 0.0079
Plasmodium falciparum phosphodiesterase delta, putative 0.0099 0.0367 0.0533
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0517 0.2563 0.3943
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0367 0.1156
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0099 0.0367 0.0533
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0545 0.271 0.3586
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0245 0.1132 0.13
Trypanosoma brucei DNA polymerase eta, putative 0.0085 0.0294 0.0419
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0113 0.013
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus granulosus thymidylate kinase 0.0074 0.0235 0.0328
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0038 0.0047 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0224 0.0311
Mycobacterium tuberculosis Probable reductase 0.022 0.1003 0.1377
Loa Loa (eye worm) glutathione reductase 0.0096 0.0355 0.0506
Trichomonas vaginalis thymidylate kinase, putative 0.0074 0.0235 0.071
Brugia malayi thymidylate kinase 0.0074 0.0235 0.0328
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Mycobacterium tuberculosis Putative ferredoxin reductase 0.022 0.1003 0.1377
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0184 0.0249
Brugia malayi hypothetical protein 0.0072 0.0224 0.0311
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0099 0.0367 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.006 0.0057
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0245 0.1132 0.1558
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0224 0.0311
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0355 0.0506
Chlamydia trachomatis thymidylate kinase 0.0074 0.0235 0.0212
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1261 0.6464 0.9053
Loa Loa (eye worm) hypothetical protein 0.0616 0.3082 0.4745
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0355 0.0514
Schistosoma mansoni thymidylate kinase 0.0074 0.0235 0.0328
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0099 0.0367 0.0533
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0099 0.0367 0.0533
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0074 0.0235 0.0297
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0184 0.0241
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Loa Loa (eye worm) thymidylate synthase 0.1261 0.6464 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1261 0.6464 0.9024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0024 0.0037
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0099 0.0367 0.0533
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0156 0.0205
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0099 0.0367 0.0533
Trichomonas vaginalis thymidylate kinase, putative 0.0074 0.0235 0.071
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0099 0.0367 0.0533

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.19 uM Inhibition of platelet aggregation using collagen as activating agent in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 1.07 uM Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 1.07 uM Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 49.5 uM Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 49.5 uM Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) ChEMBL. 1321910
IC50 (binding) uM Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis; Not tested ChEMBL. 1321910
IC50 (binding) 0 uM Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis; Not tested ChEMBL. 1321910
IC50 (binding) = 0.3 uM Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis ChEMBL. 1321910
IC50 (binding) = 0.3 uM Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis ChEMBL. 1321910

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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