Detailed information for compound 147844

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.483 | Formula: C22H28N4O2
  • H donors: 2 H acceptors: 4 LogP: 4.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C1CCCCC1)C)CCCCc1ccc2c(c1)cc1c([nH]2)nc(n1)O
  • InChi: 1S/C22H28N4O2/c1-26(17-8-3-2-4-9-17)20(27)10-6-5-7-15-11-12-18-16(13-15)14-19-21(23-18)25-22(28)24-19/h11-14,17H,2-10H2,1H3,(H2,23,24,25,28)
  • InChiKey: OPXJIJPVHIVMBI-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 3A, cGMP-inhibited Starlite/ChEMBL References
Homo sapiens purinergic receptor P2Y, G-protein coupled, 12 Starlite/ChEMBL References
Homo sapiens phosphodiesterase 3B, cGMP-inhibited References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi glutathione reductase 0.0096 0.0355 0.0514
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.1156
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0156 0.5819
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Plasmodium falciparum glutathione reductase 0.0096 0.0355 0.0514
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0156 0.0205
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0029 0.0008
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0184 0.0249
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0099 0.0367 0.0533
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis C-MYB, putative 0.0038 0.0046 0.0076
Plasmodium vivax phosphodiesterase gamma, putative 0.0099 0.0367 0.0533
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0156 0.0197
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0156 0.0241
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0099 0.0367 0.0533
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0517 0.2563 0.3938
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0099 0.0367 0.0533
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.0533
Leishmania major hypothetical protein, conserved 0.0099 0.0367 0.0568
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0099 0.0367 0.0533
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0156 0.0241
Schistosoma mansoni thymidylate kinase 0.0074 0.0235 0.0328
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0616 0.3082 0.4749
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Mycobacterium ulcerans thymidylate synthase 0.1261 0.6464 0.6456
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Brugia malayi Thioredoxin reductase 0.0096 0.0355 0.0514
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0355 0.0514
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Brugia malayi MH2 domain containing protein 0.036 0.174 0.2665
Loa Loa (eye worm) thymidylate kinase 0.0074 0.0235 0.032
Trypanosoma brucei unspecified product 0.004 0.006 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0099 0.0367 0.0533
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0367 0.1156
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0099 0.0367 0.0568
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Mycobacterium tuberculosis Hypothetical protein 0.06 0.2996 0.4177
Plasmodium vivax glutathione reductase, putative 0.0096 0.0355 0.0514
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.006 0.0057
Trypanosoma brucei thymidylate kinase, putative 0.0074 0.0235 0.0328
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.9431
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0074 0.0235 0.0212
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0616 0.3082 0.4749
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0367 0.1156
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0156 0.0205
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0355 0.0514
Leishmania major DNA polymerase kappa, putative 0.0059 0.0156 0.0241
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0099 0.0367 0.0533
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0517 0.2563 0.3943
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0024 0.0037
Leishmania major thymidylate kinase-like protein 0.0074 0.0235 0.0363
Giardia lamblia hypothetical protein 0.0099 0.0367 0.1123
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0616 0.3082 0.4749
Mycobacterium tuberculosis Probable dehydrogenase 0.022 0.1003 0.1377
Toxoplasma gondii thymidylate kinase 0.0074 0.0235 0.0328
Treponema pallidum thymidylate kinase (tmk) 0.0074 0.0235 0.0212
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0616 0.3082 0.4749
Loa Loa (eye worm) RNA binding protein 0.0064 0.0184 0.0241
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.022 0.1003 0.1113
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0224 0.0311
Trypanosoma brucei hypothetical protein, conserved 0.0099 0.0367 0.0533
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0355 0.0465
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0113 0.0138
Onchocerca volvulus 0.1261 0.6464 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0099 0.0367 0.0533
Loa Loa (eye worm) MH2 domain-containing protein 0.036 0.174 0.2659
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Toxoplasma gondii thioredoxin reductase 0.0096 0.0355 0.0514
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0024 0.0037
Entamoeba histolytica Thymidylate kinase, putative 0.0074 0.0235 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1389 0.7138 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1261 0.6464 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Echinococcus granulosus tar DNA binding protein 0.0064 0.0184 0.0249
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0099 0.0367 0.0533
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0156 0.0132
Loa Loa (eye worm) hypothetical protein 0.005 0.0113 0.013
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0245 0.1132 0.13
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0099 0.0367 0.0533
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0545 0.271 0.3586
Trypanosoma brucei DNA polymerase eta, putative 0.0085 0.0294 0.0419
Trichomonas vaginalis MYB, putative 0.0038 0.0047 0.0079
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0517 0.2563 0.3943
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0367 0.1156
Plasmodium falciparum phosphodiesterase delta, putative 0.0099 0.0367 0.0533
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0099 0.0367 0.0533
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Leishmania major DNA polymerase eta, putative 0.0085 0.0294 0.0454
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.06 0.2996 0.4634
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Leishmania major trypanothione reductase 0.0096 0.0355 0.0549
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1934 1 1
Echinococcus granulosus geminin 0.0512 0.2533 0.3897
Loa Loa (eye worm) hypothetical protein 0.0099 0.0367 0.0525
Plasmodium falciparum thymidylate kinase 0.0074 0.0235 0.0328
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Loa Loa (eye worm) hypothetical protein 0.1 0.5097 0.7875
Leishmania major cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0156 0.0205
Echinococcus granulosus thymidylate synthase 0.1261 0.6464 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Schistosoma mansoni DNA polymerase eta 0.0085 0.0294 0.0419
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0099 0.0367 0.0533
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0099 0.0367 0.0533
Trichomonas vaginalis thymidylate kinase, putative 0.0074 0.0235 0.071
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0024 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0156 0.0205
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0099 0.0367 0.0533
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0184 0.0241
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0074 0.0235 0.0297
Loa Loa (eye worm) thymidylate synthase 0.1261 0.6464 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1261 0.6464 0.9024
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0355 0.0514
Schistosoma mansoni thymidylate kinase 0.0074 0.0235 0.0328
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0099 0.0367 0.0533
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0099 0.0367 0.0533
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Chlamydia trachomatis thymidylate kinase 0.0074 0.0235 0.0212
Loa Loa (eye worm) hypothetical protein 0.0616 0.3082 0.4745
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1261 0.6464 0.9053
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0355 0.0506
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0245 0.1132 0.1558
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0224 0.0311
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0099 0.0367 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.006 0.0057
Mycobacterium tuberculosis Putative ferredoxin reductase 0.022 0.1003 0.1377
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0184 0.0249
Brugia malayi hypothetical protein 0.0072 0.0224 0.0311
Echinococcus granulosus thymidylate kinase 0.0074 0.0235 0.0328
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0038 0.0047 0.0036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0113 0.013
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Brugia malayi thymidylate kinase 0.0074 0.0235 0.0328
Trichomonas vaginalis thymidylate kinase, putative 0.0074 0.0235 0.071
Mycobacterium tuberculosis Probable reductase 0.022 0.1003 0.1377
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0224 0.0311
Loa Loa (eye worm) glutathione reductase 0.0096 0.0355 0.0506
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0156 0.0445
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0099 0.0367 0.1156
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0099 0.0367 0.0533
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Schistosoma mansoni hypothetical protein 0.0512 0.2533 0.3897
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0184 0.0249
Schistosoma mansoni hypothetical protein 0.0109 0.0422 0.0618
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0047 0.0079
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.022 0.1003 0.1377
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.022 0.1003 0.1377
Trichomonas vaginalis MYB3r3, putative 0.0038 0.0046 0.0076
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0099 0.0367 0.0533
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0545 0.271 0.2693
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Giardia lamblia CDC8 0.0074 0.0235 0.069
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0184 0.0249
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1934 1 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.006 0.0057
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0156 0.0205
Leishmania major DNA polymerase eta, putative 0.0044 0.0081 0.0126
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0545 0.271 0.2693
Schistosoma mansoni hypothetical protein 0.0034 0.0029 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0184 0.0249
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1934 1 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Echinococcus multilocularis dna polymerase eta 0.0085 0.0294 0.0419
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0184 0.0241
Brugia malayi hypothetical protein 0.06 0.2996 0.4614
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.022 0.1003 0.1377
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0099 0.0367 0.0533
Trypanosoma brucei trypanothione reductase 0.0096 0.0355 0.0514
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0047 0.0079
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus multilocularis thymidylate kinase 0.0074 0.0235 0.0328
Giardia lamblia DINP protein human, muc B family 0.0059 0.0156 0.0432
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0156 0.0241
Brugia malayi RNA binding protein 0.0064 0.0184 0.0249
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0081 0.0089
Loa Loa (eye worm) PDE1B protein 0.0099 0.0367 0.0525
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0616 0.3082 0.4749
Echinococcus multilocularis geminin 0.0512 0.2533 0.3897
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.9431
Trypanosoma brucei unspecified product 0.0059 0.0156 0.0205
Brugia malayi ImpB/MucB/SamB family protein 0.0085 0.0294 0.0419
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0245 0.1132 0.1558
Echinococcus granulosus dna polymerase kappa 0.0059 0.0156 0.0205
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.9431
Trypanosoma cruzi DNA polymerase eta, putative 0.0085 0.0294 0.0454
Trypanosoma brucei thymidylate kinase, putative 0.0074 0.0235 0.0328
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Loa Loa (eye worm) hypothetical protein 0.1099 0.5616 0.8682
Trypanosoma brucei RNA helicase, putative 0.0109 0.0422 0.0618
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1389 0.7138 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0099 0.0367 0.0525
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0099 0.0367 0.0533
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0113 0.0138
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0024 0.0037
Schistosoma mansoni hypothetical protein 0.0074 0.0235 0.0328
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Brugia malayi thymidylate synthase 0.1261 0.6464 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0099 0.0367 0.0568
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0156 0.0205
Giardia lamblia Myb 1-like protein 0.0038 0.0047 0.0076
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0184 0.0249
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0099 0.0367 0.0568
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0099 0.0367 0.0533
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1261 0.6464 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0046 0.0076
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus multilocularis thymidylate synthase 0.1261 0.6464 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Schistosoma mansoni hypothetical protein 0.0072 0.0224 0.0311
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Brugia malayi TAR-binding protein 0.0064 0.0184 0.0249
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0156 0.0186
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0024 0.0037
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0616 0.3082 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0616 0.3082 0.4749
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0081 0.0126
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0156 0.0241
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0156 0.0205
Loa Loa (eye worm) hypothetical protein 0.0099 0.0367 0.0525
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0099 0.0367 0.0533
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Trichomonas vaginalis MYB72, putative 0.0038 0.0046 0.0076
Entamoeba histolytica hypothetical protein 0.0072 0.0224 0.9431
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0099 0.0367 0.0533
Trichomonas vaginalis C-MYB, putative 0.0038 0.0046 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.036 0.174 0.2659
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0355 0.0549
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0156 0.0205
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0517 0.2563 0.3943
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0099 0.0367 0.0533
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0156 0.0241
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.1156
Trichomonas vaginalis pc-MYB2, putative 0.0038 0.0046 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0156 0.0186
Trypanosoma cruzi thymidylate kinase, putative 0.0074 0.0235 0.0363
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0038 0.0046 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.06 0.2996 1
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0156 0.0132
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0099 0.0367 0.0533
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1099 0.5616 0.8683
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Mycobacterium tuberculosis Probable oxidoreductase 0.0245 0.1132 0.1558
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0156 0.0445
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0099 0.0367 0.0533
Mycobacterium ulcerans thymidylate kinase 0.0074 0.0235 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0156 0.0205
Giardia lamblia Hypothetical protein 0.0099 0.0367 0.1123
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0156 0.0205
Plasmodium falciparum thioredoxin reductase 0.0096 0.0355 0.0514
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0367 0.0568
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0099 0.0367 0.0533
Trypanosoma brucei unspecified product 0.004 0.006 0.0057
Schistosoma mansoni hypothetical protein 0.0512 0.2533 0.3897
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0099 0.0367 0.0533
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0099 0.0367 0.1156
Loa Loa (eye worm) hypothetical protein 0.0085 0.0294 0.0411
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0545 0.271 0.4171
Trypanosoma cruzi thymidylate kinase, putative 0.0074 0.0235 0.0363
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0099 0.0367 0.0533
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0099 0.0367 0.0568
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0184 0.0249
Plasmodium falciparum phosphodiesterase gamma, putative 0.0099 0.0367 0.0533
Leishmania major hypothetical protein, conserved 0.0099 0.0367 0.0568
Echinococcus granulosus dna polymerase eta 0.0085 0.0294 0.0419
Plasmodium vivax thymidylate kinase, putative 0.0074 0.0235 0.0328
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0024 0.0037

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.026 uM Inhibition of platelet aggregation using collagen as activating agent in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 0.21 uM Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 0.21 uM Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 1.1 uM Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 1.1 uM Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) ChEMBL. 1321910
IC50 (binding) uM Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis; Not tested ChEMBL. 1321910
IC50 (binding) 0 uM Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis; Not tested ChEMBL. 1321910
IC50 (binding) = 0.04 uM Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis ChEMBL. 1321910
IC50 (binding) = 0.04 uM Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis ChEMBL. 1321910

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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