Detailed information for compound 1478591

Basic information

Technical information
  • TDR Targets ID: 1478591
  • Name: 4-[2-[4-(2-phenylpropan-2-yl)phenoxy]ethyl]mo rpholine
  • MW: 325.445 | Formula: C21H27NO2
  • H donors: 0 H acceptors: 0 LogP: 4.35 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccccc1)(c1ccc(cc1)OCCN1CCOCC1)C
  • InChi: 1S/C21H27NO2/c1-21(2,18-6-4-3-5-7-18)19-8-10-20(11-9-19)24-17-14-22-12-15-23-16-13-22/h3-11H,12-17H2,1-2H3
  • InChiKey: JNDONVBYUGJASL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-[4-(1-methyl-1-phenyl-ethyl)phenoxy]ethyl]morpholine
  • 4-[2-[4-(1-methyl-1-phenylethyl)phenoxy]ethyl]morpholine
  • IDI1_024598
  • ChemDiv3_006688

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine:threonine protein kinase N2 0.0218 0.1813 0.2097
Loa Loa (eye worm) hypothetical protein 0.056 0.5223 0.5223
Schistosoma mansoni serine/threonine protein kinase 0.0845 0.8065 0.9328
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0209 0.1723 0.1993
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0875 0.1012
Loa Loa (eye worm) hypothetical protein 0.021 0.1733 0.1733
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0043 0.007 0.0081
Echinococcus multilocularis Immunoglobulin 0.0047 0.0112 0.013
Loa Loa (eye worm) CAMK protein kinase 0.0043 0.0065 0.0065
Echinococcus multilocularis inhibitor of apoptosis protein 0.0346 0.3094 0.3578
Entamoeba histolytica PH domain containing protein kinase, putative 0.0429 0.3919 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0627 0.0627
Brugia malayi diacylglycerol kinase 0.0198 0.1612 0.1864
Onchocerca volvulus Deterin homolog 0.0346 0.3094 0.3953
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0052 0.0154 0.0154
Loa Loa (eye worm) TK/EGFR protein kinase 0.0903 0.8646 0.8646
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0299 0.2626 0.3037
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0204 0.1676 0.1939
Loa Loa (eye worm) hypothetical protein 0.0198 0.1612 0.1612
Brugia malayi RhoGAP domain containing protein 0.0209 0.1723 0.1993
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0194 0.0224
Schistosoma mansoni thyroid hormone receptor 0.0134 0.0974 0.1126
Loa Loa (eye worm) hypothetical protein 0.0047 0.0112 0.0112
Onchocerca volvulus 0.056 0.5223 0.6673
Echinococcus granulosus tyrosine protein kinase Lyn 0.005 0.0134 0.0155
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0218 0.1813 0.2097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0148 0.0171
Echinococcus multilocularis lachesin 0.0052 0.0154 0.0178
Schistosoma mansoni unc-13 (munc13) 0.0216 0.1798 0.2079
Echinococcus granulosus roundabout 2 0.0099 0.0627 0.0725
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0052 0.0154 0.0178
Echinococcus multilocularis twitchin 0.0043 0.0065 0.0075
Echinococcus multilocularis hemicentin 1 0.0052 0.0154 0.0178
Schistosoma mansoni titin 0.0052 0.0154 0.0178
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0218 0.1813 0.2097
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0279 0.2421 0.2421
Brugia malayi protein kinase C3,putative 0.0449 0.4122 0.4767
Echinococcus multilocularis epidermal growth factor receptor 0.0493 0.4552 0.5265
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.007 0.0081
Echinococcus granulosus NDR protein kinase 0.0218 0.1813 0.2097
Schistosoma mansoni serine/threonine kinase 0.0218 0.1813 0.2097
Echinococcus multilocularis protein kinase c iota type 0.0661 0.623 0.7206
Schistosoma mansoni tyrosine kinase 0.0043 0.007 0.0081
Onchocerca volvulus 0.0362 0.3251 0.4153
Brugia malayi Protein kinase domain containing protein 0.0218 0.1813 0.2097
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.1813 0.2097
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0043 0.007 0.0081
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0218 0.1813 0.2097
Schistosoma mansoni diacylglycerol kinase theta 0.0198 0.1612 0.1864
Loa Loa (eye worm) hypothetical protein 0.0052 0.0154 0.0154
Schistosoma mansoni hypothetical protein 0.0198 0.1612 0.1864
Schistosoma mansoni tyrosine kinase 0.0472 0.4343 0.5023
Trichomonas vaginalis AGC family protein kinase 0.023 0.1935 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0057 0.021 0.0243
Brugia malayi MAP kinase sur-1 0.0056 0.0194 0.0224
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0194 0.5
Echinococcus multilocularis c src tyrosine kinase 0.0043 0.007 0.0081
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0194 0.5
Brugia malayi Protein kinase domain containing protein 0.023 0.1935 0.2238
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0198 0.1612 0.1612
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0346 0.3094 0.3578
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0218 0.1813 0.2097
Echinococcus granulosus protein kinase C gamma type 0.0588 0.5508 0.637
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0377 0.3399 0.3399
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.1813 0.2097
Schistosoma mansoni tyrosine kinase 0.0493 0.4552 0.5265
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0052 0.0154 0.0178
Echinococcus granulosus roundabout 2 0.0052 0.0154 0.0178
Echinococcus multilocularis serine:threonine protein kinase N2 0.0628 0.5906 0.6831
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0786 0.748 0.8651
Echinococcus multilocularis raf serine:threonine protein kinase 0.0219 0.1821 0.2107
Onchocerca volvulus 0.0216 0.1798 0.2297
Loa Loa (eye worm) TK/INSR protein kinase 0.0299 0.2626 0.2626
Schistosoma mansoni thyroid hormone receptor 0.0134 0.0974 0.1126
Trichomonas vaginalis AGC family protein kinase 0.0218 0.1813 0.9301
Loa Loa (eye worm) RasGEF domain-containing protein 0.0198 0.1612 0.1612
Echinococcus granulosus neuroglian 0.0052 0.0154 0.0178
Echinococcus granulosus myotubularin protein 13 0.021 0.1733 0.2005
Echinococcus granulosus serine:threonine protein kinase N2 0.0218 0.1813 0.2097
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0218 0.1813 0.1813
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.0974 0.1126
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0204 0.1676 0.1939
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0043 0.007 0.0081
Brugia malayi protein kinase C II. 0.0845 0.8065 0.9328
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.021 0.0243
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0052 0.0154 0.0178
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0194 0.5
Schistosoma mansoni cell adhesion molecule 0.0063 0.0267 0.0308
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0346 0.3094 0.3578
Loa Loa (eye worm) raf kinase 0.0198 0.1612 0.1612
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0065 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0786 0.748 0.8651
Echinococcus granulosus RNA directed DNA polymerase 0.0352 0.3148 0.3641
Brugia malayi Protein kinase domain containing protein 0.0204 0.1676 0.1939
Schistosoma mansoni neuroglian 0.0052 0.0154 0.0178
Echinococcus granulosus Immunoglobulin 0.0047 0.0112 0.013
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0209 0.1723 0.1993
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0043 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0052 0.0154 0.0154
Loa Loa (eye worm) AGC/NDR protein kinase 0.0218 0.1813 0.1813
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0042 0.0059 0.0059
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0218 0.1813 0.2097
Echinococcus granulosus N chimaerin 0.0209 0.1723 0.1993
Loa Loa (eye worm) hypothetical protein 0.0047 0.0112 0.0112
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0052 0.0154 0.0154
Echinococcus multilocularis protein kinase c eta type 0.0198 0.1612 0.1864
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0043 0.007 0.0081
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0154 0.0178
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0209 0.1723 0.1723
Trichomonas vaginalis AGC family protein kinase 0.023 0.1935 1
Loa Loa (eye worm) hypothetical protein 0.0572 0.5344 0.5344
Echinococcus granulosus twitchin 0.009 0.0538 0.0622
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0154 0.0178
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0154 0.0178
Schistosoma mansoni tyrosine kinase 0.0903 0.8646 1
Echinococcus granulosus Diacylglycerol kinase theta 0.0198 0.1612 0.1864
Trichomonas vaginalis AGC family protein kinase 0.0218 0.1813 0.9301
Toxoplasma gondii diacylglycerol kinase, putative 0.0198 0.1612 0.8757
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0084 0.0476 0.0476
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0043 0.0065 0.0065
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0194 0.0194
Echinococcus multilocularis tyrosine protein kinase Abl 0.0043 0.007 0.0081
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0279 0.2421 0.28
Schistosoma mansoni lipoxygenase 0.0054 0.0175 0.0202
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0047 0.0112 0.013
Schistosoma mansoni tyrosine kinase 0.0472 0.4343 0.5023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0154 0.0154
Onchocerca volvulus 0.0821 0.7827 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0845 0.8065 0.8065
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0043 0.007 0.0081
Echinococcus multilocularis roundabout 2 0.0052 0.0154 0.0178
Loa Loa (eye worm) AGC/AKT protein kinase 0.023 0.1935 0.1935
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.007 0.0081
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0346 0.3094 0.3578
Brugia malayi p70 ribosomal S6 kinase beta 0.0218 0.1813 0.2097
Loa Loa (eye worm) hypothetical protein 0.0352 0.3148 0.3148
Echinococcus multilocularis Immunoglobulin 0.0047 0.0112 0.013
Loa Loa (eye worm) AGC/PKN protein kinase 0.0218 0.1813 0.1813
Schistosoma mansoni titin 0.0043 0.0065 0.0075
Entamoeba histolytica protein kinase, putative 0.023 0.1935 0.14
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0198 0.1612 0.1612
Echinococcus multilocularis serine:threonine protein kinase 38 0.0218 0.1813 0.2097
Loa Loa (eye worm) hypothetical protein 0.0099 0.0627 0.0627
Entamoeba histolytica protein kinase, putative 0.023 0.1935 0.14
Brugia malayi Furin-like cysteine rich region family protein 0.0903 0.8646 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0218 0.1813 0.1813
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0065 0.0075
Echinococcus multilocularis epidermal growth factor receptor 0.0903 0.8646 1
Trichomonas vaginalis AGC family protein kinase 0.023 0.1935 1
Entamoeba histolytica protein kinase, putative 0.0218 0.1813 0.0873
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.6329 0.732
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0052 0.0154 0.0178
Brugia malayi RhoGEF domain containing protein 0.0198 0.1612 0.1864
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0216 0.1798 0.2079
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0194 0.5
Loa Loa (eye worm) TK protein kinase 0.0057 0.021 0.021
Schistosoma mansoni unc-13 (munc13) 0.0216 0.1798 0.2079
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0063 0.0267 0.0308
Trichomonas vaginalis AGC family protein kinase 0.023 0.1935 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0209 0.1723 0.1993
Loa Loa (eye worm) hypothetical protein 0.0063 0.0267 0.0267
Loa Loa (eye worm) TK/ROR protein kinase 0.0057 0.021 0.021
Schistosoma mansoni nephrin 0.0084 0.0473 0.0547
Echinococcus multilocularis neuroglian 0.0084 0.0473 0.0547
Loa Loa (eye worm) hypothetical protein 0.0821 0.7827 0.7827
Echinococcus granulosus protein kinase c iota type 0.0661 0.623 0.7206
Schistosoma mansoni serine/threonine protein kinase 0.022 0.1829 0.2116
Brugia malayi diacylglycerol kinase 0.0198 0.1612 0.1864
Echinococcus granulosus lachesin 0.0052 0.0154 0.0178
Echinococcus multilocularis RNA directed DNA polymerase 0.0352 0.3148 0.3641
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0194 0.0224
Loa Loa (eye worm) hypothetical protein 0.0047 0.0112 0.0112
Schistosoma mansoni tyrosine kinase 0.0472 0.4343 0.5023
Echinococcus granulosus tyrosine protein kinase otk 0.0052 0.0154 0.0178
Brugia malayi Prion-like- 0.0052 0.0154 0.0178
Echinococcus multilocularis insulin receptor 0.0299 0.2626 0.3037
Echinococcus multilocularis Rac GTPase activating protein 1 0.0198 0.1612 0.1864
Echinococcus granulosus tyrosine protein kinase Src64B 0.0043 0.007 0.0081
Echinococcus granulosus protein kinase c epsilon type 0.0845 0.8065 0.9328
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0209 0.1723 0.1993
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0346 0.3094 0.3094
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0043 0.007 0.0081
Schistosoma mansoni rac gtpase activating protein 0.0198 0.1612 0.1864
Schistosoma mansoni tyrosine kinase 0.0299 0.2626 0.3037
Schistosoma mansoni protein kinase C mu 0.0566 0.5287 0.6115
Loa Loa (eye worm) hypothetical protein 0.0198 0.1612 0.1612
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.6329 0.732
Echinococcus multilocularis titin 0.0043 0.0065 0.0075
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0052 0.0154 0.0178
Brugia malayi Hr1 repeat family protein 0.0218 0.1813 0.2097
Echinococcus granulosus serine:threonine protein kinase N2 0.0417 0.3798 0.4392
Brugia malayi Pleckstrin Homology Domain 0.021 0.1733 0.2005
Echinococcus granulosus defective proboscis extension response 0.0047 0.0112 0.013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0194 0.5
Echinococcus granulosus peroxidasin 0.0052 0.0154 0.0178
Loa Loa (eye worm) hypothetical protein 0.0821 0.7827 0.7827
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0194 0.0224
Toxoplasma gondii AGC kinase 0.0218 0.1813 1
Echinococcus granulosus hemicentin 1 0.0052 0.0154 0.0178
Trichomonas vaginalis AGC family protein kinase 0.023 0.1935 1
Echinococcus multilocularis serine threonine protein kinase 0.0588 0.5508 0.637
Echinococcus multilocularis N chimaerin 0.0209 0.1723 0.1993
Schistosoma mansoni inhibitor of apoptosis protein 0.0346 0.3094 0.3578
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0052 0.0154 0.0178
Echinococcus granulosus leukotriene A 4 hydrolase 0.0279 0.2421 0.28
Loa Loa (eye worm) hypothetical protein 0.0052 0.0154 0.0154
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.1821 0.2107
Echinococcus multilocularis Diacylglycerol kinase theta 0.0198 0.1612 0.1864
Echinococcus multilocularis tyrosine protein kinase otk 0.0052 0.0154 0.0178
Schistosoma mansoni diacylglycerol kinase theta 0.0198 0.1612 0.1864
Schistosoma mansoni vav2 0.0221 0.1845 0.2134
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0346 0.3094 0.3578
Echinococcus multilocularis unc 13 (munc13) 0.0216 0.1798 0.2079
Trichomonas vaginalis AGC family protein kinase 0.023 0.1935 1
Echinococcus granulosus epidermal growth factor receptor 0.0493 0.4552 0.5265
Echinococcus granulosus contactin 0.0052 0.0154 0.0178
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0218 0.1813 0.1813
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0112 0.013
Schistosoma mansoni tyrosine kinase 0.0493 0.4552 0.5265
Schistosoma mansoni tyrosine kinase 0.0073 0.0364 0.0421
Echinococcus granulosus epidermal growth factor receptor 0.0903 0.8646 1
Schistosoma mansoni cell adhesion molecule 0.0052 0.0154 0.0178
Schistosoma mansoni protein kinase C 0.0216 0.1798 0.2079
Schistosoma mansoni tyrosine kinase 0.0043 0.007 0.0081
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0058 0.0219 0.0219
Schistosoma mansoni cell adhesion molecule 0.0052 0.0154 0.0178
Loa Loa (eye worm) hypothetical protein 0.0052 0.0154 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0154 0.0178
Schistosoma mansoni cell adhesion molecule 0.0052 0.0154 0.0178
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0052 0.0154 0.0178
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.1676 0.1939
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.007 0.0081
Onchocerca volvulus 0.0572 0.5344 0.6829
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0043 0.007 0.0081
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0057 0.021 0.0243
Trichomonas vaginalis AGC family protein kinase 0.023 0.1935 1
Echinococcus multilocularis protein kinase c epsilon type 0.0845 0.8065 0.9328
Loa Loa (eye worm) hypothetical protein 0.0052 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0346 0.3094 0.3094
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0218 0.1813 0.1813
Schistosoma mansoni septate junction protein 0.0052 0.0154 0.0178
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0154 0.0178
Echinococcus granulosus c src tyrosine kinase 0.0043 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0198 0.1612 0.1612
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0279 0.2421 0.28
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0052 0.0154 0.0197
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0362 0.3251 0.3251
Loa Loa (eye worm) hypothetical protein 0.0198 0.1612 0.1612
Loa Loa (eye worm) hypothetical protein 0.0052 0.0154 0.0154
Brugia malayi hypothetical protein 0.0047 0.0112 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0786 0.748 0.8651
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0566 0.5287 0.5287
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0566 0.5287 0.6115
Trichomonas vaginalis AGC family protein kinase 0.023 0.1935 1
Echinococcus granulosus inhibitor of apoptosis protein 0.0346 0.3094 0.3578
Schistosoma mansoni hypothetical protein 0.0346 0.3094 0.3578
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0467 0.4301 0.4301
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.007 0.0081
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0154 0.0178
Echinococcus multilocularis roundabout 2 0.0052 0.0154 0.0178
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0047 0.0112 0.013
Echinococcus granulosus insulin receptor 0.0299 0.2626 0.3037
Echinococcus granulosus Protein kinase C brain isozyme 0.0786 0.748 0.8651
Schistosoma mansoni protein kinase C mu 0.0198 0.1612 0.1864
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0043 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0216 0.1798 0.1798
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0052 0.0154 0.0154
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0875 0.1012
Echinococcus multilocularis peroxidasin 0.0052 0.0154 0.0178
Brugia malayi Protein kinase domain containing protein 0.0299 0.2626 0.3037
Loa Loa (eye worm) SRC-1 0.0043 0.007 0.007
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0299 0.2626 0.3037
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0047 0.0112 0.013
Loa Loa (eye worm) hypothetical protein 0.0051 0.0148 0.0148
Brugia malayi C1-like domain containing protein 0.0566 0.5287 0.6115
Onchocerca volvulus 0.0346 0.3094 0.3953
Echinococcus granulosus unc 13 munc13 0.0216 0.1798 0.2079
Schistosoma mansoni tyrosine kinase 0.0299 0.2626 0.3037
Brugia malayi RhoGAP domain containing protein 0.0198 0.1612 0.1864
Echinococcus granulosus protein kinase c eta type 0.0198 0.1612 0.1864
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0148 0.0148
Onchocerca volvulus 0.0043 0.0065 0.0083
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0175 0.0202
Schistosoma mansoni tyrosine kinase 0.0043 0.007 0.0081
Schistosoma mansoni nephrin 0.0052 0.0154 0.0178
Brugia malayi Fibronectin type III domain containing protein 0.0047 0.0112 0.013
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0175 0.0202
Schistosoma mansoni roundabout 0.0052 0.0154 0.0178
Schistosoma mansoni tyrosine kinase 0.0043 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0821 0.7827 0.7827
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0369 0.3315 0.3315
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0194 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.1813 0.2097
Trichomonas vaginalis AGC family protein kinase 0.0218 0.1813 0.9301
Brugia malayi Variant SH3 domain containing protein 0.0042 0.0059 0.0068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0154 0.0178
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0154 0.0178
Loa Loa (eye worm) hypothetical protein 0.055 0.512 0.512
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.1676 0.1939
Trypanosoma brucei rac serine-threonine kinase, putative 0.023 0.1935 1
Brugia malayi hypothetical protein 0.0128 0.0918 0.1062
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0194 0.0224
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0052 0.0154 0.0178
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0211 0.1748 0.893
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0148 0.0171
Echinococcus multilocularis roundabout 2 0.0099 0.0627 0.0725
Brugia malayi Protein kinase domain containing protein 0.0218 0.1813 0.2097
Brugia malayi SRC-1 0.0043 0.007 0.0081
Echinococcus granulosus neuroglian 0.0084 0.0473 0.0547
Schistosoma mansoni atypical protein kinase C 0.0679 0.641 0.7414
Echinococcus granulosus titin 0.0043 0.0065 0.0075
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.007 0.0081
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0218 0.1813 0.2097
Echinococcus granulosus roundabout 2 0.0052 0.0154 0.0178
Loa Loa (eye worm) hypothetical protein 0.0047 0.0112 0.0112
Brugia malayi Peroxidasin 0.0052 0.0154 0.0178
Echinococcus multilocularis hemicentin 1 0.0052 0.0154 0.0178
Loa Loa (eye worm) hypothetical protein 0.1019 0.9799 0.9799
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0216 0.1798 0.2079
Brugia malayi protein unc-22 0.0043 0.0065 0.0075
Schistosoma mansoni vesicular amine transporter 0.0047 0.0112 0.013
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0112 0.0112
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0043 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0362 0.3251 0.3251
Echinococcus multilocularis neuroglian 0.0052 0.0154 0.0178
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0346 0.3094 0.3578
Schistosoma mansoni hypothetical protein 0.0124 0.0875 0.1012
Echinococcus multilocularis 0.0275 0.2378 0.275
Echinococcus multilocularis myotubularin protein 13 0.021 0.1733 0.2005
Loa Loa (eye worm) hypothetical protein 0.0052 0.0154 0.0154
Brugia malayi Tyrosine-protein kinase abl-1 0.0043 0.007 0.0081
Echinococcus granulosus raf serine:threonine protein kinase 0.0219 0.1821 0.2107
Echinococcus granulosus microtubule associated protein 2 0.0671 0.6329 0.732
Loa Loa (eye worm) hypothetical protein 0.0198 0.1612 0.1612
Schistosoma mansoni septate junction protein 0.0052 0.0154 0.0178
Echinococcus granulosus Rac GTPase activating protein 1 0.0198 0.1612 0.1864
Loa Loa (eye worm) hypothetical protein 0.0198 0.1612 0.1612
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0352 0.3148 0.3641
Onchocerca volvulus Tyrosine kinase homolog 0.0057 0.021 0.0268
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0194 0.0224
Echinococcus granulosus titin 0.0043 0.0065 0.0075
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0065 0.0075
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.0476 0.0551
Entamoeba histolytica protein kinase, putative 0.0218 0.1813 0.0873
Loa Loa (eye worm) hypothetical protein 0.0047 0.0112 0.0112
Brugia malayi Variant SH3 domain containing protein 0.0209 0.1723 0.1993
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0493 0.4552 0.5265
Brugia malayi Ras association domain family 1 isoform A 0.0198 0.1612 0.1864
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.0154 0.0178
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.007 0.0081
Brugia malayi Protein kinase c protein 2 0.0575 0.5371 0.6212

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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