Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0155 | 0.2744 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0365 | 0.8756 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0155 | 0.2744 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 1 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0155 | 0.2744 | 1 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.0155 | 0.2744 | 1 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0155 | 0.2744 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.2237 | 0.8154 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.0155 | 0.2744 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0155 | 0.2744 | 1 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0155 | 0.2744 | 1 |
Onchocerca volvulus | 0.006 | 0 | 0.5 | |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0155 | 0.2744 | 1 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0155 | 0.2744 | 0.0993 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.8756 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0138 | 0.2237 | 0.0364 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.1943 | 0.7083 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0155 | 0.2744 | 0.5 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0155 | 0.2744 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.3241 | 0.3643 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.2237 | 0.8154 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.8756 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0155 | 0.2744 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.3801 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 0.8756 | 1 |
Trichomonas vaginalis | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0155 | 0.2744 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.3801 | 0.5 |
Brugia malayi | dUTP diphosphatase | 0.0155 | 0.2744 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0155 | 0.2744 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0155 | 0.2744 | 1 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0155 | 0.2744 | 0.5 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0155 | 0.2744 | 0.5 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.0155 | 0.2744 | 0.0993 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.