Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0137 | 0.1475 | 0.1463 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0137 | 0.1475 | 0.1475 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.0731 | 0.0665 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0216 | 0.0147 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0378 | 0.0378 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0246 | 0.2859 | 0.2859 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0248 | 0.0234 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0049 | 0.036 | 0.036 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0137 | 0.1475 | 0.1475 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0216 | 0.0216 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0049 | 0.036 | 0.036 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0137 | 0.1475 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0217 | 0.2486 | 0.2432 |
Brugia malayi | hypothetical protein | 0.0137 | 0.1475 | 0.1415 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0345 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1475 | 0.1463 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.1475 | 0.1415 |
Schistosoma mansoni | gliotactin | 0.0137 | 0.1475 | 0.1475 |
Onchocerca volvulus | 0.0137 | 0.1475 | 0.4909 | |
Loa Loa (eye worm) | carboxylesterase | 0.0137 | 0.1475 | 0.1463 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 0.1475 | 0.1475 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0137 | 0.1475 | 0.1475 |
Trichomonas vaginalis | set domain proteins, putative | 0.0247 | 0.2865 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1475 | 0.1463 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1475 | 0.1463 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0216 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 0.1475 | 0.1475 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0345 | 0.0345 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.0576 | 0.0576 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0137 | 0.1475 | 0.1475 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.1475 | 0.1415 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0039 | 0.0039 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0135 | 0.0135 |
Echinococcus multilocularis | carboxylesterase 5A | 0.081 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.1475 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1475 | 0.1463 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0039 | 0.0039 |
Onchocerca volvulus | 0.0137 | 0.1475 | 0.4909 | |
Schistosoma mansoni | acetylcholinesterase | 0.0137 | 0.1475 | 0.1475 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0279 | 0.0265 |
Onchocerca volvulus | 0.005 | 0.0378 | 0.0888 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0137 | 0.1475 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0135 | 0.0135 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.1475 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0674 | 0.0661 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1475 | 0.1463 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0247 | 0.0178 |
Echinococcus multilocularis | acetylcholinesterase | 0.081 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0216 | 0.5 |
Onchocerca volvulus | 0.0137 | 0.1475 | 0.4909 | |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0135 | 0.0066 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.081 | 1 | 1 |
Onchocerca volvulus | 0.0137 | 0.1475 | 0.4909 | |
Onchocerca volvulus | 0.0247 | 0.2865 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0345 | 0.0345 |
Echinococcus granulosus | carboxylesterase 5A | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.2859 | 0.2849 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0345 | 0.0331 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0378 | 0.0378 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0137 | 0.1475 | 0.1475 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0137 | 0.1475 | 0.1475 |
Echinococcus multilocularis | neuroligin | 0.0137 | 0.1475 | 0.1475 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0137 | 0.1475 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0304 | 0.0291 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0345 | 0.0345 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.0529 | 0.0529 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0246 | 0.2859 | 0.2859 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.036 | 0.0347 |
Brugia malayi | hypothetical protein | 0.0246 | 0.2859 | 0.2809 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0137 | 0.1475 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0378 | 0.031 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0216 | 0.0216 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0216 | 0.0216 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0216 | 0.0216 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0121 | 0.0121 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0345 | 0.0345 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0135 | 0.5 |
Onchocerca volvulus | 0.0137 | 0.1475 | 0.4909 | |
Echinococcus granulosus | neuroligin | 0.0137 | 0.1475 | 0.1475 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0049 | 0.036 | 0.036 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0039 | 0.0039 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0137 | 0.1475 | 0.1475 |
Echinococcus granulosus | acetylcholinesterase | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.081 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.081 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.081 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1475 | 0.1463 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0217 | 0.2486 | 0.2475 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0345 | 0.0345 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0216 | 0.0216 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.0529 | 0.0529 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0137 | 0.1475 | 0.1475 |
Loa Loa (eye worm) | hypothetical protein | 0.081 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 0.1475 | 0.1475 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0216 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0135 | 0.0135 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0345 | 0.0277 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0049 | 0.036 | 0.036 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0135 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0345 | 0.0345 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0216 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1475 | 0.1463 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0216 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0014 | 0.0014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.