Detailed information for compound 147920

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.58 | Formula: C21H41N5O6
  • H donors: 7 H acceptors: 6 LogP: -4.93 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCCCNCCCC[C@@H](C(=O)O)NC(=O)[C@@H](NC(=O)CC[C@@H](C(=O)O)N)CC(C)C
  • InChi: 1S/C21H41N5O6/c1-14(2)13-17(25-18(27)9-8-15(23)20(29)30)19(28)26-16(21(31)32)7-3-5-11-24-12-6-4-10-22/h14-17,24H,3-13,22-23H2,1-2H3,(H,25,27)(H,26,28)(H,29,30)(H,31,32)/t15-,16-,17-/m0/s1
  • InChiKey: QOMWTFAFMDSEDH-ULQDDVLXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.1228 0.5861 0.5861
Brugia malayi hypothetical protein 0.005 0.0129 0.0178
Echinococcus multilocularis expressed conserved protein 0.0091 0.0327 0.0301
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0042
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0093 0.0126
Schistosoma mansoni hypothetical protein 0.0207 0.0895 0.0895
Loa Loa (eye worm) pyruvate kinase 0.1434 0.6861 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0046 0.011 0.0083
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0027 0.0018 0.0016
Mycobacterium tuberculosis Conserved protein 0.0086 0.0303 0.0386
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0125 0.0173
Schistosoma mansoni hypothetical protein 0.0448 0.2065 0.2065
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0031 0.0037 0.0044
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0061 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Echinococcus granulosus tumor protein p63 0.0674 0.3166 0.3147
Echinococcus granulosus importin subunit beta 1 0.0119 0.0464 0.0438
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0021 0.0021
Brugia malayi PHD-finger family protein 0.0029 0.0029 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0125 0.0125
Mycobacterium tuberculosis Probable dehydrogenase 0.0209 0.0902 0.1263
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0156 0.0644 0.0644
Loa Loa (eye worm) pyruvate kinase 0.1434 0.6861 1
Brugia malayi CXXC zinc finger family protein 0.0058 0.017 0.0238
Schistosoma mansoni pyruvate kinase 0.1434 0.6861 0.6861
Trypanosoma brucei hypothetical protein, conserved 0.0086 0.0303 0.0433
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.004 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0095 0.0346 0.0495
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0093 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0027 0.0018 0.0016
Loa Loa (eye worm) TAR-binding protein 0.0255 0.1125 0.164
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0046 0.011 0.0083
Loa Loa (eye worm) beta-lactamase 0.0086 0.0303 0.0442
Brugia malayi nuclear receptor NHR-67 0.0045 0.0103 0.014
Echinococcus granulosus intermediate filament protein 0.011 0.0423 0.0397
Schistosoma mansoni hypothetical protein 0.0055 0.0155 0.0155
Onchocerca volvulus 0.011 0.0423 0.0576
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0021 0.0031
Plasmodium vivax flavodoxin domain containing protein 0.0072 0.0236 0.0335
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0095 0.0346 0.0464
Loa Loa (eye worm) hypothetical protein 0.0051 0.0135 0.0197
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.004 0.0049
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0103 0.0076
Echinococcus granulosus peregrin 0.0036 0.0061 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0095 0.0346 0.0495
Toxoplasma gondii hypothetical protein 0.0119 0.0463 0.0666
Giardia lamblia DINP protein human, muc B family 0.0043 0.0093 0.0094
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0096 0.0355 0.0465
Schistosoma mansoni DNA polymerase eta 0.0043 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0095 0.0346 0.0504
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0045 0.0103 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.011 0.0106
Schistosoma mansoni smad1 5 8 and 0.0033 0.0048 0.0048
Schistosoma mansoni lamin 0.011 0.0423 0.0423
Schistosoma mansoni ran 0.0087 0.0311 0.0311
Echinococcus multilocularis ubiquitin specific protease 41 0.0046 0.011 0.0083
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0548 0.2553 0.3684
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.004 0.0028
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0307 0.1378 0.2
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0155 0.0216
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0042 0.0088 0.0128
Loa Loa (eye worm) glutathione reductase 0.0092 0.0331 0.0483
Schistosoma mansoni steroid hormone receptor ad4bp 0.0095 0.0346 0.0346
Trichomonas vaginalis ap endonuclease, putative 0.0096 0.0351 0.046
Echinococcus granulosus snurportin 1 0.1268 0.6057 0.6046
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0081 0.0281 0.0401
Loa Loa (eye worm) hypothetical protein 0.0095 0.0346 0.0504
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0095 0.0346 0.0346
Echinococcus granulosus geminin 0.1228 0.5861 0.5849
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0705 0.0989
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.004 0.0049
Loa Loa (eye worm) hypothetical protein 0.005 0.013 0.0189
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0037 0.0044
Brugia malayi Pre-SET motif family protein 0.012 0.047 0.0676
Echinococcus multilocularis thyroid hormone receptor alpha 0.0095 0.0346 0.032
Schistosoma mansoni NADPH flavin oxidoreductase 0.0041 0.0085 0.0085
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0042 0.0088 0.0074
Leishmania major p450 reductase, putative 0.0081 0.0281 0.0401
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0081 0.0281 0.0401
Loa Loa (eye worm) hypothetical protein 0.0049 0.0123 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Brugia malayi TAR-binding protein 0.0255 0.1125 0.1632
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0093 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0307 0.1378 0.1983
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.016 0.0665 0.1332
Mycobacterium leprae conserved hypothetical protein 0.0086 0.0303 0.0383
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0088 0.0118
Echinococcus multilocularis importin subunit beta 1 0.0119 0.0464 0.0438
Echinococcus multilocularis FTZ F1 alpha 0.0095 0.0346 0.032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.001
Echinococcus multilocularis pyruvate kinase 0.0736 0.3466 0.3448
Onchocerca volvulus 0.0058 0.017 0.0206
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0103 0.0076
Echinococcus granulosus Smad4 0.0033 0.0048 0.0021
Loa Loa (eye worm) hypothetical protein 0.0148 0.0605 0.0882
Trypanosoma brucei unspecified product 0.0029 0.0029 0.0032
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.005 0.0129 0.0103
Loa Loa (eye worm) MH2 domain-containing protein 0.0489 0.2263 0.3299
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0655 0.3074 0.4475
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0095 0.0346 0.0346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Loa Loa (eye worm) hypothetical protein 0.0095 0.0346 0.0504
Mycobacterium ulcerans lipase LipD 0.0086 0.0303 0.0412
Brugia malayi nuclear hormone receptor family member nhr-6 0.0045 0.0103 0.014
Brugia malayi exodeoxyribonuclease III family protein 0.0096 0.0351 0.0502
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0027 0.0018 0.0016
Giardia lamblia Nitric oxide synthase, inducible 0.0072 0.0236 0.0304
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Loa Loa (eye worm) pyruvate kinase 0.0302 0.1355 0.1976
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0103 0.0103
Toxoplasma gondii pyruvate kinase PyK1 0.1434 0.6861 1
Echinococcus multilocularis peregrin 0.0036 0.0061 0.0034
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0086 0.0086
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.016 0.0665 0.064
Loa Loa (eye worm) hypothetical protein 0.0655 0.3074 0.448
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0087 0.0311 0.0413
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0354 0.0328
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0088 0.0061
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0156 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Loa Loa (eye worm) hypothetical protein 0.0051 0.0135 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.004 0.0049
Plasmodium falciparum thioredoxin reductase 0.0092 0.0331 0.0473
Schistosoma mansoni Smad4 0.0033 0.0048 0.0048
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0093 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0095 0.0346 0.0495
Loa Loa (eye worm) DR-78 0.0045 0.0103 0.015
Echinococcus granulosus expressed conserved protein 0.0091 0.0327 0.0301
Brugia malayi nuclear receptor RXR 0.0045 0.0103 0.014
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0067 0.0211 0.0297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.047 0.047
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0061 0.0034
Schistosoma mansoni hypothetical protein 0.004 0.008 0.008
Schistosoma mansoni ran 0.0087 0.0311 0.0311
Brugia malayi PHD-finger family protein 0.0035 0.0058 0.0075
Brugia malayi Inositol-1 0.0036 0.0061 0.0079
Leishmania major importin beta-1 subunit, putative 0.0096 0.0355 0.0508
Brugia malayi mbt repeat family protein 0.0049 0.0123 0.017
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0048 0.007
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0061 0.0079
Brugia malayi ecdysteroid receptor 0.0735 0.3464 0.5044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0095 0.0346 0.0504
Trichomonas vaginalis set domain proteins, putative 0.0944 0.4477 0.6506
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0045 0.0103 0.015
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0129 0.0178
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0095 0.0346 0.032
Giardia lamblia Pyruvate kinase 0.1434 0.6861 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0048 0.0048
Trypanosoma brucei glutathionylspermidine synthetase, putative 0.0027 0.0018 0.0016
Schistosoma mansoni hypothetical protein 0.0564 0.2628 0.2628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0095 0.0346 0.0504
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0046 0.011 0.011
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0125 0.0173
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.0331 0.0483
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0066 0.0207 0.0249
Leishmania major cytochrome P450 reductase, putative 0.0072 0.0236 0.0335
Loa Loa (eye worm) hypothetical protein 0.0086 0.0303 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.0346 0.0495
Loa Loa (eye worm) hypothetical protein 0.0086 0.0303 0.0442
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0086 0.0303 0.0386
Echinococcus multilocularis microtubule associated protein 2 0.2079 1 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0029 0.0029
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0081 0.0281 0.0401
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0472 0.2182 0.2161
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.0621 0.0596
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0303 0.0433
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0096 0.0351 0.0666
Leishmania major cathepsin L-like protease 0.0073 0.0242 0.0342
Entamoeba histolytica hypothetical protein 0.0564 0.2628 0.5498
Leishmania major cathepsin L-like protease 0.0073 0.0242 0.0342
Loa Loa (eye worm) hypothetical protein 0.0271 0.1204 0.1755
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0086 0.0125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0207 0.0895 0.087
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0829 0.392 0.5714
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.011 0.015
Loa Loa (eye worm) hypothetical protein 0.0448 0.2065 0.301
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0188
Loa Loa (eye worm) hypothetical protein 0.0141 0.0571 0.0832
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0123 0.0097
Brugia malayi pyruvate kinase 0.0302 0.1355 0.1968
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0031 0.0037 0.0044
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0141 0.0571 0.0546
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0021 0.0021
Echinococcus multilocularis methionine synthase reductase 0.005 0.013 0.0104
Toxoplasma gondii aldehyde dehydrogenase 0.0307 0.1378 0.2
Loa Loa (eye worm) nuclear receptor NHR-67 0.0045 0.0103 0.015
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0027 0.0027
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0093 0.0067
Brugia malayi MH2 domain containing protein 0.0489 0.2263 0.3292
Trichomonas vaginalis esterase, putative 0.0086 0.0303 0.039
Toxoplasma gondii exonuclease III APE 0.0096 0.0351 0.0502
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0103 0.0076
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.011 0.0106
Mycobacterium tuberculosis Probable esterase LipL 0.0086 0.0303 0.0386
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0158 0.0655 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0029 0.0032
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0096 0.0351 0.0325
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0086 0.0303 0.0386
Echinococcus granulosus dna polymerase kappa 0.0043 0.0093 0.0067
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.016 0.0665 0.0665
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0354 0.0328
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0093 0.0105
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.004 0.0049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0095 0.0346 0.032
Onchocerca volvulus Bile acid receptor homolog 0.0735 0.3464 0.5028
Brugia malayi MH2 domain containing protein 0.0033 0.0048 0.006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0129 0.0129
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.009 0.0089
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0093 0.0337 0.0491
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0029 0.0032
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0088 0.0118
Entamoeba histolytica Ran family GTPase 0.0087 0.0311 0.0582
Loa Loa (eye worm) MBCTL1 0.0056 0.0156 0.0228
Trichomonas vaginalis pyruvate kinase, putative 0.1434 0.6861 1
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.0331 0.0473
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0066 0.0207 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0749 0.1043
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0096 0.0351 0.0502
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0472 0.2182 0.2182
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.0331 0.0305
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0125 0.0141
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1594 0.7643 0.7637
Brugia malayi Latrophilin receptor protein 2 0.0207 0.0895 0.1295
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0095 0.0346 0.032
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0081 0.0281 0.0401
Loa Loa (eye worm) FAD binding domain-containing protein 0.0081 0.0281 0.041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0207 0.0895 0.1295
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0088 0.0118
Plasmodium falciparum nitric oxide synthase, putative 0.0081 0.0281 0.0401
Echinococcus granulosus GTP binding nuclear protein Ran 0.0087 0.0311 0.0285
Echinococcus granulosus histone lysine methyltransferase setb 0.0139 0.0564 0.0539
Loa Loa (eye worm) hypothetical protein 0.0056 0.0156 0.0228
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0123 0.0097
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.004 0.0049
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0564 0.2628 0.2609
Trypanosoma cruzi trypanothione synthetase-like protein, putative 0.0027 0.0018 0.0016
Echinococcus granulosus sterol regulatory element binding protein 0.0099 0.0369 0.0343
Plasmodium vivax pyruvate kinase 2, putative 0.0736 0.3466 0.5047
Entamoeba histolytica hypothetical protein 0.0564 0.2628 0.5498
Brugia malayi conserved hypotetical protein 0.0045 0.0103 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1134 0.1607
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.004 0.0049
Leishmania major hypothetical protein, conserved 0.0027 0.0018 0.0016
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0043 0.0003
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0051 0.0065
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0021 0.0031
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0046 0.011 0.015
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0088 0.0118
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0088 0.0118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0472 0.2182 0.318
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0103 0.014
Brugia malayi beta-lactamase 0.0086 0.0303 0.0433
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0046 0.011 0.0153
Echinococcus multilocularis GPCR, family 2 0.0207 0.0895 0.087
Trichomonas vaginalis D-aminoacylase, putative 0.0086 0.0303 0.039
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0093 0.0093
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0081 0.0281 0.0255
Mycobacterium ulcerans pyruvate kinase 0.1434 0.6861 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0209 0.0902 0.1263
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0081 0.0281 0.0401
Brugia malayi orphan nuclear receptor NR2E1 0.0045 0.0103 0.014
Echinococcus multilocularis pyruvate kinase 0.1434 0.6861 0.6852
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0061 0.0035
Toxoplasma gondii ABC1 family protein 0.0086 0.0303 0.0433
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0024 0.0024
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0061 0.0058
Schistosoma mansoni retinoic acid receptor RXR 0.0646 0.303 0.303
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0209 0.0902 0.126
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0093 0.0067
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.016 0.0665 0.092
Leishmania major pyruvate kinase 0.1434 0.6861 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Schistosoma mansoni hypothetical protein 0.0831 0.3927 0.3927
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0042 0.0088 0.0118
Toxoplasma gondii hypothetical protein 0.0042 0.0088 0.0118
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.016 0.0665 0.096
Toxoplasma gondii flavodoxin domain-containing protein 0.004 0.0082 0.011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0655 0.3074 0.448
Brugia malayi Pyruvate kinase, muscle isozyme 0.1434 0.6861 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0096 0.0351 0.0325
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0705 0.0978
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0093 0.0126
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0096 0.0351 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0114 0.0442 0.0417
Echinococcus granulosus dna polymerase eta 0.0043 0.0093 0.0067
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0096 0.0351 0.0456
Schistosoma mansoni tar DNA-binding protein 0.0255 0.1125 0.1125
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0087 0.0311 0.0444
Schistosoma mansoni microtubule-associated protein tau 0.2079 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0307 0.1378 0.1983
Brugia malayi acetyltransferase, GNAT family protein 0.0158 0.0655 0.0946
Trypanosoma brucei importin beta-1 subunit, putative 0.0119 0.0464 0.0667
Loa Loa (eye worm) hypothetical protein 0.0056 0.0156 0.0228
Schistosoma mansoni thyroid hormone receptor 0.0095 0.0346 0.0346
Schistosoma mansoni importin beta-1 0.0119 0.0464 0.0464
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0042 0.0088 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0095 0.0346 0.0495
Loa Loa (eye worm) hypothetical protein 0.005 0.0131 0.0191
Leishmania major trypanothione synthetase, putative 0.0085 0.0297 0.0424
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0061 0.0034
Trichomonas vaginalis penicillin-binding protein, putative 0.0086 0.0303 0.039
Echinococcus granulosus pyruvate kinase 0.1434 0.6861 0.6852
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0121 0.0123
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0042 0.0088 0.0061
Brugia malayi RNA, U transporter 1 0.0338 0.153 0.2222
Schistosoma mansoni aldehyde dehydrogenase 0.0307 0.1378 0.1378
Echinococcus granulosus ubiquitin specific protease 41 0.0046 0.011 0.0083
Treponema pallidum exodeoxyribonuclease (exoA) 0.0096 0.0351 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.004 0.0049
Brugia malayi Importin beta-1 subunit 0.0119 0.0464 0.0667
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0046 0.011 0.011
Schistosoma mansoni inositol monophosphatase 0.0036 0.0061 0.0061
Brugia malayi nuclear hormone receptor 0.0095 0.0346 0.0495
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0048 0.0021
Echinococcus granulosus methionine synthase reductase 0.005 0.013 0.0104
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0307 0.1378 0.1961
Mycobacterium tuberculosis Probable hydrolase 0.0086 0.0303 0.0386
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1134 0.1607
Brugia malayi Calcitonin receptor-like protein seb-1 0.0655 0.3074 0.4475
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.0331 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0095 0.0346 0.0504
Onchocerca volvulus 0.0099 0.0366 0.0493
Plasmodium falciparum phd finger protein, putative 0.0029 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.0139 0.0564 0.0822
Echinococcus multilocularis pyruvate kinase 0.1434 0.6861 0.6852
Toxoplasma gondii thioredoxin reductase 0.0092 0.0331 0.0473
Onchocerca volvulus 0.011 0.0423 0.0576
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0081 0.0281 0.0401
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0081 0.0281 0.0255
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0705 0.0978
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0093 0.0067
Schistosoma mansoni aldehyde dehydrogenase 0.0307 0.1378 0.1378
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0165 0.0231
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0207 0.0895 0.087
Plasmodium falciparum pyruvate kinase 0.1434 0.6861 1
Onchocerca volvulus 0.0086 0.0303 0.0402
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0095 0.0346 0.0346
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0121 0.0123
Schistosoma mansoni transcription factor LCR-F1 0.0564 0.2628 0.2628
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.004 0.0049
Mycobacterium tuberculosis Probable reductase 0.0209 0.0902 0.1263
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0051 0.0133 0.0193
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0141 0.0571 0.0823
Schistosoma mansoni inositol monophosphatase 0.0036 0.0061 0.0061
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0125 0.0173
Plasmodium falciparum glutathione reductase 0.0092 0.0331 0.0473
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0646 0.303 0.3011
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0066 0.0207 0.0249
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0156 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0705 0.0978
Schistosoma mansoni zinc finger protein 0.0045 0.0103 0.0103
Echinococcus multilocularis ecdysone induced protein 78C 0.0095 0.0346 0.032
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0045 0.0103 0.0103
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0045 0.0103 0.0076
Echinococcus granulosus zinc finger protein 0.0029 0.0029 0.0002
Brugia malayi Bromodomain containing protein 0.0036 0.0061 0.0078
Trichomonas vaginalis pyruvate kinase, putative 0.1434 0.6861 1
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.005 0.013 0.013
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0027 0.0018 0.0016
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0141 0.0571 0.0823
Mycobacterium ulcerans esterase/lipase LipP 0.0086 0.0303 0.0412
Onchocerca volvulus 0.0148 0.0605 0.0844
Schistosoma mansoni hypothetical protein 0.004 0.008 0.008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0307 0.1378 0.1983
Entamoeba histolytica pyruvate kinase, putative 0.1 0.475 1
Echinococcus multilocularis lamin dm0 0.011 0.0423 0.0397
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0027 0.0018 0.0016
Brugia malayi photoreceptor-specific nuclear receptor 0.0095 0.0346 0.0495
Trichomonas vaginalis sulfite reductase, putative 0.0081 0.0281 0.0358
Echinococcus multilocularis tar DNA binding protein 0.0255 0.1125 0.1101
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0121 0.0167
Loa Loa (eye worm) hypothetical protein 0.0046 0.011 0.016
Mycobacterium leprae Probable lipase LipE 0.0086 0.0303 0.0383
Echinococcus granulosus neuropeptide s receptor 0.0449 0.2071 0.205
Brugia malayi Pyruvate kinase, M2 isozyme 0.1434 0.6861 1
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0141 0.0571 0.0823
Echinococcus multilocularis Smad4 0.0033 0.0048 0.0021
Loa Loa (eye worm) hypothetical protein 0.0099 0.0366 0.0533
Echinococcus multilocularis beta LACTamase domain containing family member 0.0086 0.0303 0.0277
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0087 0.0311 0.0444
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0021 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0472 0.2182 0.2161
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0121 0.0167
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0121 0.0167
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0085 0.0058
Brugia malayi CHE-14 protein 0.0099 0.0369 0.0529
Schistosoma mansoni pyruvate kinase 0.1434 0.6861 0.6861
Trichomonas vaginalis D-aminoacylase, putative 0.0086 0.0303 0.039
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0046 0.011 0.0083
Brugia malayi hypothetical protein 0.0148 0.0605 0.0873
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0096 0.0351 0.0502
Loa Loa (eye worm) latrophilin receptor protein 2 0.0207 0.0895 0.1304
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0232 0.1015 0.143
Echinococcus granulosus dnaJ subfamily B 0.0831 0.3927 0.3911
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0125 0.0129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.004 0.0049
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0087 0.0311 0.0444
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0139 0.0564 0.0539
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0093 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Schistosoma mansoni cytochrome P450 reductase 0.0081 0.0281 0.0281
Trichomonas vaginalis importin beta-1, putative 0.0096 0.0355 0.0465
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0472 0.2182 0.3174
Entamoeba histolytica hypothetical protein 0.0564 0.2628 0.5498
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0232 0.1015 0.1427
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.016 0.0665 0.092
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0031 0.0037 0.0044
Entamoeba histolytica hypothetical protein 0.0564 0.2628 0.5498
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Schistosoma mansoni eyes absent homolog 0.0093 0.0337 0.0337
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0156 0.0156
Trypanosoma brucei amidase, putative 0.0027 0.0018 0.0016
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0096 0.0351 0.0502
Leishmania major hypothetical protein, conserved 0.0031 0.0037 0.0044
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.0251 0.0224
Echinococcus multilocularis pyruvate kinase 0.0736 0.3466 0.3448
Loa Loa (eye worm) hypothetical protein 0.0095 0.0346 0.0504
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0123 0.0123
Echinococcus multilocularis survival motor neuron protein 1 0.0271 0.1204 0.1181
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0125 0.0129
Loa Loa (eye worm) hypothetical protein 0.0095 0.0346 0.0504
Schistosoma mansoni thyroid hormone receptor 0.0095 0.0346 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0095 0.0346 0.0495
Leishmania major GTP-binding protein, putative 0.0087 0.0311 0.0444
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.005 0.0129 0.0129
Brugia malayi intermediate filament protein 0.011 0.0423 0.0607
Mycobacterium tuberculosis Probable lipase LipE 0.0086 0.0303 0.0386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Brugia malayi Cytochrome P450 family protein 0.0039 0.0075 0.01
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0032
Schistosoma mansoni nuclear receptor 0.0045 0.0103 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0564 0.2628 0.2609
Schistosoma mansoni smad1 5 8 and 0.0033 0.0048 0.0048
Schistosoma mansoni lamin 0.011 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0735 0.3464 0.5049
Schistosoma mansoni diflavin oxidoreductase 0.004 0.0082 0.0082
Echinococcus multilocularis pyruvate kinase 0.1131 0.5391 0.5379
Onchocerca volvulus 0.0095 0.0346 0.0464
Loa Loa (eye worm) hypothetical protein 0.0108 0.0413 0.0602
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0472 0.2182 0.2161
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.004 0.0014
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0087 0.0311 0.0444
Onchocerca volvulus 0.0086 0.0303 0.0402
Loa Loa (eye worm) transcription factor SMAD2 0.0489 0.2263 0.3299
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0096 0.0351 0.0502
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0123 0.0123
Toxoplasma gondii HEAT repeat-containing protein 0.0119 0.0464 0.0667
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0141 0.0571 0.0823
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0088 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0018 0.0016
Schistosoma mansoni nuclear receptor 0.0045 0.0103 0.0103
Brugia malayi hypothetical protein 0.005 0.0129 0.0178
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0125 0.0173
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0355 0.0329
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0156 0.013
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.0173 0.0253
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0096 0.0351 0.0471
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0188
Schistosoma mansoni RAR-like nuclear receptor 0.0095 0.0346 0.0346
Plasmodium falciparum pyruvate kinase 2 0.0736 0.3466 0.5047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Brugia malayi ecdysone receptor 0.0045 0.0103 0.014
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0093 0.0082
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0046 0.011 0.015
Entamoeba histolytica hypothetical protein 0.0096 0.0355 0.0674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Schistosoma mansoni hypothetical protein 0.1228 0.5861 0.5861
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0125 0.0129
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0209 0.0902 0.1263
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.016 0.0665 0.092
Trypanosoma brucei pyruvate kinase 1, putative 0.1434 0.6861 1
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0141 0.0571 0.0803
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.0331 0.0473
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.004 0.0049
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0156 0.0218
Trypanosoma cruzi importin beta-1 subunit, putative 0.0096 0.0355 0.0508
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.004 0.004
Echinococcus multilocularis protein dispatched 1 0.0105 0.0398 0.0372
Echinococcus granulosus pyruvate kinase 0.0736 0.3466 0.3448
Schistosoma mansoni hypothetical protein 0.004 0.008 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1134 0.1607
Plasmodium falciparum glutathione reductase 0.0032 0.004 0.0049
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0125 0.0173
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0081 0.0281 0.0401
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0095 0.0346 0.0346
Echinococcus multilocularis protein patched 0.0099 0.0369 0.0343
Echinococcus granulosus GPCR family 2 0.0207 0.0895 0.087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0086 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.016 0.0665 0.0969
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0021 0.0031
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0061 0.0079
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0085 0.0058
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.016 0.0665 0.064
Brugia malayi Bromodomain containing protein 0.0047 0.0116 0.016
Onchocerca volvulus Pyruvate kinase homolog 0.1434 0.6861 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0061 0.0035
Brugia malayi Smad1 0.0033 0.0048 0.006
Brugia malayi MAP kinase sur-1 0.0049 0.0125 0.0173
Echinococcus granulosus beta LACTamase domain containing family member 0.0086 0.0303 0.0277
Mycobacterium leprae Probable pyruvate kinase PykA 0.1434 0.6861 1
Plasmodium vivax prenyltransferase alpha subunit, putative 0.016 0.0665 0.096
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.004 0.0049
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0156 0.013
Schistosoma mansoni coup transcription factor 0.0095 0.0346 0.0346
Brugia malayi latrophilin 2 splice variant baaae 0.0448 0.2065 0.3003
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0046 0.011 0.0118
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0232 0.1015 0.143
Giardia lamblia Pyruvate kinase 0.0736 0.3466 0.5031
Brugia malayi tailless protein 0.0045 0.0103 0.014
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.0173 0.0243
Onchocerca volvulus 0.0055 0.0155 0.0184
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0141 0.0571 0.0823
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0346 0.032
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0125 0.0099
Onchocerca volvulus 0.012 0.047 0.0646
Onchocerca volvulus 0.0944 0.4477 0.6511
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0029 0.0002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0307 0.1378 0.1355
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0087 0.0311 0.0444
Brugia malayi hypothetical protein 0.0271 0.1204 0.1747
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0061 0.0079
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0042 0.0088 0.0118
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0088 0.0118
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0048 0.0021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.047 0.0444
Brugia malayi nuclear receptor NHR-88 0.0045 0.0103 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0209 0.0902 0.1263
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0123 0.0097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0346 0.032
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0188
Loa Loa (eye worm) FAD binding domain-containing protein 0.005 0.013 0.019
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0093 0.0126
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.017 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0369 0.0487
Echinococcus multilocularis smad 0.0033 0.0048 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.0346 0.0495
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.012 0.047 0.047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.0346 0.0495
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.005 0.0129 0.0188
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0346 0.032
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0088 0.0118
Schistosoma mansoni smad 0.0033 0.0048 0.0048
Plasmodium falciparum thioredoxin reductase 0.0032 0.004 0.0049
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0103 0.0108
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0123 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1134 0.1607
Loa Loa (eye worm) hypothetical protein 0.0086 0.0303 0.0442
Loa Loa (eye worm) RNA binding protein 0.0255 0.1125 0.164
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0027 0.0018 0.0016
Brugia malayi jmjC domain containing protein 0.0096 0.0354 0.0507
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.011 0.015
Loa Loa (eye worm) hypothetical protein 0.0044 0.0098 0.0143
Schistosoma mansoni ap endonuclease 0.0096 0.0351 0.0351
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.004 0.0049
Plasmodium vivax importin-beta 2, putative 0.0119 0.0464 0.0667
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.2071 0.205
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0095 0.0346 0.032
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.004 0.0049
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.004 0.0004
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.044 0.2027 0.2948
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0125 0.0173
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.005 0.0129 0.0103
Schistosoma mansoni ap endonuclease 0.0096 0.0351 0.0351
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0081 0.0281 0.038
Brugia malayi beta-lactamase family protein 0.0086 0.0303 0.0433
Onchocerca volvulus 0.0045 0.0103 0.0108
Trichomonas vaginalis ran, putative 0.0087 0.0311 0.0402
Echinococcus granulosus tar DNA binding protein 0.0255 0.1125 0.1101
Plasmodium vivax pyruvate kinase, putative 0.1434 0.6861 1
Brugia malayi steroid hormone receptor 0.0095 0.0346 0.0495
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0103 0.0108
Echinococcus granulosus nuclear receptor nhr 48 0.0045 0.0103 0.0076
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1268 0.6057 0.8828
Leishmania major hypothetical protein, conserved 0.0086 0.0303 0.0433
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0096 0.0351 0.0502
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.004 0.0049
Brugia malayi hypothetical protein 0.0093 0.0337 0.0481
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0095 0.0346 0.032
Loa Loa (eye worm) hypothetical protein 0.008 0.0277 0.0404
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.1434 0.6861 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.047 0.0676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0095 0.0346 0.0504
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0212 0.0916 0.0891
Echinococcus multilocularis lamin 0.011 0.0423 0.0397
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0366 0.0366
Schistosoma mansoni smad1 5 8 and 0.0033 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.004 0.008 0.008
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0141 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0081 0.0281 0.041
Schistosoma mansoni tar DNA-binding protein 0.0255 0.1125 0.1125
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0158 0.0655 0.0655
Schistosoma mansoni survival motor neuron protein 0.0055 0.0155 0.0155
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0705 0.0978
Brugia malayi hypothetical protein 0.0045 0.0103 0.014
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0027 0.0018 0.0016
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0087 0.0311 0.0454
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.004 0.0049
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0048 0.0021
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0093 0.0126
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0119 0.0464 0.0676
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0042 0.0088 0.0118
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0096 0.0351 0.0502
Echinococcus granulosus ecdysone induced protein 78C 0.0095 0.0346 0.032
Mycobacterium ulcerans hypothetical protein 0.0086 0.0303 0.0412
Brugia malayi MH2 domain containing protein 0.0033 0.0048 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0139 0.0564 0.0564
Toxoplasma gondii pyruvate kinase PyKII 0.0736 0.3466 0.5047
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0061 0.0662
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0188
Loa Loa (eye worm) flavodoxin family protein 0.0031 0.0037 0.0054
Loa Loa (eye worm) hypothetical protein 0.0086 0.0303 0.0442
Brugia malayi hypothetical protein 0.0045 0.0103 0.014
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.004 0.0017
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0032
Trypanosoma cruzi p450 reductase, putative 0.0081 0.0281 0.0401
Leishmania major cathepsin L-like protease 0.0073 0.0242 0.0342
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0059 0.0032
Echinococcus granulosus cpg binding protein 0.0064 0.0196 0.017
Leishmania major cytochrome p450-like protein 0.0028 0.0021 0.0021
Brugia malayi beta-lactamase family protein 0.0086 0.0303 0.0433
Echinococcus granulosus pyruvate kinase 0.0736 0.3466 0.3448
Loa Loa (eye worm) hypothetical protein 0.0095 0.0346 0.0504
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0042 0.0088 0.0061
Brugia malayi FAD binding domain containing protein 0.005 0.013 0.018
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0027 0.0018 0.0016
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.2071 0.205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0095 0.0346 0.0504
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0061 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0255 0.1125 0.1125
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.011 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0086 0.0303 0.0433
Echinococcus multilocularis musashi 0.011 0.0423 0.0397
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0125 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.0346 0.0495
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.004 0.0028
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.004 0.0028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.0346 0.0495
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0212 0.0916 0.0891
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0209 0.0902 0.1263
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0095 0.0346 0.0346
Leishmania major pyruvate kinase 0.1434 0.6861 1
Schistosoma mansoni cpg binding protein 0.0064 0.0196 0.0196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0472 0.2182 0.2161
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.011 0.015
Trypanosoma cruzi trypanothione synthetase 0.0085 0.0297 0.0424
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.009 0.0121
Loa Loa (eye worm) hypothetical protein 0.0095 0.0346 0.0504
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0242 0.0342
Onchocerca volvulus 0.0042 0.0088 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0086 0.0303 0.0433
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0355 0.0508
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0705 0.0978
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0255 0.1125 0.164
Toxoplasma gondii flavodoxin domain-containing protein 0.004 0.0082 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0095 0.0346 0.0504
Loa Loa (eye worm) pyruvate kinase-PB 0.1 0.475 0.6924
Loa Loa (eye worm) inositol-1 0.0036 0.0061 0.0089
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.0509 0.0509
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0596 0.2787 0.2768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0472 0.2182 0.2182
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.004 0.0049
Plasmodium vivax SET domain protein, putative 0.012 0.047 0.0676
Schistosoma mansoni zinc finger protein 0.0029 0.0029 0.0029
Plasmodium falciparum importin beta, putative 0.0119 0.0464 0.0667
Echinococcus granulosus Protein patched homolog 1 0.0099 0.0369 0.0343
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0099 0.0369 0.0538
Brugia malayi MH1 domain containing protein 0.0033 0.0048 0.006
Loa Loa (eye worm) hypothetical protein 0.1 0.475 0.6924
Onchocerca volvulus 0.0045 0.0103 0.0108
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0002 0.0003
Echinococcus multilocularis zinc finger protein 0.0029 0.0029 0.0002
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.016 0.0665 0.096
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0749 0.1043
Schistosoma mansoni hypothetical protein 0.0207 0.0895 0.0895
Mycobacterium tuberculosis Probable lipase LipD 0.0086 0.0303 0.0386
Trichomonas vaginalis D-aminoacylase, putative 0.0086 0.0303 0.039
Echinococcus granulosus thyroid hormone receptor alpha 0.0045 0.0103 0.0076
Trypanosoma cruzi trypanothione synthetase, putative 0.0027 0.0018 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1134 0.1607
Onchocerca volvulus Protein ultraspiracle homolog 0.0095 0.0346 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Echinococcus multilocularis Niemann Pick C1 protein 0.0196 0.0839 0.0814
Echinococcus multilocularis tumor protein p63 0.0674 0.3166 0.3147
Trypanosoma brucei importin beta-1 subunit, putative 0.0119 0.0464 0.0667
Schistosoma mansoni hypothetical protein 0.0316 0.1423 0.1423
Echinococcus granulosus survival motor neuron protein 1 0.0271 0.1204 0.1181
Loa Loa (eye worm) pyruvate kinase 0.1434 0.6861 1
Schistosoma mansoni hypothetical protein 0.1268 0.6057 0.6057
Brugia malayi Steroid receptor seven-up type 2 0.0095 0.0346 0.0495
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0099 0.0369 0.0538
Brugia malayi hypothetical protein 0.0564 0.2628 0.3825
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0095 0.0346 0.032
Schistosoma mansoni patched 1 0.0099 0.0369 0.0369
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0129 0.0178
Brugia malayi pyruvate kinase, muscle isozyme 0.0302 0.1355 0.1968
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0103 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1134 0.1607
Trypanosoma cruzi pyruvate kinase 2, putative 0.1434 0.6861 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.0021 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0096 0.0351 0.046
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0093 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0346 0.032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0095 0.0346 0.0346
Giardia lamblia Rab geranylgeranyltransferase 0.0042 0.0088 0.0086
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0307 0.1378 0.1355
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0472 0.2182 0.2182
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0355 0.0675
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0086 0.0303 0.0386
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0123 0.018
Mycobacterium ulcerans beta-lactamase 0.0086 0.0303 0.0412
Trypanosoma cruzi trypanothione synthetase, putative 0.0027 0.0018 0.0016
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0093 0.0082
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.011 0.0423 0.0616
Mycobacterium tuberculosis Probable oxidoreductase 0.0232 0.1015 0.143
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0029 0.0032
Trypanosoma brucei unspecified product 0.0029 0.0029 0.0032
Brugia malayi jmjC domain containing protein 0.0041 0.0086 0.0115
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.0331 0.0427
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0093 0.0126
Mycobacterium tuberculosis Conserved protein 0.0086 0.0303 0.0386
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.009 0.0112
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0029 0.0042
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0476 0.0685
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0029 0.0032
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0123 0.0138
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0125 0.0099
Echinococcus granulosus pyruvate kinase 0.1434 0.6861 0.6852
Giardia lamblia Rab geranylgeranyltransferase 0.016 0.0665 0.0931
Loa Loa (eye worm) steroid hormone receptor 0.0095 0.0346 0.0504
Brugia malayi Thioredoxin reductase 0.0092 0.0331 0.0473
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.004 0.0004
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0125 0.0183
Echinococcus granulosus FTZ F1 alpha 0.0095 0.0346 0.032
Loa Loa (eye worm) acetyltransferase 0.0158 0.0655 0.0955
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0093 0.0126
Brugia malayi RNA recognition motif domain containing protein 0.0255 0.1125 0.1632
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0139 0.0564 0.0564
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0061 0.0079
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.1134 0.1644
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0086 0.0303 0.0412
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0434 0.1996 0.2903
Echinococcus granulosus smad 0.0033 0.0048 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0086 0.0303 0.039
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0081 0.0281 0.0255
Loa Loa (eye worm) Smad1 0.0033 0.0048 0.007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.0346 0.0495
Echinococcus granulosus lamin dm0 0.011 0.0423 0.0397
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0042 0.0088 0.0118
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0145 0.0119
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0085 0.0058
Brugia malayi mbt repeat family protein 0.0049 0.0123 0.017
Onchocerca volvulus Pyruvate kinase homolog 0.1434 0.6861 1
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0103 0.0103
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.1134 0.1652
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0145 0.0119
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0081 0.0281 0.0401
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0103 0.014
Loa Loa (eye worm) hypothetical protein 0.0043 0.0093 0.0136
Schistosoma mansoni cpg binding protein 0.0058 0.017 0.017
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.016 0.0665 0.0969
Loa Loa (eye worm) hypothetical protein 0.1434 0.6861 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0045 0.0103 0.0076
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0123 0.0123
Brugia malayi Bromodomain containing protein 0.0092 0.0335 0.0479
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0086 0.0303 0.0442
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0087 0.0311 0.0285
Trypanosoma cruzi trypanothione synthetase 0.0085 0.0297 0.0424
Onchocerca volvulus 0.0049 0.0123 0.0138
Leishmania major DNA polymerase eta, putative 0.0043 0.0093 0.0126
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0141 0.0571 0.0546
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.004 0.0014
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0086 0.0059
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0096 0.0351 0.0512
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0086 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.011 0.0423 0.0616
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0048 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0355 0.0329
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0207 0.0895 0.087
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0085 0.0058
Loa Loa (eye worm) hypothetical protein 0.0086 0.0303 0.0442
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0045 0.0103 0.014
Echinococcus multilocularis cpg binding protein 0.0064 0.0196 0.017
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0242 0.0342
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Schistosoma mansoni pyruvate kinase 0.0736 0.3466 0.3466
Loa Loa (eye worm) hypothetical protein 0.0096 0.0355 0.0518
Trypanosoma brucei CHAP domain containing protein, putative 0.0027 0.0018 0.0016
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0096 0.0355 0.0465
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.0251 0.0224
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0705 0.0978
Loa Loa (eye worm) hypothetical protein 0.0086 0.0303 0.0442
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0042 0.0088 0.0108
Echinococcus granulosus lamin 0.011 0.0423 0.0397
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Brugia malayi nuclear hormone receptor 0.0045 0.0103 0.014
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0081 0.0281 0.0255
Brugia malayi glutathione reductase 0.0092 0.0331 0.0473
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0087 0.0311 0.0444
Echinococcus multilocularis pyruvate kinase 0.0736 0.3466 0.3448
Trypanosoma cruzi pyruvate kinase 2, putative 0.1434 0.6861 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0045 0.0103 0.0103
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0031 0.0037 0.0044
Loa Loa (eye worm) hypothetical protein 0.0207 0.0895 0.1304
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0072 0.0236 0.0292
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0242 0.0342
Schistosoma mansoni nuclear receptor nhr-48 0.0045 0.0103 0.0103
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0095 0.0346 0.032
Echinococcus multilocularis sterol regulatory element binding protein 0.0099 0.0369 0.0343
Trypanosoma brucei protein kinase, putative 0.0049 0.0125 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0095 0.0346 0.0495
Leishmania major DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Brugia malayi Pre-SET motif family protein 0.0829 0.392 0.571
Brugia malayi nuclear hormone receptor family member odr-7 0.0045 0.0103 0.014
Treponema pallidum NADH oxidase 0.0032 0.004 0.0098
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.004 0.0049
Schistosoma mansoni nuclear hormone receptor 0.0095 0.0346 0.0346
Chlamydia trachomatis sulfite reductase 0.005 0.013 0.0132
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0061 0.0079
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0119 0.0463 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0095 0.0346 0.0495
Schistosoma mansoni tar DNA-binding protein 0.0255 0.1125 0.1125
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0031 0.0037 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.004 0.0049
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0125 0.0099
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0103 0.0076
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0075 0.011
Loa Loa (eye worm) nuclear hormone receptor 0.0045 0.0103 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0705 0.0978
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0125 0.0129
Trypanosoma brucei unspecified product 0.0043 0.0093 0.0126
Schistosoma mansoni hypothetical protein 0.0207 0.0895 0.0895
Leishmania major trypanothione reductase 0.0092 0.0331 0.0473
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0029 0.0002
Leishmania major trypanothione synthetase, putative 0.0027 0.0018 0.0016
Brugia malayi nuclear receptor RXR 0.005 0.0129 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0181 0.0264
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0242 0.0342
Trypanosoma brucei trypanothione synthetase 0.0085 0.0297 0.0424
Loa Loa (eye worm) hypothetical protein 0.0053 0.0145 0.0211
Echinococcus granulosus pyruvate kinase 0.0736 0.3466 0.3448
Brugia malayi flavodoxin family protein 0.0081 0.0281 0.0401
Trypanosoma brucei trypanothione reductase 0.0092 0.0331 0.0473
Schistosoma mansoni cpg binding protein 0.0064 0.0196 0.0196
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.004 0.0049
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0081 0.0281 0.0401
Chlamydia trachomatis pyruvate kinase 0.1434 0.6861 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0095 0.0346 0.0504
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0027 0.0018 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.0095 0.0346 0.0495
Echinococcus multilocularis geminin 0.1228 0.5861 0.5849
Brugia malayi RNA binding protein 0.0255 0.1125 0.1632
Schistosoma mansoni intermediate filament proteins 0.011 0.0423 0.0423
Echinococcus multilocularis snurportin 1 0.1268 0.6057 0.6046
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.2071 0.205
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0258 0.0258
Brugia malayi nuclear receptor NHR-88 0.0095 0.0346 0.0495
Brugia malayi Cytochrome P450 family protein 0.0028 0.0021 0.0021
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0087 0.0311 0.0444
Brugia malayi FAD binding domain containing protein 0.0081 0.0281 0.0401
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0088 0.0061
Brugia malayi Intermediate filament tail domain containing protein 0.011 0.0423 0.0607
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0048 0.007
Onchocerca volvulus 0.0086 0.0303 0.0402
Echinococcus granulosus Niemann Pick C1 protein 0.0196 0.0839 0.0814
Schistosoma mansoni bromodomain containing protein 0.0079 0.027 0.027
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0031 0.0037 0.0044
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0046 0.011 0.0083
Echinococcus multilocularis dna polymerase eta 0.0043 0.0093 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0255 0.1125 0.1125
Loa Loa (eye worm) intermediate filament protein 0.011 0.0423 0.0616
Brugia malayi MH1 domain containing protein 0.0033 0.0048 0.006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0207 0.0895 0.087
Loa Loa (eye worm) hypothetical protein 0.0093 0.0337 0.0491
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0084 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0207 0.0895 0.0895
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0093 0.0126
Trypanosoma brucei trypanothione synthetase, putative 0.0085 0.0297 0.0424
Mycobacterium tuberculosis Conserved protein 0.0086 0.0303 0.0386
Onchocerca volvulus Pyruvate kinase homolog 0.1434 0.6861 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0093 0.0136
Plasmodium vivax glutathione reductase, putative 0.0092 0.0331 0.0473
Echinococcus multilocularis dnaJ subfamily B 0.0831 0.3927 0.3911
Leishmania major trypanothione synthetase-like protein 0.0027 0.0018 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0103 0.0076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0086 0.0303 0.0433
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0093 0.0077
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0096 0.0351 0.0482
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0121 0.0095
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Giardia lamblia Hypothetical protein 0.0072 0.0236 0.0304
Brugia malayi flavodoxin family protein 0.0031 0.0037 0.0044
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0125 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0242 0.0342
Loa Loa (eye worm) hypothetical protein 0.0045 0.0103 0.015
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0125 0.0173
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0095 0.0346 0.032
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0066 0.0207 0.0261
Trypanosoma brucei pyruvate kinase 1 0.1434 0.6861 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 27.9 uM Tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata ChEMBL. 12217358
IC50 (binding) = 27.9 uM Tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata ChEMBL. 12217358
Inhibition (binding) = 94 % Tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata ChEMBL. 12217358
Inhibition (binding) = 94 % Tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata ChEMBL. 12217358
Ki (binding) = 32 uM Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata ChEMBL. 12217358
Ki (binding) = 32 uM Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata ChEMBL. 12217358
Ki (binding) = 86 uM Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata ChEMBL. 12217358
Ki (binding) = 86 uM Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata ChEMBL. 12217358

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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