Detailed information for compound 1479424

Basic information

Technical information
  • TDR Targets ID: 1479424
  • Name: N-[(3-chloro-4-ethoxy-5-methoxyphenyl)methyl] -2,4,4-trimethylpentan-2-amine
  • MW: 327.889 | Formula: C18H30ClNO2
  • H donors: 1 H acceptors: 0 LogP: 4.93 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1c(Cl)cc(cc1OC)CNC(CC(C)(C)C)(C)C
  • InChi: 1S/C18H30ClNO2/c1-8-22-16-14(19)9-13(10-15(16)21-7)11-20-18(5,6)12-17(2,3)4/h9-10,20H,8,11-12H2,1-7H3
  • InChiKey: ZVNVJRINYFJPAT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(3-chloro-4-ethoxy-5-methoxy-phenyl)methyl]-2,4,4-trimethyl-pentan-2-amine
  • (3-chloro-4-ethoxy-5-methoxy-benzyl)-(1,1,3,3-tetramethylbutyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0102 0.0953 0.2164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.006 0.0784
Loa Loa (eye worm) hypothetical protein 0.0085 0.077 0.1446
Schistosoma mansoni lamin 0.0057 0.0459 0.1043
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0015 0 0.5
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0259 0.1106
Mycobacterium tuberculosis Probable hydrolase 0.0085 0.077 0.1232
Schistosoma mansoni ran 0.0026 0.0115 0.0261
Schistosoma mansoni hypothetical protein 0.0036 0.0231 0.0525
Schistosoma mansoni transcription factor LCR-F1 0.0228 0.2341 0.5318
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0693 0.1302
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0231 0.0434
Loa Loa (eye worm) hypothetical protein 0.0259 0.2677 0.503
Schistosoma mansoni ran 0.0026 0.0115 0.0261
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0231 0.0434
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.0784
Echinococcus granulosus mothers against decapentaplegic 5 0.0028 0.0138 0.0258
Brugia malayi MH2 domain containing protein 0.0406 0.4304 0.8086
Loa Loa (eye worm) hypothetical protein 0.0026 0.0124 0.0232
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0544 0.5817 1
Schistosoma mansoni smad1 5 8 and 0.0028 0.0138 0.0312
Schistosoma mansoni hypothetical protein 0.0078 0.0693 0.1575
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0115 0.0216
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0134 0.1745
Plasmodium falciparum sentrin-specific protease 1 0.0055 0.0436 1
Leishmania major GTP-binding protein, putative 0.0026 0.0115 0.1492
Trypanosoma brucei unspecified product 0.0021 0.006 0.0784
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0231 0.0231
Mycobacterium tuberculosis Conserved protein 0.0085 0.077 0.1232
Giardia lamblia DINP protein human, muc B family 0.0021 0.006 0.5254
Schistosoma mansoni lamin 0.0057 0.0459 0.1043
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.006 0.0113
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0028 0.0138 0.0138
Leishmania major hypothetical protein, conserved 0.0027 0.0134 0.1745
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0113
Loa Loa (eye worm) transcription factor SMAD2 0.0406 0.4304 0.8086
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0216 0.2807
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.077 1
Echinococcus granulosus lamin dm0 0.0057 0.0459 0.0862
Onchocerca volvulus 0.0057 0.0459 0.1714
Entamoeba histolytica hypothetical protein 0.0228 0.2341 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.006 0.0784
Echinococcus multilocularis protein patched 0.0051 0.0394 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0269 0.3497
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.006 0.0258
Brugia malayi beta-lactamase family protein 0.0085 0.077 0.1446
Mycobacterium ulcerans esterase/lipase LipP 0.0085 0.077 1
Leishmania major hypothetical protein, conserved 0.0085 0.077 1
Echinococcus granulosus sentrin specific protease 1 0.0055 0.0436 0.082
Echinococcus granulosus importin subunit beta 1 0.0035 0.0216 0.0406
Loa Loa (eye worm) MH1 domain-containing protein 0.0028 0.0138 0.0258
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0415 0.4402 0.827
Plasmodium vivax hypothetical protein, conserved 0.0085 0.077 1
Brugia malayi MH1 domain containing protein 0.0028 0.0138 0.0258
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1141 0.2144
Brugia malayi RNA recognition motif domain containing protein 0.0415 0.4402 0.827
Plasmodium falciparum importin beta, putative 0.0035 0.0216 0.3145
Schistosoma mansoni importin beta-1 0.0035 0.0216 0.0491
Loa Loa (eye worm) hypothetical protein 0.0085 0.077 0.1446
Echinococcus granulosus expressed protein 0.004 0.0269 0.0506
Loa Loa (eye worm) RNA binding protein 0.0415 0.4402 0.827
Loa Loa (eye worm) hypothetical protein 0.0259 0.2677 0.503
Echinococcus granulosus Smad4 0.0028 0.0138 0.0258
Echinococcus granulosus snurportin 1 0.0372 0.3923 0.737
Schistosoma mansoni hypothetical protein 0.0049 0.0374 0.085
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0259 0.3363
Trichomonas vaginalis D-aminoacylase, putative 0.0085 0.077 1
Schistosoma mansoni hypothetical protein 0.0036 0.0231 0.0525
Brugia malayi hypothetical protein 0.0499 0.5323 1
Echinococcus multilocularis musashi 0.0057 0.0459 0.0459
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0259 0.3363
Mycobacterium ulcerans lipase LipD 0.0085 0.077 1
Trichomonas vaginalis rotamase, putative 0.004 0.0269 0.3497
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.006 0.0784
Schistosoma mansoni hypothetical protein 0.0036 0.0231 0.0525
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0231 0.0434
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0231 0.0231
Onchocerca volvulus Huntingtin homolog 0.0259 0.2677 1
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0015 0 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0459 0.0862
Schistosoma mansoni intermediate filament proteins 0.0057 0.0459 0.1043
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.006 0.0784
Loa Loa (eye worm) hypothetical protein 0.0057 0.0459 0.0862
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0085 0.077 0.1232
Schistosoma mansoni survival motor neuron protein 0.0102 0.0953 0.2164
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.0784
Trichomonas vaginalis D-aminoacylase, putative 0.0085 0.077 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0085 0.077 0.1748
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.0784
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0228 0.2341 0.4397
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0459 0.0862
Entamoeba histolytica hypothetical protein 0.0228 0.2341 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0134 0.1745
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0085 0.077 0.1446
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0144 0.1865
Loa Loa (eye worm) hypothetical protein 0.0026 0.0124 0.0232
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.006 0.0113
Loa Loa (eye worm) hypothetical protein 0.0119 0.1141 0.2144
Onchocerca volvulus Huntingtin homolog 0.0259 0.2677 1
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0459 0.0862
Echinococcus multilocularis survival motor neuron protein 1 0.0499 0.5323 0.5323
Brugia malayi MH1 domain containing protein 0.0028 0.0138 0.0258
Mycobacterium leprae conserved hypothetical protein 0.0085 0.077 0.5
Brugia malayi hypothetical protein 0.0027 0.0134 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.0784
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0085 0.077 1
Brugia malayi RNA, U transporter 1 0.0099 0.0922 0.1733
Echinococcus multilocularis geminin 0.0205 0.2085 0.2085
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0085 0.077 0.1748
Echinococcus multilocularis dna polymerase eta 0.0021 0.006 0.006
Entamoeba histolytica Ran family GTPase 0.0026 0.0115 0.0491
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0168 0.0316
Schistosoma mansoni patched 1 0.0051 0.0394 0.0896
Loa Loa (eye worm) beta-lactamase 0.0085 0.077 0.1446
Mycobacterium tuberculosis Conserved protein 0.0085 0.077 0.1232
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.006 0.0113
Loa Loa (eye worm) hypothetical protein 0.0085 0.077 0.1446
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0144 0.1865
Schistosoma mansoni hypothetical protein 0.0228 0.2341 0.5318
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0055 0.0436 0.5671
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0115 0.0216
Schistosoma mansoni hypothetical protein 0.0205 0.2085 0.4735
Onchocerca volvulus 0.0102 0.0953 0.3558
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0259 0.3363
Schistosoma mansoni rotamase 0.004 0.0269 0.0611
Echinococcus granulosus dna polymerase kappa 0.0021 0.006 0.0113
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0115 0.1492
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0055 0.0436 0.0991
Trichomonas vaginalis D-aminoacylase, putative 0.0085 0.077 1
Schistosoma mansoni hypothetical protein 0.0036 0.0231 0.0525
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.0784
Echinococcus multilocularis beta LACTamase domain containing family member 0.0085 0.077 0.077
Schistosoma mansoni Smad4 0.0028 0.0138 0.0312
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0269 0.0506
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0231 0.0434
Schistosoma mansoni tar DNA-binding protein 0.0415 0.4402 1
Mycobacterium ulcerans beta-lactamase 0.0085 0.077 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0436 0.082
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0055 0.0436 0.1864
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0134 0.1745
Loa Loa (eye worm) hypothetical protein 0.0051 0.0394 0.0741
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1161 0.2638
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.006 0.0784
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0269 0.0506
Echinococcus multilocularis smad 0.0028 0.0138 0.0138
Schistosoma mansoni tar DNA-binding protein 0.0415 0.4402 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0406 0.4304 0.8086
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.006 0.0784
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.1091 0.205
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0231 0.0434
Brugia malayi TAR-binding protein 0.0415 0.4402 0.827
Trypanosoma brucei hypothetical protein, conserved 0.0085 0.077 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.1062 0.1062
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0144 0.1865
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0394 0.0741
Trichomonas vaginalis esterase, putative 0.0085 0.077 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0115 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0193 0.1961 0.7324
Loa Loa (eye worm) hypothetical protein 0.0062 0.0521 0.0978
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.0784
Loa Loa (eye worm) Smad1 0.0028 0.0138 0.0258
Echinococcus multilocularis mothers against decapentaplegic 5 0.0028 0.0138 0.0138
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1141 0.1141
Leishmania major DNA polymerase kappa, putative 0.0021 0.006 0.0784
Brugia malayi hypothetical protein 0.0259 0.2677 0.503
Echinococcus multilocularis expressed protein 0.004 0.0269 0.0269
Schistosoma mansoni smad1 5 8 and 0.0028 0.0138 0.0312
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0953 0.179
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0115 0.1492
Onchocerca volvulus 0.0057 0.0459 0.1714
Plasmodium vivax sentrin-specific protease 1, putative 0.0055 0.0436 0.5671
Plasmodium vivax importin-beta 2, putative 0.0035 0.0216 0.2807
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0394 0.0741
Loa Loa (eye worm) hypothetical protein 0.0078 0.0693 0.1302
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0134 0.1745
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.006 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0134 0.0605
Brugia malayi beta-lactamase 0.0085 0.077 0.1446
Schistosoma mansoni DNA polymerase eta 0.0021 0.006 0.0137
Mycobacterium leprae Probable lipase LipE 0.0085 0.077 0.5
Toxoplasma gondii ABC1 family protein 0.0085 0.077 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0134 0.0605
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0228 0.2341 0.2341
Brugia malayi intermediate filament protein 0.0057 0.0459 0.0862
Loa Loa (eye worm) hypothetical protein 0.0085 0.077 0.1446
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.0254
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1703 0.3198
Echinococcus multilocularis protein dispatched 1 0.0058 0.0474 0.0474
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.006 0.0784
Schistosoma mansoni smad1 5 8 and 0.0028 0.0138 0.0312
Entamoeba histolytica hypothetical protein 0.0228 0.2341 1
Echinococcus multilocularis GPCR, family 2 0.0036 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0049 0.0374 0.085
Brugia malayi hypothetical protein 0.0228 0.2341 0.4397
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0216 0.2807
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0216 0.0216
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0259 0.3363
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.006 0.0784
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.006 0.0784
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0115 0.1492
Loa Loa (eye worm) hypothetical protein 0.0085 0.077 0.1446
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0115 0.0115
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1141 0.4875
Brugia malayi MH2 domain containing protein 0.0028 0.0138 0.0258
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0394 0.0394
Loa Loa (eye worm) nuclear factor I 0.0015 0.0001 0.0003
Echinococcus granulosus beta LACTamase domain containing family member 0.0085 0.077 0.1446
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0135 0.0135
Echinococcus multilocularis snurportin 1 0.0372 0.3923 0.3923
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0216 0.2807
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.006 0.0113
Trichomonas vaginalis ran, putative 0.0026 0.0115 0.1492
Schistosoma mansoni hypothetical protein 0.0049 0.0374 0.085
Onchocerca volvulus 0.0085 0.077 0.2874
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.1091 0.205
Loa Loa (eye worm) hypothetical protein 0.0085 0.077 0.1446
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.006 0.0137
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.006 0.0784
Trichomonas vaginalis rotamase, putative 0.0039 0.0259 0.3363
Schistosoma mansoni tar DNA-binding protein 0.0415 0.4402 1
Echinococcus granulosus geminin 0.0205 0.2085 0.3916
Echinococcus multilocularis lamin 0.0057 0.0459 0.0459
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0055 0.0436 0.0991
Echinococcus granulosus expressed conserved protein 0.0112 0.1062 0.1995
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.0784
Brugia malayi MH1 domain containing protein 0.0015 0.0001 0.0003
Leishmania major importin beta-1 subunit, putative 0.0028 0.0144 0.1865
Schistosoma mansoni hypothetical protein 0.0049 0.0374 0.085
Brugia malayi Importin beta-1 subunit 0.0035 0.0216 0.0406
Schistosoma mansoni hypothetical protein 0.0205 0.2085 0.4735
Schistosoma mansoni tar DNA-binding protein 0.0415 0.4402 1
Loa Loa (eye worm) hypothetical protein 0.0499 0.5323 1
Brugia malayi RNA binding protein 0.0415 0.4402 0.827
Loa Loa (eye worm) MH2 domain-containing protein 0.0028 0.0138 0.0258
Echinococcus granulosus dna polymerase eta 0.0021 0.006 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0216 0.0406
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0055 0.0436 0.5671
Echinococcus granulosus GPCR family 2 0.0036 0.0231 0.0434
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.006 0.0137
Schistosoma mansoni smad 0.0028 0.0138 0.0312
Loa Loa (eye worm) TAR-binding protein 0.0415 0.4402 0.827
Onchocerca volvulus 0.0085 0.077 0.2874
Brugia malayi CHE-14 protein 0.0051 0.0394 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0394 0.5123
Brugia malayi N-terminal motif family protein 0.0193 0.1961 0.3684
Echinococcus granulosus tar DNA binding protein 0.0415 0.4402 0.827
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.0784
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.0784
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0115 0.1492
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0252
Onchocerca volvulus 0.0085 0.077 0.2874
Brugia malayi beta-lactamase family protein 0.0085 0.077 0.1446
Loa Loa (eye worm) hypothetical protein 0.0193 0.1961 0.3684
Echinococcus granulosus smad 0.0028 0.0138 0.0258
Mycobacterium tuberculosis Conserved protein 0.0085 0.077 0.1232
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1141 0.2144
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0259 0.3363
Loa Loa (eye worm) hypothetical protein 0.0114 0.1091 0.205
Echinococcus multilocularis lamin dm0 0.0057 0.0459 0.0459
Mycobacterium tuberculosis Probable lipase LipE 0.0085 0.077 0.1232
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.0784
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.006 0.0784
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0085 0.077 0.1232
Mycobacterium tuberculosis Probable esterase LipL 0.0085 0.077 0.1232
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0115 0.1492
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0055 0.0436 0.082
Echinococcus granulosus TGF beta signal transducer SmadC 0.0028 0.0138 0.0258
Mycobacterium ulcerans hypothetical protein 0.0085 0.077 1
Echinococcus granulosus intermediate filament protein 0.0057 0.0459 0.0862
Mycobacterium tuberculosis Probable lipase LipD 0.0085 0.077 0.1232
Brugia malayi MH2 domain containing protein 0.0028 0.0138 0.0258
Brugia malayi MH1 domain containing protein 0.0015 0.0001 0.0003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0085 0.077 0.1232
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0135 0.0254
Echinococcus multilocularis tar DNA binding protein 0.0415 0.4402 0.4402
Trichomonas vaginalis penicillin-binding protein, putative 0.0085 0.077 1
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1703 0.1703
Echinococcus multilocularis sentrin specific protease 1 0.0055 0.0436 0.0436
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0028 0.0138 0.0312
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0434
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.077 1
Echinococcus multilocularis Smad4 0.0028 0.0138 0.0138
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.1091 0.205
Echinococcus granulosus survival motor neuron protein 1 0.0499 0.5323 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0144 0.1865
Echinococcus multilocularis dna polymerase kappa 0.0021 0.006 0.006
Brugia malayi hypothetical protein 0.0018 0.0027 0.0052
Entamoeba histolytica hypothetical protein 0.0228 0.2341 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0085 0.077 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0448 0.0841
Schistosoma mansoni tar DNA-binding protein 0.0415 0.4402 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0168 0.0316
Echinococcus granulosus lamin 0.0057 0.0459 0.0862
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.006 0.0784
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3923 0.737
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0085 0.077 0.1446
Brugia malayi Smad1 0.0028 0.0138 0.0258
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0028 0.0144 0.0613
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0115 0.0216
Leishmania major DNA polymerase eta, putative 0.0021 0.006 0.0784
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0394 0.0741
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0134 0.1745
Schistosoma mansoni hypothetical protein 0.0372 0.3923 0.8912

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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