Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.01 | 0.5827 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.7329 | 0.6385 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.261 | 0.3302 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.5827 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.01 | 0.5827 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.01 | 0.5827 | 1 |
Onchocerca volvulus | 0.0148 | 1 | 1 | |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.7329 | 0.6385 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.261 | 0.3302 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0091 | 0.5128 | 0.9611 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.523 | 0.8706 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.7329 | 0.6385 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0093 | 0.523 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.01 | 0.5827 | 0.5 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0091 | 0.5128 | 0.3407 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.01 | 0.5827 | 1 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0093 | 0.523 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0091 | 0.5128 | 0.3407 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.523 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.523 | 0.8706 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.01 | 0.5827 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.523 | 0.8706 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0091 | 0.5128 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0093 | 0.523 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.261 | 0.3302 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.523 | 0.8706 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.261 | 0.3302 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0091 | 0.5128 | 0.974 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.523 | 0.8706 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0093 | 0.523 | 0.3545 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.523 | 0.8706 |
Trypanosoma brucei | polo-like protein kinase | 0.0093 | 0.523 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0093 | 0.523 | 0.3545 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.523 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0093 | 0.523 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.261 | 0.3302 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0091 | 0.5128 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.523 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.523 | 0.8706 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0091 | 0.5128 | 0.9611 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0091 | 0.5128 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 2.27 | Calculated partition coefficient (clogP) | ChEMBL. | 10509916 |
Log 1/MIC (functional) | = -0.19 | In vitro antibacterial activity of the compound against the methicillin-resistant Staphylococcus aureus 88 | ChEMBL. | 10509916 |
MIC (functional) | = 1 ug ml-1 | In vitro antibacterial activity against Staphylococcus epidermis (S.e.2) C2235. | ChEMBL. | 10509915 |
MIC (functional) | = 1 ug ml-1 | In vitro antibacterial activity against Streptococcus pyogenes ATCC 8668 (S.p.1). | ChEMBL. | 10509915 |
MIC (functional) | = 1 ug ml-1 | In vitro antibacterial activity against Streptococcus pyogenes C6003 (S.p.2). | ChEMBL. | 10509915 |
MIC (functional) | = 1.56 ug ml-1 | In vitro antibacterial activity against the methicillin-resistant Staphylococcus aureus 88 | ChEMBL. | 10509916 |
MIC (functional) | = 2 ug ml-1 | In vitro antibacterial activity against ciprofloxacin-resistant Staphylococcus aureus (CRSA) C6043. | ChEMBL. | 10509915 |
MIC (functional) | = 2 ug ml-1 | In vitro antibacterial activity against Enterococcus faecalis C6291 (E.f.1). | ChEMBL. | 10509915 |
MIC (functional) | = 2 ug ml-1 | In vitro antibacterial activity against Enterococcus faecium C6301 (E.f.2). | ChEMBL. | 10509915 |
MIC (functional) | = 4 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus (S. a.) ATCC 29213. | ChEMBL. | 10509915 |
MIC (functional) | = 4 ug ml-1 | In vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) C6068. | ChEMBL. | 10509915 |
MIC (functional) | = 4 ug ml-1 | In vitro antibacterial activity against methicillin-susceptible Staphylococcus aureus (MSSA) C2214. | ChEMBL. | 10509915 |
MIC (functional) | = 4 ug ml-1 | In vitro antibacterial activity against Staphylococcus epidermis (S.e.1) ATCC 1228. | ChEMBL. | 10509915 |
MIC (functional) | = 22 ug ml-1 | In vitro antibacterial activity against vancomycin-resistant Enterococcus faecium C6487 (VRE). | ChEMBL. | 10509915 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.