Detailed information for compound 1479472

Basic information

Technical information
  • TDR Targets ID: 1479472
  • Name: N-(4-dimethylaminophenyl)-2-(4-piperidin-1-yl piperidin-1-yl)acetamide
  • MW: 344.494 | Formula: C20H32N4O
  • H donors: 1 H acceptors: 1 LogP: 2.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1)NC(=O)CN1CCC(CC1)N1CCCCC1)C
  • InChi: 1S/C20H32N4O/c1-22(2)18-8-6-17(7-9-18)21-20(25)16-23-14-10-19(11-15-23)24-12-4-3-5-13-24/h6-9,19H,3-5,10-16H2,1-2H3,(H,21,25)
  • InChiKey: VOXIGLILQGVZGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-dimethylaminophenyl)-2-[4-(1-piperidyl)-1-piperidyl]acetamide
  • N-(4-dimethylaminophenyl)-2-[4-(1-piperidyl)-1-piperidinyl]acetamide
  • N-(4-dimethylaminophenyl)-2-(4-piperidino-1-piperidyl)acetamide
  • N-(4-dimethylaminophenyl)-2-(4-piperidin-1-ylpiperidin-1-yl)ethanamide
  • ASN 08250125

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.3534 0.3534
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0103 1 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.1768 0.1768
Schistosoma mansoni kinase 0.0052 0.3703 0.3703
Trypanosoma cruzi DNA polymerase eta, putative 0.0052 0.3702 0.3702
Echinococcus multilocularis dna polymerase eta 0.0052 0.3702 0.3702
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.3702 0.3702
Giardia lamblia Kinase, PLK 0.0103 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0103 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0052 0.3702 0.3702
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 1 1
Trypanosoma brucei polo-like protein kinase 0.0103 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0022 0 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0103 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0103 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0103 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0022 0 0.5
Schistosoma mansoni DNA polymerase eta 0.0052 0.3702 0.3702
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.3702 0.3702
Leishmania major DNA polymerase eta, putative 0.0052 0.3702 0.3702
Trichomonas vaginalis CAMK family protein kinase 0.0103 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.3534 0.3534
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 1 1
Echinococcus granulosus dna polymerase eta 0.0052 0.3702 0.3702
Schistosoma mansoni serine/threonine protein kinase 0.0103 1 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.1768 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0103 1 1
Leishmania major DNA polymerase eta, putative 0.0037 0.1768 0.1768
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.