TDR Targets

Basic information

Technical information

TDR Targets ID: 148007
Name: 2-[4-[4-(3-chlorophenyl)piperazin-1-yl]butyl] -1,3,5,6,7,7a-hexahydropyrrolo[2,1-e]imidazol e
MW: 362.94 | Formula: C20H31ClN4
H donors: 0 H acceptors: 0 LogP: 3.7 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)N1CCN(CC1)CCCCN1CN2C(C1)CCC2
InChi: 1S/C20H31ClN4/c21-18-5-3-6-19(15-18)24-13-11-22(12-14-24)8-1-2-9-23-16-20-7-4-10-25(20)17-23/h3,5-6,15,20H,1-2,4,7-14,16-17H2
InChiKey: HBNTXNSLNZMDEK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-1,3,5,6,7,7a-hexahydropyrrolo[2,1-e]imidazole
2-[4-[4-(3-chlorophenyl)piperazino]butyl]-1,3,5,6,7,7a-hexahydropyrrolo[2,1-e]imidazole
2-[4-[4-(3-chlorophenyl)piperazin-1-yl]butyl]-1,3,5,6,7,7a-hexahydropyrrolo[1,2-c]imidazole
2-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-1,3,5,6,7,7a-hexahydropyrrolo[1,2-c]imidazole

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Serotonin 1a (5-HT1a) receptor	Starlite/ChEMBL	References
Rattus norvegicus	Alpha-1a adrenergic receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	Octopamine receptor, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma mansoni	biogenic amine (5HT) receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus granulosus	biogenic amine 5HT receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Serotonin 1a (5-HT1a) receptor	422 aa	417 aa	21.1 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	436 aa	23.9 %
Echinococcus granulosus	biogenic amine 5HT receptor	Alpha-1a adrenergic receptor	466 aa	418 aa	30.4 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Serotonin 1a (5-HT1a) receptor	422 aa	339 aa	23.0 %
Echinococcus multilocularis	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	433 aa	22.4 %
Echinococcus multilocularis	neuropeptides capa receptor	Serotonin 1a (5-HT1a) receptor	422 aa	430 aa	20.0 %
Echinococcus granulosus	rhodopsin orphan GPCR	Alpha-1a adrenergic receptor	466 aa	418 aa	20.3 %
Loa Loa (eye worm)	hypothetical protein	Serotonin 1a (5-HT1a) receptor	422 aa	388 aa	26.5 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Serotonin 1a (5-HT1a) receptor	422 aa	392 aa	20.7 %
Schistosoma japonicum	FMRFamide receptor, putative	Alpha-1a adrenergic receptor	466 aa	374 aa	19.5 %
Loa Loa (eye worm)	TYRA-2 protein	Serotonin 1a (5-HT1a) receptor	422 aa	491 aa	27.3 %
Echinococcus multilocularis	orexin receptor type 2	Serotonin 1a (5-HT1a) receptor	422 aa	369 aa	22.2 %
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	Serotonin 1a (5-HT1a) receptor	422 aa	350 aa	20.6 %
Schistosoma mansoni	amine GPCR	Serotonin 1a (5-HT1a) receptor	422 aa	440 aa	31.6 %
Schistosoma japonicum	Octopamine receptor 1, putative	Serotonin 1a (5-HT1a) receptor	422 aa	424 aa	24.3 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Serotonin 1a (5-HT1a) receptor	422 aa	444 aa	29.3 %
Echinococcus multilocularis	neuropeptide Y receptor	Alpha-1a adrenergic receptor	466 aa	419 aa	19.6 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Serotonin 1a (5-HT1a) receptor	422 aa	383 aa	30.5 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Serotonin 1a (5-HT1a) receptor	422 aa	477 aa	24.3 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Serotonin 1a (5-HT1a) receptor	422 aa	448 aa	29.7 %
Echinococcus granulosus	orexin receptor type 2	Serotonin 1a (5-HT1a) receptor	422 aa	369 aa	22.0 %
Echinococcus granulosus	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	23.4 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	407 aa	23.3 %
Echinococcus granulosus	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	24.3 %
Echinococcus multilocularis	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	23.6 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	390 aa	33.6 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Serotonin 1a (5-HT1a) receptor	422 aa	410 aa	27.8 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	426 aa	29.6 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Serotonin 1a (5-HT1a) receptor	422 aa	452 aa	21.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.002	0.0083	0.0083
Loa Loa (eye worm)	RNA binding protein	0.0137	0.2651	0.2651
Schistosoma mansoni	hypothetical protein	0.0073	0.1232	0.1232
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0052	0.0773	0.3179
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0376	0.0376
Echinococcus granulosus	tar DNA binding protein	0.0137	0.2651	0.2651
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.002	0.0083	0.0083
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.002	0.0083	0.0083
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.002	0.0083	0.0083
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0079	0.136	0.136
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0079	0.136	0.5
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1232	0.1232
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0231	0.0952
Echinococcus multilocularis	expressed protein	0.002	0.0083	0.0083
Echinococcus granulosus	expressed protein	0.002	0.0083	0.0083
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.002	0.0083	0.0083
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0376	0.0376
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.002	0.0083	0.0083
Brugia malayi	RNA binding protein	0.0137	0.2651	0.2651
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.002	0.0083	0.0083
Trypanosoma cruzi	PAB1-binding protein , putative	0.0127	0.2431	1
Echinococcus multilocularis	serotonin receptor	0.0153	0.2989	0.2989
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.002	0.0083	0.0083
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0473	1	1
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.002	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0153	0.2989	0.2989
Trypanosoma brucei	PAB1-binding protein , putative	0.0127	0.2431	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.227	0.227
Schistosoma mansoni	hypothetical protein	0.0034	0.0376	0.0376
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.002	0.0083	0.0083
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.002	0.0083	0.0083
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.002	0.0083	0.0083
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0231	0.0952
Loa Loa (eye worm)	glutaminase 2	0.0265	0.5453	0.5453
Brugia malayi	G-protein alpha subunit	0.002	0.0083	0.0083
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0473	1	1
Schistosoma mansoni	chromatin regulatory protein sir2	0.0052	0.0773	0.0773
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.1232	0.1232
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.002	0.0083	0.0083
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.197	0.197
Brugia malayi	hypothetical protein	0.0082	0.1441	0.1441
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0153	0.2989	0.2989
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.002	0.0083	0.0083
Loa Loa (eye worm)	TAR-binding protein	0.0137	0.2651	0.2651
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0376	0.0376
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.002	0.0083	0.0153
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0057	0.0891	0.0891
Schistosoma mansoni	tar DNA-binding protein	0.0137	0.2651	0.2651
Schistosoma mansoni	glutaminase	0.0265	0.5453	0.5453
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.002	0.0083	0.0153
Entamoeba histolytica	G protein alpha subunit, putative	0.002	0.0083	0.1079
Brugia malayi	RNA recognition motif domain containing protein	0.0137	0.2651	0.2651
Schistosoma mansoni	hypothetical protein	0.0034	0.0376	0.0376
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0767	0.4744
Toxoplasma gondii	hypothetical protein	0.0027	0.0231	0.0952
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.002	0.0083	0.0083
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0079	0.136	1
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.002	0.0083	0.0083
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0079	0.136	0.5
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0052	0.0773	0.3179
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0052	0.0773	0.1417
Schistosoma mansoni	tar DNA-binding protein	0.0137	0.2651	0.2651
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.002	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0083
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.002	0.0083	0.0083
Loa Loa (eye worm)	G protein alpha subunit 3	0.002	0.0083	0.0083
Schistosoma mansoni	tar DNA-binding protein	0.0137	0.2651	0.2651
Echinococcus granulosus	biogenic amine 5HT receptor	0.0153	0.2989	0.2989
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0473	1	1
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.002	0.0083	0.0153
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.002	0.0083	0.0083
Brugia malayi	hypothetical protein	0.0127	0.2431	0.2431
Loa Loa (eye worm)	glutaminase	0.0265	0.5453	0.5453
Echinococcus multilocularis	tar DNA binding protein	0.0137	0.2651	0.2651
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0376	0.0376
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0052	0.0773	0.1417
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0376	0.0376
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0767	0.0767
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0079	0.136	0.5
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0079	0.136	0.2494
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0083
Schistosoma mansoni	peptidase Clp (S14 family)	0.0079	0.136	0.136
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0473	1	1
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.002	0.0083	0.0083
Toxoplasma gondii	LsmAD domain-containing protein	0.0127	0.2431	1
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.002	0.0083	0.0153
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0187	0.3731	1
Trichomonas vaginalis	glutaminase, putative	0.0265	0.5453	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0127	0.2431	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0473	1	1
Toxoplasma gondii	histone deacetylase SIR2	0.0052	0.0773	0.3179
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0376	0.0376
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0052	0.0773	1
Schistosoma mansoni	hypothetical protein	0.0057	0.0891	0.0891
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0079	0.136	0.2494
Leishmania major	hypothetical protein, conserved	0.0127	0.2431	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0376	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0127	0.2431	0.2431
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0079	0.136	0.5594
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.002	0.0083	0.0083
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0767	0.0767
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0473	1	1
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.002	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0083
Brugia malayi	hypothetical protein	0.002	0.0083	0.0083
Schistosoma mansoni	tar DNA-binding protein	0.0137	0.2651	0.2651
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.197	0.197
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.002	0.0083	0.0153
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0083
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0079	0.136	0.5594
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0052	0.0773	0.3179
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.002	0.0083	0.0083
Echinococcus granulosus	GPCR family 2	0.0034	0.0376	0.0376
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.002	0.0083	0.0083
Schistosoma mansoni	GTP-binding protein alpha subunit	0.002	0.0083	0.0083
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0052	0.0773	0.3179
Schistosoma mansoni	hypothetical protein	0.0034	0.0376	0.0376
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.002	0.0083	0.0083
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0376	0.0376
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0052	0.0773	0.1417
Loa Loa (eye worm)	hypothetical protein	0.0106	0.197	0.197
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0079	0.136	0.136
Trypanosoma cruzi	PAB1-binding protein , putative	0.0127	0.2431	1
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.002	0.0083	0.0083
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.002	0.0083	0.0083
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0052	0.0773	0.1417
Mycobacterium leprae	Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog)	0.0035	0.0411	0.1591
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0137	0.2651	0.2651
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0473	1	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0079	0.136	0.5594
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.227	0.227
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0052	0.0773	1
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.002	0.0083	0.0083
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.002	0.0083	0.0153
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0079	0.136	1
Echinococcus multilocularis	serotonin receptor	0.0153	0.2989	0.2989
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0473	1	1
Brugia malayi	N-terminal motif family protein	0.0187	0.3731	0.3731
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.002	0.0083	0.0153
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0052	0.0773	0.3179
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0052	0.0773	0.3179
Brugia malayi	MH2 domain containing protein	0.012	0.227	0.227
Loa Loa (eye worm)	hypothetical protein	0.0079	0.136	0.136
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.002	0.0083	0.0083
Schistosoma mansoni	GTP-binding protein alpha subunit	0.002	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0187	0.3731	0.3731
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0376	0.0376
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.002	0.0083	0.0083
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.002	0.0083	0.0083
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.197	0.197
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0083
Plasmodium falciparum	ataxin-2 like protein, putative	0.0127	0.2431	1
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.002	0.0083	0.0153
Brugia malayi	TAR-binding protein	0.0137	0.2651	0.2651
Schistosoma mansoni	tar DNA-binding protein	0.0137	0.2651	0.2651
Plasmodium vivax	ataxin-2 like protein, putative	0.0127	0.2431	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0079	0.136	0.5594
Brugia malayi	Probable ClpP-like protease	0.0079	0.136	0.136
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0057	0.0891	0.0891
Mycobacterium ulcerans	glutaminase	0.0265	0.5453	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.2989	0.2989
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0052	0.0773	1
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.002	0.0083	0.0083
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0376	0.0376
Brugia malayi	glutaminase DH11.1	0.0265	0.5453	0.5453
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.002	0.0083	0.0083
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.002	0.0083	0.0083

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 28.1 nM	Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane	ChEMBL.	9258372
Ki (binding)	= 28.1 nM	Binding affinities against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in rat cerebral cortex membrane	ChEMBL.	9258372
Ki (binding)	= 64.9 nM	Binding affinities against Alpha-1 adrenergic receptor (alpha1 adrenoceptor) using [3H]-prazosin as radioligand in rat cerebral cortex membrane	ChEMBL.	9258372
Ki (binding)	= 64.9 nM	Binding affinities against Alpha-1 adrenergic receptor (alpha1 adrenoceptor) using [3H]-prazosin as radioligand in rat cerebral cortex membrane	ChEMBL.	9258372
Ki ratio (binding)	= 2.3	Selectivity ratio of serotonin and alpha receptor	ChEMBL.	9258372

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL424432
PubChem: 10594858

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 148007