Detailed information for compound 1480416

Basic information

Technical information
  • TDR Targets ID: 1480416
  • Name: 1-(bis(2-hydroxyethyl)amino)-3-phenothiazin-1 0-ylpropan-2-ol
  • MW: 360.47 | Formula: C19H24N2O3S
  • H donors: 3 H acceptors: 3 LogP: 1.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN(CC(CN1c2ccccc2Sc2c1cccc2)O)CCO
  • InChi: 1S/C19H24N2O3S/c22-11-9-20(10-12-23)13-15(24)14-21-16-5-1-3-7-18(16)25-19-8-4-2-6-17(19)21/h1-8,15,22-24H,9-14H2
  • InChiKey: DDXDYUBKMZARMT-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-(bis(2-hydroxyethyl)amino)-3-phenothiazin-10-yl-propan-2-ol
  • 1-(bis(2-hydroxyethyl)amino)-3-(10-phenothiazinyl)propan-2-ol
  • Oprea1_010737
  • Oprea1_207124

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus microtubule associated protein 2 0.0732 0.8492 1
Brugia malayi jmjC domain containing protein 0.0016 0.0071 0.0103
Brugia malayi hypothetical protein 0.0034 0.028 0.0481
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0619 0.0729
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.1352 0.1352
Onchocerca volvulus 0.0021 0.0126 0.0798
Brugia malayi hypothetical protein 0.0021 0.0126 0.0202
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.171 0.3074
Leishmania major cytochrome p450-like protein 0.0028 0.021 0.0489
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0499 0.1031
Brugia malayi hypothetical protein 0.0021 0.0126 0.0202
Brugia malayi jmjC domain containing protein 0.0016 0.0071 0.0103
Brugia malayi hypothetical protein 0.013 0.1409 0.2527
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0101 0.1069 0.3527
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0198 0.2213 0.2334
Schistosoma mansoni hypothetical protein 0.0176 0.1948 0.2294
Brugia malayi jmjC domain containing protein 0.0016 0.0071 0.0103
Echinococcus granulosus bloom syndrome protein 0.048 0.5532 0.6514
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.021 0.2288
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0071 0.0071
Loa Loa (eye worm) MH2 domain-containing protein 0.0376 0.4308 0.4558
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0061
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0071 0.0084
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.01 0.0275
Schistosoma mansoni DNA helicase recq1 0.0198 0.2213 0.2606
Schistosoma mansoni hypothetical protein 0.0176 0.1948 0.2294
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0034
Schistosoma mansoni survival motor neuron protein 0.0051 0.0482 0.0567
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0126 0.0126
Echinococcus granulosus cpg binding protein 0.0031 0.0247 0.0291
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0126 0.0118
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0071 0.0061
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0198 0.2213 0.3984
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0071 0.0084
Loa Loa (eye worm) Smad1 0.0026 0.0181 0.0177
Leishmania major exosome subunit rrp6p homologue, putative 0.0059 0.0578 0.1792
Loa Loa (eye worm) hypothetical protein 0.0049 0.0459 0.0472
Schistosoma mansoni hypothetical protein 0.0106 0.1131 0.1332
Echinococcus multilocularis Smad4 0.0026 0.0181 0.0181
Entamoeba histolytica hypothetical protein 0.0038 0.0329 0.1133
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0499 0.1514
Echinococcus multilocularis GPCR, family 2 0.0049 0.0459 0.0459
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0158 0.0158
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0126 0.0126
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0329 0.0387
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0181 0.0213
Entamoeba histolytica hypothetical protein 0.0038 0.0329 0.1133
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0499 0.1031
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0354 0.405 0.477
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.171 0.3074
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0071 0.0084
Echinococcus granulosus GPCR family 2 0.0049 0.0459 0.054
Entamoeba histolytica recQ family helicase, putative 0.0257 0.2899 1
Trichomonas vaginalis DNA helicase recq1, putative 0.048 0.5532 1
Trypanosoma brucei ribosomal RNA processing protein 6 0.0059 0.0578 0.1792
Entamoeba histolytica recQ family helicase, putative 0.0097 0.1024 0.353
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.1564 0.2808
Brugia malayi jmjC domain containing protein 0.0016 0.0071 0.0103
Schistosoma mansoni hypothetical protein 0.0354 0.405 0.477
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.013 0.1409 0.148
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0059 0.0578 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0566 0.1023
Echinococcus multilocularis geminin 0.0354 0.405 0.405
Schistosoma mansoni lipoxygenase 0.0087 0.0909 0.107
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0198 0.2213 0.2213
Schistosoma mansoni polymyositis/scleroderma autoantigen-related 0.0059 0.0578 0.0681
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0158 0.0186
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.021 0.0207
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0198 0.2213 0.2606
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0061
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0619 0.0729
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0321 0.3656 1
Mycobacterium ulcerans ATP-dependent DNA helicase II UvrD2 0.0058 0.0566 0.9744
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0181 0.0213
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0599 0.0599
Onchocerca volvulus 0.0021 0.0126 0.0798
Schistosoma mansoni smad1 5 8 and 0.0026 0.0181 0.0213
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0061
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0422 0.4845 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1069 0.1119
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0198 0.2213 0.2606
Schistosoma mansoni loxhd1 0.0021 0.0126 0.0148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1564 0.1842
Treponema pallidum ATP-dependent DNA helicase 0.0101 0.1069 0.5
Schistosoma mansoni rab6-interacting 0.0021 0.0126 0.0148
Leishmania major hypothetical protein, conserved 0.0053 0.0499 0.1514
Brugia malayi hypothetical protein 0.0038 0.0329 0.0569
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.01 0.0102
Echinococcus granulosus smad 0.0026 0.0181 0.0213
Brugia malayi MH2 domain containing protein 0.0026 0.0181 0.0302
Schistosoma mansoni hypothetical protein 0.0021 0.0126 0.0148
Echinococcus multilocularis smad 0.0026 0.0181 0.0181
Schistosoma mansoni microtubule-associated protein tau 0.0732 0.8492 1
Brugia malayi jmjC domain containing protein 0.0063 0.0619 0.1095
Brugia malayi hypothetical protein 0.0053 0.0499 0.0879
Schistosoma mansoni smad1 5 8 and 0.0026 0.0181 0.0213
Loa Loa (eye worm) hypothetical protein 0.0198 0.2213 0.2334
Brugia malayi MH1 domain containing protein 0.0026 0.0181 0.0302
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0329 0.0387
Schistosoma mansoni Smad4 0.0026 0.0181 0.0213
Echinococcus multilocularis microtubule associated protein 2 0.0732 0.8492 0.8492
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0181 0.0181
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0176 0.1948 0.1948
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0071 0.0061
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0577 0.0597
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0176 0.1948 0.2294
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0198 0.2213 0.4567
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0071 0.0084
Loa Loa (eye worm) RecQ helicase 0.048 0.5532 0.5857
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0599 0.0599
Echinococcus multilocularis Helicase RNase D C terminal, HRDC domain 0.0059 0.0578 0.0578
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0071 0.0084
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0227 0.0226
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0071 0.0071
Brugia malayi 3'-5' exonuclease family protein 0.0059 0.0578 0.1022
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0459 0.0805
Loa Loa (eye worm) cytochrome P450 0.0019 0.01 0.0091
Schistosoma mansoni smad 0.0026 0.0181 0.0213
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0257 0.2899 1
Entamoeba histolytica hypothetical protein 0.0038 0.0329 0.1133
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0071 0.0084
Schistosoma mansoni cpg binding protein 0.0031 0.0247 0.0291
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0566 0.1529
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0459 0.054
Echinococcus granulosus dnaJ subfamily B 0.0421 0.4833 0.5691
Schistosoma mansoni polycystin 1-related 0.0021 0.0126 0.0148
Mycobacterium ulcerans hypothetical protein 0.0059 0.0578 1
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.1131 0.2024
Loa Loa (eye worm) hypothetical protein 0.0251 0.2831 0.299
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0126 0.0148
Schistosoma mansoni hypothetical protein 0.0049 0.0459 0.054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.171 0.18
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0459 0.0805
Echinococcus granulosus geminin 0.0354 0.405 0.477
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0091 0.0107
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0126 0.0148
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0459 0.0459
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.2831 0.3333
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0329 0.0329
Onchocerca volvulus 0.003 0.0227 0.1527
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0459 0.054
Brugia malayi Smad1 0.0026 0.0181 0.0302
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0071 0.0084
Schistosoma mansoni hypothetical protein 0.0049 0.0459 0.054
Schistosoma mansoni hypothetical protein 0.0176 0.1948 0.2294
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0071 0.0195
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.01 0.0102
Schistosoma mansoni hypothetical protein 0.0049 0.0459 0.054
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0024 0.0158 0.0186
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0071 0.0147
Schistosoma mansoni cytochrome P450 0.0019 0.01 0.0118
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0101 0.1069 0.2923
Trypanosoma brucei cytochrome P450, putative 0.0028 0.021 0.0489
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0014 0.0014
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0181 0.0213
Trichomonas vaginalis DNA helicase recq, putative 0.0257 0.2899 0.5241
Loa Loa (eye worm) hypothetical protein 0.013 0.1409 0.148
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0599 0.0705
Brugia malayi Cytochrome P450 family protein 0.0019 0.01 0.0156
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0091 0.0091
Brugia malayi MH1 domain containing protein 0.0026 0.0181 0.0302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0617 0.0727
Giardia lamblia Sgs1 DNA helicase, putative 0.0198 0.2213 1
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0499 0.1366
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0257 0.2899 1
Schistosoma mansoni Smad4 0.0011 0.0014 0.0017
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0101 0.1069 0.3527
Leishmania major cytochrome p450-like protein 0.0019 0.01 0.0102
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0071 0.0195
Schistosoma mansoni hypothetical protein 0.0038 0.0329 0.0387
Brugia malayi Cytochrome P450 family protein 0.0028 0.021 0.0354
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.4833 0.4833
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0619 0.0729
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0118
Trichomonas vaginalis DNA helicase recq, putative 0.048 0.5532 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0578 0.1045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1564 0.1842
Onchocerca volvulus 0.0051 0.0482 0.335
Loa Loa (eye worm) hypothetical protein 0.0053 0.0499 0.0515
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0176 0.1948 0.1948
Schistosoma mansoni lipoxygenase 0.0125 0.1352 0.1592
Schistosoma mansoni smad 0.0011 0.0014 0.0017
Brugia malayi MH1 domain containing protein 0.0014 0.0046 0.0058
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0126 0.0339
Brugia malayi Cytochrome P450 family protein 0.0059 0.0577 0.1019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0198 0.2213 0.6052
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.01 0.0118
Schistosoma mansoni cpg binding protein 0.0031 0.0247 0.0291
Mycobacterium tuberculosis Probable ATP-dependent DNA helicase II UvrD2 0.0058 0.0566 0.9744
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0198 0.2213 0.2213
Echinococcus granulosus Helicase RNase D C terminal HRDC domain 0.0059 0.0578 0.0681
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1564 0.1564
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0014 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.021 0.0489
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0176 0.1948 0.2294
Schistosoma mansoni Smad4 0.0011 0.0014 0.0017
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0482 0.0847
Schistosoma mansoni hypothetical protein 0.0049 0.0459 0.054
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.0118
Schistosoma mansoni hypothetical protein 0.0421 0.4833 0.5691
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0176 0.1948 0.2294
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0198 0.2213 0.3984
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1564 0.1564
Echinococcus granulosus Smad4 0.0026 0.0181 0.0213
Onchocerca volvulus Huntingtin homolog 0.013 0.1409 1
Loa Loa (eye worm) CYP4Cod1 0.0028 0.021 0.0207
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.021 0.0489
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0325 0.3701 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.171 0.18
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.01 0.0102
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.01 0.0102
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0181 0.0177
Echinococcus multilocularis bloom syndrome protein 0.048 0.5532 0.5532
Schistosoma mansoni blooms syndrome DNA helicase 0.0379 0.4343 0.5114
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.1564 0.1645
Echinococcus multilocularis cpg binding protein 0.0031 0.0247 0.0247
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0176 0.1948 0.3505
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0599 0.0705
Schistosoma mansoni DNA helicase recq5 0.0198 0.2213 0.2606
Schistosoma mansoni apoptosis regulator bax 0.0176 0.1948 0.2294
Loa Loa (eye worm) 3'-5' exonuclease 0.0059 0.0578 0.0599
Plasmodium vivax JmjC domain containing protein 0.0016 0.0071 0.0193
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.01 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1564 0.1842
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.2831 0.2831
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.1352 0.1592
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.021 0.0207
Entamoeba histolytica exosome component 10, putative 0.0059 0.0578 0.1994
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0459 0.0459
Schistosoma mansoni rab6-interacting 0.0021 0.0126 0.0148
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0058 0.0566 0.1168
Loa Loa (eye worm) nuclear factor I 0.0014 0.0046 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0071 0.0061
Trypanosoma cruzi ribosomal RNA processing protein 6, putative 0.0059 0.0578 0.1792
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1564 0.1842
Brugia malayi Doublecortin family protein 0.0021 0.0126 0.0202
Echinococcus granulosus RUN 0.0021 0.0126 0.0148
Schistosoma mansoni smad1 5 8 and 0.0026 0.0181 0.0213
Leishmania major cytochrome p450-like protein 0.0019 0.01 0.0102
Onchocerca volvulus Huntingtin homolog 0.013 0.1409 1
Plasmodium vivax exosome complex exonuclease RRP6, putative 0.0059 0.0578 0.1562
Toxoplasma gondii 3'-5' exonuclease domain-containing protein 0.0059 0.0578 0.1582
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0499 0.1514
Entamoeba histolytica recQ family DNA helicase 0.0101 0.1069 0.3687
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0198 0.2213 0.6052
Brugia malayi MH2 domain containing protein 0.0026 0.0181 0.0302
Loa Loa (eye worm) hypothetical protein 0.0176 0.1948 0.2053
Brugia malayi MH1 domain containing protein 0.0014 0.0046 0.0058
Brugia malayi hypothetical protein 0.0251 0.2831 0.5105
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0126 0.0259
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0459 0.0472
Echinococcus multilocularis 0.0019 0.01 0.01
Brugia malayi jmjC domain containing protein 0.0061 0.0599 0.106
Schistosoma mansoni cpg binding protein 0.003 0.0227 0.0268
Loa Loa (eye worm) apoptosis regulator protein 0.0176 0.1948 0.2053
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0539 0.1473
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0619 0.0642
Schistosoma mansoni blooms syndrome DNA helicase 0.0101 0.1069 0.1259
Brugia malayi cytochrome P450 0.0019 0.01 0.0156
Echinococcus multilocularis RUN 0.0021 0.0126 0.0126
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0181 0.0181
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0097 0.1024 0.2765
Loa Loa (eye worm) transcription factor SMAD2 0.0376 0.4308 0.4558
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1564 0.1842
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0014 0.0017
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0257 0.2899 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0227 0.0386
Brugia malayi Cytochrome P450 family protein 0.0028 0.021 0.0354
Entamoeba histolytica hypothetical protein 0.0038 0.0329 0.1133
Loa Loa (eye worm) hypothetical protein 0.0106 0.1131 0.1185
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0499 0.1349
Mycobacterium leprae conserved hypothetical protein 0.0059 0.0578 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0126 0.0148
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0071 0.0084
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0499 0.1514
Echinococcus granulosus phd:f box containing protein 0.0016 0.0071 0.0084
Brugia malayi MH2 domain containing protein 0.0376 0.4308 0.7782
Brugia malayi Bloom's syndrome protein homolog 0.048 0.5532 1
Schistosoma mansoni hypothetical protein 0.0019 0.01 0.0118
Loa Loa (eye worm) hypothetical protein 0.0812 0.9434 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0181 0.0177
Schistosoma mansoni hypothetical protein 0.0051 0.0482 0.0567
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0071 0.0071

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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