Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bloom syndrome protein | 0.0289 | 0.4972 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.2478 | 0.6462 |
Loa Loa (eye worm) | RecQ helicase | 0.0289 | 0.4972 | 0.4972 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0231 | 0.0231 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0193 | 0.2979 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0289 | 0.4972 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.1441 | 0.2898 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.012 | 0.1446 | 0.1446 |
Entamoeba histolytica | recQ family DNA helicase | 0.0061 | 0.0231 | 0.0241 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.012 | 0.1446 | 0.2908 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0254 | 0.4242 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.012 | 0.1446 | 0.1779 |
Echinococcus multilocularis | geminin | 0.0169 | 0.2478 | 0.4185 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.012 | 0.1446 | 0.4422 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0061 | 0.0231 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.012 | 0.1446 | 0.4422 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0155 | 0.2175 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.1441 | 0.1441 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0229 | 0.3708 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.012 | 0.1446 | 0.3494 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0155 | 0.2175 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.012 | 0.1446 | 0.1779 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.1441 | 0.1441 |
Echinococcus granulosus | geminin | 0.0169 | 0.2478 | 0.4185 |
Schistosoma mansoni | apoptosis regulator bax | 0.0083 | 0.0683 | 0.13 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0683 | 0.0683 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0155 | 0.2175 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0289 | 0.4972 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.0683 | 0.13 |
Schistosoma mansoni | DNA helicase recq1 | 0.012 | 0.1446 | 0.3494 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.012 | 0.1446 | 0.2908 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.012 | 0.1446 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.012 | 0.1446 | 0.1779 |
Echinococcus granulosus | bloom syndrome protein | 0.0289 | 0.4972 | 1 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0083 | 0.0683 | 0.13 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.012 | 0.1446 | 0.1779 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0196 | 0.3027 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0289 | 0.4972 | 1 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0083 | 0.0683 | 0.1373 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.0683 | 0.13 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1446 | 0.1446 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.0683 | 0.13 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.2478 | 0.6462 |
Entamoeba histolytica | recQ family helicase, putative | 0.0155 | 0.2175 | 1 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0083 | 0.0683 | 0.0683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.