Detailed information for compound 1480421

Basic information

Technical information
  • TDR Targets ID: 1480421
  • Name: 2-(cyclohexylmethylamino)-N-(2-methyl-5-morph olin-4-ylsulfonylphenyl)acetamide
  • MW: 409.543 | Formula: C20H31N3O4S
  • H donors: 2 H acceptors: 3 LogP: 2.21 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(ccc1C)S(=O)(=O)N1CCOCC1)CNCC1CCCCC1
  • InChi: 1S/C20H31N3O4S/c1-16-7-8-18(28(25,26)23-9-11-27-12-10-23)13-19(16)22-20(24)15-21-14-17-5-3-2-4-6-17/h7-8,13,17,21H,2-6,9-12,14-15H2,1H3,(H,22,24)
  • InChiKey: NHKPBFDEHVRJBB-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(cyclohexylmethylamino)-N-(2-methyl-5-morpholinosulfonyl-phenyl)acetamide
  • 2-(cyclohexylmethylamino)-N-(2-methyl-5-morpholinosulfonylphenyl)acetamide
  • 2-(cyclohexylmethylamino)-N-(2-methyl-5-morpholin-4-ylsulfonyl-phenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.012 0.1446 0.1779
Schistosoma mansoni hypothetical protein 0.0083 0.0683 0.13
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0196 0.3027 1
Entamoeba histolytica recQ family DNA helicase 0.0061 0.0231 0.0241
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0155 0.2175 0.5
Trichomonas vaginalis DNA helicase recq, putative 0.0289 0.4972 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0229 0.3708 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.012 0.1446 0.1779
Schistosoma mansoni DNA helicase recq5 0.012 0.1446 0.3494
Loa Loa (eye worm) ATP-dependent DNA helicase 0.012 0.1446 0.1446
Loa Loa (eye worm) hypothetical protein 0.0083 0.0683 0.0683
Schistosoma mansoni hypothetical protein 0.0169 0.2478 0.6462
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0683 0.13
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.012 0.1446 0.2908
Loa Loa (eye worm) RecQ helicase 0.0289 0.4972 0.4972
Schistosoma mansoni hypothetical protein 0.0169 0.2478 0.6462
Echinococcus multilocularis bloom syndrome protein 0.0289 0.4972 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.012 0.1446 0.1446
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0683 0.1373
Brugia malayi MH2 domain containing protein 0.0119 0.1441 0.2898
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1441 0.1441
Echinococcus granulosus ATP dependent DNA helicase Q1 0.012 0.1446 0.1779
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0254 0.4242 1
Giardia lamblia Sgs1 DNA helicase, putative 0.012 0.1446 0.5
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0155 0.2175 1
Echinococcus granulosus bloom syndrome protein 0.0289 0.4972 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0193 0.2979 1
Brugia malayi Bloom's syndrome protein homolog 0.0289 0.4972 1
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0683 0.13
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.012 0.1446 0.4422
Entamoeba histolytica recQ family helicase, putative 0.0155 0.2175 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.012 0.1446 0.2908
Trichomonas vaginalis DNA helicase recq1, putative 0.0289 0.4972 1
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0683 0.0683
Echinococcus granulosus geminin 0.0169 0.2478 0.4185
Echinococcus multilocularis geminin 0.0169 0.2478 0.4185
Schistosoma mansoni DNA helicase recq1 0.012 0.1446 0.3494
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.012 0.1446 0.1779
Schistosoma mansoni hypothetical protein 0.0083 0.0683 0.13
Treponema pallidum ATP-dependent DNA helicase 0.0061 0.0231 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1441 0.1441
Schistosoma mansoni hypothetical protein 0.0083 0.0683 0.13
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.012 0.1446 0.4422
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0155 0.2175 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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