Detailed information for compound 1480424

Basic information

Technical information
  • TDR Targets ID: 1480424
  • Name: ethyl 4-[2-hydroxy-3-(4-propylphenoxy)propyl] piperazine-1-carboxylate
  • MW: 350.453 | Formula: C19H30N2O4
  • H donors: 1 H acceptors: 2 LogP: 2.69 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)N1CCN(CC1)CC(COc1ccc(cc1)CCC)O
  • InChi: 1S/C19H30N2O4/c1-3-5-16-6-8-18(9-7-16)25-15-17(22)14-20-10-12-21(13-11-20)19(23)24-4-2/h6-9,17,22H,3-5,10-15H2,1-2H3
  • InChiKey: PHKVJGGOGZQNSY-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-[2-hydroxy-3-(4-propylphenoxy)propyl]-1-piperazinecarboxylic acid ethyl ester
  • 4-[2-hydroxy-3-(4-propylphenoxy)propyl]piperazine-1-carboxylic acid ethyl ester
  • Oprea1_267225
  • Oprea1_263404
  • AF-399/15128697

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) RecQ helicase 0.0174 0.4564 0.4539
Echinococcus granulosus geminin 0.0165 0.426 0.9096
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0072 0.1204 0.1861
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0081 0.149 0.3426
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0093 0.1899 0.5
Entamoeba histolytica recQ family helicase, putative 0.0093 0.1899 1
Echinococcus granulosus bloom syndrome protein 0.0174 0.4564 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0093 0.1899 0.5
Schistosoma mansoni hypothetical protein 0.0165 0.426 1
Trichomonas vaginalis DNA helicase recq, putative 0.0174 0.4564 1
Treponema pallidum ATP-dependent DNA helicase 0.0037 0.0046 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2659 0.2626
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0081 0.149 0.0851
Loa Loa (eye worm) apoptosis regulator protein 0.0081 0.149 0.1451
Giardia lamblia Sgs1 DNA helicase, putative 0.0072 0.1204 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.0436 0.0392
Schistosoma mansoni hypothetical protein 0.0081 0.149 0.3426
Schistosoma mansoni blooms syndrome DNA helicase 0.0138 0.336 0.7864
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0072 0.1204 0.4422
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0153 0.3869 1
Schistosoma mansoni hypothetical protein 0.0081 0.149 0.3426
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2659 0.2626
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0081 0.149 0.2553
Schistosoma mansoni DNA helicase recq5 0.0072 0.1204 0.2748
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0081 0.149 0.0851
Schistosoma mansoni hypothetical protein 0.0165 0.426 1
Brugia malayi MH2 domain containing protein 0.0116 0.2659 0.5386
Echinococcus multilocularis bloom syndrome protein 0.0174 0.4564 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0436 0.0392
Echinococcus multilocularis geminin 0.0165 0.426 0.9096
Loa Loa (eye worm) hypothetical protein 0.0072 0.1204 0.1163
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0118 0.2711 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0072 0.1204 0.4422
Loa Loa (eye worm) hypothetical protein 0.0081 0.149 0.1451
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0093 0.1899 1
Schistosoma mansoni apoptosis regulator bax 0.0081 0.149 0.3426
Schistosoma mansoni DNA helicase recq1 0.0072 0.1204 0.2748
Schistosoma mansoni hypothetical protein 0.0081 0.149 0.3426
Brugia malayi Bloom's syndrome protein homolog 0.0174 0.4564 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0081 0.149 0.0851
Entamoeba histolytica recQ family DNA helicase 0.0037 0.0046 0.0241
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0072 0.1204 0.1861
Trichomonas vaginalis DNA helicase recq1, putative 0.0174 0.4564 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0117 0.2665 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0081 0.149 0.0851
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0072 0.1204 0.1163

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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