Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.426 | 1 |
Schistosoma mansoni | apoptosis regulator bax | 0.0081 | 0.149 | 0.3426 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.2659 | 0.5386 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.2659 | 0.2626 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.149 | 0.3426 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.149 | 0.1451 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0081 | 0.149 | 0.0851 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0436 | 0.0392 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0093 | 0.1899 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.426 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0436 | 0.0392 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0081 | 0.149 | 0.3426 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0153 | 0.3869 | 1 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0081 | 0.149 | 0.2553 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0117 | 0.2665 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0174 | 0.4564 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.426 | 0.9096 |
Echinococcus multilocularis | bloom syndrome protein | 0.0174 | 0.4564 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0037 | 0.0046 | 0.0241 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0174 | 0.4564 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0072 | 0.1204 | 0.2748 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1204 | 0.1163 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0081 | 0.149 | 0.0851 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0072 | 0.1204 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0118 | 0.2711 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0072 | 0.1204 | 0.4422 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.2659 | 0.2626 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0072 | 0.1204 | 0.1163 |
Echinococcus granulosus | bloom syndrome protein | 0.0174 | 0.4564 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0093 | 0.1899 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0072 | 0.1204 | 0.1861 |
Echinococcus multilocularis | geminin | 0.0165 | 0.426 | 0.9096 |
Loa Loa (eye worm) | RecQ helicase | 0.0174 | 0.4564 | 0.4539 |
Entamoeba histolytica | recQ family helicase, putative | 0.0093 | 0.1899 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0174 | 0.4564 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0072 | 0.1204 | 0.4422 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0081 | 0.149 | 0.1451 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0138 | 0.336 | 0.7864 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0072 | 0.1204 | 0.1861 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.149 | 0.3426 |
Schistosoma mansoni | DNA helicase recq5 | 0.0072 | 0.1204 | 0.2748 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0081 | 0.149 | 0.0851 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0081 | 0.149 | 0.0851 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0093 | 0.1899 | 0.5 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0037 | 0.0046 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.149 | 0.3426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.