Detailed information for compound 1480553

Basic information

Technical information
  • TDR Targets ID: 1480553
  • Name: methyl 2-(2,5-dioxo-1-phenylpyrrolidin-3-yl)s ulfanylbenzoate
  • MW: 341.381 | Formula: C18H15NO4S
  • H donors: 0 H acceptors: 3 LogP: 2.9 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccccc1SC1CC(=O)N(C1=O)c1ccccc1
  • InChi: 1S/C18H15NO4S/c1-23-18(22)13-9-5-6-10-14(13)24-15-11-16(20)19(17(15)21)12-7-3-2-4-8-12/h2-10,15H,11H2,1H3
  • InChiKey: FGVRWAVMOLPJKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-(2,5-dioxo-1-phenyl-pyrrolidin-3-yl)sulfanylbenzoate
  • 2-[(2,5-dioxo-1-phenyl-3-pyrrolidinyl)thio]benzoic acid methyl ester
  • 2-[(2,5-diketo-1-phenyl-pyrrolidin-3-yl)thio]benzoic acid methyl ester
  • MLS000703972
  • SMR000226054
  • methyl2-[(2,5-dioxo-1-phenyl-3-pyrrolidinyl)thio]benzoate
  • AG-670/42226071

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0237 0.0151
Loa Loa (eye worm) runx1 0.0062 0.1035 0.1034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.2001 0.1973
Echinococcus granulosus histone deacetylase 6 0.0018 0.011 0.0123
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.011 0.0159
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0433 0.0483
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.1101 0.123
Echinococcus multilocularis GPCR, family 2 0.0033 0.0433 0.0483
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.1485 0.1659
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0072 0.1227 0.1371
Brugia malayi Cadherin domain containing protein 0.0016 0.0072 0.0072
Echinococcus multilocularis histone deacetylase 0.0018 0.011 0.0123
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0172 0.0191
Schistosoma mansoni gliotactin 0.0025 0.0258 0.0288
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0081
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0736 0.0822
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1911 0.1911
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0972 0.7226
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0172 0.0658
Schistosoma mansoni hypothetical protein 0.0033 0.0433 0.0483
Schistosoma mansoni slit 0.0016 0.0072 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Echinococcus granulosus histone deacetylase 3 0.0061 0.1017 0.1136
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0091 0.0148
Onchocerca volvulus 0.003 0.0373 0.0372
Plasmodium falciparum histone deacetylase 1 0.0061 0.1017 1
Plasmodium vivax hypothetical protein, conserved 0.0076 0.1318 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0597 0.0597
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0033 0.0433 0.0483
Echinococcus granulosus histone deacetylase 6 0.0018 0.011 0.0123
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0172 0.0658
Toxoplasma gondii histone deacetylase HDAC2 0.0061 0.1017 0.7583
Loa Loa (eye worm) hypothetical protein 0.0066 0.1101 0.1101
Echinococcus multilocularis laminin 0.0041 0.0597 0.0667
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0081
Echinococcus granulosus histone deacetylase 6 0.0018 0.011 0.0123
Loa Loa (eye worm) histone deacetylase 7A 0.0018 0.011 0.011
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0237 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1326 0.1326
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0172 0.0083
Mycobacterium leprae conserved hypothetical protein 0.0076 0.1318 0.5362
Echinococcus multilocularis histone deacetylase 6 0.0018 0.011 0.0123
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0025 0.0258 0.136
Schistosoma mansoni cpg binding protein 0.0033 0.0431 0.0482
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1318 1
Loa Loa (eye worm) Notch2 0.0016 0.0072 0.0072
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.1318 0.1267
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.011 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.1318 1
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.1318 1
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0237 0.1191
Onchocerca volvulus 0.003 0.0373 0.0372
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.1017 0.7546
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1911 0.1911
Onchocerca volvulus 0.0016 0.0072 0.0072
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0258 0.0288
Brugia malayi mbt repeat family protein 0.0058 0.0936 0.0936
Echinococcus granulosus carboxylesterase 5A 0.0146 0.2762 0.3086
Echinococcus multilocularis BC026374 protein (S09 family) 0.0025 0.0258 0.0288
Loa Loa (eye worm) hypothetical protein 0.0025 0.0258 0.0257
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.1318 0.1472
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0061 0.1017 0.7546
Leishmania major histone deacetylase, putative 0.0061 0.1017 0.7546
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0041 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0105 0.1911 0.1911
Brugia malayi Fibulin-1 precursor 0.0041 0.0597 0.0597
Schistosoma mansoni hypothetical protein 0.0205 0.3968 0.4434
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0936 0.1046
Echinococcus granulosus acetylcholinesterase 0.0146 0.2762 0.3086
Echinococcus granulosus dnaJ subfamily B 0.0446 0.8949 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Echinococcus multilocularis neurogenic locus notch protein 4 0.0016 0.0072 0.0081
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.011 0.0123
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0237 0.1578
Toxoplasma gondii thioredoxin reductase 0.0048 0.0736 0.533
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0736 0.0736
Toxoplasma gondii histone deacetylase HDAC5 0.0018 0.011 0.0305
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.2001 0.1973
Echinococcus granulosus lamin 0.003 0.0373 0.0416
Brugia malayi Histone deacetylase family protein 0.0018 0.011 0.011
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0025 0.0258 0.0288
Onchocerca volvulus 0.0025 0.0258 0.0257
Echinococcus multilocularis fibropellin Ia 0.0016 0.0072 0.0081
Brugia malayi mbt repeat family protein 0.0058 0.0936 0.0936
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0237 0.1191
Schistosoma mansoni histone deacetylase hda2 0.0018 0.011 0.0123
Trypanosoma brucei histone deacetylase 1 0.0061 0.1017 0.7546
Mycobacterium tuberculosis Conserved protein 0.0076 0.1318 0.1267
Loa Loa (eye worm) hypothetical protein 0.0041 0.0597 0.0597
Schistosoma mansoni intermediate filament proteins 0.003 0.0373 0.0416
Trichomonas vaginalis esterase, putative 0.0076 0.1318 1
Onchocerca volvulus 0.0016 0.0072 0.0072
Echinococcus granulosus histone deacetylase 7 0.0018 0.011 0.0123
Echinococcus granulosus fibropellin Ia 0.0016 0.0072 0.0081
Loa Loa (eye worm) hypothetical protein 0.0041 0.0597 0.0597
Echinococcus multilocularis carboxylesterase 5A 0.0146 0.2762 0.3086
Toxoplasma gondii histone deacetylase HDAC1 0.0018 0.011 0.0305
Schistosoma mansoni ap endonuclease 0.0021 0.0172 0.0191
Schistosoma mansoni cpg binding protein 0.0031 0.0395 0.0441
Onchocerca volvulus 0.0076 0.1318 0.1318
Echinococcus multilocularis slit 2 protein 0.0016 0.0072 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0807 0.0902
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1326 0.1482
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1326 0.1326
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0076 0.1318 0.1318
Echinococcus granulosus para nitrobenzyl esterase 0.0025 0.0258 0.0288
Plasmodium vivax histone deacetylase 1, putative 0.0061 0.1017 0.7546
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0373 0.0372
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.1101 0.123
Plasmodium vivax histone deacetylase, putative 0.0018 0.011 0.0159
Loa Loa (eye worm) hypothetical protein 0.0076 0.1318 0.1318
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0025 0.0258 0.0257
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0091 0.0101
Loa Loa (eye worm) hypothetical protein 0.0076 0.1318 0.1318
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0041 0.0597 0.0667
Schistosoma mansoni lozenge 0.0062 0.1035 0.1156
Loa Loa (eye worm) hypothetical protein 0.0033 0.0433 0.0433
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.1318 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0172 0.1051
Giardia lamblia Histone deacetylase 0.0061 0.1017 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0025 0.0258 0.0172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Brugia malayi Cadherin domain containing protein 0.0016 0.0072 0.0072
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0736 0.0822
Entamoeba histolytica hypothetical protein 0.0024 0.0237 0.0774
Echinococcus granulosus neuroligin 0.0025 0.0258 0.0288
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0736 0.0666
Leishmania major histone deacetylase, putative 0.0061 0.1017 0.7546
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0172 0.0658
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.1017 0.7546
Trypanosoma cruzi histone deacetylase 1, putative 0.0061 0.1017 0.7546
Plasmodium vivax histone deacetylase, putative 0.0018 0.011 0.0159
Schistosoma mansoni hypothetical protein 0.0354 0.7055 0.7884
Loa Loa (eye worm) beta-lactamase 0.0076 0.1318 0.1318
Echinococcus granulosus neurogenic locus protein delta 0.0016 0.0072 0.0081
Echinococcus granulosus slit 2 protein 0.0016 0.0072 0.0081
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0172 0.0172
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0041 0.0597 0.0597
Schistosoma mansoni BC026374 protein (S09 family) 0.0025 0.0258 0.0288
Loa Loa (eye worm) hypothetical protein 0.0025 0.0258 0.0257
Brugia malayi notch-like transmembrane receptor 0.0016 0.0072 0.0072
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.1485 0.1659
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0231 0.4515 0.5045
Leishmania major histone deacetylase, putative 0.0018 0.011 0.0159
Leishmania major histone deacetylase, putative 0.0018 0.011 0.0159
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0433 0.0483
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.1485 0.1659
Mycobacterium ulcerans lipase LipD 0.0076 0.1318 1
Brugia malayi TAR-binding protein 0.0076 0.1326 0.1326
Loa Loa (eye worm) hypothetical protein 0.0076 0.1318 0.1318
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0016 0.0072 0.0081
Schistosoma mansoni hypothetical protein 0.0033 0.0433 0.0483
Schistosoma mansoni lamin 0.003 0.0373 0.0416
Schistosoma mansoni ap endonuclease 0.0021 0.0172 0.0191
Mycobacterium leprae Probable lipase LipE 0.0076 0.1318 0.5362
Schistosoma mansoni cell polarity protein 0.0016 0.0072 0.0081
Mycobacterium tuberculosis Probable reductase 0.0109 0.2001 0.1973
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0237 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0237 0.1191
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0083 0.0083
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.1318 0.1267
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0258 0.0288
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.1101 0.123
Echinococcus granulosus protein jagged 1 0.0016 0.0072 0.0081
Echinococcus multilocularis protein jagged 1 0.0016 0.0072 0.0081
Echinococcus multilocularis acetylcholinesterase 0.0146 0.2762 0.3086
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0061 0.1017 0.7546
Brugia malayi EGF-like domain containing protein 0.0016 0.0072 0.0072
Echinococcus granulosus laminin 0.0041 0.0597 0.0667
Echinococcus multilocularis geminin 0.0205 0.3968 0.4434
Onchocerca volvulus Putative cubilin 0.0016 0.0072 0.0072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0433 0.0483
Echinococcus multilocularis histone deacetylase 7 0.0018 0.011 0.0123
Brugia malayi Delta serrate ligand family protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0025 0.0258 0.0257
Loa Loa (eye worm) hypothetical protein 0.0025 0.0258 0.0257
Echinococcus multilocularis histone deacetylase 3 0.0061 0.1017 0.1136
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0237 0.1191
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0041 0.0597 0.0597
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0091 0.0101
Echinococcus multilocularis histone deacetylase 8 0.0018 0.011 0.0123
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) acetylcholinesterase 1 0.0146 0.2762 0.2761
Schistosoma mansoni hypothetical protein 0.0033 0.0433 0.0483
Schistosoma mansoni histone deacetylase 1 2 3 0.0018 0.011 0.0123
Schistosoma mansoni histone deacetylase hda2 0.0018 0.011 0.0123
Echinococcus granulosus acetylcholinesterase 0.0146 0.2762 0.3086
Brugia malayi CXXC zinc finger family protein 0.0031 0.0395 0.0395
Mycobacterium tuberculosis Conserved protein 0.0076 0.1318 0.1267
Plasmodium falciparum histone deacetylase 2 0.0018 0.011 0.0211
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0237 0.1191
Echinococcus multilocularis Tolloid protein 1 0.0041 0.0597 0.0667
Echinococcus multilocularis histone deacetylase 1 0.0061 0.1017 0.1136
Plasmodium falciparum glutathione reductase 0.0048 0.0736 0.6969
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0091 0.0196
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.1318 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.1485 0.1485
Brugia malayi EGF-like domain containing protein 0.0016 0.0072 0.0072
Onchocerca volvulus 0.0497 1 1
Echinococcus multilocularis cpg binding protein 0.0033 0.0431 0.0482
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.1318 0.1267
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0081
Loa Loa (eye worm) hypothetical protein 0.0076 0.1318 0.1318
Echinococcus multilocularis fibrillin 1 0.0041 0.0597 0.0667
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.011 0.0159
Onchocerca volvulus Neurogenic locus notch homolog 0.0016 0.0072 0.0072
Schistosoma mansoni notch 0.0016 0.0072 0.0081
Trypanosoma brucei histone deacetylase 4 0.0018 0.011 0.0159
Echinococcus multilocularis protein jagged 1 0.0016 0.0072 0.0081
Echinococcus granulosus neural cadherin 0.0016 0.0072 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Onchocerca volvulus Slit protein homolog 0.0016 0.0072 0.0072
Trypanosoma brucei histone deacetylase 3 0.0018 0.011 0.0159
Toxoplasma gondii calcium binding egf domain-containing protein 0.0041 0.0597 0.4213
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0373 0.0373
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.1101 0.123
Loa Loa (eye worm) hypothetical protein 0.0497 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0172 0.0658
Echinococcus multilocularis lamin dm0 0.003 0.0373 0.0416
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0172 0.0658
Brugia malayi intermediate filament protein 0.003 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0146 0.2762 0.2761
Echinococcus multilocularis notch 0.0016 0.0072 0.0081
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0025 0.0258 0.0288
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.1017 0.7546
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0736 0.5259
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0172 0.0872
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1318 1
Schistosoma mansoni notch 0.0016 0.0072 0.0081
Loa Loa (eye worm) intermediate filament protein 0.003 0.0373 0.0372
Brugia malayi Carboxylesterase family protein 0.0025 0.0258 0.0258
Brugia malayi Histone deacetylase 1 0.0061 0.1017 0.1017
Onchocerca volvulus Arrow homolog 0.0041 0.0597 0.0597
Echinococcus granulosus lamin dm0 0.003 0.0373 0.0416
Echinococcus granulosus histone deacetylase 0.0018 0.011 0.0123
Echinococcus multilocularis para nitrobenzyl esterase 0.0025 0.0258 0.0288
Echinococcus granulosus neurogenic locus notch protein 0.0016 0.0072 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Schistosoma mansoni histone deacetylase 0.0061 0.1017 0.1136
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.2253 0.2232
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.1318 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.1101 0.1101
Trypanosoma brucei trypanothione reductase 0.0048 0.0736 0.5259
Loa Loa (eye worm) hypothetical protein 0.0146 0.2762 0.2761
Brugia malayi Carboxylesterase family protein 0.0025 0.0258 0.0258
Echinococcus multilocularis neurogenic locus notch protein 0.0016 0.0072 0.0081
Echinococcus granulosus notch 0.0016 0.0072 0.0081
Brugia malayi EGF-like domain containing protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Entamoeba histolytica histone deacetylase, putative 0.0061 0.1017 1
Brugia malayi beta-lactamase family protein 0.0076 0.1318 0.1318
Schistosoma mansoni notch 0.0016 0.0072 0.0081
Toxoplasma gondii ABC1 family protein 0.0076 0.1318 1
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.011 0.0159
Echinococcus granulosus BC026374 protein S09 family 0.0025 0.0258 0.0288
Schistosoma mansoni lamin 0.003 0.0373 0.0416
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0072 0.1227 0.1227
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0237 1
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0936 0.1046
Loa Loa (eye worm) notch protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1119 0.125
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0807 0.0807
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.2001 0.1973
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0081
Loa Loa (eye worm) carboxylesterase 0.0025 0.0258 0.0257
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0433 0.0433
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0172 0.0171
Echinococcus multilocularis neurogenic locus protein delta 0.0016 0.0072 0.0081
Echinococcus multilocularis acetylcholinesterase 0.0146 0.2762 0.3086
Plasmodium vivax glutathione reductase, putative 0.0048 0.0736 0.5259
Brugia malayi hypothetical protein 0.0025 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0807 0.0902
Echinococcus multilocularis neurogenic locus protein delta 0.0016 0.0072 0.0081
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0083 0.0083
Brugia malayi beta-lactamase family protein 0.0076 0.1318 0.1318
Brugia malayi Muscle positioning protein 4 0.0016 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0081
Loa Loa (eye worm) hypothetical protein 0.0497 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0807 0.0902
Loa Loa (eye worm) histone deacetylase 3 0.0061 0.1017 0.1017
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0172 0.0191
Trypanosoma brucei histone deacetylase 2 0.0018 0.011 0.0159
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0936 0.1046
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0807 0.0807
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.1318 0.1472
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0038
Loa Loa (eye worm) glutathione reductase 0.0048 0.0736 0.0736
Brugia malayi GCC2 and GCC3 family protein 0.0016 0.0072 0.0072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0807 0.0902
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0936 0.1046
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0025 0.0258 0.0172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0807 0.0902
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.1318 1
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.1318 1
Onchocerca volvulus 0.0025 0.0258 0.0257
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1326 0.1482
Brugia malayi histone deacetylase 1 (HD1) 0.0061 0.1017 0.1017
Schistosoma mansoni neuroligin 3 (S09 family) 0.0025 0.0258 0.0288
Loa Loa (eye worm) MBCTL1 0.0066 0.1101 0.1101
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.1017 0.7546
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0237 0.1322
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.2253 0.2232
Plasmodium falciparum histone deacetylase, putative 0.0018 0.011 0.0211
Brugia malayi EGF-like domain containing protein 0.0016 0.0072 0.0072
Onchocerca volvulus 0.0031 0.0395 0.0394
Echinococcus granulosus cpg binding protein 0.0033 0.0431 0.0482
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.1318 0.1267
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.2001 0.8753
Toxoplasma gondii histone deacetylase HDAC3 0.0061 0.1017 0.7583
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.2001 0.1973
Brugia malayi histone deacetylase 11 0.0018 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0258 0.0257
Brugia malayi beta-lactamase 0.0076 0.1318 0.1318
Echinococcus multilocularis histone deacetylase 6 0.0018 0.011 0.0123
Brugia malayi Carboxylesterase family protein 0.0025 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) histone deacetylase 1 0.0061 0.1017 0.1017
Loa Loa (eye worm) hypothetical protein 0.0058 0.0936 0.0936
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0172 0.5527
Onchocerca volvulus 0.0076 0.1318 0.1318
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.1227 0.1227
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.1318 0.1267
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0025 0.0258 0.0257
Schistosoma mansoni notch 0.0016 0.0072 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Toxoplasma gondii exonuclease III APE 0.0021 0.0172 0.0797
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0016 0.0072 0.0072
Plasmodium falciparum thioredoxin reductase 0.0048 0.0736 0.6969
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0172 0.0658
Echinococcus granulosus geminin 0.0205 0.3968 0.4434
Echinococcus granulosus Tolloid protein 1 0.0041 0.0597 0.0667
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.1318 0.1267
Schistosoma mansoni histone deacetylase 0.0061 0.1017 0.1136
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0736 0.5259
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.8949 1
Echinococcus granulosus GPCR family 2 0.0033 0.0433 0.0483
Echinococcus granulosus tar DNA binding protein 0.0076 0.1326 0.1482
Brugia malayi EGF-like domain containing protein 0.0016 0.0072 0.0072
Echinococcus granulosus neurogenic locus notch protein 0.0016 0.0072 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0433 0.0483
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0936 0.1046
Loa Loa (eye worm) carboxylesterase 0.0146 0.2762 0.2761
Schistosoma mansoni hypothetical protein 0.0205 0.3968 0.4434
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.2253 0.2232
Leishmania major trypanothione reductase 0.0048 0.0736 0.5259
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.1318 0.1318
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0936 0.1046
Leishmania major hypothetical protein, conserved 0.0076 0.1318 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.1326 0.1326
Onchocerca volvulus Histone deacetylase 10 homolog 0.0018 0.011 0.011
Brugia malayi EGF-like domain containing protein 0.0016 0.0072 0.0072
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.1017 0.7546
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0361 0.0361
Echinococcus granulosus protein jagged 2 0.0016 0.0072 0.0081
Toxoplasma gondii calcium binding egf domain-containing protein 0.0041 0.0597 0.4213
Brugia malayi Histone deacetylase family protein 0.0018 0.011 0.011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1911 0.1911
Echinococcus multilocularis musashi 0.003 0.0373 0.0416
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.1017 0.7546
Brugia malayi EGF-like domain containing protein 0.0016 0.0072 0.0072
Schistosoma mansoni cpg binding protein 0.0033 0.0431 0.0482
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.2001 0.1973
Mycobacterium ulcerans carboxylesterase, LipT 0.0025 0.0258 0.136
Brugia malayi RNA binding protein 0.0076 0.1326 0.1326
Loa Loa (eye worm) hypothetical protein 0.003 0.0373 0.0372
Trichomonas vaginalis spcc417.12 protein, putative 0.0025 0.0258 0.136
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0936 0.0936
Echinococcus granulosus protein jagged 2 0.0016 0.0072 0.0081
Schistosoma mansoni septate junction protein 0.0016 0.0072 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0807 0.0902
Echinococcus granulosus protein jagged 1 0.0016 0.0072 0.0081
Echinococcus multilocularis protein jagged 2 0.0016 0.0072 0.0081
Mycobacterium ulcerans beta-lactamase 0.0076 0.1318 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0172 0.0658
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0807 0.0902
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1326 0.1482
Trypanosoma cruzi histone deacetylase 1, putative 0.0061 0.1017 0.7546
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0091 0.0148
Loa Loa (eye worm) carboxylesterase 0.0025 0.0258 0.0257
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.2253 1
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0081
Echinococcus multilocularis Protein lozenge 0.0062 0.1035 0.1156
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0172 0.5527
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0172 0.0658
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.1318 0.1472
Schistosoma mansoni notch 0.0016 0.0072 0.0081
Echinococcus multilocularis neuroligin 0.0025 0.0258 0.0288
Onchocerca volvulus 0.0016 0.0072 0.0072
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0016 0.0072 0.0072
Onchocerca volvulus 0.0016 0.0072 0.0072
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0237 0.1322
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1326 0.1326
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0091 0.0101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0395 0.0394
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0486 0.9775 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0041 0.0597 0.0597
Onchocerca volvulus 0.0076 0.1318 0.1318
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0258 0.0288
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1326 0.1482
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.011 0.0159
Onchocerca volvulus 0.0084 0.1485 0.1485
Schistosoma mansoni acetylcholinesterase 0.0025 0.0258 0.0288
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.1318 0.1267
Loa Loa (eye worm) hypothetical protein 0.0041 0.0597 0.0597
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0072 0.0072
Echinococcus multilocularis fat cadherin tumor suppressor 0.0016 0.0072 0.0081
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1326 0.1482
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0231 0.4515 0.5045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.1318 0.1472
Brugia malayi Thioredoxin reductase 0.0048 0.0736 0.0736
Echinococcus multilocularis lamin 0.003 0.0373 0.0416
Echinococcus multilocularis histone deacetylase 6 0.0018 0.011 0.0123
Loa Loa (eye worm) hypothetical protein 0.0076 0.1318 0.1318
Brugia malayi histone deacetylase 3 (HD3) 0.0061 0.1017 0.1017
Onchocerca volvulus 0.0016 0.0072 0.0072
Toxoplasma gondii histone deacetylase HDAC4 0.0018 0.011 0.0305
Mycobacterium ulcerans hypothetical protein 0.0076 0.1318 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0433 0.0433
Schistosoma mansoni laminin gamma-3 chain 0.0016 0.0072 0.0081
Schistosoma mansoni egf-like domain protein 0.0041 0.0597 0.0667
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.1101 0.123
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.1485 0.1485
Onchocerca volvulus 0.0025 0.0258 0.0257
Trypanosoma brucei histone deacetylase, putative 0.0018 0.011 0.0159
Onchocerca volvulus 0.0058 0.0936 0.0936
Plasmodium vivax histone deacetylase 2, putative 0.0018 0.011 0.0159
Echinococcus granulosus histone deacetylase 8 0.0018 0.011 0.0123
Onchocerca volvulus 0.0025 0.0258 0.0257
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0146 0.2762 0.3086
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0041 0.0597 0.0597
Echinococcus multilocularis neurogenic locus notch protein 0.0016 0.0072 0.0081
Onchocerca volvulus 0.0025 0.0258 0.0257
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0072
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0072 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.1318 1
Echinococcus granulosus intermediate filament protein 0.003 0.0373 0.0416
Loa Loa (eye worm) histone deacetylase 11 0.0018 0.011 0.011
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.011 0.0159
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.005 0.0055
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0061 0.1017 0.7546
Loa Loa (eye worm) hypothetical protein 0.0061 0.1017 0.1017
Mycobacterium tuberculosis Conserved protein 0.0076 0.1318 0.1267
Echinococcus multilocularis neural cadherin 0.0016 0.0072 0.0081
Brugia malayi Carboxylesterase family protein 0.0146 0.2762 0.2762
Brugia malayi glutathione reductase 0.0048 0.0736 0.0736
Brugia malayi Calcium binding EGF domain containing protein 0.0041 0.0597 0.0597
Loa Loa (eye worm) histone deacetylase 0.0018 0.011 0.011
Brugia malayi Carboxylesterase family protein 0.0025 0.0258 0.0258
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0936 0.1046
Echinococcus granulosus histone deacetylase 1 0.0061 0.1017 0.1136
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.1318 0.1318
Echinococcus granulosus delta-like protein 1 0.0016 0.0072 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1326 0.1482
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0025 0.0258 0.0172
Schistosoma mansoni notch 0.0016 0.0072 0.0081
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.005 0.0055
Echinococcus granulosus neurogenic locus notch protein 4 0.0016 0.0072 0.0081
Schistosoma mansoni hypothetical protein 0.0446 0.8949 1
Brugia malayi Carboxylesterase family protein 0.0146 0.2762 0.2762

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2593 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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