Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | Bloom syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0574 | 0.4422 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0037 | 0.1298 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0043 | 0.1642 | 0.1642 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0574 | 0.0841 |
Brugia malayi | hypothetical protein | 0.003 | 0.098 | 0.3073 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0023 | 0.0574 | 0.0469 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0048 | 0.1895 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0574 | 0.4422 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0055 | 0.2239 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.098 | 0.0545 |
Echinococcus multilocularis | bloom syndrome protein | 0.0055 | 0.2239 | 0.2152 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0055 | 0.2239 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0055 | 0.2239 | 0.2235 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0055 | 0.2239 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0055 | 0.2239 | 0.2152 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.8024 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0037 | 0.1321 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0029 | 0.0918 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0023 | 0.0574 | 0.0469 |
Schistosoma mansoni | DNA helicase recq1 | 0.0023 | 0.0574 | 0.0574 |
Schistosoma mansoni | DNA helicase recq5 | 0.0023 | 0.0574 | 0.0574 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.098 | 0.7548 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.098 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0023 | 0.0574 | 0.0469 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.098 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.098 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.098 | 0.3072 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0023 | 0.0574 | 0.0469 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.0574 | 0.0841 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.011 | 0.011 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0023 | 0.0574 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.098 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.098 | 0.3072 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5849 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.1821 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.1821 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 75.6863 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.