Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.4517 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.006 | 0.006 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0537 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1664 | 0.1664 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1664 | 0.097 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1664 | 0.3683 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1845 | 0.4427 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.035 | 0.035 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.2076 | 0.1417 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4168 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4168 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3205 | 0.3205 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5245 | 0.5245 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3205 | 0.3205 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0537 | 0.1287 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0247 | 0.0592 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1845 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2501 | 0.2501 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2314 | 0.2314 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.035 | 0.0774 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0247 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2083 | 0.2083 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3205 | 0.264 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0247 | 0.0592 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.5663 | 0.5302 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3205 | 0.264 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0537 | 0.1188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.