Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 0.0638 | 0.0702 |
Loa Loa (eye worm) | hypothetical protein | 0.3332 | 0.9091 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0709 | 0.1084 | 0.1192 |
Echinococcus granulosus | acetylcholinesterase | 0.3332 | 0.9091 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 0.0638 | 0.0702 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 0.0638 | 0.0702 |
Onchocerca volvulus | 0.0563 | 0.0638 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 0.0638 | 0.0702 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0563 | 0.0638 | 0.5 |
Onchocerca volvulus | 0.0563 | 0.0638 | 0.5 | |
Onchocerca volvulus | 0.0563 | 0.0638 | 0.5 | |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.1675 | 0.4032 | 0.4016 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3332 | 0.9091 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.363 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.3332 | 0.9091 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3332 | 0.9091 | 1 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0611 | 0.0784 | 0.0172 |
Loa Loa (eye worm) | carboxylesterase | 0.0563 | 0.0638 | 0.0702 |
Onchocerca volvulus | 0.0563 | 0.0638 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 0.0638 | 0.0702 |
Echinococcus granulosus | carboxylesterase 5A | 0.3332 | 0.9091 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 0.0638 | 0.0702 |
Onchocerca volvulus | 0.0563 | 0.0638 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.3332 | 0.9091 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3332 | 0.9091 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.3375 | 0.922 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 0.0638 | 0.0702 |
Brugia malayi | Carboxylesterase family protein | 0.3332 | 0.9091 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3332 | 0.9091 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3332 | 0.9091 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0563 | 0.0638 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3332 | 0.9091 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3332 | 0.9091 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.132 | 0.2948 | 0.3243 |
Loa Loa (eye worm) | carboxylesterase | 0.0563 | 0.0638 | 0.0702 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5012 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 0.7667 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.