Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1094 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1177 | 0.0283 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3192 | 0.7159 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3192 | 0.7159 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3192 | 0.7159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3172 | 0.7089 | 0.9861 |
Echinococcus granulosus | acetylcholinesterase | 0.3192 | 0.7159 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.3192 | 0.7159 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3192 | 0.7159 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3192 | 0.7159 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3192 | 0.7159 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.3192 | 0.7159 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1177 | 0.0283 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3192 | 0.7159 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3192 | 0.7159 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2140, AID2686] | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2135, AID2682] | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | PUBCHEM_BIOASSAY: SAR Selectivity Analysis of small molecule inhibitors of PEST using pCAP in a fluorescence assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2135] | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2135, AID449727] | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit HePTP - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1059, AID1077, AID1784, AID2085, AID521] | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2140, AID449726, AID488869] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.